[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aphasia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aphasia":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,50,0,25,[9,51,82,106,131,152,177,206,234,256,274,296,319,352,376,407,455,480,503,527,549,574,594,618,641],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":21,"enrollmentInfo":22,"targetDuration":4,"studyType":25,"phases":26,"briefSummary":28,"conditions":29,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100592251","effects-of-aphasia-identification-cards-on-service-workers-comprehension-of-people-with-aphasia-100592251",false,"NCT06990997","Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia","Effects of Aphasia Identification Cards on Comprehension of Aphasic Language by Unfamiliar Communication Partners","PAUSE","Inclusion Criteria:\n\n* Adult age 18-59\n* Currently employed as a service worker\n* Understand spoken and written English well\n* High school diploma or equivalency\n* Normal vision or corrected vision with glasses or contact lenses\n\nExclusion Criteria:\n\n* Language disorder\n* Hearing impairment\n* Intellectual disability\n* History of acquired neurological disorder (e.g., stroke or moderate\u002Fsevere brain injury)",true,"ALL","18 Years","59 Years",{"count":23,"type":24},160,"ESTIMATED","INTERVENTIONAL",[27],"NA","The goal of this clinical trial is to learn whether healthy volunteers are more successful at understanding people with aphasia if they have first viewed an aphasia identification (ID) card. The main questions this study aims to answer are:\n\n* Does viewing an aphasia ID card improve healthy volunteers' understanding of the language errors made by people with aphasia?\n* Does viewing an aphasia ID card improve healthy volunteers' understanding of people with aphasia who make long pauses in their speech?\n\nResearchers will compare aphasia ID cards to a control condition (no ID card) to see whether aphasia ID cards improve healthy volunteers' understanding.\n\nHealthy volunteers will visit the study site for a single session (about 2 hours long). During the session they will:\n\n* Complete brief tests of their vision, hearing and thinking\n* Listen to sentences produced by a speaker with aphasia while their eye movements are recorded\n* Complete a survey about the experience of listening to the speaker with aphasia",[30],"Aphasia",[30,32,33,34,35,36,37],"Communication partner","Service worker","Language processing","Language comprehension","aphasia identification card","eye-tracking","RECRUITING","2026-08-11",{"date":41,"type":42},"2026-08-14","ACTUAL",{"date":44,"type":42},"2025-09-22",{"date":46,"type":24},"2027-02-28",{"name":48,"class":49},"University of Massachusetts, Amherst","OTHER",1,{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":25,"phases":61,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":50},"100532474","combined-exercise-and-targeted-therapy-for-post-stroke-reading-deficits-100532474","NCT06213272","Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits","Improving Reading Competence in Aphasia With Combined Aerobic Exercise and Phono-Motor Treatment","Inclusion Criteria:\n\n* fluent and literate in English prior to stroke\n* 1st ever stroke\n* more than 3 months post-stroke\n* post-stroke reading deficits, defined as reading aloud accuracy \\\u003C83% for single words or \\\u003C65% for readable nonwords\n* living within a 50-mile radius from Kessler Foundation.\n\nExclusion Criteria:\n\n* contraindication to MRI\n* prior neurological disease\n* developmental learning or reading disability (i.e., developmental dyslexia)\n* contraindication to exercise\n* concurrent speech and language therapy","85 Years",{"count":60,"type":24},70,[27],"The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment. This approach is expected to increase cerebral circulation and help to rebuild and strengthen the damaged phonological neural networks. Through this combinatory approach, the study aims to enhance the reading and language improvements seen with existing treatments.",[64,30,65],"Stroke","Reading Disorder",[67,68,69,70,71,72,73],"exercise","stroke","aphasia","reading therapy","phono-motor therapy","aerobic exercise treatment","MRI",{"date":75,"type":42},"2026-08-13",{"date":77,"type":42},"2024-04-18",{"date":79,"type":24},"2029-03-01",{"name":81,"class":49},"Kessler Foundation",{"id":83,"slug":84,"hasResults":12,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":25,"phases":91,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":50},"100587572","effect-of-anomia-rehabilitation-combined-with-metacognitive-training-in-patients-with-chronic-vascular-aphasia-100587572","NCT06930131","Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia","METALEX","Inclusion Criteria:\n\n* First cerebral infarction\n* Chronic phase (\\> 3 months)\n* Patient affiliated to a health insurance scheme\n* Usual french language\n* Severity score measures using the Boston Diagnostic Aphasia Examination battery scale corresponding to the mild or moderate level (score greater than or equal to 2)\n\nExclusion Criteria:\n\n* Contraindication to undergoing brain MRI\n* Cognitive impairment pre-existing stroke (CQI code \\> 3.4) (Law et al., 1995)\n* Chronic alcohol or drug abuse\n* Unstabilised psychiatric illness\n* Uncorrected sensory deficits\n* Diagnosed as having a progressive general pathology",{"count":90,"type":24},18,[27],"The postulate of this study is that rehabilitation combining linguistic and metacognitive training will result in a significant improvement in language performance correlated with changes in functional cerebral connectivity networks. In addition, it could potentiate the generalisation of effects to verbal and non-verbal communication skills, having a direct impact on patients' quality of life. This research is a prospective, randomized controlled, open-label, single-centre study. It is part of the management of patients with aphasia who have suffered a cerebral infarction and aims to evaluate the effect of combined language semantics\u002Fmetacognition rehabilitation.",[30,64],[30,64,95,96,97],"Chronic","Cognitive rehabilitation","SCED","2026-08-10",{"date":39,"type":42},{"date":101,"type":42},"2025-02-21",{"date":103,"type":24},"2027-12",{"name":105,"class":49},"University Hospital, Toulouse",{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":58,"enrollmentInfo":113,"targetDuration":4,"studyType":25,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":50},"100391341","transcranial-alternating-current-stimulation-tacs-in-aphasia-100391341","NCT04375722","Transcranial Alternating Current Stimulation (tACS) in Aphasia","Exogenous Tuning of Neural Oscillations as a Mode of Treatment in Post-stroke Aphasia","Inclusion Criteria:\n\nHealthy Controls\n\n* 18 years of age or older\n* Fluent in English\n* No history of neurological or psychiatric disorders\n\nStroke Patients\n\n* Diagnosed with post-stroke aphasia by referring physician\u002Fneuropsychologist\n* Consent date \\>=1 months after stroke onset\n* Right-handed\n* Fluent in English\n* 18 years of age or older\n\nExclusion Criteria:\n\n* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing\n* Presence of major untreated or unstable psychiatric disease\n* A chronic medical condition that is not treated or is unstable\n* The presence of cardiac stimulators or pacemakers\n* Any metal implants in the skull\n* Contraindications to MRI or tACS\n* History of seizures\n* History of dyslexia or other developmental learning disabilities",{"count":5,"type":24},[27],"This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.",[30,64],[118,119,120,121],"language","language impairment","transcranial alternating current stimulation","tACS","2026-07-28",{"date":124,"type":42},"2026-07-29",{"date":126,"type":42},"2020-01-04",{"date":128,"type":24},"2030-12",{"name":130,"class":49},"Medical College of Wisconsin",{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":18,"sex":19,"minAge":137,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":25,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":149,"locationsCount":151},"100419528","neural-bases-of-vocal-sensorimotor-impairment-in-aphasia-100419528","NCT04742894","Neural Bases of Vocal Sensorimotor Impairment in Aphasia","Inclusion Criteria:\n\n* A total of 50 individuals with aphasia due to chronic left hemisphere stroke (\\> 6 months post-stroke) and 50 age- and gender-matched healthy control subjects will be recruited in this study. The general inclusion criteria for all subjects include: age range 21-75 years, right-handed, and native speaker of English. The aphasic subjects have previously undergone neuro-psychological speech\u002Flanguage testing and have been diagnosed with one type of aphasia (e.g., Broca's, Wernicke's, conduction or anomic). Subjects in the control group will meet the inclusion criteria with having normal voice, speech, language, and hearing function and no history of neurological and psychiatric disorder. We expect that a significant proportion of aphasic patients will show symptoms associated with Apraxia of Speech (AOS) or dysarthria; however, these patients will not be excluded unless their deficits will preclude them from performing the experimental tasks.\n\nExclusion Criteria:\n\n* Subjects with moderate to severe hearing, memory, and\u002For cognitive impairments will be excluded for both groups. In addition, subjects with history of peripheral laryngeal disorders (e.g., paresis or vocal fold paralysis) will be excluded. Subjects will undergo safety screening and will be excluded if there are any factors counter-indicative for EEG and\u002For MRI scanning.","21 Years","75 Years",{"count":140,"type":24},100,[27],"Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.",[30],"2026-07-24",{"date":122,"type":42},{"date":147,"type":42},"2021-07-11",{"date":46,"type":24},{"name":150,"class":49},"The University of Texas at Dallas",3,{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":25,"phases":162,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":168,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":174,"locationsCount":176},"100649179","listen-aphasia-pilot-study-100649179","NCT07732140","Listen Aphasia Pilot Study","LISTEN: Supporting Communication in Patients With Tumor-Related Aphasia","LISTEN","Inclusion Criteria:\n\nPatient inclusion criteria are as follows:\n\n* A histologically or cytologically confirmed primary or secondary brain tumor with expected ongoing deterioration in language as determined by their oncologist\n* Mild-to-moderate aphasia or other acquired communication disorder as determined by their oncologist or speech-language pathologist\n* ECOG Performance Status of ≤2 or Karnofsky Performance Status ≥60\n* Expected overall survival of \\>6 months\n* Ability to understand and the willingness to sign a written consent form\n* Age ≥18 years\n* Willingness to participate in study interviews and be recorded for the study (for monitoring of study fidelity)\n* Cancer survivors will also be included\n\nCare-partner inclusion criteria are as follows:\n\n* Identified by their patient as someone who is integral to their care\n* Age ≥18 years\n* Ability to understand and the willingness to sign a written consent form\n* Willingness to participate in study interviews and be recorded for the study (monitoring of study fidelity)\n\nExclusion Criteria:\n\nPatient exclusion criteria are as follows:\n\n* Unable to read or respond to questions in English\n* Severe dysarthria as determined by their oncologist\n* Aphasia that is moderate-to-sever enough that the patient cannot consent without a proxy\n* Expected survival of ≤ 6 months\n* Severe cognitive impairment as determined by their oncologist\n\nCare-partner exclusion criteria are as follows:\n\n-Unable to read or respond to questions in English",{"count":161,"type":24},80,[27],"This is a feasibility and pilot study to refine and test LISTEN, an AI-based augmentative and alternative communication (AAC) smartphone app, integrated into the patient's personal electronic device, to augment and facilitate communication in patients with tumor-related aphasia (TRA) and their care partners. The study will assess the feasibility and acceptability of LISTEN in patients with TRA and their care partners.",[30,165],"Malignant Brain Tumor",[167,165],"Tumor-Related Aphasia (TRA)","NOT_YET_RECRUITING","2026-07-23",{"date":122,"type":42},{"date":172,"type":24},"2027-01",{"date":128,"type":24},{"name":175,"class":49},"Dana-Farber Cancer Institute",2,{"id":178,"slug":179,"hasResults":12,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":19,"minAge":185,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":25,"phases":189,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":151},"100645801","phase-2-superiority-trial-of-aphasia-focused-rehabilitation-with-tdcs-stimulation-100645801","NCT07688551","Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation","Transcranial Direct Current Stimulation to Treat Aphasia: A Superiority Study","STARS","Inclusion Criteria:\n\n* Be willing and able to give informed consent.\n* Be willing and able to comply with study requirements.\n* Be between 25 and 80 years of age.\n* Have used English as the primary language for \\> 15 years.\n* Have the diagnosis of aphasia due to a left hemisphere stroke, confirmed by study physician based on past clinical MRI scan or research scan.\n* Be greater than 6 months post-stroke.\n* Have Broca's aphasia diagnosed by the WAB-R (fluency score ≤ 5, auditory verbal comprehension score 4-10, repetition score 0-7.9, naming and word finding score \\\u003C 9).\n* Correctly name 140 or fewer items on the PNT.\n\nExclusion Criteria:\n\n* History of brain surgery except for during the treatment of the acute stroke.\n* Seizures during the previous 12-months.\n* Compromised skin at or near electrode sites (e.g., rash, eczema, wounds, infection).\n* Correctly name more than 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test).\n* Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) score of 25 or below.\n* Participants with open skull defects (e.g., greater than 1 cm) in the area underneath the anode electrode positioning or participants with metal implants or electrical stimulators.\n* Participants with continuous oxygen therapy which cannot be discontinued for more than 1 hour.\n* Any condition or situation that the PI determines would significantly interfere with the participant's ability to complete the study.","25 Years","80 Years",{"count":188,"type":24},130,[190,191],"PHASE2","PHASE3","The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia and is more effective than Speech Therapy alone.",[30,194],"Broca's Aphasia",[196,183,30,64],"tDCS","2026-07-20",{"date":199,"type":42},"2026-07-21",{"date":201,"type":42},"2026-07-14",{"date":203,"type":24},"2030-06",{"name":205,"class":49},"University of South Carolina",{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":213,"enrollmentInfo":214,"targetDuration":4,"studyType":25,"phases":216,"briefSummary":217,"conditions":218,"keywords":219,"overallStatus":168,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":50},"100644757","effects-of-semantic-context-on-criterion-learning-naming-treatment-in-aphasia-100644757","NCT07673198","Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia","Word Retrieval in Aphasia","Inclusion Criteria:\n\n* English as a native or primary language\n* Adults with stroke who are at least 6 months post-onset\n\nExclusion Criteria:\n\n* History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease\n* History of a learning disability that significantly impacted language development, such as developmental language disorder\n* Insufficient stamina to participate in the protocol","89 Years",{"count":215,"type":24},12,[27],"Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today. A common problem in aphasia involves difficulty retrieving known words in the course of language production and comprehension. The overarching goal of this project is to develop and test early efficacy, efficiency, and the tolerability of a lexical treatment for aphasia in multiple-session regimens that are comprised of retrieval practice, distributed practice, and training dedicated to the elicitation of correct retrievals. The aim of this work is to add to and refine the evidence base for the implementation and optimization of these elements in the treatment of production and comprehension deficits in aphasia, and make important steps towards an ultimate goal of self-administered lexical treatment grounded in retrieval practice principles (RPP) to supplement traditional speech-language therapy that is appropriate for People with Aphasia (PWA) from a broad level of severity of lexical processing deficit in naming and\u002For comprehension. This project cumulatively builds on prior work to develop a theory of learning for lexical processing impairment in aphasia that aims to ultimately explain why and for whom familiar lexical treatments work, and how to maximize the benefits they confer.",[30],[220,221,222,223,224],"anomia","retrieval practice","word-finding problem","communication disorder","naming impairment","2026-07-10",{"date":227,"type":42},"2026-07-13",{"date":229,"type":24},"2026-08",{"date":231,"type":24},"2028-08",{"name":233,"class":49},"Albert Einstein Healthcare Network",{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":25,"phases":243,"briefSummary":244,"conditions":245,"keywords":247,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":50},"100590965","post-stroke-aphasia-tms-100590965","NCT06974279","Post-Stroke Aphasia TMS","Precision Neuromodulation in Post-Stroke Aphasia Using TMS","TaMS","Inclusion Criteria:\n\n* Diagnosed with left hemisphere stroke\n* Consent date \\>= 1 month after stroke onset\n* Fluent in English\n* 18 years of age or older\n\nExclusion Criteria:\n\n* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing\n* Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)\n* A chronic medical condition that is not treated or is unstable\n* The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e.g., cochlear implants) or in the eye, metal in the body (e.g., splinters, fragments, clips)\n* Pregnancy\n* History of skull fractures, or skin diseases\n* History of ongoing or unmanaged seizures\n* Presence of factors that potentially decrease seizure thresholds: on pro-convulsant medications, untreated sleep deprivation or insomnia, ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)\n* History of dyslexia or other developmental learning disabilities",{"count":5,"type":24},[27],"The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).",[30,64,246],"Language",[30,64,246,248],"TMS","2026-07-09",{"date":225,"type":42},{"date":252,"type":42},"2025-09-01",{"date":254,"type":24},"2036-12-31",{"name":130,"class":49},{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":25,"phases":265,"briefSummary":266,"conditions":267,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":268,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":50},"100519792","transcranial-alternating-current-stimulation-tacs-for-the-recovery-of-phonological-short-term-memory-in-patients-with-aphasia-after-stroke-100519792","NCT06048159","Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke","TACS for the Recovery of Phonological STM After Stroke","Inclusion Criteria:\n\n* Diagnosed with left hemisphere stroke\u002Faphasia\n* Consent date \\>= 1 month after stroke onset\n* Fluent in English\n* 18 years of age or older\n\nExclusion Criteria:\n\n* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing\n* Presence of major untreated or unstable psychiatric disease\n* A chronic medical condition that is not treated or is unstable\n* The presence of cardiac stimulators or pacemakers\n* Contraindications to MRI or tACS, e.g. patients with metallic implants, and\u002For history of skull fractures, pregnancy, skin diseases\n* History of ongoing or unmanaged seizures\n* History of dyslexia or other developmental learning disabilities",{"count":264,"type":24},120,[27],"This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.",[64,30],{"date":225,"type":42},{"date":270,"type":42},"2023-11-06",{"date":272,"type":24},"2033-01",{"name":130,"class":49},{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":58,"enrollmentInfo":281,"targetDuration":4,"studyType":25,"phases":283,"briefSummary":284,"conditions":285,"keywords":286,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":290,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":50},"100471956","language-processing-and-tms-100471956","NCT05425615","Language Processing and TMS","Probing Language Processes Using Transcranial Magnetic Stimulation","Inclusion Criteria:\n\n* Diagnosed with left hemisphere stroke\n* Consent date \\>= 1 month after stroke onset\n* Right-handed\n* Fluent in English\n* 18 years of age or older\n\nExclusion Criteria:\n\n* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing\n* Non-decisional per decisionality questionnaire or other clinical assessment\n* Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)\n* A chronic medical condition that is not treated or is unstable\n* Presence of\n\n  1. cardiac stimulators or pacemakers or intracardiac lines\n  2. neurostimulators\n  3. medication infusion device\n  4. any other implants near the scalp (e.g., cochlear implants) or in the eye\n  5. metal in the body\n* Pregnancy\n* History of skull fractures, or skin diseases\n* History of ongoing or unmanaged seizures or a family history of epilepsy\n* Presence of factors that potentially decrease seizure thresholds\n* On pro-convulsant medications\n* Untreated Sleep deprivation or insomnia\n* Ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)\n* History of dyslexia or other developmental learning disabilities",{"count":282,"type":24},135,[27],"This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.",[64,30,246],[248,287,30,288,289],"Transcranial Magnetic Stimulation","Semantic processing","Phonological processing",{"date":227,"type":42},{"date":292,"type":42},"2024-06-05",{"date":294,"type":24},"2032-06",{"name":130,"class":49},{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":12,"sex":19,"minAge":303,"maxAge":304,"enrollmentInfo":305,"targetDuration":4,"studyType":25,"phases":307,"briefSummary":308,"conditions":309,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":50},"100552287","neuroplasticity-biomarkers-in-aphasia-100552287","NCT06471127","Neuroplasticity Biomarkers in Aphasia","Genetic and MRI Biomarkers of Neuroplasticity Predict Aphasia Recovery and Phenotypes","Inclusion Criteria:\n\n1. Ages 40-90\n2. Right-handed (prior to stroke)\n3. Proficient English speakers\n4. History of a single ischemic stroke in the middle cerebral artery territory that is lateralized to the left or right (Aim 1) cerebral hemisphere.\n5. Presence of aphasia (Aims 2-3)\n6. Capacity to understand the nature of the study and provide informed consent\n7. Acute or subacute stroke at the time of Aim 1 enrollment; Stroke #12 months old (chronic) at the time of Aims 2-3 enrollment\n8. Medically stable\n\nExclusion Criteria:\n\n1. History of significant medical or neurological disorder (other than stroke)\n2. History of significant or poorly controlled psychiatric disorders\n3. Current abuse of alcohol or drugs, prescription or otherwise\n4. Clinically significant and uncorrected vision or hearing loss\n5. Anything other than standard of care stroke treatment such as Plavix, aspirin (81-300 mg daily), beta-blockers, diabetes medications or choles- terol-lowering agents, thrombolytics (e.g., tPA), anticoagulation agents such as Heparin, Warfarin\u002FCoumadin","40 Years","90 Years",{"count":306,"type":24},90,[27],"Patients with stroke frequently suffer from aphasia, a disorder of expressive and\u002For receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized brain networks and a molecular level of neuronal repair and plasticity. The proposed work will evaluate genetic and neural network biological markers of neuroplasticity associated with variability in aphasia, with a future goal to improve prognostics and identify therapeutic targets to reduce the long-term burdens of aphasia.",[30,246,64],"2026-07-06",{"date":312,"type":42},"2026-07-07",{"date":314,"type":42},"2025-03-17",{"date":316,"type":24},"2029-05-31",{"name":318,"class":49},"University of Wisconsin, Madison",{"id":320,"slug":321,"hasResults":12,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":4,"eligibilityCriteria":325,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":213,"enrollmentInfo":326,"targetDuration":4,"studyType":25,"phases":328,"briefSummary":329,"conditions":330,"keywords":340,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":50},"100595742","phase-2-comparing-traditional-semantic-feature-analysis-tsfa-and-semantic-feature-analysis--metacognitive-strategy-training-sfamst-100595742","NCT07036406","Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)","Comparing the Effectiveness of Traditional Semantic Feature Analysis (SFA) Versus SFA Plus Metacognitive Strategy Training (SFA+MST) for People With Acquired Aphasia","Inclusion Criteria:\n\n* Have aphasia due to a single acute event (e.g., left-hemisphere stroke, traumatic brain injury)\n* Be at least six-months post aphasia-onset,\n* Be a proficient English speaker,\n* Have normal or corrected to normal hearing (i.e., hearing aids) and vision (i.e., eyeglasses),\n* Have no history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems\n\nExclusion Criteria:\n\n* A history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems,\n* Children under the age of 18,\n* Adults over the age of 89,\n* Uncorrected hearing and vision.",{"count":327,"type":24},40,[190],"The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired aphasia. The main questions it aims to answer are:\n\n* What are the comparative outcomes in picture naming accuracy and strategy use during picture naming following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n* What are the comparative outcomes in percent of informative content and rate of informative content during spontaneous speech production following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n\nResearchers will compare outcomes between these two treatments to see if SFA+MST yields larger effects in picture naming and spontaneous speech outcomes than traditional SFA.\n\nParticipants will complete:\n\n* 5-7 pre-treatment assessment sessions where they will be asked to name pictures, tell stories\u002Fdescribe pictures, answer questions, and complete questionnaires,\n* 3 treatment sessions of SFA \\*OR\\* SFA+MST per week for 8 weeks, for a total of 24 sessions,\n* 7 weekly probes (i.e., short, intermittent assessments throughout the treatment phase),\n* 3 post-treatment assessment sessions immediately after treatment ends, where they will complete the same assessment tasks as they did pre-treatment (e.g., naming pictures, telling stories, etc.),\n* 2 retention assessment sessions, one 30 days and the other 60 days following the final treatment session, where they will be asked to name pictures, tell stories\u002Fdescribe pictures, and describe what they learned during the study.",[30,331,332,333,334,335,336,337,338,339],"Aphasia Following Cerebral Infarction","Aphasia, Acquired","Aphasia, Rehabilitation","Aphasia, Anomic","Aphasia, Broca","Aphasia, Conduction","Aphasia, Expressive","Aphasia Non Fluent","Aphasia, Mixed",[30,341,64,342,246],"Anomia","Communication","2026-06-23",{"date":345,"type":42},"2026-06-25",{"date":347,"type":42},"2025-07-28",{"date":349,"type":24},"2027-07",{"name":351,"class":49},"Teachers College, Columbia University",{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":58,"enrollmentInfo":359,"targetDuration":4,"studyType":25,"phases":361,"briefSummary":362,"conditions":363,"keywords":364,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":50},"100590534","phase-2-transcranial-magnetic-stimulation--language-therapy-to-treat-subacute-aphasia-100590534","NCT06968663","Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia","Electrical Field Guided Transcranial Magnetic Stimulation to Treat Subacute Post-stroke Aphasia","Inclusion Criteria:\n\n* Left hemisphere stroke resulting in aphasia\n* The stroke must have occurred between 2 and 6 weeks prior to enrollment\n* Must be able to understand the nature of the study, and give informed consent\n* English proficiency\n* Right-handed\n\nExclusion Criteria:\n\n* History of serious and\u002For ongoing issues with substance abuse\n* Previous head trauma with loss of consciousness for more than 5 minutes\n* History of major psychiatric illness\n* Dementia, or other neurological conditions\n* Epilepsy, or seizure after the stroke event\n* Pacemaker\n* Diagnosis of tinnitus\n* Pregnancy",{"count":360,"type":24},63,[190],"The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke.\n\nThe main questions this study aims to answer are:\n\n1. Can TMS combined with mCILT improve overall speech?\n2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment?\n\nResearchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia.\n\nImportantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting.\n\nParticipants will:\n\n* Complete a screening and medical intake to determine eligibility\n* Undergo MRI scans\n* Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment\n* Complete follow-up assessments immediately and 4 months after treatment",[64,30,331],[69,68,287,365,366],"Non-invasive brain stimulation","language therapy","2026-06-16",{"date":369,"type":42},"2026-06-18",{"date":371,"type":42},"2024-08-01",{"date":373,"type":24},"2029-07-31",{"name":375,"class":49},"University of Pennsylvania",{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":4,"eligibilityCriteria":382,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":383,"targetDuration":4,"studyType":25,"phases":384,"briefSummary":386,"conditions":387,"keywords":393,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":405,"locationsCount":50},"100555412","early-phase-1-educational-support-group-program-for-bilingual-and-spanish-speaking-carepartners-and-people-with-progressive-aphasia-100555412","NCT06511752","Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia","Educational Support Group Program for Carepartners of Bilingual and Spanish-speaking Persons With Progressive Forms of Aphasia and for Persons With Progressive Forms of Aphasia","Inclusion Criteria:\n\nAll participants must:\n\n* speak Spanish and\u002For English (although participants may speak other languages in addition to Spanish and\u002For English)\n* identify as Hispanic and\u002For Latinx,\n* or their spouse\u002Ffamily member with PA identifies as Hispanic and\u002For Latinx\n* see and hear well enough to participate\n* have access to a computer or mobile device with video capability\n* have an internet connection\n\nAdditional inclusion criteria for PA\u002F language-led dementia support group participants:\n\n* Individuals with PA:\n* Has a diagnosis of PA, or language-led dementia, and aphasia is one of the primary causes of difficulty with activities of daily living\n* Aware of language difficulties and willing to discuss them\n* Able to actively engage in group discussion and complete activities with minimal support\n* Able to regularly attend meetings\n* Willing to follow the rules of the support group for interacting with others respectfully\n\nAdditional inclusion criteria for care partner support group plus implementation phase participants:\n\n* Individuals with PA:\n* Diagnosis of aphasia or dementia that is progressive in nature, and aphasia is one of the primary causes of difficulty with activities of daily living\n* Have some ability to communicate and understand communication in order to participate in training sessions\n* Are functionally able to engage in training sessions (e.g., able to maintain some attention, minimal challenging behavior that would cause disruption)\n* Have a care partner who also consents to participating in the project\n* Care partners:\n* Self-identification as a caregiver of an individual with a diagnosis of PA or language-led dementia\n* Willing to discuss caregiving for individuals with PA\u002F language-led dementia\n* Able to regularly attend meetings\n* Willing to follow the rules of the support group for interacting with others respectfully\n\nExclusion Criteria:\n\n• Beyond the inclusion criteria included above, no additional exclusion criteria apply",{"count":264,"type":24},[385],"EARLY_PHASE1","The current study aims to examine the benefits of an education\u002Fsupport group program for individuals with progressive aphasia (caused by various etiologies, diagnoses) and their carepartners. The current study utilizes pre-, post-treatment, and follow-up assessments to measure effects of a psychoeducational support group and an implementation\u002Fcommunication skills training phase on measures of psychosocial function, communicative effectiveness and speech\u002Flanguage function. Analysis of study-specific surveys and semi-structured interviews will provide qualitative data regarding outcomes. Before beginning the education and support group, focus groups will be run in order to set priorities for the themes to be included in the education program. Participants will join via tele-based means if preferred and these participants may reside in the United States, or internationally including Mexico and Spain.",[388,389,390,30,391,392],"Alzheimer Disease","Dementia","Primary Progressive Aphasia","Progressive Aphasia","Progressive Aphasia in Alzheimer's Disease",[394,395,396,397,398],"bilingual","Spanish","Castellano","multicultural","multilingual","2026-06-08",{"date":401,"type":42},"2026-06-10",{"date":403,"type":42},"2024-05-21",{"date":128,"type":24},{"name":406,"class":49},"University of Texas at Austin",{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":18,"sex":19,"minAge":303,"maxAge":4,"enrollmentInfo":414,"targetDuration":4,"studyType":25,"phases":416,"briefSummary":417,"conditions":418,"keywords":429,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":448,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":151},"100496255","cognitive-reserve-and-response-to-speech-language-intervention-in-bilingual-speakers-with-primary-progressive-aphasia-100496255","NCT05741853","Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia","Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia","Inclusion Criteria:\n\n* Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)\n* Bilingual in Spanish and Catalan or bilingual in Spanish and English\n* Different proficiency levels across languages are expected, any prior experience in both languages is acceptable\n* Intervention study: Score of 15 or higher on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination\n\nExclusion Criteria:\n\n* Other central nervous system or medical diagnosis that can cause symptoms\n* Other psychiatric diagnosis that can cause symptoms\n* Significant, uncorrected visual or hearing impairment that would interfere with participation\n* Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)\n* Intervention Study: Score of less than 15 on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination",{"count":415,"type":24},60,[27],"Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA.\n\nThe overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how \"strong\" each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA (60 individuals will be recruited). The investigators will conduct an assessment before treatment, after treatment and at two follow-ups (6 and 12-months post-treatment) in both languages. When possible, a structural scan of the brain (magnetic resonance image) will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment. In addition to the intervention described herein, 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention. Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA.",[390,389,419,388,420,421,422,423,424,425,426,427,30,428],"Dementia, Frontotemporal","Neurodegenerative Diseases","Frontotemporal Lobar Degeneration","Apraxia, Motor","Dysarthria","Communication Disorders","Language Disorders","Speech Disorders","Neurocognitive Disorders","Bilingual Aphasia",[430,431,432,390,433,434,435,436,437,438,439,440,441,442,443,444,395,396,445,446,447],"Dementia, ADRD","Bilingualism","Multilingualism","Bilingual Primary Progressive Aphasia","Cognitive Reserve","Language Decline","Bilingual Language Decline","Speech-Language Therapy","Bilingual Speech-Language Therapy","Spanish speakers","Spanish-Catalan Bilinguals","Spanish-English Bilinguals","Hispanic","Catalán","Catalan","Speech Therapy","Latino","Cognition",{"date":401,"type":42},{"date":450,"type":42},"2023-05-01",{"date":452,"type":24},"2027-11-30",{"name":454,"class":49},"Stephanie Grasso",{"id":456,"slug":457,"hasResults":12,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":461,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":463,"targetDuration":4,"studyType":25,"phases":465,"briefSummary":466,"conditions":467,"keywords":468,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":479,"locationsCount":50},"100640815","recovery-from-post-stroke-aphasia-with-rtms-targeting-left-or-right-anterior-temporal-lobe-100640815","NCT07608588","Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe","Recovery From Post-Stroke Aphasia With rTMS Targeting the Anterior Temporal Lobe: Interhemispheric Activation Changes and Lesion-Connectome-Based Predictive Outcomes","ATLAS","Inclusion Criteria:\n\n* Right-handedness (assesed using the Edinburgh Handedness Inventory)\n* Native English speakers\n* Single left hemispheric stroke\n* Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician\n\nExclusion Criteria:\n\n* Severely impaired auditory comprehension (WAB Comprehension score of 0 or 1)\n* Major phonological impairments (defined as \\> 2 errors in non-word repetition of one- and two-syllable items on the PALPA, 2)\n* Contraindications to rTMS (e.g., uncontrolled epilepsy, history of seizures, intracranial ferromagnetic body, cochlear implant, or factors that lower seizure threshold (see Rossi et al., 2021)\n* Contraindication to MRI\n* Stroke involving the left ATL\n* Severe depression or psychiatric history\n* Illiteracy\n* Known neurodegenerative disorders\n* Severe uncorrected visual or hearing impairments",{"count":464,"type":24},45,[27],"This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.",[64,30],[69,68,469,470,471],"rTMS","brain stimulation","speech and language therapy","2026-05-26",{"date":474,"type":42},"2026-05-29",{"date":476,"type":42},"2026-05-15",{"date":478,"type":24},"2027-07-30",{"name":205,"class":49},{"id":481,"slug":482,"hasResults":12,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":486,"eligibilityCriteria":487,"healthyVolunteers":12,"sex":19,"minAge":185,"maxAge":58,"enrollmentInfo":488,"targetDuration":4,"studyType":25,"phases":489,"briefSummary":490,"conditions":491,"keywords":492,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":50},"100395729","targeted-tdcs-to-enhance-speech-language-treatment-outcome-in-persons-with-chronic-post-stroke-aphasia-100395729","NCT04432883","Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","Targeted Transcranial Direct Current Stimulation to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia","AphasiatDCS","Inclusion Criteria:\n\n1. aged 25-85\n2. must be greater than 6 months post-stroke\n3. must have a diagnosis of aphasia based on impaired performance on the Western Aphasia Battery-Revised, Boston Naming Test, or during discourse production\n4. must be left-hemisphere dominant as demonstrated by aphasia onset subsequent to left hemisphere damage\n5. must be stimulable for naming\n\nExclusion Criteria:\n\n1. comorbid neurological disease.\n2. damage to the anterior right hemisphere.\n3. significant mood disorder.\n4. substance\u002Falcohol dependence or abuse within the past year\n5. presence of any implanted electrical device or contraindications to tDCS or MRI\n6. recent medical instability (within 4 weeks)\n7. pregnancy",{"count":5,"type":24},[27],"62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis\u002Fphonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.",[64,30],[64,30,470,493,471],"communication problems","2026-05-20",{"date":496,"type":42},"2026-05-22",{"date":498,"type":42},"2022-10-18",{"date":500,"type":24},"2027-04-30",{"name":502,"class":49},"University of New Mexico",{"id":504,"slug":505,"hasResults":12,"nctId":506,"briefTitle":507,"officialTitle":508,"acronym":4,"eligibilityCriteria":509,"healthyVolunteers":18,"sex":19,"minAge":510,"maxAge":4,"enrollmentInfo":511,"targetDuration":4,"studyType":25,"phases":513,"briefSummary":514,"conditions":515,"keywords":516,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":215},"100636790","lexure-for-post-stroke-aphasia-100636790","NCT07570264","LEXURE for Post-Stroke Aphasia","A Prospective, Multicenter, Randomized, Evaluator-Blinded, Confirmatory Study to Evaluate the Efficacy and Safety of LEXURE for Improving Language Function in Patients With Post-Stroke Aphasia","Inclusion Criteria:\n\n1. Diagnosed with hemorrhagic or ischemic stroke\n2. At least 3 months have elapsed since stroke onset\n3. History of aphasia resulting from stroke\n4. Aphasia Quotient (AQ) score between 26 and 90 (inclusive) on the Korean version of the Western Aphasia Battery (K-WAB) or the Paradise Korean version of the Western Aphasia Battery-Revised (PK-WAB-R)\n5. Adults aged 19 years or older\n6. Native Korean speakers\n7. Able to use the investigational device or perform workbook-based training without difficulty\n8. Willing to participate voluntarily and provide written informed consent\n\nExclusion Criteria:\n\n1. Diagnosed with language impairment due to causes other than stroke (e.g., traumatic brain injury, brain tumor, or neurodegenerative disease)\n2. History of language impairment due to developmental disorders\n3. Currently receiving speech-language therapy or participating in another clinical trial related to language function\n4. Currently receiving medication for severe psychiatric disorders (e.g., bipolar disorder, major depressive disorder, schizophrenia, alcohol dependence, or substance abuse)\n5. Illiterate individuals\n6. Individuals deemed unsuitable for participation in this study by the investigator\n7. Severe cognitive impairment that would interfere with understanding or performing the study interventions","19 Years",{"count":512,"type":24},116,[27],"This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the other half will receive workbook-based language training as an active comparator.",[30],[69,68],"2026-05-12",{"date":519,"type":42},"2026-05-14",{"date":521,"type":42},"2026-04-16",{"date":523,"type":24},"2026-12-30",{"name":525,"class":526},"Nunaps Inc","INDUSTRY",{"id":528,"slug":529,"hasResults":12,"nctId":530,"briefTitle":531,"officialTitle":532,"acronym":533,"eligibilityCriteria":534,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":535,"targetDuration":4,"studyType":537,"phases":4,"briefSummary":538,"conditions":539,"keywords":4,"overallStatus":168,"whyStopped":4,"lastUpdateSubmitDate":540,"lastUpdatePostDateStruct":541,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":4},"100634138","implementing-transcranial-direct-current-stimulation-in-a-rehabilitation-setting-100634138","NCT07535788","Implementing Transcranial Direct Current Stimulation in a Rehabilitation Setting","Implementing Transcranial Direct Current Stimulation (tDCS) in an Acute Rehabilitation Setting","tDCS implement","Inclusion Criteria:\n\n* ischemic or hemorrhagic stroke\n* aphasia\n\nExclusion Criteria:\n\n* not a patient at either inpatient and outpatient settings of Casa Colina Hospital and Centers for Healthcare",{"count":536,"type":24},30,"OBSERVATIONAL","This study looks at whether transcranial Direct Current Stimulation (tDCS) can be effectively implemented in inpatient and outpatient rehabilitation settings during routine speech therapy for people who recently had a stroke and now have aphasia (difficulty speaking or understanding language)",[30,64],"2026-04-15",{"date":542,"type":42},"2026-04-17",{"date":544,"type":24},"2026-05-04",{"date":546,"type":24},"2027-05-30",{"name":548,"class":49},"Casa Colina Hospital and Centers for Healthcare",{"id":550,"slug":551,"hasResults":12,"nctId":552,"briefTitle":553,"officialTitle":553,"acronym":554,"eligibilityCriteria":555,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":556,"enrollmentInfo":557,"targetDuration":4,"studyType":25,"phases":559,"briefSummary":560,"conditions":561,"keywords":562,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":540,"lastUpdatePostDateStruct":566,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":572,"locationsCount":176},"100579832","mirror-speech-entrainment-a-novel-technique-for-voice-personalized-speech-entrainment-for-nonfluent-aphasia-100579832","NCT06829420","Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia","MSE","Inclusion Criteria:\n\n* Adults between the ages of 18-70 years old\n* Dominant English-speaking\n* Aphasia due to left hemisphere stroke\n\nExclusion Criteria:\n\n* Individuals with aphasia due to other causes such as dementia, Alzheimer's disease and Parkinsonism\n* Non-dominant English adult speakers\n* Persons with significant difficulties with language comprehension\n* Persons with concomitant cognitive disability\n* Persons with uncorrected sensory deficits.","70 Years",{"count":558,"type":24},20,[27],"The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA). The main question the study aims to answer is:\n\n\\- What is the impact of personalized voice on speech entrainment in PWA compared to traditional speech entrainment?\n\nSpeech entrainment is a technique used by speech-language pathologists to improve the speech production of PWA. Traditionally, speech therapists act as the model for participants to speak along with to improve their speech production. This study proposes the use of one's own voice (digitally altered) to improve speech production.\n\nThe study uses a mobile health approach to administer speech entrainment treatment through a mobile app.\n\n* Smartphones with the mobile app pre-installed will be mailed to participants at no cost.\n* Participants will complete treatment in the comfort of their homes.\n* The experimental treatments involve: mirror speech entrainment (speaking along to one's own voice) and traditional speech entrainment (speaking along to someone else's voice).",[338,64,30],[30,563,564,565],"Nonfluent aphasia","Speech entrainment","Speech synchronization",{"date":567,"type":42},"2026-04-21",{"date":569,"type":42},"2025-05-01",{"date":571,"type":24},"2027-08-01",{"name":573,"class":49},"University of South Florida",{"id":575,"slug":576,"hasResults":12,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":4,"eligibilityCriteria":580,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":581,"targetDuration":4,"studyType":25,"phases":582,"briefSummary":583,"conditions":584,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":592,"locationsCount":50},"100489463","phase-2-balancing-effortful-and-errorless-learning-in-naming-treatment-for-aphasia-100489463","NCT05653440","Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia","Integrating Complementary Learning Principles in Aphasia Rehabilitation Via Adaptive Modeling (Sub-study 1: Balancing Effortful and Errorless Learning Via Adaptive Naming Deadlines)","Inclusion Criteria:\n\n* Existing diagnosis of chronic (\\>6 months) aphasia subsequent to left hemisphere ischemic or hemorrhagic stroke.\n* Impaired performance on 2\u002F8 sections of the Comprehensive Aphasia Test.\n\nExclusion Criteria:\n\n* History of other acquired or progressive neurological disease.\n* Significant language comprehension impairments\n* Unmanaged drug \u002F alcohol dependence.\n* Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.",{"count":536,"type":24},[190],"Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life.\n\nThis study is one of two that are part of a larger grant. This record is for sub-study 1, which will adaptively balance effort and accuracy using speeded naming deadlines.",[30,64],"2026-04-07",{"date":587,"type":42},"2026-04-13",{"date":589,"type":42},"2023-11-27",{"date":591,"type":24},"2028-01-31",{"name":593,"class":49},"University of Pittsburgh",{"id":595,"slug":596,"hasResults":12,"nctId":597,"briefTitle":598,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":304,"enrollmentInfo":601,"targetDuration":4,"studyType":537,"phases":4,"briefSummary":602,"conditions":603,"keywords":604,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":50},"100632814","development-and-validation-of-language-and-communication-assessment-scales-100632814","NCT07518576","Development and Validation of Language and Communication Assessment Scales","SCALE_COM","Inclusion Criteria:\n\nPatient admitted to the hospital for an intensive neurorehabilitation cycle or attending as an outpatient Diagnosis of language and communication disorders following a stroke in the right or left hemisphere Age \\> 18 years Ability to provide informed consent Native speaker of Italian (L1 Italian)\n\nExclusion Criteria:\n\n* Unstable clinical conditions that may interfere with participation in the study (e.g., active symptomatic infections, stupor, need for oxygen therapy)",{"count":5,"type":24},"The aim of speech therapy for people with aphasia is to improve their ability to communicate in daily life. Traditional evaluations focus on linguistic tasks, but they do not fully address everyday communication skills, which are crucial for creating personalized treatment goals. The study suggests a multimodal approach to language assessment, stressing the importance of gestures in communication. It calls for the development of tools that evaluate communication in a wider context, including factors like motivation, attention, awareness, and alternative communication strategies. Additionally, there is a need for tools specifically designed to assess communicative gestures.",[425,30],[605,69,606,607,608],"language disorders","conversation","gestures","assessment","2026-04-02",{"date":611,"type":42},"2026-04-08",{"date":613,"type":42},"2022-05-09",{"date":615,"type":24},"2026-12-31",{"name":617,"class":49},"IRCCS San Camillo, Venezia, Italy",{"id":619,"slug":620,"hasResults":12,"nctId":621,"briefTitle":622,"officialTitle":623,"acronym":624,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":19,"minAge":137,"maxAge":186,"enrollmentInfo":626,"targetDuration":4,"studyType":25,"phases":627,"briefSummary":628,"conditions":629,"keywords":631,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":634,"lastUpdatePostDateStruct":635,"startDateStruct":636,"completionDateStruct":638,"leadSponsor":640,"locationsCount":50},"100414869","telerehabilitation-for-aphasia-terra-100414869","NCT04682223","Telerehabilitation for Aphasia (TERRA)","Center for the Study of Aphasia Recovery (C-STAR): Telerehabilitation for Aphasia (TERRA)","TERRA","Inclusion Criteria:\n\n1. Participants must have sustained a left hemisphere ischemic or hemorrhagic stroke at least 12 months prior to enrollment.\n2. Participants must primarily speak English for at least the past 20 years.\n3. Participants must be capable of giving informed consent or indicating another to provide informed consent.\n4. Participants must be between 21-80 years of age.\n5. Participants must be magnetic resonance imaging (MRI) compatible (e.g., no metal implants, not claustrophobic) on a 3-Tesla (3T) scanner.\n\nExclusion Criteria:\n\n1. Participants must not have previous neurological disease affecting the brain (e.g. history of traumatic brain injury).\n2. Participants must not have severely limited speech production (severe unintelligibility) and\u002For auditory comprehension that interferes with adequate participation in the therapy provided (i.e., WAB-R Spontaneous Speech rating scale score of 0-1 or WAB-R Comprehension score of 0-1).\n3. Participants must not have a history of stroke to the right hemisphere of the brain.\n4. Participants must not have a bilateral, cerebellar or brainstem stroke.\n5. Participants must not have anything that makes them be 3T MRI incompatible\n6. Insufficient intelligible speech to provide accurate responses with discourse\u002Fnaming.",{"count":140,"type":24},[27],"Speech-language therapy is generally found to be helpful in the rehabilitation of aphasia. However, not all patients with aphasia have access to adequate treatment to maximize their recovery. The goal of this project is to compare the efficacy of telerehabilitation or Aphasia Remote Therapy (ART) to the more traditional In-Clinic Therapy (I-CT).",[30,64,630],"Stroke Rehabilitation",[69,68,632,633],"telerehabilitation","speech-language therapy","2026-04-01",{"date":609,"type":42},{"date":637,"type":42},"2021-05-05",{"date":639,"type":24},"2027-03",{"name":205,"class":49},{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":647,"eligibilityCriteria":648,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":186,"enrollmentInfo":649,"targetDuration":4,"studyType":25,"phases":650,"briefSummary":651,"conditions":652,"keywords":656,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":662,"lastUpdatePostDateStruct":663,"startDateStruct":665,"completionDateStruct":667,"leadSponsor":669,"locationsCount":671},"100614570","aphasia-physical-exercise-study-randomized-trial-100614570","NCT07281313","Aphasia Physical EXercise Study: Randomized Trial","High-intensity Exercise in Stroke Recovery: Randomized Trial","APEX","Inclusion Criteria:\n\n* Aphasia following ischemic or hemorrhagic stroke\n* Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient \\\u003C 93.8 at study intake)\n* At least 6 months from the last stroke\n* Proficient in English before the stroke\n* At least 8 years of education\n* Between the ages of 18 and 80\n* Independent with ambulation without a device (single-point cane accepted)\n* Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.\n\nExclusion Criteria:\n\n* Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse\n* Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing\n* Self-report uncontrolled cardiorespiratory and\u002For metabolic disorders incompatible with exercise",{"count":264,"type":24},[27],"The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is:\n\n• Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and\u002For psychosocial domains?\n\nParticipants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting.\n\nOutcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.",[332,30,653,654,331,655],"Aphasia, Fluent","Aphasia, Non-fluent","Aphasia Following Nontraumatic Intracerebral Hemorrhage",[69,657,658,659,660,661,68,118],"physical exercise","high intensity interval training","cognition","physical fitness","balance","2026-03-17",{"date":664,"type":42},"2026-03-19",{"date":666,"type":42},"2025-12-01",{"date":668,"type":24},"2030-03-01",{"name":670,"class":49},"University of California, Berkeley",4]