[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"asymptomatic-pfalciparum-malaria\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:asymptomatic-pfalciparum-malaria":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100656083","phase-1-artemisia-annua-infusion-for-the-treatment-of-asymptomatic-plasmodium-falciparum-infection-100656083",false,"NCT07819825","Artemisia Annua Infusion for the Treatment of Asymptomatic Plasmodium Falciparum Infection","Clinical Assessment of the Safety and Efficacy of Artemisia Annua Infusion Preparation for the Treatment of Asymptomatic Plasmodium Falciparum Infection in Semi-immune Adults in Gabon","ART-CT001","Inclusion Criteria:\n\n* Age: 18 to 45 years\n* Absence of fever (body temperature \\\u003C37.5ºC axillary or \\\u003C38.0°C oral, rectal or tympanic temperature)\n* Asymptomatic P. falciparum infection with parasitemia between 500 and 2,000 asexual P. falciparum parasites per μl of blood\n* Have been living in an endemic area for at least 5 years.\n* Written informed consent from the participant\n* Residence in the vicinity of the study centre\n* Willingness to comply with the follow-up schedule\n\nExclusion Criteria:\n\n* History of fever over the last 72 hours\n* Non-Plasmodium falciparum infection\n* Intake of any antimalarial drug or antibiotic with antimalarial activity within the previous 28 days and\u002For after half-life time\n* Presence of signs and symptoms related by the medical doctor to malaria\n* Known history or evidence of clinically significant medical disorders\n* Severe malnutrition\n* Haemoglobin concentration \\\u003C7 g\u002FdL\n* Known hypersensitivity and contraindications to any study medication\n* Pregnancy or lactation\n* Participation in other interventional studies","ALL","18 Years","45 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","The goal of this clinical trial is to determine whether Artemisia annua dried leaves, used as an infusion, can treat individuals with malaria parasites but no symptoms. The main question it aims to answer is:\n\nCan Artemisia annua infusion be used to treat malaria?\n\nResearchers will compare those receiving Artemisia annua infusion with those receiving an infusion of Centaurii herba (which has no effect on malaria parasites) to see whether all individuals treated with Artemisia annua infusion are cured, which should not be the case for those receiving Centaurii herba infusion.\n\nParticipants will\n\n* drink Artemisia annua infusion over seven days (three days at our research centre and four days at their home\n* visit the research centre once a week for three weeks after treatment for one month for safety reasons",[28],"Asymptomatic P.Falciparum Malaria",[30,31,32],"Plasmodium falciparum","Artemisia annua","infusion","NOT_YET_RECRUITING","2026-09-09",{"date":36,"type":37},"2026-09-15","ACTUAL",{"date":39,"type":22},"2026-09-01",{"date":41,"type":22},"2027-06",{"name":43,"class":44},"Centre de Recherche Médicale de Lambaréné","OTHER"]