[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"atherosclerosis-cerebral\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:atherosclerosis-cerebral":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100343585","phase-4-the-effect-of-intensive-statin-in-ischemic-stroke-with-intracranial-atherosclerotic-plaques-100343585",false,"NCT03753555","The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques","The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques: a Prospective, Random, Single-center Study Based on High Resolution Magnetic Resonance Imaging","INSIST-HRMRI","Inclusion Criteria:\n\n1. Patient age between 18-80 years\n2. Time of onset: within 1 week\n3. NIHSS score ≤12\n4. Acute ischemic stroke confirmed by head CT or MRI\n5. Premorbid mRS ≤1\n6. The degree of stenosis of carotid artery, vertebral artery and intracranial portion of internal carotid artery on the lesion side \\\u003C50%\n7. The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion\n8. Signed informed consent\n\nExclusion Criteria:\n\n1. Intracranial hemorrhage found by head CT\n2. Stroke attributable to cardioembolic origin (atrial fibrillation, valvular heart disease, aortic arch atherosclerosis)\n3. Severe hepatic or renal dysfunction\n4. Pregnant females\n5. Abnormal elevation of creatine phosphokinase\n6. Expected stent angioplasty\n7. Blood sugar is out of control\n8. Receiving statins within 1 month before onset\n9. Obstinate hypertension with more than 140\u002F90 mmHg after medication\n10. Not willing and able to comply with scheduled visits, lifestyle guidelines, treatment plan, laboratory tests, and other study procedures\n11. Unsuitable for this clinical studies assessed by researcher","ALL","18 Years","80 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Intracranial atherosclerotic disease is the most common cause of ischemic stroke that is directly attributed to the progression or rupture of intracranial high-risk plaque in Asia. Many studies mainly from Euro-American population with a focus on extracranial carotid plaque have fully demonstrated the advantages of intensive statin therapy on stabilizing or reversing plaque burden, reversing plaque composition presenting that lipid-rich necrotic core (LRNC) is gradually replaced by fibrous tissue, and even reversing pattern of arterial remodeling to reduce the occurrence of cerebrovascular events. Yet, direct evidence of the effect of intensive statin therapy on intracranial atherosclerotic plaques is lacking and the effect of statin intensity and duration on intracranial plaque burden and composition is still unclear. High resolution magnetic resonance imaging (HRMRI) is a new and non-invasive technique that enable to assess the morphologic characteristics of vascular wall and plaque composition of intracranial artery. Based on above discussion, the investigators conduct this study to further determine the effect of intensive statin in ischemic stroke with intracranial atherosclerotic plaques.",[28,29],"Stroke, Ischemic","Atherosclerosis, Cerebral","RECRUITING","2026-04-22",{"date":33,"type":34},"2026-04-27","ACTUAL",{"date":36,"type":34},"2018-12-01",{"date":38,"type":22},"2027-11-30",{"name":40,"class":41},"General Hospital of Shenyang Military Region","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":42},"100308137","cuhk-stroke-biobank-100308137","NCT03291392","CUHK Stroke Biobank","Inclusion Criteria:\n\n1. Adult equal or more 18 years of age and Chinese ONLY.\n2. Stroke patients, their family members, and\u002For the normal subjects without intracranial stenosis or extracranial stenosis, are eligible to join the study.\n3. Subject is willing to have blood taken, cerebral spinal fluid and\u002For body tissue drawn for storage in the research bank.\n\nExclusion Criteria:\n\n* None",true,{"count":51,"type":22},500,"OBSERVATIONAL","The purpose of the study are:\n\n1. To make quality, characterized samples and related data available for future studies, including Genome Wide Association Studies (GWAS), genomics, and biomarker research;\n2. To use these samples and related medical information to answer research questions aimed at understanding the genetics and underlying biology of acquired disease and injury to the brain, heart and blood vessels with the express purpose of advancing the search for effective modalities for prevention, treatment, and recovery;\n3. To develop additional operational infrastructure to support this project across the Prince of Wales Hospital and divisions, including (1) tracking of patient consent, (2) management of collection and sample processing processes, (3) sample inventory and QC\u002FQA processes, and (4) release of materials to investigators for further research.",[28,55,29],"Genetic Disease",[57,58,59,60],"Genetics","Stroke","Biobank","Atherosclerosis","2026-02-21",{"date":63,"type":34},"2026-02-24",{"date":65,"type":34},"2015-06-15",{"date":67,"type":22},"2027-12-31",{"name":69,"class":41},"Chinese University of Hong Kong"]