[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"autism-disorders-and-maternal-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:autism-disorders-and-maternal-stress":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100649681","perinatal-autism-genetics-and-epigenetics-study-100649681",false,"NCT07738003","Perinatal Autism Genetics and Epigenetics Study","Perinatal Experience and Epigenetic Change in Autism: Discovering Modifiable Pathways for Intervention","PAGES","Inclusion Criteria:\n\nA. Criteria for Pregnant Women:\n\n1. Pregnant women in their 1st or 2nd trimester of a singleton pregnancy.\n2. Age 18 to 50 years\n3. Currently use a smart phone\n\nB. ASD Group at age 18 to 27 months\n\n1. M-CHAT score \\>= 4 or POSI score \\>= 3\n2. Child has subsequently clinically confirmed diagnosis of ASD, based on ADOS\u002FTAP testing and\u002For other clinical evaluation\n\nC. Developmental Delay (DD) Group at age 18 to 27-months\n\n1. Developmental screening score on SWYC in the \"at risk\" range.\n2. Child has subsequently clinically confirmed developmental delay on clinical evaluation and\u002For self-report measure\n\nD. Typically Developing (TD) Group at age 18 to 27 months - None\n\nExclusion Criteria:\n\nA. Criteria for Pregnant Women:\n\n1. Non-English speaking mother\n2. History of severe mental illness in the past year, resulting in inpatient admission\n\nB. All children\n\n1. \\\u003C35 weeks gestational age at birth\n2. History of serious neonatal complications requiring NICU admission for one week or more\n3. Known genetic or syndromic condition (e.g. Down Syndrome, etc.) that impacts learning and brain development\n4. Hearing impairment\n\nC. ASD Group at age 18 to 27 months\n\n\\- None\n\nD. Developmental Delay (DD) Group at age 18 to 27 months\n\n1. Screen positive for ASD (M-CHAT \\>= 4 AND POSI \\>= 3)\n2. First-degree relative who has been diagnosed with ASD\n\nE. Typically Developing (TD) Group at age 18 to 27 months\n\n1. Screen positive for ASD (M-CHAT \\>= 4 AND POSI \\>= 3)\n2. Developmental screening\u002Fassessment score in the \"at risk\" range.\n3. First-degree relative who has been diagnosed with ASD",true,"ALL","0 Years","50 Years",{"count":22,"type":23},7200,"ESTIMATED","OBSERVATIONAL","The University of Iowa's Center for Disabilities and Development is researching how pregnancy, early childhood experiences, and genetic factors influence child development, with a focus on autism spectrum disorder (ASD). Pregnant women are invited to participate in a study that tracks their pregnancy and child's early development, through simple, at-home activities using a cell phone. Participants complete short questionnaires, join an online interview, and videotape their baby's play after birth. They are also sent a kit to swab their baby's mouth to collect cheek cells for genetic testing. The study will explore whether stress and early social experience lead to genetic changes associated with autism or other developmental conditions.",[27,28,29,30],"Autism Disorders and Maternal Stress","Development Delay","Prenatal Stress","Social Behavior",[32,33,34,35,36],"autism","epigenetics","prenatal stress","social experience","developmental delay","RECRUITING","2026-07-31",{"date":40,"type":41},"2026-08-03","ACTUAL",{"date":43,"type":41},"2026-05-12",{"date":45,"type":23},"2030-05",{"name":47,"class":48},"University of Iowa","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":18,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":49},"100631236","cft-guided-self-help-intervention-parents-of-autistic-children-100631236","NCT07498049","CFT Guided Self-help Intervention: Parents of Autistic Children","Testing a Compassion-focused Guided Self-help Intervention for Parents of Autistic Children - Single Case Series Design","CFT-GSH-PAC","Inclusion Criteria:\n\n* Participants must be a parent who lives with their autistic child. The parent must be aged 18 years and above and their child must be aged between 6 and 17 years old. The parent participant must have good use of the English language to provide informed consent, access the workbook material, listen to the audio tracks, engage verbally in the support telephone calls and change interviews and complete outcome measures. The child must have a formal diagnosis of autism spectrum disorder as confirmed following assessment by a doctor or practitioner psychologist. Participants must be technology-literate and have access to technology to access video calls for screening and check-in calls as needed.\n\nExclusion Criteria:\n\n* Those who are currently receiving psychological or mental health input from professionals, those experiencing thoughts related to self-harm and\u002For suicide and those who are dependent on alcohol or drugs, those with a learning disability or other cognitive impairment will be excluded from this research.","18 Years",{"count":60,"type":23},8,"INTERVENTIONAL",[63],"NA","This research will aim to test how practical, achievable and effective a brief, guided, self-help compassion focused intervention is for parents of autistic children aged 6-17 years old.\n\nThe demands of parenting can be rewarding but also challenging, and it is known that parents of autistic children experience additional pressures. As a result of this, parents of autistic children may be more likely to experience increased stress, anxiety, low mood and lower quality of life, compared to those parenting children who are not autistic.\n\nThere has been only a small amount of research so far regarding whether interventions that focus on building compassion, would be beneficial to parents of autistic children. The purpose of this study is to test whether a short, self-guided compassion-focused intervention is practical, achievable and effective for parents of autistic children. The intervention is based on Compassion Focused Therapy (CFT) and involves reading workbook material and listening to audio tracks. There will also be some questionnaires to complete and 30-minute weekly support calls with the lead researcher.\n\nThis intervention was adapted previously, from an intervention for parents in general, to be more suitable and focused on the needs of parents of autistic children. This study will be the first time the adapted intervention has been used by parents.\n\nThe intervention will be tested by 6-8 parents and will be about 13 weeks long. We will collect some demographic data at the start of the study, and there will be the opportunity to complete an evaluation questionnaire.",[27,66,67,68,69,70,71,72,73],"Autism","Autism Disorder","Autism Spectrum Disorder","Autism in Children","Parent","Parent Mental Health","Parent Stress","Parent Support","NOT_YET_RECRUITING","2026-03-23",{"date":77,"type":41},"2026-03-27",{"date":79,"type":23},"2026-04",{"date":81,"type":23},"2027-09",{"name":83,"class":48},"University of Nottingham"]