[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"basal-ganglia-hemorrhage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:basal-ganglia-hemorrhage":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100647711","minimally-invasive-surgery-for-spontaneous-deep-intracerebral-hemorrhage-100647711",false,"NCT07710313","Minimally Invasive Surgery for Spontaneous Deep Intracerebral Hemorrhage","Effectiveness and Safety of Minimally Invasive Surgery for Spontaneous Deep Intracerebral Hemorrhage: A Prospective and Retrospective Observational Cohort Study","MIS-DEEP ICH","Inclusion Criteria:\n\n* Age 18 to 80 years\n* Spontaneous basal ganglia intracerebral hemorrhage confirmed by non-contrast CT\n* Hematoma volume between 30 and 80 mL (calculated using the ABC\u002F2 method)\n* Time from symptom onset to enrollment ≤ 72 hours (for patients with an unknown onset time, the last known well time will be used)\n* Glasgow Coma Scale (GCS) score between 5 and 14\n* Pre-stroke modified Rankin Scale (mRS) score of 0 to 1\n\nExclusion Criteria:\n\n* Secondary intracerebral hemorrhage due to trauma, brain tumor, arteriovenous malformation, cerebral aneurysm, or hemorrhagic transformation of ischemic stroke\n* Infratentorial hemorrhage involving the brainstem or cerebellum\n* Primary thalamic hemorrhage\n* Intraventricular extension occupying more than 50% of either lateral ventricle\n* NIHSS score \\\u003C 5\n* Bilaterally fixed and dilated pupils with no light reflexes\n* Decerebrate posturing\n* Platelet count \\\u003C 75,000\u002FμL\n* IINR \\> 1.4 after correction\n* Ongoing anticoagulation that cannot be rapidly reversed\n* Indication for long-term anticoagulation within 5 days of symptom onset\n* End-stage renal disease\n* End-stage liver disease\n* Presence of a mechanical heart valve\n* Comorbid condition associated with a life expectancy \\\u003C 6 months\n* Inability or unwillingness of the participant or legally authorized representative to provide written informed consent","ALL","18 Years","80 Years",{"count":21,"type":22},300,"ESTIMATED","OBSERVATIONAL","This observational cohort study evaluates the real-world effectiveness and safety of minimally invasive surgery (MIS) versus standard medical management in adults with spontaneous deep intracerebral hemorrhage. Patients presenting to Tam Anh General Hospital and People's Hospital 115 within 72 hours of hemorrhage onset will be enrolled and followed for 180 days. Clinical, radiological, and treatment-related variables will be collected, with primary outcome measures including survival and functional outcomes during follow-up period.",[26,27,28],"Intracerebral Hemorrhage","Spontaneous Intracerebral Hemorrhage","Basal Ganglia Hemorrhage",[27,30,28,31,32,33],"Deep Intracerebral Hemorrhage","Minimally Invasive Surgery","Robotic-Assisted Surgery","Hematoma Evacuation","NOT_YET_RECRUITING","2026-07-15",{"date":37,"type":38},"2026-07-17","ACTUAL",{"date":40,"type":22},"2026-07-01",{"date":42,"type":22},"2028-12-31",{"name":44,"class":45},"Tam Anh Research Institute","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100608723","rainbow-ich-trial-of-ai-guided-minimally-invasive-neurosurgery-for-ich-100608723","NCT07205263","RAINBOW-ICH Trial of AI Guided Minimally Invasive Neurosurgery for ICH","A Multicenter, Randomized, Controlled, Umbrella Trial for Minimally Invasive Neurosurgery With Al-assisted Robotic Guidance for Hemorrhagic Stroke (RAINBOW-ICH)","RAINBOW-ICH","Umbrella Trial Inclusion Criteria:\n\n1. Age ≥18 years；\n2. Clinical diagnosis of spontaneous hemorrhagic stroke；\n\nUmbrella Trial Exclusion Criteria:\n\n1\\. Radiologically diagnosed cerebrovascular abnormalities, as well as ischemic infarction converting to intracerebral hemorrhage, or recent (within 1 year) recurrence of intracerebral hemorrhage；\n\nEach substudy will specify additional inclusion and exclusion criteria in the respective Substudy-specific Registration. Patients who fulfill the overall umbrella trial criteria will be assessed for enrollment into each substudy.",{"count":55,"type":22},1000,"INTERVENTIONAL",[58],"NA","Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke, with high rates of death and disability worldwide. Despite advances in medical and surgical care, effective therapeutic options remain limited. To address this gap, the RAINBOW-ICH trial has been designed as a nationwide, multicenter, randomized umbrella trial evaluating the efficacy and safety of AI-assisted, robotic-guided minimally invasive neurosurgery compared with conventional strategies across major ICH subtypes.\n\nUnder a single master protocol, RAINBOW-ICH incorporates multiple parallel randomized controlled substudies, each targeting a distinct ICH population-large basal ganglia hemorrhage, moderate basal ganglia hemorrhage, intraventricular hemorrhage, and brainstem hemorrhage. This umbrella design allows efficient use of resources while generating high-quality evidence tailored to the specific needs of different ICH subgroups, thereby supporting a more patient-centered approach to care.",[28,61,62,63],"Intraventricular Hemorrhage","Brainstem Stroke","Intracranial Hemorrhage, Spontaneous",[65,66,62,67,28,68],"Umbrella Trial","Intraventricular hemorrhage","Robotic-guided","Minimally invasive surgery","RECRUITING","2026-01-06",{"date":72,"type":38},"2026-01-08",{"date":74,"type":38},"2025-09-30",{"date":76,"type":22},"2027-12",{"name":78,"class":45},"Second Affiliated Hospital, School of Medicine, Zhejiang University",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":56,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":97,"locationsCount":79},"100551871","a-trial-for-minimally-invasive-neurosurgery-with-ai-assisted-robotic-guidance-for-moderate-basal-ganglia-hemorrhage-rainbow-mbh-100551871","NCT06465719","A Trial for Minimally Invasive Neurosurgery With AI-assisted Robotic Guidance for Moderate Basal Ganglia Hemorrhage (RAINBOW-MBH)","A Multicenter, RAndomlzed, coNtrolled, umBrella Trial fOr Minimally Invasive Neurosurgery With Al-assisted Robotic Guidance for Moderate Basal Ganglia Hemorrhage (RAINBOW-MBH)","RAINBOW-MBH","Inclusion Criteria:\n\n1. Age ≥18 years at randomization\n2. Hypertensive basal ganglia hemorrhage confirmed by CT\u002FCTA\n3. Hematoma volume 15-30 mL (excluding 30 mL)\n4. Functional impairment (aphasia, hemiparesis with strength ≤3, or NIHSS ≥15)\n5. CT shows stable hematoma (≥6h interval, change \\\u003C5 mL)\n6. GCS ≥9\n7. Surgery feasible within 72h after onset\n8. Pre-ICH mRS ≤1\n9. Informed consent obtained according to laws and ethics\n\nExclusion Criteria:\n\n1. Hematoma involving the thalamus, midbrain, or other areas\n2. Radiologically diagnosed cerebrovascular abnormalities, as well as ischemic infarction converting to intracerebral hemorrhage, or recent (within 1 year) recurrence of intracerebral hemorrhage\n3. Signs of impending brain herniation, such as midline shift \\>1 cm or changes in the ipsilateral pupil;\n4. Any irreversible coagulopathy disorders or known coagulation system disease; platelet count \\\u003C100,000; INR \\>1.4; use of anticoagulants within 7 days prior to this hemorrhage;\n5. Pregnant or possibly pregnant\n6. Patients with severe concomitant diseases that may interfere with outcome assessment\n7. Poor compliance or follow-up difficulties",{"count":89,"type":22},330,[58],"A nationwide, prospective, multicenter randomized controlled clinical trial to evaluate the therapeutic effects of the fiber tract-based artificial intelligence (AI) Robot Guiding System on the perioperative and long-term recovery of patients with moderate-volume basal ganglion hemorrhage.",[28],{"date":72,"type":38},{"date":74,"type":38},{"date":96,"type":22},"2027-12-31",{"name":78,"class":45}]