[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"beta-thalassemia-transfusion-dependent\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:beta-thalassemia-transfusion-dependent":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100648543","phase-2-gene-therapy-for-patients-with-transfusion-dependent--thalassemia-100648543",false,"NCT07721480","Gene Therapy for Patients With Transfusion-Dependent β-Thalassemia","An Open Label Study Evaluating the Safety and Efficacy of HGI-001 Injection in Patients With Transfusion-Dependent β-Thalassemia","Inclusion Criteria:\n\n1. Subjects between 12 and 45 years of age at the time of consent and are able to provide written informed consent.\n2. Diagnosis of TDT, also known as β-thalassemia major, without genotype restriction, and a valid test report can be provided.\n3. A history of at least 100 mL\u002Fkg\u002Fyear of pRBCs transfusion or ≥ 8 transfusions of pRBCs per year for previous 2 years.\n4. Sufficient blood transfusion for at least 3 months before screening (transfusion records can be provided), and Hb is maintained ≥9.0 g\u002FdL before each transfusion.\n5. The level of ferritin \\\u003C5000ng\u002FmL; Cardiac magnetic resonance imaging (MRI) T2 and liver MRI T2 findings suggest iron overload at a moderate level or below.\n6. Clinically stable, and eligible for autologous hematopoietic stem cell transplant (auto-HSCT).\n7. Adequate organ function for the conditioning with busulfan.\n\nExclusion Criteria:\n\n1. Uncorrected bleeding disorder;\n2. Uncontrolled epilepsy or mental disorders;\n3. Received hydroxyurea, ruxolitinib, decitabine, or cytarabine within 3 months prior to enrollment;\n4. Usage of psychoactive substance, drug, or alcohol abuse within six months prior to screening.\n5. Pulmonary hypertension without effective intervention.\n6. Persistent toxicity (≥ CTCAE grade 2) induced by previous treatment.\n7. Positive for anti-RBC antibodies.\n8. Positive for hepatitis B surface antigen (HBsAg) and HBV DNA copy number \\> upper limit of normal (ULN) (HBV DNA test not required for patients negative for HBsAg), positive for hepatitis C virus (HCV) antibody, unless HCV RNA is negative (HCV RNA-negative subjects are not excluded), positive human immunodeficiency virus (HIV), or positive for Treponema pallidum antibody (TP-Ab) (subjects who are positive for the antibody due to vaccination can be enrolled).\n9. Has or has had malignant tumors or myeloproliferative disease or immunodeficiency disease;\n10. Clinically significant and active bacterial, viral, fungal, or parasitic infection.","ALL","12 Years","45 Years",{"count":20,"type":21},6,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Thalassemia is a group of recessively inherited hemoglobin disorders characterized by reduced or no production of hemoglobin and chronic anemia of varying severity. Severe β-thalassemia is transfusion-dependent thalassemia (TDT) and requires life-long transfusion, iron overload is a common complication of TDT. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative option currently available for TDT, but it carries significant acute and long-term risks. In this study, the autologous HSCT-based gene therapy (referred to as \"gene therapy for thalassemia, \" by using HGI-001) is based on the principle that the autologous haemopoietic stem cells (HSCs) collected from the patient him\u002Fherself are transduced outside human body, which will restore the function of RBCs, so as to achieve the effect of treating or even curing thalassemia. Currently data suggests that gene therapy for TDT patients has shown remarkable therapeutic effects, avoiding immune rejection, and is widely accepted by the medical community, positioning it as a highly promising treatment approach. To date, the efficacy and safety of HGI-001 have been evaluated through both in vitro and in vivo studies. In an early-phase clinical study of HGI-001 conducted in China, five patients achieved transfusion-independent post-treatment. Among them, four have maintained this state for over two years, with the longest duration reaching 3.5 years. The study noted no severe adverse events. The long-term safety and efficacy of HGI-001 continue to be under active surveillance.",[27],"Beta Thalassemia Transfusion Dependent",[29],"transfusion dependent, beta thalassemia, gene therapy","NOT_YET_RECRUITING","2026-07-17",{"date":33,"type":34},"2026-07-23","ACTUAL",{"date":36,"type":21},"2026-09",{"date":38,"type":21},"2030-12",{"name":40,"class":41},"Prince of Wales Hospital, Shatin, Hong Kong","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100608901","evaluation-of-physiological-and-psychological-factors-involved-in-exercise-intolerance-in-patients-with--ttd-100608901","NCT07207577","Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD","Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With Transfusion-dependent β-thalassemia","THALEX","Inclusion Criteria:\n\n* Patients aged 18 years or older\n\n  * Patients with transfusion-dependent β-thalassaemia (B0 or B+)\n  * Patients who have undergone blood transfusions at intervals of between 1 and 8 weeks for at least 5 years.\n  * Have given their free and informed written consent after being informed of the purpose of the study, its conduct and its risks.\n  * Be affiliated with a social security scheme.\n  * Not participating in any other interventional studies during the duration of this study\n\nControl subjects must meet all of the following criteria to participate in the study:\n\n* Subject aged 18 years or older\n* Matched in age and gender to a βTTD patient included in the study.\n* Declaring to be free of known acute or chronic pathologies.\n* Have given their free written consent after being informed of the purpose of the study, its conduct and its risks.\n* Be affiliated with a social security scheme.\n* Not participate in any other interventional study during the duration of this study.\n* Have 'low' or 'moderate' IPAQ results (inactive or slightly active).\n\nExclusion Criteria:\n\n* \\- Having received a bone marrow transplant.\n* History of thromboembolic disease.\n* Hospitalised for cardiac decompensation in the last 12 months.\n* Lack of use of limbs (amputee, paraplegic, quadriplegic)\n* Unable to comply with protocol requirements for social, family or other reasons, as determined by the investigator.\n* Known concomitant medical condition that could affect compliance with the protocol\n* benefiting of enhanced protection, namely minors, persons deprived of their liberty by judicial or administrative decision, adults under legal protection and, finally, patients in emergency situations.\n* Unable to give consent.\n* Pregnant or breastfeeding women.",true,"18 Years",{"count":53,"type":21},36,[55],"NA","The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects. The main question it aims to answer is:\n\nis there a difference in power output at first lactate threshold between patients with transfusion-dependent β-thalassemia and control subjects during maximal incremental exercise test.\n\nParticipants will have to realise differents exams including measurement of body compposition, maximal incremental exercise test, vertical jump, vasoreactivity test, blood sampling, quality of life questionnaires and neuromuscular assessments.",[27],[59,60,61],"physical ability","Beta thalassemia transfusion dependent","control subjects","RECRUITING","2025-09-26",{"date":65,"type":34},"2025-10-06",{"date":67,"type":34},"2025-09-04",{"date":69,"type":21},"2028-10",{"name":71,"class":41},"Centre Hospitalier Metropole Savoie",1]