[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bile-acid-diarrhea\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bile-acid-diarrhea":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100618972","magnesium-in-gastrointestinal-disease-100618972",false,"NCT07338565","Magnesium in Gastrointestinal Disease","Magnesium Status in Patients With Gastrointestinal Disease","MAGIC","Inclusion Criteria:\n\n\\- Age 18 or older, mentally competent, and able to understand Danish.\n\nGroup 1:\n\n\\- Diagnosed with IBD (DK50X, Crohn's disease, or DK51X, ulcerative colitis), ileostomy (DZ932) or bile acid diarrhoea (DSK908B) (Se-HCAT scintigraphy showing residual activity \\\u003C10%).\n\nGroup 2:\n\n\\- Healthy individuals.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding.\n* Use of oral magnesium supplements for more than 2 weeks before inclusion.",true,"ALL","18 Years",{"count":21,"type":22},120,"ESTIMATED","OBSERVATIONAL","Individuals with gastrointestinal diseases - such as Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhoea - are at increased risk of magnesium deficiency. Magnesium is a vital mineral that supports many essential functions in the body, including muscle contraction, nerve signalling, heart rhythm, and bone health. Deficiency may contribute to fatigue, muscle cramps, abnormal heart rhythms, and reduce the quality of life.\n\nThe purpose of this study is to investigate the prevalence of magnesium deficiency in individuals with these conditions and to identify the most accurate and practical methods for assessing magnesium status in clinical care.\n\nAlthough plasma magnesium is commonly used in routine blood tests, it represents only about 1% of the body's total magnesium and may not reflect true magnesium levels within cells or tissues. Hence, this study compares several different ways of measuring magnesium, including:\n\n* Plasma magnesium\n* Magnesium levels in red and white blood cells (PBMC, RBC, and buffy coat)\n* Magnesium levels in muscle tissue (via biopsy)\n* A magnesium retention test, based on how much magnesium is excreted after an infusion\n\nThe study includes four groups:\n\n1. Patients with inflammatory bowel disease.\n2. Patients with an ileostomy.\n3. Patients with bile acid diarrhoea.\n4. Healthy individuals (control group).\n\nAll participants will provide blood and urine samples, and some may undergo optional biopsies of muscle or intestinal tissue. Participants will also complete questionnaires and undergo tests of muscle strength and body composition.\n\nThe findings are expected to enhance the understanding and detection of magnesium deficiency in patients with gastrointestinal diseases and to aid in the development of more effective tools for identifying and treating this common yet often overlooked condition.",[26,27,28,29,30,31,32,33,34,35,36,37],"Colitis Ulcerosa","Colitis Ulcerative","Crohns Disease","Morbus Crohn","Ileostomy - Stoma","Ileostoma","Ileostomies","Bile Acid Diarrhea","Bile Acid Malabsorption","Magnesium Deficiency","Magnesium Level","Magnesium","RECRUITING","2026-01-05",{"date":41,"type":42},"2026-01-14","ACTUAL",{"date":44,"type":42},"2025-11-03",{"date":46,"type":22},"2027-12-01",{"name":48,"class":49},"University of Aarhus","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":50},"100536020","the-8x5-diet-for-bile-acid-diarrhoea-a-feasibility-randomised-controlled-trial-100536020","NCT06259396","The 8x5 Diet for Bile Acid Diarrhoea: A Feasibility Randomised Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years, of any ethnic group, living in the United Kingdom and not planning to move home for the next three months\n* Self-reported diagnosis of bile acid diarrhoea that was confirmed by 7-day SeHCAT testing\n* Self-reported ongoing chronic diarrhoea despite use of appropriate medication\n* Able to participate in either diet group with the intention to remain in the group to which they were assigned for the 8 week study period\n* Body mass index ≥20 kg m-2\n* Able to converse in English (or via their carer, without assistance from an interpreter) using a computer\u002Flaptop, smart phone, or tablet\n* Able to provide informed written consent\n* Able to provide the address of their general practioner so that the research team can inform them of their participation.\n\nExclusion Criteria:\n\n* Unable to provide self-reported written confirmation that their diagnosis of bile acid diarrhoea was by SeHCAT testing\n* Pregnant\u002Fbreastfeeding\u002Fplanning a pregnancy in the next six months\n* Inflammatory bowel disease, previous or current microscopic colitis, or other serious morbidities such as liver disease, pancreatic disease, AIDS\u002FHIV, radiotherapy for cancer, assessed at screening via patient self-report\n* Diarrhoea that is inadequately active: \\<3 stools per day or \\<1 watery stool (Bristol Stool Form types 6-7) per day as the mean of one week\n* Currently participating in another research study or has taken part in the previous 3 months\n* If taking insulin, metformin (other than slow-release), anti-obesity medication, or using commercially available formulated supplements to replace meals in previous three months\n* Use of antibiotics in the previous four weeks\n\nMedically necessary dietary exclusions or issues deemed incompatible with the trial:\n\n* Food allergies, other than oral allergy syndrome\u002Fpollen-food syndrome\n* Exclusion of gluten (i.e. coeliac disease), lactose, biogenic amines, or any other dietary exclusion assessed as unsuitable as screening by the trial team. This includes if the participant knows they would refuse to eat: starchy foods, fruit and vegetables, protein-rich foods, or dairy and alternatives (e.g. following a ketogenic diet)\n* An eating disorder or disordered eating which is active or in the last 12 months\n* Alcohol or drug abuse, or self-harm, or depression, or suicide ideation in the last 12 months\n* Shift worker\n* If unwilling to keep a weighed 7-day food diary",{"count":58,"type":22},76,"INTERVENTIONAL",[61],"NA","Bile acid diarrhoea is a common cause of chronic watery diarrhoea. Treatment is life-long medication. However, about 50% of people have ongoing, bothersome diarrhoea. Findings from recent research on diet therapies and food intolerances have been used to develop a healthy dietary pattern called The 8x5 Diet. We will test the practicalities of conducting a randomised controlled trial of this dietary intervention.",[33],[65,66,67,68,69],"diet intervention","nutrition","feasibility","diarrhoea","adults","2024-12-10",{"date":72,"type":42},"2024-12-16",{"date":74,"type":42},"2024-04-02",{"date":76,"type":22},"2025-03-31",{"name":78,"class":49},"University of Manchester"]