[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"bony-defects\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:bony-defects":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100653698","phase-1-minimally-invasive-non-surgical-periodontal-therapy-alone-vs-minimally-invasive-non-surgical-periodontal-therapy-with-i-prf-with-or-without-chlorhexidine-on-stage-iii-periodontitis-patients-100653698",false,"NCT07791238","Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients","Impact of I-PRF With or Without Chlorhexidine on Minimally Invasive Non-Surgical Periodontal Therapy in Stage III Periodontitis: A Randomized Clinical Trial","MINST","Inclusion Criteria:\n\n* Patient-related criteria:\n\n  * Patient consulting in the outpatient clinic.\n  * Age ≥ 18 years old.\n  * Able to tolerate the study procedures.\n  * Patient ready to perform oral hygiene instructions.\n  * Compliance with the maintenance program.\n  * Provide informed consent.\n  * Accepts the 6 months follow-up period.\n\nTeeth related criteria:\n\n* Presence of at least one radiographic intrabony defect depth ≥3 mm.\n* Patients with at least 10 teeth per arch.\n* Presence at least of two teeth with PD ≥ 6 mm per quadrant.\n* Isolated inter-proximal defect on a single-rooted tooth or mandibular molar, not extending to the furcation area.\n* Untreated patients diagnosed with stage III with slow\u002Fmoderate rate of progression grade (A\u002FB) Periodontitis.\n\nExclusion Criteria:\n\n* Patient-related criteria:\n\n  * Medically compromised patients.\n  * Pregnant or nursing women.\n  * Uncooperative patients.\n  * Smokers (\\> 10 cigarettes\u002Fday).\n\nTeeth related criteria:\n\n* Furcation involvement.\n* Mobility ≥ degree 1\n* Acute periodontal or endodontic abscesses\n* Third molars\n* Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months.\n* Antibiotic treatment or anti-inflammatory treatment within 6 months prior to periodontal therapy.\n* Previous periodontal surgery.","ALL","18 Years",{"count":20,"type":21},63,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","This study aims to assess the effect of chlorhexidine augmented I-PRF together with MINST and I-PRF alone with MINST versus MINST alone in the treatment of stage III periodontitis patients.",[28,29],"Bony Defects","Periodontal Disease",[31,32,15,33,34],"Intrabony defects","periodontitis","i-PRF","CHX","NOT_YET_RECRUITING","2026-08-25",{"date":38,"type":39},"2026-08-27","ACTUAL",{"date":41,"type":21},"2026-09-30",{"date":43,"type":21},"2027-10-30",{"name":45,"class":46},"Cairo University","OTHER"]