[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-activity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-activity":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,73,100,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100648901","cardiorespiratory-fitness-and-acute-high-intensity-exercise-effects-on-brain-and-cognitive-function-in-older-adults-100648901",false,"NCT07727577","Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults","ExBrain","Inclusion Criteria:\n\n* Physical active in the last three months (\\>3x\u002Fweek of 30 minutes of moderate exercise)\n* To participate in the study, participants must answer \"no\" to all the Physical Activity Readiness questionnaire (PAR-Q) questions and have no signs and symptoms of cardiovascular, metabolic, and kidney diseases following the decision tree of the American College of Sports Medicine screening procedure.\n* Agree to have their data stored in a human performance database for future use. Agree to have their data stored in a repository per the requirement of peer-reviewed scientific journals, which may require data to be stored in a repository as a condition for publication. Such repositories are online databases, in which coded data is linked (no link to participants personally) to the journal article citation. Must read, understand, and sign the informed consent form.\n\nExclusion Criteria:\n\n* Use of illicit drugs, excessive alcohol, and\u002For performance-enhancing drugs.\n* Have any current orthopedic injury.\n* Have implanted medical devices.\n* Serious medical conditions limiting the ability to safety participate in either the PA interventions; these include dementia, symptomatic heart or vascular disease, severe hypertension, recent myocardial infarction, stroke, severe insulin-dependent diabetes mellitus, psychiatric disease, renal disease, liver disease or active cancer\n* Mini-mental examination score \\\u003C 23",true,"ALL","55 Years","79 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether a single session of high-intensity interval exercise (HIIT) affects cognitive performance and brain activity in older adults, and whether cardiorespiratory fitness influences these effects. The main questions it aims to answer are:\n\n* Does a single HIIT session change performance on a task-switching test of cognitive flexibility?\n* Does a single HIIT session change prefrontal brain activity during cognitive testing, as measured by functional near-infrared spectroscopy (fNIRS)?\n* Do older adults with higher cardiorespiratory fitness show greater cognitive and brain changes in response to HIIT than those with lower fitness?\n\nParticipants will:\n\n* Visit the laboratory on two separate days\n* Complete a sub-maximal graded exercise test during the first visit to measure cardiorespiratory fitness\n* Complete a single \\~30-minute HIIT cycling session during the second visit\n* Complete a task-switching cognitive test before and after the HIIT session\n* Have their brain activity monitored with fNIRS while completing the cognitive tests",[28,29,30,31],"Healthy Aging","Cognitive Benefits","Cardio Respiratory Fitness","Brain Activity",[33,34,35,36],"Cognitive Flexibility","Prefrontal Cortex Activation","Aging","Acute effects of high-intensity interval exercise on cognitive flexibility and prefrontal brain activity in healthy older adults","NOT_YET_RECRUITING","2026-08-11",{"date":40,"type":41},"2026-08-12","ACTUAL",{"date":43,"type":22},"2026-09-01",{"date":45,"type":22},"2028-08-01",{"name":47,"class":48},"Colby-Sawyer College","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":49},"100639786","human-neural-correlates-of-multi-timescale-inference-100639786","NCT07606469","Human Neural Correlates of Multi-Timescale Inference","Neuronal Mechanisms of Human Cognition","Inclusion Criteria:\n\n* Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures.\n* no lesions identified in the participants' brains\n* capable of giving consent\n\nExclusion Criteria:\n\n* seizure activity during task recording\n* electrodes in regions of interest are identified to be the seizure focus\n* task performance outside of the normal range as determined from online studies with healthy participants","18 Years",{"count":59,"type":22},30,"OBSERVATIONAL","Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.",[63,31],"Cognition","2026-05-18",{"date":66,"type":41},"2026-05-26",{"date":68,"type":22},"2026-06-15",{"date":70,"type":22},"2028-06-30",{"name":72,"class":48},"University of Colorado, Boulder",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":49},"100614569","mindfulness-oriented-respiratory-distress-symptom-intervention-for-lung-cancer-100614569","NCT07281300","Mindfulness-Oriented Respiratory Distress Symptom Intervention for Lung Cancer","Mindfulness-Oriented Respiratory Distress Symptom Intervention for Patients With Lung Cancer: A Feasibility Randomized Controlled Trial","Inclusion Criteria:\n\n* HK patients who can understand Cantonese, aged 18 years or older;\n* A confirmed diagnosis of an intrathoracic malignancy, including small cell lung cancer, non-small cell lung cancer, or mesothelioma; at any stage of cancer treatment or palliative care;\n* Self-reported impact on daily life from at least two of the three symptoms, where one symptom is breathlessness;\n* Stability of COPD, if present;\n* WHO Performance Status of 0-2;\n* fMRI can be conducted;\n* Expected lifespan of more than six months.\n\nExclusion Criteria:\n\n* Cognitive impairments, severe psychotic symptoms, or other medical conditions that might hinder participation;\n* Participating in mindfulness or other psychological support interventions or symptom management interventions.",{"count":81,"type":22},64,[25],"Lung cancer is the leading cause of cancer mortality, posing a critical public health challenge in both Hong Kong and global populations. Patients with lung cancer frequently experience a distressing symptom cluster characterized by breathlessness-driven respiratory distress, accompanied by persistent cough and fatigue, which collectively impose a substantial disease burden. While our research team leader previously developed and validated a multi-component Respiratory Distress Symptom Intervention (RDSI) in England, demonstrating clinical efficacy for lung cancer management, its impact on psychological distress (anxiety and depression) proved limited. This limitation may reflect insufficient integration of psychological components, a crucial consideration given the well-established bidirectional relationship between respiratory symptoms and psychological distress. Emerging evidence indicates that mindfulness interventions provide dual therapeutic benefits by improving patient adherence and effectively addressing both physical symptoms, such as breathlessness and fatigue, as well as psychological distress, including anxiety and depression. Meanwhile, current evaluation methodologies have mainly focused on behavioral data collection, such as self-reported questionnaires, to reflect the effect before and after the intervention. Neuroimaging data can help understand the brain mechanisms underlying breathlessness and elucidate the effectiveness of interventions, thereby improving intervention strategies.",[85,86,87,88,89,31],"Symptom Cluster","Breathlessness","Coughing","Fatigue Symptom","Lung Cancer Patients","RECRUITING","2026-04-14",{"date":93,"type":41},"2026-04-17",{"date":95,"type":41},"2025-08-12",{"date":97,"type":22},"2027-07-30",{"name":99,"class":48},"The Hong Kong Polytechnic University",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":16,"sex":17,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":110,"briefSummary":111,"conditions":112,"keywords":116,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":49},"100609063","the-effect-of-near-infrared-light-therapy-on-brain-function-and-cognition-in-young-and-older-adults-100609063","NCT07209683","The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults","Age-specific Neurovascular Effects of Transcranial Photobiomodulation","Inclusion Criteria:\n\n* Age: 21-85 years of age\n* Adequate hearing and visual acuity to participate in the examinations\n* Ability to read and write in English\n* Competence to provide informed consent\n\nExclusion Criteria:\n\n* Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer\n* Cerebrovascular accident other than TIA within 60 days prior to Visit 0\n* Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse\n* Participant currently uses commercial brain stimulation \u002F neuromodulation device or an experimental device as part of a research study, e.g. tDCS, tACS, TBS, DBS, TMS, TPBM, etc.\n* Participant currently takes dietary supplements with an expected cerebrovascular benefit, such as NAD- or NR-supplement, L-citrulline, urolithin\n* Unstable medical condition, including uncontrolled diabetes, chronic heart issues, heart failure, chronic obstructive pulmonary disease, Stage 2 hypertension uncontrolled by medication (\\>160\u002F100 mmHg)\n* Any other medical condition or medication which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol.\n* Pregnancy or trying to become pregnant in the next 1 months (self-reported), breastfeeding","21 Years","85 Years",{"count":59,"type":22},[25],"The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in older adults.\n\nThe main questions it aims to answer are:\n\n* Does tPBM enhance neurovascular coupling responses during memory and finger tapping tasks?\n* Are these improvements linked to better cognitive performance and lower levels of brain inflammation and oxidative stress?\n\nResearchers will compare an active tPBM treatment arm to a sham treatment arm to see if tPBM leads to measurable improvements in brain activity and cognitive function compared to no active stimulation.\n\nParticipants will:\n\n* Receive either active tPBM or sham stimulation sessions for 4 weeks, every other day using a portable intervention device.\n* Complete questionnaires and an iPAD-based cognitive testing protocol\n* Complete memory and motor tasks while their brain activity is measured using non-invasive techniques: simultaneous functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), transcranial doppler (TCD) flowmetry.\n* Retinal vessel reactivity will be measured during flickering light stimulus using a special camera (dynamic vessel analysis, DVA).\n* Provide blood samples to test for biomarkers of inflammation, oxidative stress and brain cell damage.",[63,113,114,115,31],"Neurovascular Coupling Mechanism and Cognitive Function","Neurovascular Control","Brain Aging",[117,118,119,120,121,122,123,124,125],"transcranial photobiomodulation","neurovascular coupling","aging","cognitive function","near-infrared spectroscopy","electroencephalography","dynamic vessel analysis","home-based intervention","randomized double-blinded clinical trial","2026-02-04",{"date":128,"type":41},"2026-02-06",{"date":130,"type":41},"2025-10-01",{"date":132,"type":22},"2026-12-31",{"name":134,"class":48},"University of Oklahoma",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":49},"100603185","neurocognitive-correlates-of-the-influence-of-number-word-syntax-on-magnitude-processing-100603185","NCT07133230","Neurocognitive Correlates of the Influence of Number Word Syntax on Magnitude Processing","NUMWORD","Inclusion Criteria:\n\n* Subject aged 18 to 45 years;\n* Female or male;\n* Right-handed preference;\n* Subject, or legal representative, who has given consent to participate;\n* Native language: French\n* Subject affiliated with a social security system;\n* Having signed their consent to participate (and their legal representative if applicable),\n* Subjects have read the information letter and given their free and informed consent;\n* Normal medical, neurological, and neuroradiological examinations\n* For women of childbearing age, be on effective contraception\n\nExclusion Criteria:\n\n* Not corresponding to the targeted age range;\n* Subject with contraindications to an MRI examination (pacemaker or neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign bodies in the eyes or brain near neural structures, metal prostheses, patient agitation: non-cooperative or agitated patients, minors, claustrophobic subjects, pregnant women, ventriculoperitoneal neurosurgical shunt valves, dental braces);\n* Subject with chronic alcohol or drug use;\n* Abuse or dependence on substances (except nicotine) or toxic substances for more than 5 years or having led to comas (overdoses);\n* Subject with sudden-onset cognitive disorders that could indicate a stroke; a history of head trauma with loss of consciousness for more than 1 hour, or encephalitis;\n* Subject with chronic neurological, psychiatric, endocrine, hepatic, or infectious conditions;\n* Subject with a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrine, or immunological disorder, cancer);\n* Subject on medication: taking medications likely to interfere with brain imaging measurements (psychotropics, anxiolytic hypnotics, neuroleptics, anti-Parkinsonians, benzodiazepines, steroidal anti-inflammatories, antiepileptics, central analgesics, and muscle relaxants);\n* Color blindness;\n* Inability to comply with the study for geographical or psychiatric reasons;\n* Tattoo incompatible with MRI;\n* Cerebral palsy;\n* Fine motor skills disorder;\n* Pregnant women at the time of inclusion;\n* Adult subjects under legal protection or unable to give consent (article L.1121-8 of the French Public Health Code) (under guardianship or curatorship);\n* Children and parents under legal protection measures","45 Years",{"count":144,"type":22},84,"Linguistic irregularities in number naming systems, such as the inversion of number words, affect the processing of Arabic numerals. Recently, it has been claimed that there is even a syntactic representation of number words. participant investigate the neurofunctional correlates of the syntactic processing of number words by examining different levels of place-value processing in a study with two complementary successive phases (Group 1 and Group 2) in healthy adults. In the first phase with Group 1, participant evaluate the unit-decade compatibility effect (UDCE) in two-digit magnitude comparisons. In the second phase with Group 2, participant investigate the carry-over effect in two-digit addition problems.",[31],"2025-08-19",{"date":149,"type":41},"2025-08-20",{"date":151,"type":22},"2025-09",{"date":153,"type":22},"2027-10-30",{"name":155,"class":48},"Centre Hospitalier St Anne"]