[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-death\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-death":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100652071","miniature-in-line-respirator-100652071",false,"NCT07768215","Miniature In-line Respirator","First-In-Human Trial of Miniature In-Line, Pressure-Cycled, Emergency Respirator Device in Human Organ Donors","* INCLUSION CRITERIA\n\n  1. Diagnosis of brain death\n  2. Provision of signed and dated informed consent form for organ donation and research by donor family or surrogate decisionmaker.\n  3. Male or female, with no age restriction (see size exclusion).\n  4. Decedent transferred to the Gift of Life at Penn Medicine Donor Care Center (study site) for routine organ donor management and organ recovery procedures.\n\nEXCLUSION CRITERIA\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Brain-dead research donor will be excluded if their baseline CO(2) or pulse oximetry is out of the accepted range for the study (defined as end tidal CO(2) between 35- and 45-mm Hg and the O(2) saturation measured by pulse oximetry \\> 94%) while on optimized ventilation.\n2. Brain-dead research donors with severe respiratory disease. This may include:\n\n   * Bullous lung disease - noted on pre-op imaging or by history.\n   * h\u002Fo pneumothoraces\n   * h\u002Fo severe asthma, COPD, or other significant lung disease\n3. Brain-dead research donors with morbid obesity (BMI \\>=40).\n4. Brain-dead research donor body weight of \\\u003C 25kg.\n5. Potential Brain-dead lung transplant donors (as determined by Gift of Life Donor Program staff according to at the time of study site (Donor Care Center) admission)\n6. Intraoperative arterial blood gas values outside the range of normal for pH, PaO2, PaCO2, HCO3, O2Sat as measured in pre-device ABG (while on optimized ventilation).\n\nAcceptable range for Arterial Blood Gas (ABG values)\n\nParameter - pH \u002F Range - 7.35-7.45\n\nParameter - PaO2 \u002F Range - \\>=75 mm Hg\n\nParameter - PaCO2 \u002F Range - 35-45 mm Hg\n\nParameter - HCO3 \u002F Range - 22-26 mEq\u002FL\n\nParameter - SpO2 \u002F Range - 94-100","ALL","1 Year","100 Years",{"count":20,"type":21},5,"ESTIMATED","INTERVENTIONAL",[24],"NA","This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to help move air in and out of the lungs. It has no moving parts and is designed to provide short-term breathing support in situations where standard ventilators may not be available, such as emergencies, disasters, battlefield settings, transport, or ventilator shortages.\n\nThe study will enroll up to 5 brain-dead organ donors who are already receiving mechanical ventilation at the Gift of Life Donor Care Center at the Hospital of the University of Pennsylvania. Donors will only be included after authorization for organ donation and research has been obtained through standard procedures. Donors who may donate lungs or who have significant lung disease will not be included.\n\nDuring the study, investigators will briefly replace the standard ventilator with the Hope inVent device for up to 15 minutes. The standard ventilator will remain immediately available, and the donor will be continuously monitored by the clinical and research teams. Investigators will measure whether the device can maintain acceptable breathing measures, including oxygen level and carbon dioxide level. They will also record breathing pressures and tidal volume, which is the amount of air delivered with each breath. If the device does not perform as expected or if any safety concern occurs, the donor will be returned immediately to the standard ventilator.\n\nThere is no direct benefit to the organ donor. Information from this study may help determine whether this type of simple, low-cost breathing device could be useful for future patients who need emergency or short-term ventilator support when standard ventilators are not available.",[27,28],"Brain Death","Respiration, Artificial",[30,13,31],"Hope inVent Respirator","Pressure-Cycled Ventilation","NOT_YET_RECRUITING","2026-08-20",{"date":35,"type":36},"2026-08-21","ACTUAL",{"date":38,"type":21},"2026-08-26",{"date":40,"type":21},"2028-12-01",{"name":42,"class":43},"National Institutes of Health Clinical Center (CC)","NIH",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100537603","pupillometric-evaluation-in-patients-declared-brain-dead---a-prospective-quality-control-study-100537603","NCT06279975","Pupillometric Evaluation in Patients Declared Brain Dead - a Prospective Quality Control Study","Investigative Neurological Study With Pupillometric Evaluation os a Clinical Tool in Patients Declared Brain Dead (INSPECT) - a Prospective Quality Control Study","INSPECT","Inclusion Criteria:\n\n* Suspected diagnosis of brain death\n* Brain death diagnostic procedures planned\n* Treated at the intensive care unit at the University Hospital Basel (USB)","18 Years",{"count":55,"type":21},50,"OBSERVATIONAL","The aim of the study is to verify the reliability of the current purely clinical examination of the pupils (without the support of a pupillometer) in the context of clinically suspected brain death, compared to the results of a non-invasive, automated, and highly precise monocular pupillometric examination.",[27,59],"Adults",[61,27,62],"Pupillometry","Diagnosis","RECRUITING","2026-06-15",{"date":66,"type":36},"2026-06-17",{"date":68,"type":36},"2023-12-18",{"date":70,"type":21},"2030-12",{"name":72,"class":73},"University Hospital, Basel, Switzerland","OTHER",2,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":85,"conditions":86,"keywords":100,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100629619","non-invasive-detection-and-preservation-of-neurocognitive-signals-in-the-peri-death-period-using-brain-computer-interface-and-artificial-intelligence-100629619","NCT07477028","Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence","Feasibility of Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence: A Prospective Observational Study (NeuroCogPresv)","NeuroCogPresv","Inclusion Criteria:\n\n1. Adults ≥18 years with terminal illness or severe acute trauma\n2. Do-not-resuscitate (DNR\u002FDNI) order in place\n3. Surrogate decision-maker available and willing to provide informed consent\n4. Expected survival ≤7 days (physician estimate)\n\nExclusion Criteria:\n\n1. Brain death already declared \\> 24 hours prior to enrollment\n2. Contraindication to EEG\u002FBCI headset placement (e.g., severe scalp injury)\n3. Patient lacks a legally authorized representative",{"count":84,"type":21},20,"Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power, cross-frequency coupling, and distinct spreading depolarization waves. This prospective, observational feasibility study utilizes rapid-deployment, high-density, noninvasive BCI hardware paired with proprietary AI analytics to detect, classify, and securely archive these terminal neurocognitive signals.\n\nObjectives: (1) Quantify transient gamma-band activity and cross-frequency connectivity post-clinical death; (2) Validate the efficacy of machine learning models for real-time signal classification in high-noise clinical environments; (3) Establish a highly secure, encrypted bio-informational archive of peri-life EEG data.\n\nDesign: Prospective, open-label, multicenter, observational cohort (n\\>20).",[87,88,89,27,90,91,92,93,94,95,96,97,98,99],"Terminal Illness","End-of-Life Care","Death","Death Anxiety","Consciousness","Electroencephalography","Gamma Oscillations","Near-Death Phenomena","Cognitive","Cognition","Memory","EEG","Severe Acute Trauma",[101,102,103,89,93,96,91,104,105,106,97,107,108,109,110],"AI","BCI","Brain Computer Interface","Pefi-death","Brain death","Reservation","Life","Life experience","Transfer","Convergence","2026-03-12",{"date":113,"type":36},"2026-03-17",{"date":115,"type":21},"2026-09-01",{"date":117,"type":21},"2035-09-30",{"name":119,"class":120},"Noah Tech, Corp.","INDUSTRY"]