[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-health":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,59,85,115,151,181,224,255,290],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100650884","long-term-effects-of-avocado-consumption-on-health-in-pre-diabetic-individuals-100650884",false,"NCT07752225","Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals","Effects of Long-term Avocado Consumption on Brain and Peripheral Cardiovascular Health in Pre-diabetic Individuals","Inclusion Criteria:\n\n* Men and women, aged between 40-75 years\n* Pre-diabetes: (A1C of 5.7%-6.4%, a fasting plasma glucose (FPG) of 100-125 mg\u002FdL, or a 2-hour oral glucose tolerance test (OGTT) result of 140-199 mg\u002FdL)\n* BMI ³ 25 kg\u002Fm2\n* Fasting serum total cholesterol \\\u003C 8.0 mmol\u002FL\n* Systolic blood pressure \\\u003C 160 mmHg and diastolic blood pressure \\\u003C 100 mmHg\n* Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study\n\nExclusion Criteria:\n\n* Age less than 40 years old or older than 75 years\n* BMI \\\u003C 25 kg\u002Fm2\n* Type 1 or type 2 diabetes\n* habitual consumption of more than 1 avocado\u002F week\n* Left-handedness\n* Fasting serum total cholesterol \\> 8.0 mmol\u002FL\n* Current smoker, or smoking cessation \\\u003C 12 months\n* Abuse of drugs\n* More than 3 alcoholic consumptions per day\n* Use medication to treat blood pressure, lipid or glucose metabolism\n* Use of an investigational product within another biomedical intervention trial within the previous 1-month\n* Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis\n* Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident\n* Contra-indications for MRI imaging (e.g. pacemaker, surgical clips\u002Fmaterial in body, metal splinter in eye, claustrophobia)\n* Blood donation in the 8 weeks before the start of the study\n* Difficulties to draw blood","ALL","40 Years","75 Years",{"count":20,"type":21},34,"ESTIMATED","INTERVENTIONAL",[24],"NA","Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with overweight or obesity. Secondary objective is to assess the effects of 12-week daily avocado consumption on brain insulin sensitivity after intranasal insulin delivery, vascular function, markers of metabolic health, cognition, and psychological well-being. For that purpose a total of 34 men and women between the ages of 40-75 years old, will participate in a randomised crossover intervention study.",[27,28,29,30,31,32,33,34],"Prediabetes","Brain Insulin Sensitivity","Cerebral Blood Flow","Satiety and Food Intake","Food Reward","Brain Health","Vascular Function","Obesity & Overweight",[36,37,38,29,39,40,41,42,43,44,45],"Avocados","Brain insulin sensitivity","Brain vascular function","CBF","pCASL MRI","CANTAB","Overweight","Obesity","cognitive performance","brain health","NOT_YET_RECRUITING","2026-08-03",{"date":49,"type":50},"2026-08-07","ACTUAL",{"date":52,"type":21},"2026-09-01",{"date":54,"type":21},"2028-08-31",{"name":56,"class":57},"Maastricht University Medical Center","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":16,"minAge":66,"maxAge":18,"enrollmentInfo":67,"targetDuration":69,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":73,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":58},"100648334","a-prospective-clinical-study-observed-the-effects-of-tubeless-anesthesia-method-that-preserves-spontaneous-breathing-and-the-double-lumen-bronchial-intubation-on-the-brain-health-during-the-perioperative-period-100648334","NCT07721038","A Prospective Clinical Study Observed the Effects of Tubeless Anesthesia Method That Preserves Spontaneous Breathing and the Double-lumen Bronchial Intubation on the Brain Health During the Perioperative Period","Tubeless Anesthesia With Preserved Spontaneous Breathing and the Construction of a Perioperative Brain Health Safety System for Thoracic Surgery Patients Study 2: A Prospective Clinical Study Observing the Impact of Two Anesthesia Techniques-Tubeless With Preserved Spontaneous Breathing Versus Double-Lumen Endotracheal Intubation-on Perioperative Brain Health","Inclusion Criteria:\n\n* Patient age: 18 - 75 years old\n* Patients meeting the standards of the American Society of Anesthesiologists (ASA) I-III grade and the New York Heart Association (NYHA) I-II class\n* Body Mass Index (BMI) \\\u003C 30 kg\u002Fm2\n* Intraoperative blood loss less than 300 ml\n* No severe cardiac or pulmonary dysfunction \\[first-second forced vital capacity (FEV1%) predicted value\\] \\> 50%, ejection fraction (EF) \\> 50%\n* No contraindications related to paravertebral nerve block and intercostal nerve block\n* Able to sign the informed consent form and possess communication, reading and writing abilities\n* Postoperative hospital stay of at least one day\n* No preoperative sleep disorders, no cognitive dysfunction (PSQI ≤ 10 points, PCS ≤ 38 points, MMSE \\> 27 points)\n\nExclusion Criteria:\n\n* Already diagnosed with a mental disorder or had a preoperative Mini-Mental State Examination (MMSE) score of less than 27\n* History of opioid abuse\n* Patients who were admitted to the ICU after surgery\n* Have severe cardiovascular, respiratory diseases\n* Experienced critical rescue during or after the surgery\n* Complicated with coagulation dysfunction, severe hypoxia or hypercapnia, or liver and kidney dysfunction\n* Difficult airway management\n* Changed anesthetic agent or surgical plan\n* Severe lacunar cerebral infarction, ischemic stroke or other neurological diseases\n* Changed anesthetic agent or surgical plan during the surgery;","18 Years",{"count":68,"type":21},400,"6 Months","OBSERVATIONAL","This project conducts a prospective cohort study. By using multiple questionnaire survey methods such as the Pittsburgh Sleep Quality Index (PSQI) electronic wristband, QOR15, Pain Catastrophizing Scale (PCS), European Five-Dimensional Health Scale (EQ-5D), Revised American Pain Society Patient Follow-up Questionnaire (APS-POQ-R), Mini-Mental State Examination (MMSE), as well as perioperative stress and related indicators, hypothalamic-pituitary-adrenal axis (HPA) endocrine indicators, sublingual microcirculation, electroencephalogram, etc., comprehensive assessment is made of the correlations between the two different anesthesia methods of Tubeless retention of spontaneous breathing and double-lumen bronchial intubation and postoperative sleep, chronic pain and cognitive function, to construct a perioperative brain health safety system to improve prognosis; at the same time, optimize the perioperative sedation and analgesia plan and promote the postoperative brain health recovery of patients.",[32],[74,75,45],"Tubeless anesthesia","double-lumen bronchial intubation","2026-07-19",{"date":78,"type":50},"2026-07-22",{"date":80,"type":21},"2026-07-20",{"date":82,"type":21},"2028-12-31",{"name":84,"class":57},"Guangzhou Medical University",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":16,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":101,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":58},"100647614","effects-of-acute-ketone-supplementation-on-the-brain-100647614","NCT07711990","Effects of Acute Ketone Supplementation on the Brain","Effects of Acute Ketone Supplementation on the Brain [KETO-BRAIN]","KETO-BRAIN","Inclusion Criteria:\n\n1. Age ≥45 years and ≤65 years\n2. Able to comply with study requirements including presenting for each test session following an overnight fast and not following a ketogenic diet during the duration of the study.\n3. BMI between 18.5 and 30 kg\u002Fm2\n\nExclusion Criteria:\n\n1. Non-English Speaking\n2. Currently taking a ketone ester supplement, ketone salt supplement, or on a ketogenic diet\n3. Pregnancy, a urine pregnancy test will be given to all women before scanning to confirm nonpregnant status\n4. Currently breastfeeding\n5. Allergies to components in the test products, including milk protein, and not lactose intolerant\n6. History of high blood pressure\n7. History of alcoholism (previous 2 years)\n8. History of illicit drug use\n9. History of head trauma involving loss of consciousness or skull fracture\n10. Diagnosed neurological disease\n11. Taking psychiatric prescriptive medications (antipsychotics, antidepressants, or barbiturates) or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)\n12. Current smoker\n13. Currently consuming a habitual ketogenic diet, or was consuming a habitual ketogenic diet in the past three months\n14. Any condition or material in the body that is a contraindication for MRI procedures",true,"45 Years","65 Years",{"count":97,"type":21},24,[24],"The purpose of this study is to determine how a ketone ester supplement affects brain function, brain blood flow, and brain metabolism in healthy middle-aged and older adults. Ketones are naturally produced by the body during periods of fasting or carbohydrate restriction and serve as an alternative fuel source for the brain. Researchers are interested in whether increasing blood ketone levels through supplementation can alter brain activity and blood flow in ways that may support healthy brain function.\n\nParticipants will consume a ketone ester supplement and a placebo in separate study visits. Brain imaging, blood measurements, and cognitive testing will be used to evaluate the effects of each intervention. Findings from this study will help researchers better understand how ketones influence the healthy aging brain and may provide preliminary data for future studies in populations at risk for cognitive decline.",[32],[102,103,104],"ketone supplement","brain MRI","brain MRS","RECRUITING","2026-07-16",{"date":108,"type":50},"2026-07-17",{"date":110,"type":50},"2026-06-15",{"date":112,"type":21},"2029-12",{"name":114,"class":57},"Christopher Crabtree",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":93,"sex":16,"minAge":95,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":124,"conditions":125,"keywords":130,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":147,"leadSponsor":149,"locationsCount":58},"100640391","assessing-the-influence-of-habitual-beef-intake-on-key-molecular-markers-of-brain-health-100640391","NCT07623785","Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health","Inclusion Criteria:\n\nAdults aged 65 years and older.\n\nGenerally healthy with no acute illnesses.\n\nFluent in English.\n\nWilling to consume lean beef and dairy products (cottage cheese and whey protein) daily during the intervention phases.\n\nWilling to maintain current, habitual diet, physical activity levels, and body weight throughout the study.\n\nWilling to fast for 12 hours prior to clinical visits and provide blood, urine, stool, and saliva samples.\n\nExclusion Criteria:\n\nDiagnosed with Alzheimer's disease, Parkinson's disease, or other severe cognitive disorders.\n\nHistory of gastrointestinal diseases (e.g., Crohn's disease, celiac disease) or major gastrointestinal surgery.\n\nUncontrolled diabetes, severe liver or kidney disease, or a recent cardiovascular event (within the past 6 months).\n\nAllergies or severe intolerances to beef or dairy, or adherence to a strict vegetarian or vegan diet.\n\nBody weight fluctuation of \\>5% within the past 3 months.\n\nUse of systemic antibiotics within the 2 months prior to baseline.\n\nCurrent heavy smoking or excessive alcohol consumption.",{"count":122,"type":21},20,[24],"his study investigates whether eating lean beef every day can help support brain health and healthy aging in older adults. As people age, protecting memory and cognitive function becomes increasingly important. Lean beef is a rich source of essential nutrients-such as vitamin B12, iron, zinc, and creatine-that are known to support brain function. However, the direct biological effects of a beef-rich diet on brain health markers are not fully understood.\n\nIn this study, researchers will recruit 20 generally healthy older adults (aged 65 and older) to participate in a dietary feeding trial. Participants will complete two separate 2-week dietary phases. During one phase, participants will consume 5.5 ounces (156 grams) of provided lean beef daily. During the other phase, they will consume an iso-caloric, protein-matched, non-beef control food daily. A two-week \"washout\" period, where participants return to their normal diets, will separate the two phases to ensure there are no overlapping effects.\n\nResearchers will collect blood, urine, stool, and saliva samples at the beginning and end of each 2-week dietary phase. These samples will be analyzed to see if the lean beef diet improves specific biological markers in the blood related to memory, nerve protection, and overall brain aging. Ultimately, the findings from this study will help determine if incorporating lean beef into a regular diet can be a natural, food-based strategy to help preserve neurological health in older adults.",[126,32,127,128,129],"Healthy Aging","Cardiometabolic Health","Normal Aging","Cognitive Decline Prevention in Robust Older Adults",[131,132,133,134,135,136,137,138,139,140,141,142],"lean beef","red meat","dietary intervention","brain biomarkers","p-tau217","amyloid beta","bdnf","lipidomics","older adults","neuroprotection","nutrition","metabolomics","2026-05-28",{"date":145,"type":50},"2026-06-03",{"date":145,"type":21},{"date":148,"type":21},"2027-07-31",{"name":150,"class":57},"South Dakota State University",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":66,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":160,"conditions":161,"keywords":165,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":180},"100628092","lombard-cohort-of-brain-health-services-100628092","NCT07457138","Lombard Cohort of Brain Health Services","LoBHeS","Inclusion Criteria:\n\n* Adults (≥18 years)\n* Diagnosis of SCD, FCD, or \"well worried\" individuals without objective cognitive impairment\n* Evaluation at one of the Lombardy BHS\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosis of mild cognitive impairment or dementia at baseline visit\n* Enrollment in another interventional study with an expected effect on cognition\n* Pregnancy or breastfeeding",{"count":159,"type":21},1000,"The goal of this multicenter prospective observational cohort study is to better understand the clinical, neuropsychological, and biological characteristics of individuals attending Brain Health Services (BHS) in the Lombardy region. The study focuses on adults with subjective cognitive decline (SCD), functional cognitive disorder (FCD), or \"well worried\" individuals without objective cognitive impairment.\n\nThe main questions it aims to answer are:\n\n* What clinical, cognitive, and biological differences exist between individuals who are positive versus negative for Alzheimer's disease (AD) plasma biomarkers (p-tau217) at baseline?\n* What factors predict positivity to AD biomarkers at baseline?\n* How does communication of biomarker results (risk disclosure) affect psychological well-being shortly after receiving results?\n* What factors predict longitudinal changes in AD biomarkers over 5 years?\n* Do baseline biomarkers predict the development of mild cognitive impairment (MCI) or dementia during follow-up?\n\nParticipants will:\n\n* Undergo standard clinical evaluation at their local BHS\n* Provide blood samples for plasma biomarker analysis (e.g., p-tau217, GFAP, NfL, ApoE)\n* Undergo neuropsychological testing and cognitive screening\n* Complete questionnaires assessing psychological impact and risk perception (before and after biomarker disclosure)\n* Undergo additional center-specific procedures when clinically indicated (e.g., MRI, lumbar puncture, polysomnography)\n* Be followed annually for 5 years\n\nThe study plans to enroll approximately 1000 participants across multiple BHS in Lombardy and will follow them for a total duration of 7 years. The results will help clarify the role of biomarkers in early cognitive complaints and support the development of preventive strategies within BHS.",[162,163,164,32],"Subjective Cognitive Decline (SCD)","Functional Cognitive Disorder","Alzheimer's Disease",[166,167,164,163,168,169,170],"Brain Health Services","Subjective Cognitive Decline","pTau-217","GFAP","NfL","2026-03-13",{"date":173,"type":50},"2026-03-17",{"date":175,"type":50},"2026-02-01",{"date":177,"type":21},"2033-02-01",{"name":179,"class":57},"University of Milano Bicocca",5,{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":93,"sex":16,"minAge":95,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":202,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":58},"100628795","l-serine-and-strength-training-in-the-elderly-100628795","NCT07466290","L-serine and Strength Training in the Elderly","AAAging","Inclusion Criteria:\n\n* Men and women between the ages of 65 and 85\n* Mini-Mental-State \\>23\n* Independently mobile, without aids (walker, cane, etc.)\n\nExclusion Criteria:\n\n* Chronic diseases that contraindicate medical training therapy\n* Regular strength training (\\>1x\u002Fweek) in the last 6 months before confinement\n* Frailty Index ≥ 3\n* Lack of written consent to test physical performance\n* Regular use of Cortison-containing medications or Antibiotika\n* MR-specific exclusion criteria: claustrophobia, metal equipment or other magnetic Material in or on the body\n* Non-compliance with the study protocol: \\\u003C70% of the planned L-serine administration, \\\u003C70% of the strength training","85 Years",{"count":190,"type":21},126,[24],"This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people.\n\nHealthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training.\n\nCognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.",[32,194,195,196,197,198,199,200,201],"Longevity","Cognitive Performance","Strength Training Effects","Healthy Ageing","Ageing","Cognition","Memory","Muscle Strength",[197,203,204,205,206,207,208,200,209,210,211,212,213,214],"Brain ageing","Older adults","L-serine supplementation","Resistance training","Cognitive function","Cognitive ageing","Hippocampus","Magnetic resonance imaging","Electroencephalography","Brain connectivity","Muscle strength","Synaptic plasticity","2026-03-06",{"date":217,"type":50},"2026-03-12",{"date":219,"type":21},"2026-03",{"date":221,"type":21},"2028-12",{"name":223,"class":57},"University of Vienna",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":95,"enrollmentInfo":232,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":233,"conditions":234,"keywords":238,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":4},"100590539","sleep-glucose-and-brain-health-in-obesity-and-overweight-individuals-100590539","NCT06968728","Sleep, Glucose, and Brain Health in Obesity and Overweight Individuals","The Interplay Between Sleep Disturbances, Glucose Regulation, and Brain Health in Individuals With Overweight and Obesity","NNF","* Be between 40 and 65 years of age\n* Be classified as having normal weight, overweight, or obesity\n* Not be pregnant\n* Not be currently using glucose-lowering medications or undergoing glucose therapy\n* Not have a diagnosis of type 1 or type 2 diabetes mellitus\n* Not have kidney disease, thyroid disorders, or inflammatory bowel disease\n* Not have undergone bariatric surgery\n* Not actively participating in a weight-loss diet\n* Not using medications that affect glucose levels or taking sleep-inducing pills\n* Not working night shifts\n* Not have traveled across time zones in the past 3 months\n* Not have any severe chronic medical illnesses or severe psychiatric disorders\n* Be able and willing to wear all required study monitoring devices\n* Own a smartphone with Bluetooth capability",{"count":68,"type":21},"The primary aim of the NNF study is to investigate both cross-sectional and longitudinal associations between sleep patterns-measured over two consecutive weeks at baseline and again one year later-and indicators of glycemic control and brain health in a cohort of middle-aged adults. Through this effort, the investigators hope to identify potential sleep-related biomarkers and behavioral targets for early intervention to support metabolic and cognitive health.",[235,236,237,32],"Obesity and Overweight","Type 2 Diabetes","Sleep",[239,240,241,242,45,243,244,245],"obesity","overweight","type 2 diabetes","glucose control","diet","sleep disruption","gut microbiota","2025-05-13",{"date":248,"type":50},"2025-05-18",{"date":250,"type":21},"2025-05-15",{"date":252,"type":21},"2030-01-15",{"name":254,"class":57},"Uppsala University",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":93,"sex":16,"minAge":263,"maxAge":95,"enrollmentInfo":264,"targetDuration":4,"studyType":22,"phases":266,"briefSummary":267,"conditions":268,"keywords":271,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":4},"100583289","investigating-the-combined-effects-of-intermittent-hypoxia-and-exercise-on-cognitive-and-cerebral-function-in-middle-aged-adults-100583289","NCT06874387","Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults","Towards a Better Understanding of the Combination of Intermittent Hypoxia and Physical Exercise: Comparison of Effects on Cognitive and Cerebral Capacities in Middle-Aged Adults","HYPOX-AGE","* Inclusion Criteria:\n\n  * Adults aged 50 to 65 years (male and female)\n  * Montreal Cognitive Assessment (MoCA) score ≥ 24\n  * No participation in any structured exercise intervention in the last 6 months\n  * No exposure to altitudes above 1,500 m in the preceding 3 months\n  * No chronic kidney, cardiovascular, metabolic, neurological, or orthopedic -disease\n  * No history of significant respiratory conditions (e.g., asthma, exercise-induced -bronchospasm, dyspnea on exertion)\n  * No current immunosuppressive treatment (e.g., corticosteroids, antidepressants)\n  * No history of cancer or arthritis treatments\n  * No recent blood donation (within the last 2 months)\n  * Must be covered by a Social Security system or equivalent\n  * Signed informed consent after receiving clear and transparent study information\n  * Eligibility confirmed by a medical doctor during the inclusion process\n* Exclusion Criteria:\n\n  * Active smoking\n  * Major cardiovascular complications within the last 3 months (e.g., myocardial i-infarction, unstable angina, severe arrhythmias)\n  * Severe hypertension (≥180 mmHg systolic or ≥110 mmHg diastolic)\n  * Chronic respiratory insufficiency (e.g., COPD, sleep apnea)\n  * Diabetes mellitus\n  * Need for continuous or intermittent oxygen therapy\n  * Participation in another clinical study at the same time\n  * Use of corticosteroids or other systemic immunosuppressants\n  * Any condition compromising safety or study compliance, as determined by the medical team\n  * Pregnancy or breastfeeding\n  * Legal or administrative protections (e.g., individuals under guardianship, persons deprived of liberty)\n  * High baseline physical activity levels (PASE score \\>90 indicating moderate-to-intense physical activity)","50 Years",{"count":265,"type":21},176,[24],"This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65 years old). The hypothesis is that (1) each intervention alone (IHT or PA) provides cognitive benefits and (2) combining IHT with PA may yield additive or synergistic effects, particularly when administered simultaneously rather than sequentially. By comparing these distinct interventions, the study aims to determine which approach best preserves or enhances cognitive performance in middle-aged adults. Findings from this research may inform non-pharmacological strategies to promote healthy aging and reduce the risk of age-related cognitive decline.",[269,32,270],"Cognitive Ability, General","Cerebral Oxygenation",[272,273,274,275,276,32,277,278,126,279,280],"intermittent Hypoxia Training","Hypoxic Conditioning","Physical Activity","Exercise Intervention","Cognitive Function","Non-Pharmacological Interventions","Middle-Aged Adults","Cognitive Decline Prevention","Neuroplasticity","2025-03-07",{"date":283,"type":50},"2025-03-13",{"date":285,"type":21},"2025-04-01",{"date":287,"type":21},"2026-12-30",{"name":289,"class":57},"Ayoub Boulares",{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":93,"sex":298,"minAge":66,"maxAge":299,"enrollmentInfo":300,"targetDuration":4,"studyType":22,"phases":302,"briefSummary":303,"conditions":304,"keywords":310,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":58},"100568593","the-effects-of-night-shift-work-on-health-across-the-menstrual-cycle-100568593","NCT06683248","The Effects of Night Shift Work on Health Across the Menstrual Cycle","The Effects of Night Shift Work on Health Across the Menstrual Cycle: a Pilot Study","MENSLEEP","Inclusion Criteria:\n\n\\- Healthy\n\nExclusion Criteria:\n\n* Use of hormonal contraceptives\n* Chronic disease\n* Regular use of nicotine\n* Use of medication\n* Consumes excessive amounts of alcohol or coffee","FEMALE","35 Years",{"count":301,"type":21},60,[24],"The study aims to investigate the effects of sleep deprivation on women's health across different phases of the menstrual cycle.",[305,306,32,307,308,309],"Sleep Deprivation","Menstrual Cycle","Metabolism","Microbiota","Immune System",[311],"Estrogen","2024-11-11",{"date":314,"type":50},"2024-11-14",{"date":316,"type":50},"2022-04-25",{"date":318,"type":21},"2025-12-31",{"name":254,"class":57}]