[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-injuries-focal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-injuries-focal":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100659459","advanced-space-time-resolved-techniques-for-functional-neuroimaging-at-7-tesla-mri-100659459",false,"NCT07865546","Advanced Space-time Resolved Techniques for Functional Neuroimaging at 7 Tesla MRI","Advanced Space-time Resolved Techniques for fUnctional neuROimaging Characterization of Structurally Abnormal Eloquent coRtical Areas","AURORA","Inclusion criteria Healthy Volunteers\n\n* Age ≥ 18 years;\n* No history of diagnosed psychiatric disorders;\n* Sufficient understanding of the Italian language (required both for informed consent and for comprehension of fMRI task instructions);\n* Provision of written informed consent.\n\nPatients\n\n* Age 6-65 years;\n* Diagnosis of drug-resistant epilepsy (PMID: 19889013), with or without structural brain abnormalities, and candidate for surgical treatment (PMID: 21145290, 24497269, 31876960), or presence of pre-, peri-, or post-natal brain lesions documented by prior brain MRI;\n* Normal intellectual functioning or mild cognitive impairment sufficient to ensure adequate collaboration during the 7T functional neuroimaging study;\n* Sufficient understanding of the Italian language (required both for informed consent and comprehension of fMRI task instructions);\n* Provision of written informed consent (and assent when applicable, according to age and regulations).\n\nExclusion Criteria (All Participants)\n\n* Contraindications to 7T MRI;\n* Neuropsychiatric comorbidities preventing adequate collaboration during functional neuroimaging;\n* Pregnancy;\n* Refusal to receive information regarding incidental findings identified during MRI examination.",true,"ALL","6 Years","65 Years",{"count":22,"type":23},180,"ESTIMATED","INTERVENTIONAL",[26],"NA","In recent years, the in vivo study of the central nervous system has undergone significant advancement through the implementation of magnetic resonance imaging (MRI)-based neuroimaging techniques. In particular, the advent of high- and ultra-high-field MRI systems has substantially contributed to a deeper understanding of the pathophysiological mechanisms underlying neurological diseases and has supported the development of personalized approaches in medicine. In the field of neuroimaging, the application of MRI techniques to investigate brain function and connectivity in vivo is increasingly expanding at ultra-high magnetic field strength (7T).\n\nThis research project aims to develop, implement, and optimize advanced techniques to improve image quality through deep learning-based approaches and real-time monitoring of magnetic field fluctuations, with the goal of achieving functional neuroimaging at very high spatial and temporal resolution on a 7T scanner.\n\nThese techniques will be applied in healthy volunteers to address fundamental questions in basic neuroscience, as well as in clinical populations with central nervous system disorders, including patients with focal epilepsy and patients with congenital brain lesions associated with persistent neurological deficits.\n\nThe basic neuroscience component will allow investigation of mechanisms of brain function and connectivity between eloquent cortical regions and subcortical structures. In the clinical setting, improved delineation of activation maps in eloquent brain areas and characterization of their reorganization under pathological conditions are expected to enhance personalized therapeutic decision-making and deepen our understanding of neuroplasticity mechanisms, with potential impact on clinical care pathways.",[29,30,31,32],"Neurological Disorders","Neuroscience","Epilepsy","Brain Injuries, Focal",[34,35,36,37,38],"epilepsy","7T MRI","functional MRI","brain lesion","ultra-high field MRI","RECRUITING","2026-10-04",{"date":42,"type":43},"2026-10-08","ACTUAL",{"date":45,"type":43},"2024-10-16",{"date":47,"type":23},"2027-10-16",{"name":49,"class":50},"Imago 7 Fondazione di Ricerca onlus","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":18,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":64,"conditions":65,"keywords":66,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100656620","vr-versus-task-oriented-circuit-training-on-ul-sensorimotor-in-children-with-immature-brain-injury-100656620","NCT07827365","VR Versus Task-Oriented Circuit Training on UL Sensorimotor in Children With Immature Brain Injury","Effect of Virtual Reality Versus Task-Oriented Circuit Training on Upper Limb Sensorimotor Function in Children With Immature Brain Injury :Randomized Controlled Trial","Inclusion Criteria:\n\n* Forty four children with cerebral palsy,\n* Age will range as (12:18) years old\n* spastic cerebral palsy\n* Gross motor function classification system: level I\\&II\n* level I-III on the Manual Ability Classification System (MACS)\n\nExclusion Criteria:\n\n* difficulty to communicate or to understand program instructions\n* surgery\u002FBotox injection during the last 6 months in the upper extremity\n* uncontrolled severe seizures\n* fixed deformities in the affected side;\n* Attention deficit\u002Fhyperactivity disorders.","12 Years","18 Years",{"count":62,"type":23},44,[26],"To investigate and compare the effect of virtual reality and task-oriented circuit training on pinch grip and quality of life in children with with immature brain injury. BACKGROUND: Children with immature brain injury may have limited use of their hands for functional activities and for fine motor skills. The primary function of the hand is hand grip, which has a great Influence on activities and tasks of daily life",[32],[67],"Virtual Reality, sensorimotor Function, Children, immature Brain Injury","NOT_YET_RECRUITING","2026-09-14",{"date":71,"type":43},"2026-09-18",{"date":73,"type":23},"2026-09-20",{"date":75,"type":23},"2027-01-15",{"name":77,"class":50},"October 6 University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":17,"sex":18,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":51},"100579353","the-impact-of-self-processing-on-mental-time-travel-100579353","NCT06823193","The Impact of Self-processing on Mental Time Travel","How Self-processing Affects Mental Time Travel: a Neuropsychological Study","Inclusion Criteria:\n\n* the absence of general cognitive impairment, assessed by neuropsychological testing\n* the presence of a focal brain lesion will be adopted as an inclusion criterion for patients.\n\nExclusion Criteria:\n\n* psychiatric disorders\n* multiple brain lesions","40 Years","80 Years",{"count":88,"type":23},66,[26],"Mental time travel (MTT) refers to the ability to project oneself backward into the past or forward into the future to envision past and future events. This study examines the role of the ventromedial prefrontal cortex (vmPFC) in orienting toward past and future events during MTT.",[32],[93,94,95],"Mental Time Travel","Projection","Self\u002Fother distinction","2026-02-20",{"date":98,"type":43},"2026-02-23",{"date":100,"type":43},"2024-12-01",{"date":102,"type":23},"2026-09-30",{"name":104,"class":50},"Istituti Clinici Scientifici Maugeri SpA"]