[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-injuries":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,36,0,25,[9,42,69,100,141,165,195,220,260,295,318,355,375,401,426,457,482,505,528,556,584,604,632,657,679],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100556475","ketamine-infusion-as-a-method-of-cerebral-protection-in-children-100556475",false,"NCT06525584","Ketamine Infusion as a Method of Cerebral Protection in Children","Ketamine Infusion in the Postoperative Period as a Method of Cerebral Protection in Children During Surgical Correction of Congenital Heart Defects","Inclusion Criteria:\n\n* age from 1 to 60 months\n* body weight from 3.5 to 20 kg\n* planned surgical intervention to correct a congenital heart defect (atrial or ventricular septal defect) with CPBё\n* the presence of informed consent for participation in the study signed by the child's legal representative\n\nExclusion Criteria:\n\n* lack of informed consent of the patient and parents to participate in the study,\n* emergency and urgent surgical interventions;\n* the presence of clinically significant anemia;\n* hypo-thermic during operation, episodes of desaturation in the perioperative period;\n* the presence of another congenital heart diseases besides the atrial or ventricular septal defect, as well as their combination;\n* a history of central nervous system diseases;\n* an installed pacemaker;\n* hemodynamic instability requiring preoperative pharmacological and\u002For mechanical support;\n* any episodes of cerebrovascular accidents in the history or periop-erative period;\n* the presence of a patient with severe concomitant diseases that worsen mental and somatic conditio;\n* acute infection and exacerbation of chronic infection in the perioperative period;\n* concomitant autoimmune diseases;\n* the presence of malignant neoplasms;\n* surgical complications in the postoperative period.","ALL","1 Month","5 Years",{"count":21,"type":22},196,"ESTIMATED","INTERVENTIONAL",[25],"NA","The study is devoted to the use of ketamine infusion in a subanesthetic dose in the postoperative period in children after surgical correction of congenital heart defects in children.",[28],"Brain Injuries","RECRUITING","2026-08-13",{"date":32,"type":33},"2026-08-17","ACTUAL",{"date":35,"type":33},"2023-11-05",{"date":37,"type":22},"2028-12-30",{"name":39,"class":40},"Kemerovo State Medical University","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":41},"100638702","portable-mri-for-pediatric-hypoxic-ischemic-brain-injury-100638702","NCT07577336","Portable MRI for Pediatric Hypoxic Ischemic Brain Injury","Ultralow-Field Portable MRI for Detection of Pediatric Hypoxic Ischemic Brain Injury","pMRI for pHIBI","Inclusion Criteria\n\n* Patients hospitalized in the Pediatric Intensive Care Unit, Cardiac Intensive Care Unit, or the Neonatal Intensive Care Unit\n* Ages 0-17 years at study enrollment\n* Acute neurologic deficit suspected secondary to Hypoxic Ischemic Brain Injury (HIBI) or patients at high risk for HIBI\n\nExclusion Criteria o Pregnancy Any patient who has a contraindication to having an MRI\n\nPatients with a passive or active implant will:\n\n•First be reviewed on MRISafety.com to determine MR conditionality •If device is listed as Conditional or Unsafe for a 1.5T or a 3T, device will then be reviewed by MRI Safety Officer or MRI Physician Section chief to determine true conditionality for the portable MRI","17 Years",{"count":52,"type":22},200,[25],"This study will evaluate the sensitivity and specificity of low field portable MRI (pMRI) for detection of hypoxic ischemic brain injuries in pediatric patients compared to clinically obtained neuroimaging to define pediatric diagnostic limitations and to determine the diagnostic capabilities of this neuroimaging modality following optimization of image acquisition. The results of this study will help determine optimal clinical implementation opportunities in pediatric patients.",[56,57,58,28,59,60],"Acute Brain Injury","Hypoxia, Brain","Ischemia, Brain","Trauma, Brain","Stroke","2026-08-11",{"date":30,"type":33},{"date":64,"type":33},"2026-07-06",{"date":66,"type":22},"2027-12",{"name":68,"class":40},"Children's Mercy Hospital Kansas City",{"id":70,"slug":71,"hasResults":12,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100651824","epidural-spinal-cord-stimulation-for-respiratory-recovery-in-brain-injury-100651824","NCT07766681","Epidural Spinal Cord Stimulation for Respiratory Recovery in Brain Injury","An Exploratory Clinical Trial of Epidural Spinal Cord Stimulation for Respiratory Recovery in Patients With Brain Injury","BREATH","Inclusion Criteria:\n\n* Age 18 to 74 years. Body mass index less than 30 kg\u002Fm². Imaging-confirmed stroke or traumatic brain injury. Glasgow Coma Scale score of 3 to 8, with relatively stable vital signs. Requirement for invasive mechanical ventilation through an oral or nasal endotracheal tube or tracheostomy for at least 24 hours.\n\nWritten informed consent provided by the participant's legally authorized representative; if the participant regains decision-making capacity, continued participation will be reconfirmed with the participant.\n\nWillingness and ability of the participant or legally authorized representative to comply with the study intervention and follow-up procedures.\n\nExclusion Criteria:\n\n* Suspected or confirmed infection at the planned electrode implantation site, severe uncontrolled systemic infection, known metal allergy relevant to the implanted device, or uncontrolled intracranial hypertension.\n\nRespiratory failure primarily attributable to severe pneumonia, pulmonary contusion, pneumothorax, hemothorax, chronic obstructive pulmonary disease with respiratory failure, severe asthma, or a requirement for home oxygen therapy within the previous 6 months.\n\nNew York Heart Association class III or IV heart failure or presence of an implanted cardiac pacemaker.\n\nSevere hepatic dysfunction, including Child-Pugh class C, severe renal dysfunction with estimated glomerular filtration rate ≤30 mL\u002Fmin\u002F1.73 m², or dialysis dependence.\n\nStatus epilepticus or active convulsions. Cervical spinal cord injury, other spinal cord injury, major chest wall deformity, myasthenia, or respiratory dysfunction primarily caused by brainstem injury.\n\nSevere psychiatric or pre-existing neurological or cognitive disorders that would interfere with study evaluation or completion, including amyotrophic lateral sclerosis, dementia, Parkinson disease, Huntington disease, or another clinically significant central nervous system disorder unrelated to the index brain injury.\n\nExpected survival of 72 hours or less, or a decision to withhold endotracheal intubation, cardiopulmonary resuscitation, or other life-sustaining treatment.\n\nPregnancy or breastfeeding. Any other condition that, in the investigator's judgment, may place the participant at unacceptable risk or interfere with completion of the study.","18 Years","74 Years",{"count":80,"type":22},10,[25],"Patients with severe brain injury may develop impaired respiratory drive, diaphragm dysfunction, prolonged mechanical ventilation, and difficulty recovering spontaneous breathing. Epidural spinal cord stimulation may activate preserved spinal respiratory circuits and improve respiratory muscle activity. This prospective, single-center, non-randomized, single-arm exploratory study will enroll 10 patients with stroke or traumatic brain injury who have impaired consciousness and require invasive mechanical ventilation. Participants will undergo epidural spinal cord stimulation in addition to standard clinical care. Diaphragmatic electrical activity, respiratory function, diaphragm ultrasound findings, diaphragm electromyography, duration of mechanical ventilation, pulmonary infection, length of stay, mortality, safety events, and 6-month neurological outcome will be assessed. The study aims to evaluate the safety and preliminary efficacy of epidural spinal cord stimulation for improving respiratory function after brain injury.",[28,84],"Respiratory Failure",[86,87,88],"Epidural spinal cord stimulation","Respiratory failure","Diaphragmatic electrical activity","NOT_YET_RECRUITING","2026-08-09",{"date":92,"type":33},"2026-08-14",{"date":94,"type":22},"2026-08-05",{"date":96,"type":22},"2028-12-31",{"name":98,"class":40},"Zhongda Hospital",3,{"id":101,"slug":102,"hasResults":12,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":41},"100638143","prospective-observational-multimodal-neuromonitoring-during-high-risk-adult-surgery-100638143","NCT07577726","Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery","Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery: A Single-Center Cohort Study of Quantitative EEG, Noninvasive Intracranial Dynamics, and Perioperative Physiologic Correlates","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled to undergo major spine surgery, liver transplantation, on-pump cardiac surgery, major vascular surgery, major thoracic surgery, major abdominal surgery, or neurosurgical craniotomy at UT Southwestern Medical Center\n* Able to provide informed consent (self or legally authorized representative when applicable)\n* Safe and feasible placement of SedLine and\u002For Brain4Care monitoring as determined by the clinical and research teams\n* Anticipated availability of perioperative clinical data needed for study analyses\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Prisoner status\n* Pregnancy\n* Unable to provide informed consent in English (consent documents available in English only)\n* Declining participation\n* Lack of subject or legally authorized representative consent when required\n* Clinical condition preventing safe or feasible placement of study monitors (e.g., incompatible surgical field location, significant facial or scalp injury, open wounds at intended sensor placement site)\n* Operative workflow or clinical urgency precluding reasonable completion of consent and monitor placement prior to start of surgery\n* Anticipated clinical data capture insufficient for meaningful analysis",{"count":108,"type":22},300,"OBSERVATIONAL","This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center. The study acquires synchronized multimodal neuromonitoring data - including SedLine quantitative EEG (qEEG) extracted from standard-of-care clinical monitoring and, where deployed, Brain4Care (B4C) noninvasive intracranial dynamics data - and links these data to perioperative hemodynamic, medication, laboratory, procedural, and outcome variables. No alteration of routine clinical care occurs. The primary goal is to characterize associations between monitor-derived features and perioperative clinical variables, and to establish a multimodal dataset supporting future analyses of perioperative brain health in high-risk surgical populations.",[112,113,114,28,115],"Postoperative Cognitive Complications","Delirium","Perioperative\u002FPostoperative Complications","Anesthesia",[117,118,119,120,121,122,123,124,125,126,127,128,129,130,131],"quantitative EEG","SedLine","Brain4Care","intracranial dynamics","cerebrovascular reactivity","perioperative neuromonitoring","postoperative delirium","perioperative brain health","cardiac surgery","liver transplantation","spine surgery","Moberg Clinical Platform","cerebral autoregulation","high-risk surgery","intraoperative monitoring","2026-05-04",{"date":134,"type":33},"2026-05-11",{"date":136,"type":22},"2026-07",{"date":138,"type":22},"2028-12",{"name":140,"class":40},"University of Texas Southwestern Medical Center",{"id":142,"slug":143,"hasResults":12,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100634134","prophylactic-anti-epileptic-regimen-in-traumatic-brain-injury-100634134","NCT07535736","Prophylactic Anti-epileptic Regimen in Traumatic Brain Injury","Role of Prophylactic Anti-epileptic Regimen in Traumatic Brain Injury","Inclusion Criteria:\n\n1. Patients with a confirmed diagnosis of traumatic brain injury (clinical and\u002For radiological), including both surgical and conservative management\n2. Admission within 24 hours of injury\n3. Eligible for antiepileptic prophylaxis according to clinical guidelines\n4. Written informed consent obtained.\n\nExclusion Criteria:\n\n1. Pre-existing epilepsy or seizure disorder.\n2. Seizure episode before or during admission unrelated to acute TBI.\n3. Prior use of antiepileptic drugs before admission.\n4. Severe renal impairment (creatinine clearance \\\u003C30 mL\u002Fmin).\n5. Hepatic failure.\n6. Pregnancy or lactation.\n7. Known hypersensitivity to antiepileptic drugs","75 Years",{"count":150,"type":22},70,"To evaluate the effectiveness and safety of anti-epileptic drugs in the prevention of early and late post-traumatic seizures among patients with trauma brain injury",[153,28],"Antiepileptic Efficacy and Safety",[155],"Anti-epileptic, Brain Injury, Efficacy, Safety, Trauma","2026-04-10",{"date":158,"type":33},"2026-04-17",{"date":160,"type":22},"2026-05-01",{"date":162,"type":22},"2027-06-30",{"name":164,"class":40},"Assiut University",{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":17,"minAge":172,"maxAge":148,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":177,"conditions":178,"keywords":181,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":41},"100624815","phase-2-remotely-administered-tdcs-to-improve-cognitive-function-in-veterans-with-mtbi-and-ptsd-principal-investigator-100624815","NCT07414537","Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator","Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD","Inclusion Criteria:\n\n* History of chronic mTBI as measured by Ohio State University Traumatic Brain Injury Identification Method\n* mTBI occurred \\> 5 years prior to study enrollment\n* History of PTSD with symptoms within the last month as confirmed PTSD Checklist (past month) score greater than or equal to 33,\n* Cognitive impairment as defined by telephone Montreal Cognitive Assessment \\\u003C 19\n* No history of reported or documented age-related or neurodegenerative condition\n* Access to internet for 1 hour per day\n* Willing and able to comply with all study related procedures and capable of independently reading and understanding study materials and providing informed consent.\n\nExclusion Criteria:\n\n* Skin lesions at the stimulation site that may increase conductance\n* Metallic objects in the face or head (e.g. braces, fillings, implants)\n* Pregnancy\u002Flactation or planning to become pregnant during study\n* History of other significant neurological disorders including seizure disorder, central nervous system tumors, stroke, cerebral aneurysm\n* History of primary psychotic disorder, bipolar I disorder, active substance use disorder (moderate or greater, measured by Drug Abuse Screening Test-10)\n* Active suicidal intent or plan, measured by Columbia-Suicide Severity Rating Scale\n* Other conditions or circumstances that, in the opinion of investigator team, have the potential to prevent completion and\u002For have a confounding effect on outcome assessments.\n* Unable to tolerate 2mA transcranial direct current stimulation (tDCS)","20 Years",{"count":174,"type":22},46,[176],"PHASE2","Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are common combat-related conditions that can result in impairments in cognition, including memory, attention and multi-tasking. There are few effective interventions to improve cognition in Veterans with cognitive impairment due to these conditions. Non-invasive brain stimulation techniques, like transcranial direct current stimulation (tDCS), can be used to stimulate activity in areas of the brain to optimize recovery and rehabilitation. In this study, the investigators are conducting a randomized controlled trial of tDCS to improve cognitive function in Veterans with cognitive impairment due to co-morbid TBI and PTSD. TDCS is remotely administered and paired with cognitive training.",[179,28,180],"Cognition","Stress Disorders, Post-Traumatic",[182,183,184],"Cognitive impairment","Rehabilitation","Neuromodulation","2026-02-09",{"date":187,"type":33},"2026-02-17",{"date":189,"type":22},"2027-05-24",{"date":191,"type":22},"2030-11-30",{"name":193,"class":194},"VA Office of Research and Development","FED",{"id":196,"slug":197,"hasResults":12,"nctId":198,"briefTitle":199,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":201,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":23,"phases":204,"briefSummary":205,"conditions":206,"keywords":207,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":41},"100562773","the-gut-brain-axis-during-neurorehabilitation-prebiotic-treatment-to-alter-the-gut-microbiome-and-neurologic-symptoms-100562773","NCT06607523","The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter the Gut Microbiome and Neurologic Symptoms","Brain Injury Patients\n\nInclusion\n\n* Ages 18 and above\n* Admitted to Moody Neurorehabilitation Institute for care\n* Less than 6 months post-injury\n* English speaking\n* Must be able to eat and drink by mouth\n* Willing and able to comply with study procedures\n* Willing and able to provide consent (with LAR if needed)\n\nExclusion\n\n* Significant heart, liver, kidney, blood or respiratory disease\n* HIV, Hepatitis B or Hepatitis C\n* Pregnancy or becoming pregnant during the study\n* History of inflammatory bowel disease\n* History of celiac disease\n* Active diverticular disease\n* Known allergy to study agent\n* Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation\n\nCommunity Control Subjects\n\nInclusion\n\n* Ages 18 and above\n* Have a family member who is admitted to Moody Neurorehabilitation Institute for care OR is working at Moody Neurorehabilitation Institute\n* English speaking\n* Willing and able to comply with study procedures\n* Willing and able to provide consent\n* FACs score ≤ 50\n\nExclusion\n\n* Trauma to head in last 6 months\n* Stroke in last 6 months\n* Significant heart, liver, kidney, blood or respiratory disease\n* HIV, Hepatitis B or Hepatitis C\n* Pregnancy or becoming pregnant during the study\n* History of inflammatory bowel disease\n* History of celiac disease\n* Active diverticular disease\n* Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation",true,{"count":203,"type":22},130,[25],"The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the microbiome leading to changes in fatigue and cognition.",[28],[208,209,210,179],"Brain Injury","Neurorehabilitation","Fatigue","2025-12-12",{"date":213,"type":33},"2025-12-19",{"date":215,"type":33},"2025-03-06",{"date":217,"type":22},"2028-10-01",{"name":219,"class":40},"The University of Texas Medical Branch, Galveston",{"id":221,"slug":222,"hasResults":12,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":226,"eligibilityCriteria":227,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":228,"enrollmentInfo":229,"targetDuration":4,"studyType":23,"phases":231,"briefSummary":232,"conditions":233,"keywords":244,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":259},"100547838","remotely-supervised-tdcs-for-complex-attention-in-mtbi-cognetric-100547838","NCT06413173","Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)","Remotely Supervised tDCS Combined With Cognitive Training to Improve Complex Attention in Active Duty Service Members and Veterans With Mild TBI (Cognetric)","COGNETRIC","Inclusion Criteria:\n\n1. Active-Duty Service Members.\n2. Ages 18 to 60.\n3. All genders.\n4. All racial and ethnic groups.\n5. History of mild TBI (as defined by the DOD\u002FVA criteria used in conjunction with the OSU TBI-ID) sustained at least 3 months and no more than 10 years prior to enrollment.\n6. Self-reported attention and\u002For concentration difficulties.\n7. At least one cognitive symptom reported on the Neurobehavioral Symptom Inventory (NSI) cognitive subscale.\n\nExclusion Criteria:\n\n1. Presence of a medical, psychiatric, physical or non-physical disease, disorder, condition, injury, disability or pre-existent history such that study participation, in the opinion of the PI: (a) may pose a significant risk to the participant; (b) raises the possibility that the participant is unlikely to successfully complete all of the requirements of the study according to the study protocol; or (c) might adversely impact the integrity of the data or the validity of the study results. Specific conditions include (but are not limited to) a history of: brain tumor, epilepsy, cerebral vascular accident (CVA), Schizophrenia, Bipolar Disorder, and Mania.\n2. History of prior treatment with ECT or neuromodulation in the last 12 months.\n3. Current, diagnosed substance dependence.\n4. Newly prescribed medication within the previous 3 weeks.\n5. Diagnosis of intellectual disability or pervasive developmental disorder (i.e., premorbid IQ less than or equal to 70).\n6. Any medical condition or treatment other than mild TBI (e.g., stroke, tumor, HIV, moderate-severe TBI), with significant neurological disorder or insults that, based on the Principal Investigator's judgment, would impact risk.\n7. Psychosis or mania within 30 days of enrollment, as determined by the PI, based on a psychiatric history and examination and\u002For a review of available medical records\n8. Contraindications for tDCS (e.g., metallic cranial plates\u002Fscrews or implanted device, eczema or skin lesions on scalp)\n9. A positive pregnancy report.","60 Years",{"count":230,"type":22},160,[25],"The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called \"Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training\" (RS-tDCS+) which has shown promise for improving complex attention in both healthy and clinical populations. RS-tDCS+ is a home-based, low-risk, non-invasive technique that is designed to boost cognitive training by enhancing learning and the brain's ability to reorganize connections. This study will evaluate RS-tDCS+ for improving complex attention in Active Duty Service Members (ADSM) and Veterans with a history of mTBI. Different tests of complex attention and symptom questionnaires will be used to determine the effects of real versus sham (placebo) RS-tDCS+. Second, the investigators will investigate electrical and connectivity changes in the brain associated with RS-tDCS+ using electroencephalogram (EEG) and magnetic resonance imaging (MRI). Third, the investigators will investigate the lasting effects of any observed changes by evaluating participants at 1 and 6 weeks post-treatment. Lastly, the investigators will explore the impact of individual differences (e.g., PTSD, depression, sleep quality, time since injury, baseline impairment, age, sex, ADSM versus Veteran) on treatment outcome.",[234,235,236,28,237,238,239,240,241,242,243],"Brain Concussion","Brain Trauma","Attention Concentration Difficulty","Brain Injuries, Traumatic","Neurocognitive Dysfunction","Attention Impaired","Memory Impairment","Mild Traumatic Brain Injury","Mild Cognitive Impairment","Post Concussive Symptoms",[245,246,247,248,249,184],"Military Health","Brain Stimulation","Cognitive Training","Cognitive Rehabilitation","Telehealth","2025-11-07",{"date":252,"type":33},"2025-11-12",{"date":254,"type":33},"2024-07-25",{"date":256,"type":22},"2028-09-30",{"name":258,"class":194},"United States Naval Medical Center, San Diego",2,{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":201,"sex":17,"minAge":267,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":269,"briefSummary":270,"conditions":271,"keywords":277,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":41},"100254540","mobile-health-self-management-and-support-system-for-chronic-and-complex-health-conditions-100254540","NCT02592291","Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions","Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions (Component 3)","Inclusion Criteria:\n\n1. 12 years or older.\n2. have a diagnosis of a chronic and complex condition such as Spina Bifida, Spinal Cord Injury, Cerebral Palsy and Traumatic Brain Injury, etc.\n3. live in a community setting (not within a residential facility that provides care to them).\n4. pass all the functional screening tests which include basic usage of a smart phone, and impairment severity assessments\n\nExclusion Criteria:\n\n1. Diagnosis of severe intellectual disability or severe and persistent psychiatric illness.\n2. Failing all the screening tests due to severe impairments that cannot be accommodated by the mHealth system (for patient participants)","12 Years",{"count":230,"type":22},[25],"This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to those who receive standard of care only.",[272,273,274,28,275,276],"Spinal Cord Injuries","Cerebral Palsy","Spinal Dysraphism","Spina Bifida","Traumatic Brain Injury",[278,279,280,281,282,283,284,285],"Mobile health","Apps","Applications","Smart phone","mHealth","Chronic and Complex Conditions","Self-Management","Self-Care","2025-10-01",{"date":288,"type":33},"2025-10-03",{"date":290,"type":33},"2019-10-01",{"date":292,"type":22},"2026-09",{"name":294,"class":40},"University of Pittsburgh",{"id":296,"slug":297,"hasResults":12,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":303,"targetDuration":305,"studyType":109,"phases":4,"briefSummary":306,"conditions":307,"keywords":308,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":314,"leadSponsor":316,"locationsCount":4},"100608202","construction-of-a-prognostic-model-for-severe-brain-injured-patients-based-on-integrated-metabolic-neurological-monitoring-100608202","NCT07198490","Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring","Construction of a Prognostic Model for Severe Brain-Injured Patients Based on Integrated Metabolic-Neurological Monitoring: A Prospective Observational Study","CPM-Brain","Inclusion Criteria:\n\n* Diagnosis of severe TBI, large-volume stroke, or HIE\n* Expected ICU stay \\>72 hours\n* Informed consent from legal surrogate\n\nExclusion Criteria:\n\n* Terminal organ failure\n* Pre-existing severe neurological disease\n* Skull defect preventing monitoring\n* Pregnancy or lactation",{"count":304,"type":22},50,"8 Months","This is a prospective, observational cohort study aimed at constructing a machine learning-based prognostic model for severe brain-injured patients. The study will synchronously collect continuous glucose monitoring (CGM), electroencephalography (EEG), near-infrared spectroscopy (fNIRS), transcranial Doppler (TCD), and serum neuronal injury biomarkers (NSE, S100β) within 72 hours post-injury. The goal is to investigate the correlation between glycemic variability (GV) and neurological function and to develop an integrated model for early prediction of 3-6 month neurological outcomes (GOSE score).",[28],[309],"continuous glucose monitoring,Neurological Multimodal Monitoring,Brain Injury,Intensive Care Unit","2025-09-29",{"date":312,"type":33},"2025-09-30",{"date":286,"type":22},{"date":315,"type":22},"2026-12-31",{"name":317,"class":40},"Xingui Dai",{"id":319,"slug":320,"hasResults":12,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":324,"eligibilityCriteria":325,"healthyVolunteers":12,"sex":17,"minAge":326,"maxAge":50,"enrollmentInfo":327,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":329,"conditions":330,"keywords":340,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":352,"locationsCount":354},"100544564","screening-emotions-in-adolescents-at-the-hospital-for-mtbi-100544564","NCT06370520","Screening Emotions in Adolescents at the Hospital for mTBI","Screening Emotions in Adolescents Receiving Care at the Hospital for mTBI (SEARCH-mTBI)","SEARCH-mTBI","Inclusion Criteria:\n\nChildren 11 to less than 18 years old who meet the Centers for Disease Control and Prevention (CDC) definition of mTBI\\*. In brief, this is defined as a Glasgow Coma Scale (GCS) score of 13 to 15 with:\n\n\\- Head injury (e.g., direct blow or sudden deceleration\u002Facceleration) plus any neurological sign and\u002For symptom such as headache, nausea, history of loss of consciousness, confusion, dizziness, amnesia (not limited to these symptoms\u002Fsigns)\n\nAND\u002FOR\n\n\\- Traumatic intracranial abnormalities on CT or MRI (such as intracranial hemorrhage, skull fracture, or diffuse axonal injury)\n\n\\*mTBI is defined as an acute brain injury resulting in neurological symptoms such as confusion or disorientation, headache, nausea, loss of consciousness, amnesia, seizure, focal signs or symptoms, and\u002For have traumatic intracranial abnormalities on CT or MRI imaging. mTBI patients have GCS scores of 13 to 15. Per CDC precedent, we will use the term mTBI which encompasses other commonly used terms such as \"concussion\" or \"minor head injury\". This will include patients who may have neuroimaging findings of traumatic abnormalities (e.g., intracranial hemorrhage, diffuse axonal injury, skull fractures) which are risk factors for mental health problems; however, neuroimaging is not required for enrollment into the study.\n\nExclusion Criteria:\n\n* Presentation to the ED \\>72 hours post-injury\n* TBI requiring emergent neurosurgical intervention at the time of enrollment\n* Other injuries requiring emergent surgery at the time of enrollment\n* Parent or child unable to accurately complete the study questionnaires due to preexisting functional limitations (e.g., severe developmental delay)\n* Previous known enrollment into the study\n* Patient or parent does not speak English or Spanish","11 Years",{"count":328,"type":22},2592,"The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing significant new or worsening mental health conditions.\n\nThe main aims the study wish to answer are:\n\n* Does the adolescent have new or worsening depression or anxiety defined as a change from their previous medical history using self-reported questionnaires at either one or three months post-injury?\n* Does the adolescent have unmet mental health care needs, defined as not receiving any mental or behavior health care in patients with new or worsening anxiety or depression as defined by the self reported questionnaires?\n\nParticipants will be enrolled after being diagnosed in the emergency department (ED) with an mTBI. During the ED visit, the child's parent\u002Fcaregiver and the adolescent will complete several questionnaires related to mental health which include tools to measure anxiety and depression. Participants will be asked to complete these questionnaires again at 1 month and 3 months post enrollment.",[331,28,332,333,334,335,336,337,338,339],"Brain Injury Traumatic Mild","Brain Injuries, Acute","Head Injury With Intracranial Hemorrhage","Head Injury Trauma","Brain Injury Traumatic Focal With Loss of Consciousness","Skull Fractures","Diffuse Axonal Injury","Intracranial Hemorrhages","Head Injury",[341,342,343,28,344,345],"Child","Concussion","Wounds and Injuries","Head Injuries Trauma","Loss of Consciousness","2025-09-22",{"date":348,"type":33},"2025-09-26",{"date":350,"type":33},"2024-05-22",{"date":138,"type":22},{"name":353,"class":40},"University of California, Davis",6,{"id":356,"slug":357,"hasResults":12,"nctId":358,"briefTitle":359,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":41},"100606206","high-risk-of-death-or-disability-in-brain-hemorrhage-role-of-spot-sign-and-secondary-markers-100606206","NCT07172542","High Risk of Death or Disability in Brain Hemorrhage: Role of Spot Sign and Secondary Markers","Inclusion Criteria:\n\n* Spontaneous intracerebral hemorrhage confirmed by contrast-enhanced CT scan.\n* Follow-up CT scan performed within 24 to 48 hours.\n\nNon-inclusion Criteria :\n\n* Absence of initial contrast-enhanced CT or follow-up CT.\n* Hematoma due to trauma, epidural hematoma (EDH), subdural hematoma (SDH), or subarachnoid hemorrhage (SAH).\n\nExclusion Criteria:\n\n* Patient deceased before the initial contrast-enhanced CT.\n* Major missing clinical data.",{"count":304,"type":22},"This study looks at patients with brain hemorrhage to see if a special sign on brain scans, called the \"Spot Sign,\" combined with other scan features, can predict a higher risk of death or disability. By comparing patient outcomes with existing prediction scores, the study aims to understand whether these scan markers provide extra value in identifying patients at higher risk.",[364,365,60,28],"Intracerebral Hemorrhage","Cerebral Hemorrhage","2025-09-08",{"date":368,"type":33},"2025-09-15",{"date":370,"type":22},"2025-10-15",{"date":372,"type":22},"2026-05-15",{"name":374,"class":40},"Centre Hospitalier de Gonesse",{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":379,"acronym":380,"eligibilityCriteria":381,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":384,"conditions":385,"keywords":388,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":41},"100555416","correlation-between-noninvasive-blood-vessel-functionality-parameters-and-cerebral-hemodynamics-in-neurocritical-care-patients-100555416","NCT06511804","Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients","Mespere ICP","Inclusion Criteria:\n\nSubjects who meet all the following inclusion criteria may be included:\n\n1. Adults (\\> 18 years of age);\n2. Able and willing to provide written informed consent for participation by self or legally authorized representatives.\n3. Clinical diagnosis of traumatic brain injury (TBI), brain hemorrhage, brain tumor, neurotrauma (including closed head injuries, penetrating head injuries, or other forms of neurotrauma), hemorrhage (intracerebral or subarachnoid), or stroke.\n4. Continuous Blood Pressure Monitoring: Patients must have continuous blood pressure monitoring in place during the study period, obtained from an arterial line. This criterion ensures that we have real-time data on mean arterial pressure (MAP) and systolic pressure (SBP).\n5. Intracranial Pressure (ICP) Monitoring: Patients must have intracranial pressure (ICP) monitoring in place during the study period. This criterion ensures that we can assess the correlation between our blood vessel functionality parameters (VDC, VR, and VRx) and ICP, a key indicator of intracranial dynamics.\n\nExclusion Criteria:\n\n1. Subjects who meet any of the following exclusion criteria will be excluded:\n2. Expected to be at increased risk due to study participation (e.g. due to hemodynamic instability), in the medical opinion of an investigator;\n3. Pregnant as determined per site standard practice;\n4. Previously participated in this study, or are enrolled in another research study that could be expected to interfere with participation, in the opinion of the investigator;\n5. Require or are anticipated to require emergent medical care in which study participation may reasonably delay his\u002Fher medical care or increase risk or unfavorable outcome, in the opinion of the investigator;\n6. Allergy to adhesive tape;\n7. Ongoing photodynamic therapy.","100 Years",{"count":7,"type":22},"The purpose of this clinical research project is to employ Mespere LifeSciences NeurOs Cerebral Oximetry system, equipped with noninvasive sensors approved by the FDA, to monitor and investigate the correlation within a cohort of patients suffering from traumatic brain injury (TBI), stroke, brain tumor, and brain bleeding. This study aims to investigate and establish the correlation between blood vessel functionality parameters-specifically, Vasodilation\u002FConstriction Index (VDC), Vascular Resistance Index (VR), and Volume Reactivity Index (VRx)-with the crucial physiological indicators, Intracranial Pressure (ICP) and Mean Arterial Pressure (MAP). By doing so, the investigators seek to address fundamental questions surrounding cerebral hemodynamics and autoregulation in various neurological conditions.",[28,386,387],"Intracranial Pressure Increase","Monitoring",[389,390,391],"intracranial pressure","monitoring","noninvasive","2025-05-26",{"date":394,"type":33},"2025-05-30",{"date":396,"type":33},"2024-11-17",{"date":398,"type":22},"2026-06-30",{"name":400,"class":40},"University of Louisville",{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":405,"acronym":406,"eligibilityCriteria":407,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":408,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":410,"conditions":411,"keywords":413,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":41},"100592878","therapeutic-drug-monitoring-of-beta-lactams-and-renal-hyperclearance-in-patients-admitted-to-intensive-care-for-acute-brain-injury-100592878","NCT06999161","Therapeutic Drug Monitoring of Beta-lactams and Renal Hyperclearance in Patients Admitted to Intensive Care for Acute Brain Injury","BETALACT-ARC","Inclusion Criteria:\n\n* Adult patients (≥18 years old)\n* Admitted to the intensive care unit for acute brain injury\n* Exhibiting Augmented Renal Clearance (ARC), defined by a urinary creatinine clearance (ClCrU) greater than 130 mL\u002Fmin\u002F1.73 m² on at least one measurement\n* Receiving Therapeutic Drug Monitoring (TDM)-guided treatment with one of the following beta-lactam antibiotics: amoxicillin\u002Fclavulanic acid, cefotaxime, piperacillin\u002Ftazobactam, cefepime, or meropenem\n* Affiliated with or benefiting from a health insurance scheme\n\nExclusion Criteria:\n\n* Estimated life expectancy \\\u003C24 hours\n* Patients who have expressed opposition to study participation\n* Patients under legal protection (guardianship, curatorship, or court protection)\n* Patients currently in an exclusion period determined by participation in another study\n* Patients already enrolled in a study that precludes concurrent participation in an observational study",{"count":409,"type":22},140,"Augmented Renal Clearance (ARC), defined as a supraphysiological increase in renal function, is frequently observed in critically ill patients, particularly those with acute brain injury. ARC complicates the management of renally eliminated drugs, specifically beta-lactam antibiotics, by enhancing drug clearance and thereby increasing the risk of underdosing and therapeutic failure. Although pharmacological therapeutic drug monitoring (TDM) is recommended to optimize dosing, it remains limited by issues of accessibility, highlighting the need for alternative approaches to identify at-risk patients and adjust dosing based on renal function.\n\nEarly identification of patients at risk for subtherapeutic beta-lactam plasma concentrations could enable timely dose adjustments. A combined assessment of renal function and beta-lactam TDM could enhance our understanding of the kinetics of both parameters. These data may support the development of predictive models capable of proposing individualized dosing regimens based on renal function.\n\nOptimizing beta-lactam plasma concentrations in this patient population could improve infection management and potentially enhance clinical outcomes.",[412,28],"Critical Illness",[414,415,416],"Beta-Lactams","Renal Clearance","Therapeutic Drug Monitoring","2025-05-22",{"date":419,"type":33},"2025-05-31",{"date":421,"type":33},"2025-05-05",{"date":423,"type":22},"2025-12",{"name":425,"class":40},"Centre Hospitalier Universitaire de Nīmes",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":433,"enrollmentInfo":434,"targetDuration":4,"studyType":23,"phases":435,"briefSummary":436,"conditions":437,"keywords":439,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":41},"100592583","biofeedback-training-for-hemianopia-100592583","NCT06995313","Biofeedback Training for Hemianopia","Biofeedback Training to Improve Fixation Stability, Visual Function Outcomes, and Quality of Life in Hemianopia Cases","Inclusion Criteria:\n\nHemianopia cases with more than 6 months from the date of the lesion, previously diagnosed accordingly by micro perimetry and other tests as needed, 18-90 years old, ability to follow the visual and auditory stimuli and training instructions.\n\nExclusion Criteria:\n\nPrevious or current treatment for low vision rehabilitation, ocular diseases, other serious clinical conditions not related to the hemianopia, both eyes with media opacity that impairs microperimetry testing, lack of ability to perform the tests and training.","90 Years",{"count":150,"type":22},[25],"This is a prospective study that compares biofeedback training on the microperimetry (BT) to a control group in patient s with hemianopia. The patients receive 5 sessions of 20 minutes to stimulate with light and sound the brain in using the best residual area on the visual fields post-brain injury visual loss. Visual tests and quality of life questionnaire are performed pre-and-post-training.",[438,28],"Hemianopia",[440,441,442,443,444,445,446,447],"hemianopsia","biofeedback training","brain tumor","brain trauma","visual fields","visual loss","low vision","fixation stability","2025-05-20",{"date":450,"type":33},"2025-05-29",{"date":452,"type":33},"2021-12-08",{"date":454,"type":22},"2026-07-08",{"name":456,"class":40},"University Health Network, Toronto",{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":17,"minAge":464,"maxAge":465,"enrollmentInfo":466,"targetDuration":4,"studyType":23,"phases":468,"briefSummary":469,"conditions":470,"keywords":471,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":475,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":480,"locationsCount":41},"100458481","animal-assisted-therapy-after-pediatric-brain-injury-mediators-and-moderators-of-treatment-response-100458481","NCT05250180","Animal Assisted Therapy After Pediatric Brain Injury: Mediators and Moderators of Treatment Response.","Using Dogs to Promote Therapeutic Engagement During Inpatient Rehabilitation Following Pediatric Acquired Brain Injury: Understanding Mechanisms and Moderators of Treatment Response.","Inclusion Criteria:\n\n* Diagnosis: Participants must be admitted to the inpatient rehabilitation unit for treatment of an acquired brain injury (TBI, brain tumor, infection, etc).\n* Consent: The family must provide informed consent by parents or legal guardians.\n* Assent: The child\u002Fadolescent must provide a signature indicating assent to participate in the study.\n* Age at the time of screening: 4-21 years old\n* Sex: includes both males and females\n* Responsiveness: Rancho score greater than 2 at the time of enrollment (as noted in the medical chart).\n\nExclusion Criteria:\n\n* Allergies: Patient has a significant allergy to dogs\n* Fear: Patient has a significant fear of dogs\n* Disease: Participant is on contact precautions or has a communicable disease that may pose a risk to the dog or dog handler or has a compromised immune system where interacting with the dog and\u002For handler would be of significant risk to the patient.\n* Medical History: History of developmental delay prior to ABI.\n* Behavioral History: Participant or family has a history of animal abuse or cruelty.\n* Responsiveness: Rancho score of 2 or less","4 Years","24 Years",{"count":467,"type":22},90,[25],"Children requiring inpatient rehabilitation treatment following acquired brain injury (ABI) are at risk for poor engagement in rehabilitative therapies. A within subject crossover design will be used to determine whether involving dogs in physical and occupational therapies while receiving inpatient rehabilitation improves patient engagement, how involving dogs improves engagement, and identify who is most likely to benefit. This project addresses the critical need to establish an evidence base for animal-assisted therapies in pediatric rehabilitation, incorporates innovative methods, and has the potential to lead to improved clinical care for children and adolescents receiving intensive rehabilitation following ABI.",[28],[472,473,474],"Pediatric brain injury","Animal assisted therapy","inpatient rehabilitation",{"date":476,"type":33},"2025-05-08",{"date":478,"type":33},"2022-07-22",{"date":398,"type":22},{"name":481,"class":40},"Children's Hospital Medical Center, Cincinnati",{"id":483,"slug":484,"hasResults":12,"nctId":485,"briefTitle":486,"officialTitle":487,"acronym":488,"eligibilityCriteria":489,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":148,"enrollmentInfo":490,"targetDuration":4,"studyType":23,"phases":492,"briefSummary":493,"conditions":494,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":41},"100534259","effect-of-transcranial-direct-current-stimulation-in-altered-states-of-consciousness-100534259","NCT06236503","Effect of Transcranial Direct Current Stimulation in Altered States of Consciousness","Effect of Daily Transcranial Direct Current Stimulation on the Cognitive Evolution of Patients in an Altered State of Consciousness","tDCS-GCA","Inclusion Criteria:\n\n* Patients diagnosed with a minimally conscious state will be evaluated and stimulated, provided that written informed consent is obtained from a family member.\n\nExclusion Criteria:\n\npatients in coma patients with metallic brain implants, craniotomy or pacemaker",{"count":491,"type":22},100,[25],"Transcranial Direct Current Stimulation (tDCS) is a non-invasive, painless brain stimulation treatment that uses low-intensity direct electrical currents to stimulate specific parts of the brain. Transcranial Direct Current Stimulation (tDCS) can both facilitate anodic stimulation and inhibit cathodic stimulation specific brain areas since many neurological and psychiatric disorders are connected to hypoactivity or hyperactivity in specific areas of the nervous system. This phenomenon is based on two processes: the reorganization of functional neural circuits and their reconstruction. In light of the studies mentioned above, it is presumed that Transcranial Direct Current Stimulation (tDCS) can be a valuable tool to facilitate the process of neuroplasticity in individuals with chronic neurological diseases and in patients with impaired consciousness following severe brain injury. A previous study demonstrated that a single session of transcranial direct current electrical stimulation could temporarily improve signs of consciousness in patients in a minimally conscious state (MCS)",[495,28],"Neurologic Disorder","2025-04-29",{"date":498,"type":33},"2025-05-01",{"date":500,"type":33},"2023-01-10",{"date":502,"type":22},"2025-12-30",{"name":504,"class":40},"IRCCS Centro Neurolesi Bonino Pulejo",{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":511,"eligibilityCriteria":512,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":513,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":515,"conditions":516,"keywords":517,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":522,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":526,"locationsCount":41},"100528539","modeling-outcome-in-patients-with-acquired-brain-injuries-100528539","NCT06162091","Modeling Outcome in Patients With Acquired Brain Injuries","Modeling Trajectories of Functional Outcome in Patients With Severe Acquired Brain Injuries Using a Non-Linear Dynamic Evolution Approach.","MOF-ABI","Inclusion Criteria:\n\n* patients with clinical diagnosis of severe acquired brain injury of different etiology (traumatic, hemorrhagic vascular,ischemic vascular, anoxic, infectious, other etiology\n* interval since the acute occurrence that led to the clinical condition of ≤3 months duration\n* age of 18 years or older\n* informed consent signed by family member\u002Fcaregiver\u002Fsupporting caregiver\n\nExclusion Criteria:\n\n* Positive remote medical history of pre-existing disabling neurological or orthopedic conditions and psychiatric disorders",{"count":514,"type":22},190,"Acquired brain injury (ABI) is the leading cause of death and disability worldwide. The degree of severity varies according to a combination of numerous demographics, etiological, clinical, cognitive, behavioral, psychosocial and environmental factors, which can interfere with the effectiveness of rehabilitation interventions and, therefore, with the final outcome.\n\nThe most important goal of the modern clinic is to predict in time the progression of possible recovery after the brain injury event in order to provide more effective treatment, but the high heterogeneity and clinical variability and the unpredictability of the onset of comorbidities makes this a hard target to reach.\n\nIn recent years, artificial intelligence algorithms have been applied to more precisely define the role of critical variables that can help clinical practice to predict the final outcome. The classical approach of these algorithms provides only probabilistic values on the final outcome, without considering the typology of clinical interventions and overall complications that may appear throughout the hospitalization period.\n\nThe objective of this multicentric study is to define a new statistical approach that can describe the dynamics of individual clinical changes occuring during the inpatient intensive rehabilitation care period. The proposed approach combines a principal component analysis (PCA) for dimension reduction (capturing the maximum amount of information and reducing the dimensionality problem) and a nonlinear mathematical modeling for describing the evolution of the clinical course in terms of the resulting new PCA dimensions. By using this approach, we may determine the individual patient's temporal trajectories while examining particular clinical factors. The secondary objective of this study is to validate a new version of the Early Rehabilitation Barthel Index (ERBI), a well-known clinical scale used to measure functional changes in patients with severe acquired brain injury.",[28],[518,519,520,521],"acquired brain injury","functional outcome","Modeling trajectories","mathematical models",{"date":498,"type":33},{"date":524,"type":33},"2024-01-10",{"date":419,"type":22},{"name":527,"class":40},"Istituto per la Ricerca e l'Innovazione Biomedica",{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":535,"enrollmentInfo":536,"targetDuration":538,"studyType":109,"phases":4,"briefSummary":539,"conditions":540,"keywords":542,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":548,"lastUpdatePostDateStruct":549,"startDateStruct":551,"completionDateStruct":552,"leadSponsor":554,"locationsCount":41},"100566827","pet-ct-to-assess-brain-damage-in-cardiac-arrest-patients-100566827","NCT06660238","PET-CT to Assess Brain Damage in Cardiac Arrest Patients","Assessment of Cerebral Metabolism, Cerebral Blood Flow and Cerebral Oxygen Damage in Patients With Cardiac Arrest Using PET-CT","Inclusion Criteria:\n\n* age ≥18 years.\n* sustained hemodynamic stability for ≥24h.\n* the patients were unconscious and not able to obey verbal commands. • Advanced life support and target temperature management within 6 hours of return of spontaneous circulation (ROSC).\n\nExclusion Criteria:\n\n* Patients with hemodynamic instability.\n* Patients who could not complete cranial PET-CT examination for special reasons. • Patients during pregnancy.\n* Patients who combined traumatic brain injury, stroke, cerebral hemorrhage and other diseases.\n* Patients whose family members did not agree to be enrolled.","80 Years",{"count":537,"type":22},30,"6 Months","This was a single-center, observational study. Patients with successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management. After successful return of spontaneous circulation (ROSC) for 72 hours and hemodynamic stability for 24 hours, the patients underwent positron emission computed tomography (PET-CT) examination after resuscitation. The supervising physician accompanied the patient and used monitors to monitor vital signs during the examination. Patients who were on ventilators were mechanically ventilated with a magnetic ventilator (HAMILTON-MRI, United States). In addition to conventional cerebral oxygen metabolism, cerebral blood flow, oxygen extraction fraction, cerebral blood volume and other indicators were added in this experiment. These indicators can evaluate the patient's cerebral metabolism, cerebral blood flow and cerebral blood oxygen damage degree. The neurological outcome was followed up 6 months after onset according to the cerebral performance category（CPC）.",[541,28],"Cardiac Arrest",[543,544,545,546,547],"Cardiac arrest","Positron Emission Tomography-Computed Tomography","cerebral metabolism","cerebral blood flow","cerebral oxygenation","2025-04-10",{"date":550,"type":33},"2025-04-11",{"date":498,"type":22},{"date":553,"type":22},"2027-12-31",{"name":555,"class":40},"Capital Medical University",{"id":557,"slug":558,"hasResults":12,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":562,"eligibilityCriteria":563,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":564,"targetDuration":565,"studyType":109,"phases":4,"briefSummary":566,"conditions":567,"keywords":570,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":41},"100431469","validity-and-reliability-study-of-the-pain-indicator-behavior-scale-brain-damage-escid-dc-100431469","NCT04898491","Validity and Reliability Study of the Pain Indicator Behavior Scale-Brain Damage (ESCID-DC)","Validity and Reliability Study of the Pain Indicator Behavior Scale Adapted to Measure Pain in Critically Ill Patients With Acquired Brain Damage, Non-communicative and With an Artificial Airway (ESCID-DC).","ESCID-DC","Inclusion Criteria:\n\n1. Age equal to or greater than 18 years.\n2. Inability to communicate verbally or motor.\n3. Have a artificial airway.\n4. Informed consent of the family member or representative of the patient.\n\nExclusion Criteria:\n\n1. Previous pathology of cognitive impairment.\n2. Previous brain injury.\n3. Previous psychiatric disorder.\n4. Previous dementia.\n5. Previous chronic substance abuse.\n6. Previous chronic diabetics.\n7. Previous spinal cord injury.\n8. Previous severe polyneuropathy (diagnosed or suspected).\n9. Confirmed diagnosis of brain death.\n10. Continuous infusion of muscle relaxants and \u002F or barbiturate coma.\n11. Level of deep sedation (RASS -5).",{"count":108,"type":22},"18 Months","A multicentre observational study to validate the adaptation of the Pain Indicator Behavior Scale (ESCID) for patients with acquired Brain Damage (ESCID-DC), as a measuring instrument.",[568,28,569],"Pain","Behavior",[568,571,572,573,574],"Brain injury","Brain damage","Intensive Critical Unit","Nursing","2025-03-28",{"date":577,"type":33},"2025-04-02",{"date":579,"type":33},"2022-06-01",{"date":581,"type":22},"2025-06-30",{"name":583,"class":40},"Candelas Lopez Lopez",{"id":585,"slug":586,"hasResults":12,"nctId":587,"briefTitle":588,"officialTitle":589,"acronym":590,"eligibilityCriteria":591,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":172,"enrollmentInfo":592,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":593,"conditions":594,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":596,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":41},"100583219","evaluation-of-patients-affected-by-traumatic-and-hypoxic-ischemic-brain-injury-100583219","NCT06873477","Evaluation of Patients Affected by Traumatic and Hypoxic-ischemic Brain Injury","Clinical and Epidemiological Evaluation of Patients Affected by Traumatic and Hypoxic-ischemic Brain Injury","PETRA","Inclusion Criteria:\n\n* Patients aged 0-20 years with brain damage due to severe traumatic brain injury or perinatal asphyxia evaluated at the Pediatric Emergency Department\n* Informed consent signed by the parents, the adult patient, or the legal guardian\u002Frepresentative.\n* Adult patients with psycho-cognitive impairments that affect their ability to provide consent, with prior acquisition of informed consent from the guardian\u002Flegal representative.\n\nExclusion Criteria:\n\n* Refusal to sign the informed consent\n* Patients with congenital malformations or genetic syndromes\n* Patients with neuromuscular diseases\n* Patients with encephalopathies of etiology other than severe head trauma or asphyxia\n* Patients with hemodynamically significant congenital heart diseases",{"count":304,"type":22},"According to the World Health Organization, perinatal asphyxia is the leading cause of severe neurological disabilities and the second leading cause of neonatal death among term infants, with an incidence of 3.94-5.12 per 1,000 live births. Perinatal asphyxia leads to neonatal hypoxic-ischemic encephalopathy, which remains a common cause of neonatal death and long-term disabilities, affecting 1.5-3 per 1,000 live births in developed countries and up to 26 per 1,000 live births in developing countries. This condition is characterized by altered levels of consciousness or manifests with seizures, often associated with difficulties in initiating and maintaining breathing, as well as depression of tone and reflexes. Currently, therapeutic hypothermia is the standard treatment for neonates with moderate to severe hypoxic-ischemic encephalopathy; however, it does not provide complete neuroprotection and is only partially effective. Therefore, new treatments with good therapeutic windows are urgently needed to ensure the best possible preservation of neurological tissue for patients exposed to hypoxic-ischemic insult. Traumatic brain injury is a common cause of morbidity and mortality among children and young adults in developed countries. The incidence of traumatic brain injury has increased in recent years, yet the prognosis for these patients has not substantially changed. In recent studies the key intermediary role of the immune system and neuroinflammation has been proposed to explain the pathophysiology of traumatic brain injury, both in the acute phase and in the long term. Indeed, neuroinflammatory processes can persist for several months, contributing to chronic alterations and accelerating brain aging in patients with post-traumatic brain injury. Currently, therapies that have shown promising results in patients with post-traumatic brain injuries are unfortunately still limited, especially in the context of severe traumatic brain injury. Thus, there is an urgent need for new treatments with a broader therapeutic window that can counteract early and chronic pathophysiological events.",[28,595],"Brain Ischemia",{"date":597,"type":33},"2025-03-12",{"date":599,"type":33},"2025-01-15",{"date":601,"type":22},"2027-07-31",{"name":603,"class":40},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":610,"eligibilityCriteria":611,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":612,"targetDuration":4,"studyType":23,"phases":614,"briefSummary":615,"conditions":616,"keywords":617,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":623,"lastUpdatePostDateStruct":624,"startDateStruct":626,"completionDateStruct":628,"leadSponsor":630,"locationsCount":41},"100513475","the-home-study-healthy-options-made-easy-telehealth-nutrition-sessions-for-people-living-with-brain-injury-100513475","NCT05965947","The HOME Study (Healthy Options Made Easy): Telehealth Nutrition Sessions for People Living With Brain Injury","Medical Nutrition Therapy and Diet Quality Among Survivors of Brain Injury - The HOME Study (Healthy Options Made Easy): Telehealth Nutrition Sessions for People Living With Brain Injury","HOME","Inclusion Criteria:\n\n* At least 18 years of age\n* History of brain injury\n* Live in Alabama\n* Live at home in the community\n* Have internet access to join Zoom sessions\n\nExclusion Criteria:\n\n* Under 18 years of age\n* No history of brain injury\n* Lives outside of Alabama\n* Currently in a hospital, rehabilitation facility, group home, or other location other than 'home'\n* Pregnant or breastfeeding\n* Not able\u002Fwilling to participate based on the Decision-Making Capacity Assessment",{"count":613,"type":22},134,[25],"Brain injury is a leading cause of disability in the United States. When survivors of brain injury recover from the initial injury and return home to live in the community, they often face chronic health conditions that warrant nutrition therapy, such as diabetes, high blood pressure, high cholesterol, and overweight and obesity. Typically, these individuals do not receive nutrition counseling.\n\nThus, the purpose of this clinical trial is to compare changes in diet quality between community-dwelling individuals with a history of brain injury who receive three individualized nutrition therapy sessions versus handouts only.\n\nOur research question is:\n\nCan nutrition counseling improve dietary intake among this population?\n\nParticipants will complete a survey, participate in three days of dietary recalls via Zoom or telephone, and receive either three individualized nutrition counseling sessions with a Registered Dietitian or standard of care (handouts).\n\nResearchers will compare the diets of the recipients of the nutrition counseling to a control group who receives nutrition handouts to see if nutrition sessions with a Registered Dietitian improve dietary intake.",[28],[618,619,620,621,622],"brain injury","Medical Nutrition Therapy","Registered Dietitian","diet quality","Healthy Eating Index","2024-12-04",{"date":625,"type":33},"2024-12-09",{"date":627,"type":33},"2023-06-12",{"date":629,"type":22},"2025-10-31",{"name":631,"class":40},"University of Alabama, Tuscaloosa",{"id":633,"slug":634,"hasResults":12,"nctId":635,"briefTitle":636,"officialTitle":637,"acronym":638,"eligibilityCriteria":639,"healthyVolunteers":12,"sex":17,"minAge":640,"maxAge":4,"enrollmentInfo":641,"targetDuration":4,"studyType":23,"phases":643,"briefSummary":644,"conditions":645,"keywords":648,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":623,"lastUpdatePostDateStruct":651,"startDateStruct":652,"completionDateStruct":654,"leadSponsor":655,"locationsCount":41},"100298062","rehabilitation-of-visual-function-after-brain-injury-100298062","NCT03160131","Rehabilitation of Visual Function After Brain Injury","Rehabilitation of Visual Function After Brain Injury - Effect of Neuro Vision Technology (NVT)","IBOS-NVT","Inclusion criteria:\n\n* 14 years or older with brain injury.\n* Persons who experience significant vision impairment.\n* Eye sight 6\u002F18 or better.\n* The time from symptoms onset to study inclusion is between 6 weeks and 9 months.\n\nExclusion criteria:\n\n* Cognitive dysfunction.\n* Persons with anosognosia or severe neglect.\n* Inability to move independently at least 35 meters with or without assistance, including wheelchairs.\n* Inability to understand Danish or with communication disorders that prevent participation in tests.\n* Terminal disorder, other progressive disorder.\n* Significant abuse of alcohol or euphoric or narcotic drugs.\n* Serious disorders such as mental illness, especially severe depression.\n* New brain injury or other significant disorders emerging after study inclusion.\n* Impaired vision not due to brain damage, where the disorder is not considered to be permanent or where the field of vision does not cause significant disability.","14 Years",{"count":642,"type":22},56,[25],"In Denmark, about 120,000 people suffer from brain damage, of whom approx. 75,000 with brain damage after stroke. Serious and often lasting vision impairments affect 20% to 35% of people after stroke. Vision is the most important sense in humans, and even smaller permanent injuries can drastically reduce quality of life.\n\nVision impairments after brain damage inhibits rehabilitation and enhances other invalidating effects. Reduced vision results in impaired balance, increased risk of serious falls, increased support needs, reduced quality of life, and impaired ability to perform activities of daily living. Restoration of visual field impairments occur only to a small extent during the first month after brain damage, and therefore the time window for spontaneous improvements is very limited. Hence, brain-impaired persons with visual impairment will most likely experience chronically impaired vision already 4 weeks after brain injury and the need for visual compensatory rehabilitation is substantial.\n\nNeuro Vision Technology (NVT) is an supervised training course where people with visual impairments are trained in compensatory techniques using special equipment. Through the NVT process, the individual's vision problems are carefully investigated and personal data is used to organize individual training sessions that practice the individual in coping with situations that cause problems in everyday life.\n\nThe purpose of this study is to investigate whether rehabilitation with NVT can cause significant and lasting improvement in functional capacity in persons with chronic visual impairments after brain injury. Improving eyesight is expected to increase both physical and mental functioning, thus improving the quality of life. Participants included in the project will be investigated in terms of both visual and mental functions, including quality of life, cognition and depression. Such an investigation has not been performed previously and can have a significant impact on vision rehabilitation both nationally and internationally.",[646,28,647,276],"Stroke, Ischemic","Stroke Hemorrhagic",[60,649,438,650,183],"Visual impairment","Neuro Vision Technology",{"date":625,"type":33},{"date":653,"type":33},"2017-08-01",{"date":601,"type":22},{"name":656,"class":40},"University Hospital, Gentofte, Copenhagen",{"id":658,"slug":659,"hasResults":12,"nctId":660,"briefTitle":661,"officialTitle":662,"acronym":4,"eligibilityCriteria":663,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":664,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":665,"conditions":666,"keywords":667,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":670,"lastUpdatePostDateStruct":671,"startDateStruct":673,"completionDateStruct":675,"leadSponsor":677,"locationsCount":41},"100559968","electroencephalography-in-the-management-of-neuroelectric-stimulation-in-patients-with-severe-traumatic-brain-injuries-100559968","NCT06571032","Electroencephalography in the Management of Neuroelectric Stimulation in Patients With Severe Traumatic Brain Injuries","Evaluation of Electroencephalography in the Management of Neuroelectric Stimulation in Patients With Severe Traumatic Brain Injuries: A Prospective Study","Inclusion Criteria:\n\n* 7 days after severe traumatic brain injuries (GCS score 3-8);\n* Over 18 years old, regardless of gender;\n* The patient's legal representative is informed and voluntarily signs the consent form.\n\nExclusion Criteria:\n\n* Unstable vital signs;\n* History of mental disorders or neurodegenerative diseases;\n* Uncontrolled epilepsy;\n* Severe arrhythmias or patients with implanted cardiac pacemakers;\n* Various conditions that interfere with scalp EEG collection;\n* Pregnant women.",{"count":304,"type":22},"The goal of this observational retrospective study is to evaluate the electroencephalography (EEG)'s poficiency in the treatment of neuroelectric stimulation in patients with severe traumatic brain injuries (TBI).\n\nThe main questions it aims to answer are:\n\n1. Whether EEG of patients with severe TBI will change after they receiving neuroelectrial stimulation? If yes, how does it change?\n2. How can EEG be used to evaluate the condition of patients with severe TBI?",[28],[668,669],"Electroencephalography","Severe traumatic brain injuries","2024-11-13",{"date":672,"type":33},"2024-11-15",{"date":674,"type":33},"2024-08-15",{"date":676,"type":22},"2025-12-31",{"name":678,"class":40},"RenJi Hospital",{"id":680,"slug":681,"hasResults":12,"nctId":682,"briefTitle":683,"officialTitle":684,"acronym":4,"eligibilityCriteria":685,"healthyVolunteers":12,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":686,"targetDuration":4,"studyType":109,"phases":4,"briefSummary":688,"conditions":689,"keywords":691,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":695,"lastUpdatePostDateStruct":696,"startDateStruct":698,"completionDateStruct":700,"leadSponsor":702,"locationsCount":41},"100552982","mechanical-ventilation-on-hippocampus-100552982","NCT06480162","Mechanical Ventilation on Hippocampus","Impact of Mechanical Ventilation on Hippocampal Oscillation and Respiratory-hippocampus Coupling","Inclusion Criteria:\n\n* Age: ≥ 18 years\n* ASA: I - II\n* w\u002F electrode inside hippocampus (≥ 1 contacts)\n* Singed consent form\n\nExclusion Criteria:\n\n* Seizure occurrence ≤ 36 hours before op.\n* Structural brain damage\n* History of using: opioids, enzyme-inducing medications, sleep aids, or excessive alcohol consumption\n* History of mechanical ventilation (\\>24h)\n* Cognitive impairment\n* Operation within 6 months\n* Participate in other clinical trials in the last four weeks\n* Pregnant or breastfeeding",{"count":687,"type":22},20,"Ventilator-associated brain injury (VABI) frequently occurs in ICU patients. Although animal studies indicate the hippocampus as a key target of VABI, its relevance in human patients remains uncertain. In this study, the investigators aim to monitor hippocampal EEG activity during the weaning process of patients off mechanical ventilation, and also exploring the coupling between breathing patterns and hippocampal activity.",[690,28],"Mechanical Ventilation Complication",[692,693,694],"Ventilator Associated Brain Injury","Hippocampus Oscillation","Mechanical Ventilation","2024-08-06",{"date":697,"type":33},"2024-08-09",{"date":699,"type":33},"2024-05-08",{"date":701,"type":22},"2025-06-01",{"name":703,"class":40},"Beijing Sanbo Brain Hospital"]