[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"brain-lesion-general\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:brain-lesion-general":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100612147","closed-loop-rtms-eeg-during-visuomotor-integration-100612147",false,"NCT07249801","Closed-loop rTMS-EEG During Visuomotor Integration.","State-dependent Entrainment of Intrinsic Brain Rhythms to Improve Interregional Functional Coupling.","SYNC","Inclusion Criteria:\n\n* adult volunteers (age ≥18 years)\n* right-hand dominance (defined with the Edinburg Handedness Scale)\n* voluntary whole-hand grip force (Medical Research Council scale for muscle force ≥2)\n* capable of repeated grasp and release with 5% of maximum voluntary contraction (standardized with an in-house computer-based assessment involving whole-hand grip force tracking upon visual cues with a digital dynamometer).\n\nExclusion Criteria:\n\n* presence of any MRI risk factors (such as an electrically, magnetically, mechanically activated metal or nonmetal implant including cardiac pacemaker, intracerebral vascular clips, any other electrically sensitive support system, or claustrophobia)\n* presence of any contraindications to repetitive transcranial magnetic stimulation, rTMS (e.g., history of seizures or epileptic activity, currently taking medications that lower seizure thresholds)\n* any neurological or psychiatric disorders affecting cognitive function (e.g., established dementia) affecting the ability to understand the purpose of the study and give informed consent or ability to complete cognitive testing\n* substance use disorder\n* visual impairment that precludes completion of scanner tasks\n* uncontrolled hypertension despite treatment\n* intake of tricyclic anti-depressants\n* musculoskeletal disorders affecting bimanual grasp- and release\n* pregnancy (or suspected\u002Fpossible pregnancy or plan to become pregnant in the short term). If the participant is a woman of childbearing potential, a urine pregnancy test will be performed on a standard basis.\n* severe aphasia affecting particularly of receptive nature (NIH Stroke Scale, NIHSS Language subsection ≥2) affecting the ability to understand the purpose of the study and give informed consent\n* pregnancy","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This pilot study aims at establishing personalized state-based rTMS for precision neurorehabilitation, we designed a within-subject cross-over study to test closed-loop repetitive transcranial magnetic stimulation and electroencephalography (rTMS-EEG) comparing the targeting of two key nodes in the frontoparietal network during bimanual visuomotor force tracking in persons with upper extremity sensorimotor impairment affecting eye-hand control.",[27,28],"Visuomotor Skills","Brain Lesion (General)",[30,31,32,33],"visuomotor processing","electroencephalography (EEG)","transcranial magnetic stimulation (TMS)","eye-hand control","RECRUITING","2026-09-11",{"date":37,"type":38},"2026-09-15","ACTUAL",{"date":40,"type":38},"2025-11-01",{"date":42,"type":21},"2027-02-28",{"name":44,"class":45},"Medical University of South Carolina","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100540266","genetic-and-molecular-characterization-of-nervous-system-lesions-100540266","NCT06314607","Genetic and Molecular Characterization of Nervous System Lesions","ONCONEUROTEK 2","Inclusion Criteria:\n\n* Any patient operated on for a brain lesion (e.g. tumors: glioma, LCPSNC, meningioma, or rare tumor) and\u002For followed up for one of these pathologies.\n* Age ≥ 18 years\n* Consent or non-opposition of the patient or his\u002Fher legal representative (guardian) to participate in the study.\n\nExclusion Criteria: NA",{"count":55,"type":21},10000,"OBSERVATIONAL","Primary and secondary brain tumors, the leading cause of death from cancer before the age of 35, represent a complex and heterogeneous group of pathologies with a generally poor prognosis. Knowledge of these tumors has made enormous strides thanks to access to biological samples, leading to a much more robust, reliable and precise histo-pronostic classification, but also, increasingly, to the identification of theranostic targets.\n\nDespite these advances, there is a real need to refine diagnostic and prognostic classification, identify the biological mechanisms involved in the formation and progression of these pathologies, develop new targeted strategies, and devise minimally invasive follow-up methods (liquid biopsies).\n\nIn addition, certain non-tumoral brain lesions (e.g. malformations) can be similarly classified according to their molecular and mutational profile.\n\nThis project aims to make a decisive contribution to these objectives.",[59,28],"Brain Tumor",[61,62],"Brain tumor","Cerebral Lesions","2024-08-30",{"date":65,"type":38},"2024-09-04",{"date":67,"type":38},"2024-03-26",{"date":69,"type":21},"2034-03",{"name":71,"class":45},"Assistance Publique - Hôpitaux de Paris",3]