[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"branch-atheromatous-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:branch-atheromatous-disease":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100651333","cognitive-outcomes-in-bad-related-stroke-100651333",false,"NCT07761182","Cognitive Outcomes in BAD-related Stroke","Cognitive Outcomes in Patients With Branch Atheromatous Disease-Related Stroke: A Prospective Cohort Study","Inclusion Criteria:\n\n1. Age: 18-80 years.\n2. Time from onset to enrollment: 8-14 days; if onset time is unknown, time from last known normal to enrollment must be 8-14 days.\n3. Meet the following imaging inclusion criteria:\n\n3\\. 1 DWI infarct: single (isolated) deep (subcortical) infarct 3.2 The culprit vessel is the lenticulostriate artery, and the DWI lesion meets at least one of the following criteria (A\u002FB): A. comma-shaped infarct expanding fan-wise from bottom to top on coronal view; or B. involvement of ≥3 axial slices (slice thickness 5-7 mm) 3.3 No ≥50% stenosis of the ipsilateral middle cerebral artery (confirmed by MRA, CTA, or DSA) 4. Informed consent form signed by the patient or their legally authorized representative.\n\nExclusion Criteria:\n\n1. Baseline imaging showing intracranial hemorrhagic disease, vascular malformation, space-occupying lesion, or other non-ischemic intracranial pathology.\n2. Transient ischemic attack or stroke mimics.\n3. Cardioembolic causes: including atrial fibrillation, valvular heart disease, infective endocarditis, etc.\n4. Tandem extracranial vascular stenosis ≥50% ipsilateral to the infarct lesion.\n5. Prior diagnosis of dementia (Alzheimer's disease, frontotemporal dementia, or Lewy body dementia) or significant cognitive decline (IQCODE \\> 3.38).\n6. Contraindications to photon-counting CT or 5T-MRI.\n7. Pregnancy or lactation.\n8. Life expectancy \\\u003C 1 year.","ALL","18 Years","80 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","Branch atheromatous disease (BAD) is a distinct subtype of ischemic stroke that is particularly prevalent among Chinese and other Asian populations. Patients with BAD are prone to early neurological deterioration and poor functional outcomes, and BAD is increasingly recognized as an independent disease entity. However, the association between BAD and cognitive impairment remains unclear. This nationwide, multicenter, prospective observational study will prospectively collect epidemiological, clinical, neuroimaging, functional, and cognitive outcome data from patients with BAD. The study aims to investigate the occurrence of cognitive impairment after BAD and identify the clinical and neuroimaging characteristics associated with cognitive impairment. In particular, the relationship between early neurological deterioration (END) and cognitive impairment will be investigated. As an exploratory objective, this study will further explore the potential brain network mechanisms underlying cognitive impairment associated with END events.",[25,26,27],"Branch Atheromatous Disease","Cognitive","Deterioration, Clinical","NOT_YET_RECRUITING","2026-08-07",{"date":31,"type":32},"2026-08-12","ACTUAL",{"date":34,"type":21},"2026-09-01",{"date":36,"type":21},"2028-10-01",{"name":38,"class":39},"Peking Union Medical College Hospital","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":49,"targetDuration":51,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100646260","early-identification-and-diagnosis-of-bad-related-stroke-100646260","NCT07693816","Early Identification and Diagnosis of BAD-related Stroke","Establishment and Validation of a Novel Intelligent Diagnostic Model for BAD-related Stroke Based on the Fusion of Multi-source Clinical Image Information and Its Promotion","SMART-BAD","Inclusion Criteria:\n\n* Age 18 to 80 years.\n* Diagnosis of acute ischemic stroke.\n* Time from symptom onset to enrollment ≤ 1 week; if the onset time is unknown, time from last known well to enrollment ≤ 1 week.\n* Availability of required baseline clinical and neuroimaging assessments according to the study protocol.\n* Written informed consent provided by the participant or legally authorized representative.\n\nParticipants will be classified into the BAD-related stroke cohort if they meet all predefined BAD-related stroke diagnostic criteria, including:\n\n* A single isolated deep subcortical infarct on diffusion-weighted imaging.\n* The presumed culprit perforating artery is the lenticulostriate artery or the paramedian pontine artery.\n* For lenticulostriate artery territory infarction: a comma-shaped lesion extending from inferior to superior direction on coronal DWI or involvement of ≥3 axial DWI slices with 5-7 mm slice thickness.\n* For paramedian pontine artery territory infarction: a lesion extending from the deep pons to the ventral surface of the pons on axial DWI.\n* No ≥50% stenosis of the corresponding parent artery, confirmed by MRA, CTA, or DSA.\n\nParticipants with acute ischemic stroke who do not meet BAD-related stroke criteria will be classified into the non-BAD acute ischemic stroke cohort.\n\nExclusion Criteria:\n\nGeneral exclusion criteria for all participants:\n\n* Intracranial hemorrhage, vascular malformation, aneurysm, brain abscess, malignant intracranial mass, or other non-ischemic intracranial lesion on baseline CT, MRI, MRA, CTA, or DSA.\n* Pre-stroke modified Rankin Scale score ≥2.\n* Life expectancy ≤6 months.\n* Unable to tolerate MRI examination.\n* Pregnancy or breastfeeding.\n* Participation in another clinical study within 3 months before informed consent or current participation in another clinical study that may interfere with this study.\n\nAdditional criteria that preclude classification as BAD-related stroke:\n\n* Ipsilateral extracranial tandem artery stenosis ≥50%.\n* Definite cardioembolic source, including atrial fibrillation, myocardial infarction, clinically significant valvular heart disease, dilated cardiomyopathy, infective endocarditis, atrioventricular conduction disease, or heart rate \\\u003C50 beats\u002Fmin as defined in the protocol.\n* Receipt of or planned acute-phase endovascular treatment after stroke onset.\n* Stroke due to other determined causes, such as moyamoya disease, arterial dissection, or vasculitis.",{"count":50,"type":21},1602,"90 Days","Branch atheromatous disease (BAD)-related stroke is an important subtype of acute ischemic stroke involving penetrating arteries and is associated with early neurological deterioration. Early recognition and standardized diagnosis remain challenging in routine clinical practice because clinical symptoms are often non-specific and the diagnosis requires integrated clinical and imaging assessment.\n\nThis multicenter prospective observational study will collect demographic, clinical, laboratory, electrocardiographic, ultrasound, and multimodal neuroimaging data from adults with acute ischemic stroke within 1 week of symptom onset. Participants will receive routine clinical care determined by their treating physicians; no treatment or management strategy will be assigned by the study protocol. An independent central clinical-imaging adjudication committee will classify participants as BAD-related stroke or non-BAD acute ischemic stroke according to predefined diagnostic criteria. The study aims to develop and externally validate artificial intelligence-assisted screening and diagnostic models for BAD-related stroke and to evaluate their discrimination, calibration, and potential clinical utility.",[25,54,55],"Acute Ischemic Stroke","Cerebral Infarction",[57,58,59,60,61,62,63,64,65,66],"Branch atheromatous disease","Acute ischemic stroke","Artificial intelligence","Machine learning","Deep learning","Diagnostic model","Multimodal imaging","Magnetic resonance imaging","Lenticulostriate artery","Paramedian pontine artery","RECRUITING","2026-07-05",{"date":70,"type":32},"2026-07-09",{"date":72,"type":21},"2026-07-15",{"date":74,"type":21},"2028-12-31",{"name":38,"class":39},11]