[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"breast-milk\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:breast-milk":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,80,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644410","phase-1-breast-milk-enema-administration-to-stimulate-passage-of-meconium-100644410",false,"NCT07661992","Breast-milk Enema Administration to Stimulate Passage of Meconium","Breast-Milk Enema Administration to Stimulate Meconium Passage in Preterm Infants","BEAM","Inclusion Criteria:\n\n* Preterm infants born at \\>23 and \\\u003C28 weeks' gestational age born at Atrium Health Wake Forest Baptist Hospital or transferred in the first 24 hours of life.\n* postnatal age \\>48 hours, absence of spontaneous passage of meconium by \\>48 hours of life\n* availability of mother's own milk\n* written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Infants with Necrotizing Enterocolitis (NEC) ≥ stage II\n* spontaneous intestinal perforation (SIP)\n* gastrointestinal or anorectal malformations\n* infants that have developed severe hemodynamic instability or sepsis with need for vasoactive drugs\n* significant hematologic abnormalities such as neutropenia or thrombocytopenia.\n* Infants will also be excluded in the absence of written informed consent from a parent or legal guardian.","ALL","23 Weeks","28 Weeks",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","Lack of passage of meconium in preterm infants delays feeding advancement and may represent a risk factor for necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP). Usual management of meconium impaction has included glycerin suppositories and normal saline enemas. Various methods are used in routine neonatal care to promote meconium evacuation; however, there is no consensus on the agents used and the frequency of applications",[28],"Breast-milk",[30,31,32],"Meconium","rectal enemas","low birth weight infants","NOT_YET_RECRUITING","2026-07-24",{"date":36,"type":37},"2026-07-28","ACTUAL",{"date":39,"type":22},"2026-10",{"date":41,"type":22},"2027-07",{"name":43,"class":44},"Wake Forest University Health Sciences","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":45},"100648095","the-effect-of-breast-milk-10-and-20-dextrose-on-pain-and-physiological-variables-during-heel-puncture-in-infants-100648095","NCT07716813","The Effect of Breast Milk, 10% and 20% Dextrose on Pain and Physiological Variables During Heel Puncture in Infants","The Effect of Oral Breast Milk and 20% Dextrose Solution Administered With Supportive Positioning Methods on Pain and Physiological Variables During Heel Puncture Blood Sampling in Preterm Infants: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Parental consent for the baby's participation in the study\n* Admission to Mersin University Hospital NICU between July 16, 2026 and December 30, 2026,\n* Gestational age at birth between 33 weeks and 37 weeks,\n* Postnatal age less than 7 days,\n* Heel prick blood test planned within the scope of NTP,\n* Stable clinical condition,\n* Absence of genetic or metabolic problems,\n* Developed sucking-swallowing and breathing coordination,\n* Having been fed at least 30 minutes before the procedure,\n* No experience with invasive procedures in the last 6 hours before the procedure,\n* No administration of non-opioid analgesics in the last 4 hours before the procedure,\n* No administration of opioid analgesics and sedative agents in the last 24 hours before the procedure,\n* Spontaneous respiration at 21% FiO2,\n* Absence of neurological problems (e.g., asphyxia, hypoxic ischemic encephalopathy, intraventricular hemorrhage, periventricular leukomalacia, spinal cord injury…),\n* Absence of contraindications to oral glucose\u002Fbreast milk administration (e.g., necrotizing enterocolitis or suspicion thereof, feeding intolerance, tracheoesophageal fistula, absence of esophageal atresia…),\n* Absence of endocrine problems (e.g., hypoglycemia, hyperglycemia, large for gestational age, absence of a diabetic mother…),\n\nExclusion Criteria:\n\n* Parental disapproval of infant's participation in the study\n* No hospitalization at Mersin University Hospital NICUs between July 16, 2026 and December 30, 2026,\n* Gestational age at birth less than 33 weeks or greater than 37 weeks,\n* Postnatal age greater than 7 days,\n* Heel prick blood test not planned within the scope of NTP,\n* Clinical condition not stable,\n* Lack of developed sucking-swallowing and breathing coordination,\n* Having been fed within 30 minutes of the procedure,\n* Having had invasive procedures experience in the last 6 hours before the procedure,\n* Having received non-opioid analgesics in the last 4 hours before the procedure,\n* Having received opioid analgesics and sedative agents in the last 24 hours before the procedure,\n* Genetic or metabolic problem The following are contraindications:\n* Being on invasive or non-invasive mechanical ventilation support,\n* Having a neurological problem,\n* Oral glucose\u002Fbreast milk administration being contraindicated,\n* Having an endocrine and metabolic problem.","32 Weeks","37 Months",{"count":56,"type":22},96,[58],"NA","Pain, defined by the International Association for the Study of Pain as a subjective, sensory, and emotional experience, differs from nociception, which is merely a neural activity. Premature newborns, whose inhibitory fibers are not yet mature due to anatomical and physiological development and who have insufficient endogenous opioid release, experience painful stimuli much more intensely. The inability of this age group to verbally express pain makes the diagnosis, assessment, and management of pain entirely dependent on healthcare professionals. Pain that is not effectively managed leads to stress and loss of comfort in the short term, while in the long term it can cause permanent neurodevelopmental problems and alter the individual's pain threshold later in life.\n\nPremature infants, especially those in Neonatal Intensive Care Units (NICUs), are exposed to invasive procedures that cause moderate to severe pain, such as heel prick tests, much more frequently than healthy term infants. In this context, pain management is a fundamental and essential nursing responsibility for the infant's neuroprotective developmental care. The literature shows that various non-pharmacological methods, such as oral sucrose, non-nutritive sucking (NNS), facilitated flexion, and wrapping, are used to alleviate pain during interventional procedures. Although more readily available in NICUs, studies on the effectiveness of oral glucose solutions are more limited compared to sucrose.\n\nThis research, designed to address this gap in the existing literature, aims to investigate the effect of \"oral breast milk, 20%, and 10% dextrose solution administered with supportive positioning methods\" on pain reduction during heel prick blood sampling in premature newborns. The results of this research are expected to contribute to the development of a new, easily applicable, effective, and evidence-based nursing intervention strategy for NICUs.",[61,62,63,64,65],"Newborn Care","Pain Management","Physiological Parameters During Newborn Care İn Newborn's","Breast Milk","Premature",[67,68,69,70,71],"premature baby","pain","breast milk","nursing care","dextrose","2026-07-22",{"date":34,"type":37},{"date":75,"type":22},"2026-07-18",{"date":77,"type":22},"2026-09-30",{"name":79,"class":44},"Mersin University",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":102,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":113,"locationsCount":45},"100616529","the-effect-of-piomi-and-chronobiological-nutrition-on-readiness-for-feeding-full-transition-to-oral-feeding-and-body-weight-100616529","NCT07306793","The Effect of PIOMI and Chronobiological Nutrition on Readiness for Feeding, Full Transition to Oral Feeding and Body Weight","The Effect of Oral Motor Intervention and Chronobiological Approach to Feeding Models Applied to Preterm Infants on Infants' Readiness to Feed, Transition to Total Oral Feeding, and Body Weight","PIOMI","Inclusion Criteria:\n\n* Preterm infants with a postnatal age of 29-33 weeks,\n* Whose vital signs and clinical condition have been stable for at least 24 hours,\n* Whose APGAR score at 1 and 5 minutes (Activity-Pulse-Grimace-Appearance-Respiration) is 4 or higher.\n\nExclusion Criteria:\n\n* Infants with major congenital anomalies (such as congenital heart disease, cleft palate, cleft lip) or birth trauma,\n* Infants with RDS,\n* Infants diagnosed with asphyxia,\n* Infants with intraventricular hemorrhage,\n* Infants with Neonatal Withdrawal Syndrome,\n* Infants with Fetal Alcohol Syndrome,\n* Infants included in the study group who develop any complications or whose stable condition deteriorates during the follow-up period,\n* Infants with feeding intolerance or who are interrupted from feeding for more than 48 hours,\n* Infants who develop sepsis,\n* Infants who develop necrotizing enterocolitis,\n* Infants receiving mechanical ventilation support,\n* Infants who receive narcotic analgesia or sedation,",true,"29 Weeks","33 Weeks",{"count":92,"type":22},54,[58],"This is a randomized controlled experimental study evaluating the effects of oral motor intervention and chronobiological approach to feeding model applied to preterm infants on feeding readiness, transition to total oral feeding and body weight.",[96,97,98,99,64,100,101],"Neonatal İntensive Care","Nutrition With A Chronobiological Approach","Readiness For Feding","Body Weight","Nutrition","Premature Birth",[96,97,98,99,103,104,105],"Transitioning To Total Oral Feeding","Premature Infant Oral Motor Intervention (PIOMI)","Prematüre","RECRUITING","2026-01-01",{"date":109,"type":37},"2026-01-06",{"date":111,"type":37},"2025-03-01",{"date":77,"type":22},{"name":114,"class":44},"Aydin Adnan Menderes University",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":88,"sex":122,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":127,"phases":4,"briefSummary":128,"conditions":129,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":45},"100566133","impact-of-breast-milk-mirnas-on-the-infant-gut-microbiota-100566133","NCT06651216","Impact of Breast Milk miRNAs on the Infant Gut Microbiota","MiMilk","Inclusion Criteria:\n\n* Pregnant women in the 3rd trimester of pregnancy (3T) with a normal course of pregnancy up to 39 weeks consulting for the monitoring visit at the Robert-Debré hospital.\n* Patients who did not receive antibiotic treatment or probiotics in 3T.\n* Patient with a negative PV for Strepto B\n* Patients who do not have complications such as pre-eclampsia or gestational diabetes.\n* Breastfeeding (+\u002F- milk pump) or exclusive artificial breastfeeding.\n* No opposition from the mother\n* Ability to master the French language required.\n* Freezer at home.\n* Affiliation to a social security scheme.\n\nExclusion Criteria:\n\n* Cesarean delivery\n* Perinatal pathologies (Anoxia, IUGR, etc.)\n* Neonatal pathologies (FGR, malformations, etc.)\n* Initial choice of mixed breastfeeding\n* Patient under AME (State Medical Aid)Critères d'exclusions :\n* Antibiotics for the mother or child before day 60\n* Antifungal for the mother or child before day 60\n* Complete cessation of breastfeeding before day 60","FEMALE","18 Years","50 Years",{"count":126,"type":22},200,"OBSERVATIONAL","The first 1000 days of life are a critical period for future health. A healthy gut microbiota (GM) is essential for preventing both short-term and long-term health issues. Breast milk (BM) plays a key role in establishing the GM, as, unlike formula milk, it contains miRNAs that may interact with and modulate the microbiota.\n\nPrimary Objective: To study the effect of BM on the composition of fecal miRNAs in exclusively breastfed infants compared to those fed with formula milk at different times (D10, D30, D60, M6, M12).\n\nSecondary Objectives:\n\nAnalyze the effect of BM miRNAs on infant fecal microbiota, taking environmental confounding factors into account.\n\nStudy the influence of BM microbiota on miRNA profiles in the milk. Examine the effect of BM microbiota on the infants' gut microbiota. Explore the links between BM miRNAs, infant gut microbiota, and intestinal inflammation.",[64,130],"Stools","2024-10-18",{"date":133,"type":37},"2024-10-21",{"date":135,"type":22},"2024-11-01",{"date":137,"type":22},"2027-05-31",{"name":139,"class":44},"Assistance Publique - Hôpitaux de Paris"]