[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"btk-degraders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:btk-degraders":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100600588","determinants-of-the-response-to-btk-degraders-btkd-in-chronic-lymphocytic-leukemia-100600588",false,"NCT07099443","Determinants of the Response to BTK Degraders (BTKd) in Chronic Lymphocytic Leukemia","REBELLE","Inclusion Criteria:\n\n* Patient with CLL candidates ou exposed to BTKd\n* Patient who has provided informed consent to participate in the study.\n* Patient covered by a social security health insurance plan\n\nExclusion Criteria:\n\n* Minor patients.\n* Adults under guardianship.\n* Protected persons.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","The aim of the REBELLE cohort - bio-collection is to collect samples from patients with Chronic Lymphocytic Leukemia candidates or those exposed to BTK degraders to evaluate the mechanisms of resistance to these new molecules. To do this, an additional blood or bone marrow sample to those planned in the context of patient care or a residual lymph node biopsy sample will be collected after signing consent.",[24,25],"Chronic Lymphocytic Leukemia","BTK Degraders",[24,27,28,29],"Bruton tyrosine kinase inhibitors","BCL-2 inhibitors","BTK degraders","RECRUITING","2026-07-07",{"date":33,"type":34},"2026-07-08","ACTUAL",{"date":36,"type":34},"2025-10-09",{"date":38,"type":20},"2039-09-15",{"name":40,"class":41},"Nantes University Hospital","OTHER",14]