[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"burn-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:burn-infection":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100659502","sepsis-biomarker-monitoring-in-burn-patients-100659502",false,"NCT07866521","Sepsis Biomarker Monitoring in Burn Patients","A Randomized Trial of Blinded vs Unblinded Sepsis Biomarker Monitoring in Burn Patients","Inclusion Criteria:\n\n1. Adults aged 18 - 89 years\n2. Diagnosed with Burn injury of any mechanism\n3. Admitted to the Burn Surgical Team at UMC Hospital with a critical condition\u002FICU status. Critically ill burns overflowed to TSICU may still be enrolled.\n4. Expected ICU stay \\> 48 hours\n5. Subject will be approached during the first 24 hours after burn injury with an invitation to participate\n\nExclusion Criteria:\n\n1. Inability to approach\u002Fconsent within 24 hours after the time of injury\n2. Existing sepsis requiring antibiotics within 24 hours of admission\n3. Prisoners\n4. Incomplete chart data\n5. Acute or chronic pancreatitis\n6. Abdominal pathologies\n7. Advanced renal failure (acute or chronic)\n8. Pre-existing multiple organ failure\n9. Limited life span, expected death within 3 days of admission due to the severity of injury\n10. Lower acuity burns admitted to the burn stepdown.","ALL","18 Years","89 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if using pancreatic stone protein (PSP) test results helps doctors find and treat sepsis earlier in adults with serious burn injuries. The study will also look at whether using PSP is safe and practical in the burn intensive care unit. The main questions it aims to answer are:\n\n* Does seeing PSP test results help doctors start the right antibiotics sooner?\n* Does using PSP reduce unnecessary antibiotic use?\n* Does using PSP improve recovery and other health outcomes?\n\nResearchers will compare two groups of patients. One group will receive standard care, and their PSP test results will be hidden from their care team. The other group will receive standard care, but their care team will be able to see the PSP test results and use them to help make treatment decisions.\n\nParticipants will:\n\n* Be randomly assigned to one of the two study groups.\n* Have a small blood sample taken within 24 hours after being admitted to the burn ICU and then once each weekday while they are in the ICU.\n* Receive the usual care for burn injuries and sepsis throughout the study.",[27,28,29,30],"Sepsis","Burn","Inflammation","Burn Infection",[27,32,33],"Burn Injury","Pancreatic Stone Protein","NOT_YET_RECRUITING","2026-10-05",{"date":37,"type":38},"2026-10-08","ACTUAL",{"date":40,"type":21},"2026-11-01",{"date":42,"type":21},"2028-08-31",{"name":44,"class":45},"Texas Tech University Health Sciences Center","OTHER"]