[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"calcium-hydroxide\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:calcium-hydroxide":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100568638","phase-4-comparison-between-egyptian-mta-biodentine-versus-calcium-hydroxide-as-indirect-pulp-capping-materials-in-permanent-teeth-100568638",false,"NCT06683833","Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth","Comparative Analysis of Egyptian MTA, Biodentine, and Calcium Hydroxide as Indirect Pulp Capping Materials in Permanent Teeth. (A 6m Randomized Clinical Trial)","Inclusion Criteria:\n\n* Adult patients aged 22: 45 years old.\n* Males or females.\n* Patients with vital teeth with deep carious lesions.\n* Patients in good general health.\n* Good oral hygiene.\n* Co-operative patients who show interest to participate in the study.\n\nExclusion Criteria:\n\n* Patients with systemic diseases.\n* Patients with known allergic or adverse reaction to the tested materials.\n* Patients with bad oral hygiene.\n* Patient who frequently use analgesic or any drugs that could mask the pain.","ALL","22 Years","45 Years",{"count":20,"type":21},35,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Compare the clinical performance and patient satisfaction of Egyptian MTA, Biodentine versus Calcium Hydroxide as indirect pulp capping materials in permanent teeth",[27,28,29,30,31,32],"Deep Caries","Indirect Pulp Capping","Mineral Trioxide Aggregate (MTA)","Calcium Hydroxide","Biodentine","Patient Reported Outcome Measures",[34,35,36,37,31,38,39],"Deep caries","Indirect pulp capping","Mineral trioxide aggregate (MTA)","Calcium hydroxide","Patient reported outcomes measures (PROMS)","Randomized clinical trial","RECRUITING","2026-03-17",{"date":43,"type":44},"2026-03-18","ACTUAL",{"date":46,"type":44},"2025-09-03",{"date":48,"type":21},"2026-07-03",{"name":50,"class":51},"Cairo University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100600710","early-phase-1-effect-of-bio-c-temp-versus-calcium-ydroxide-as-intracanal-dressings-on-postoperative-pain-intensity-and-periapical-mmp-9-level-in-patients-with-necrotic-pulp-100600710","NCT07101029","Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp","Effect of Bio-C Temp Versus Calcium Hydroxide as an Intracanal Dressing on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Age between 18-50 years old.\n2. Males and females.\n3. Healthy patients categorized as I or II according to The American Society of Anesthesiologists.\n\n   (ASA I or II), with no underlying allergies.\n4. Single-rooted mandibular premolar teeth, having single root canal:\n\n   * Diagnosed clinically with pulp necrosis.\n   * Absence of spontaneous pulpal pain.\n   * Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2\\*2 mm radiographically.\n5. Patients accepting to participate in the trial.\n6. Patients who can understand pain scale and can sign the informed consent\n\nExclusion Criteria:\n\n1. Medically compromised patients having significant systemic disorders (ASA III or IV).\n2. Pregnant females.\n3. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.\n4. Teeth with multiple canals. 9\n5. Teeth that show association with acute periapical abscess, swelling or fistulous tract.\n6. Teeth with vital pulp.\n7. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam.\n8. Immature teeth.\n9. Teeth with greater than grade I mobility or pocket depth greater than 4 mm.\n10. Teeth showing radiographic evidence of external or internal root resorption, vertical root fracture, perforation or calcification.\n11. Patients with two or more adjacent teeth requiring endodontic treatment.\n12. Patients reporting bruxism, clenching or TMJ problems.\n13. Inability to perceive the given instructions.","18 Years","50 Years",{"count":63,"type":21},30,[65],"EARLY_PHASE1","To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on:\n\n* Intensity of postoperative pain\n* levels of MMP -9 in Periapical Fluids.",[68,69,30,70,71],"Intracanal Dressing","Apical Periodontitis","Biomarkers","Inflammatory Mediators",[73,30,74,75,70,76],"Bio-C Temp","Intracanal medicament","Matrix Metalloproteinase 9","Post operative pain","NOT_YET_RECRUITING","2025-07-28",{"date":80,"type":44},"2025-08-03",{"date":82,"type":21},"2025-08",{"date":84,"type":21},"2026-07",{"name":50,"class":51}]