[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"caloric-restriction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:caloric-restriction":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100613880","phase-4-the-impact-of-semaglutide-compared-to-energy-restriction-on-type-2-diabetes-100613880",false,"NCT07272343","The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes","A Study on the Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes Combined With Metabolic-associated Fatty Liver Disease and Its Molecular Mechanisms","Inclusion Criteria:\n\n1. Age 18-75 years;\n2. BMI≥25 kg\u002Fm²;\n3. Diagnosed as type 2 diabetes mellitus patients according to the \"Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2020 Edition)\";\n4. HbA1c≤8.5%;\n5. Duration of diabetes ≤3 months, and no use of antihyperglycemic drugs;\n6. Willing to participate in this study, and after full informed consent, agrees to strictly follow the treatment plan and promises to attend follow-up visits on time, and signs the informed consent form.\n\nExclusion Criteria:\n\n1. BMI \\\u003C 25 kg\u002Fm²;\n2. Age \\\u003C 18 years, or \\> 75 years;\n3. History of type 1 diabetes, acute pancreatitis, or diabetes secondary to pancreatectomy;\n4. History of bariatric surgery or planned bariatric surgery, or currently attempting weight loss within the past 3 months, or use of weight-loss medications within the past 3 months;\n5. Use of GLP-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, dipeptidyl peptidase-4 inhibitors, thiazolidinediones, or other related drugs within the past 3 months;\n6. Pregnant or breastfeeding women, or those planning to conceive during the study period;\n7. Patients with severe diseases of important organ systems, such as severe cardiovascular and cerebrovascular diseases, respiratory diseases, gastrointestinal diseases, renal insufficiency, hematologic diseases, neurological diseases, or malignancies;\n8. Personal or family history of medullary thyroid carcinoma;\n9. Patients with severe mental disorders or communication barriers that prevent accurate understanding of the study content and compliance with the trial procedures.","ALL","18 Years","75 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","To evaluate the effects of subcutaneous injection of semaglutide for 12 weeks on patients with type 2 diabetes mellitus (T2DM), compared with concurrent energy-restricted management, on glycemic control, weight loss, inflammatory markers, liver fat content, and other parameters. The study also observed the subcutaneous and visceral fat of the participants and explored the molecular mechanisms of action, providing high-quality evidence-based support for the timing and targets of intervention in this population.",[27,28,29],"Type 2 Diabetes Mellitus (T2DM)","Semaglutide","Caloric Restriction",[31,32,29],"Type 2 Diabetes Mellitus","semaglutide","RECRUITING","2026-03-31",{"date":36,"type":37},"2026-04-02","ACTUAL",{"date":39,"type":37},"2023-02-10",{"date":41,"type":21},"2026-07-01",{"name":43,"class":44},"Second Affiliated Hospital of Nanchang University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":45},"100586172","the-effect-of-time-restricted-eating-on-glycemic-and-proinflammatory-biomarkers-among-prediabetic-obese-jordanian-adults-aged-18-40-years-old-100586172","NCT06911918","The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old","The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old: A Randomized Control Study","Inclusion Criteria:\n\n* IR individuals diagnosed with IR by the physicians as indicated by HOMA-IR score\n* female and male, BMI ≥ 30 to 39.9 kg\u002Fm2\n* age between 18 and 40 years\n* stable weight for 3 months before the beginning of the study\n* sedentary lifestyle\n\nExclusion Criteria:\n\n* previous weight loss surgery\n* pregnancy or intent to become pregnant\n* breastfeeding\n* chronic diseases\n* drug therapies that could interfere with the effectiveness of the dietary intervention (e.g., use of corticosteroids, and anti-diabetic drugs)\n* diabetic type 1 and 2 individuals\n* anyone physically active to reduce the influence of confounding covariates","40 Years",{"count":55,"type":21},120,[57],"NA","Obesity, a global epidemic, significantly contributes to prediabetes, cardiovascular diseases, and other chronic diseases due to its pro-inflammatory nature. This studyl investigates the effects of time-restricted eating (TRE) with calorie restriction (CR), TRE without CR, and CR without TRE on glycemic control and pro-inflammatory biomarkers among prediabetic obese Jordanian adults aged 18-40 years. The study assesses changes in pro-inflammatory biomarkers (IL-1β, TNF-α, IL-6), insulin resistance (HOMA-IR), and body composition over 12 weeks.\n\nParticipants (n=120) will be randomized into four intervention arms: (1) TRE with CR, (2) TRE without CR, (3) CR without TRE, and (4) a control group with no dietary restrictions and no TRE. Biweekly anthropometric assessments will evaluate pro-inflammatory biomarkers and biochemical measures at baseline and the end of the study. The findings will provide insights into the comparative effectiveness of TRE and CR, potentially offering a safe, cost-effective intervention to prevent obesity-induced inflammation, prediabetes, and progression to type 2 diabetes mellitus.",[60,61,62,29,63],"Insulin Resistance","Inflammation Biomarkers","Time Restricted Eating","Obesity (Disorder)",[65,60,66,29,67],"Time restricted eating","Obesity","Inflammation cytokines","NOT_YET_RECRUITING","2025-03-27",{"date":71,"type":37},"2025-04-04",{"date":73,"type":21},"2025-04-05",{"date":75,"type":21},"2025-11",{"name":77,"class":44},"University of Jordan"]