[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carbon-monoxide-poisoning\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carbon-monoxide-poisoning":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,75,101,131,155,180],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100560200","phase-1-carbon-monoxide-hyperbaric-oxygen-with-steroid-therapy-100560200",false,"NCT06574048","Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy","Trial of Dexamethasone vs Placebo as an Adjunctive Therapy to Hyperbaric Oxygen Treatment HBO in Patients With Acute Carbon Monoxide Poisoning","CODex","Inclusion Criteria:\n\n* Acute CO poisoning, intentional or non-intentional exposure, receiving HBO treatment during hospitalization\n* Age \\>18 years\n* Nebraska Medicine admission\n\nExclusion Criteria:\n\n* Mechanical ventilation\n* No hospital admission or admission to hospital Critical Care Medicine Service\n* Allergy to dexamethasone\n* Pre-Existing neurological condition confounding outcome determination","ALL","19 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instigate a demyelinating process resulting in long term neurological sequelae in some, but not all patients. In other demyelinating disorders, steroids are a part of first line treatment. HBO is already used for acute CO poisoning, so this pilot study will try to ascertain if the addition of steroids in concert with each hyperbaric oxygen session will yield improved outcomes.",[28,29,30,31],"Carbon Monoxide Poisoning","Carbon Monoxide Intoxication","Carbon Monoxide Encephalopathy","Carbon Monoxide-induced Parkinsonism","NOT_YET_RECRUITING","2026-08-11",{"date":35,"type":36},"2026-08-14","ACTUAL",{"date":38,"type":21},"2026-10",{"date":40,"type":21},"2028-01",{"name":42,"class":43},"University of Nebraska","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100608409","prenatal-tobacco-exposure-and-newborn-outcomes-a-maternal-urinary-cotinine-study-100608409","NCT07201181","Prenatal Tobacco Exposure and Newborn Outcomes: A Maternal Urinary Cotinine Study","Association of Prenatal Tobacco Exposure Verified by Maternal Urinary Cotinine With Umbilical Cord Blood Lactate, Fetal Carboxyhemoglobin, and Early Neonatal Outcomes: A Prospective Single-Center Observational Study","Inclusion Criteria:\n\n* Pregnant individual expected to deliver a liveborn infant at the study hospital and providing written informed consent before delivery.\n* Singleton pregnancy with an anticipated gestational age of ≥35 completed weeks at delivery.\n* Maternal clean-catch urine sample obtainable within 24 hours before delivery, preferably at admission and before intravenous fluid administration, for urinary cotinine and creatinine measurement.\n* Availability of routine umbilical cord blood gas analysis at birth, including at minimum lactate, pH, and base excess, with fetal carboxyhemoglobin recorded when available.\n* Availability of routine neonatal clinical data, including birthweight, anthropometric measurements, Apgar scores, vital signs, and early postnatal assessments according to unit practice.\n\nExclusion Criteria:\n\n* Multiple gestation.\n* Major congenital anomaly, known chromosomal or genetic disorder, or major metabolic disease likely to affect neonatal adaptation or the study outcomes.\n* Emergency clinical circumstances in which obtaining informed consent or the maternal urine sample could delay or interfere with urgent maternal or neonatal care.\n* Inability to obtain an adequate maternal urine sample before delivery for cotinine and creatinine measurement.\n* Severe perinatal condition preventing acquisition or reliable interpretation of the primary outcome data, including major birth trauma or prolonged intensive care requirement.\n* Missing umbilical cord blood lactate measurement or other critical primary outcome data.\n* Previous enrollment of the same mother-newborn dyad.",true,"0 Minutes","72 Hours",{"count":56,"type":21},126,"OBSERVATIONAL","Prenatal exposure to tobacco smoke, through either active maternal smoking or secondhand exposure, has been associated with impaired fetal oxygenation, metabolic stress, and adverse early neonatal outcomes. This prospective, single-center observational cohort study will objectively assess maternal tobacco exposure using cotinine measured in maternal urine and examine its association with early neonatal biochemical, metabolic, and clinical outcomes.\n\nConsecutive eligible mother-newborn dyads will be recruited at a tertiary academic hospital after written informed consent is obtained. A clean-catch midstream maternal urine sample will be collected within 24 hours before delivery, preferably at admission to the delivery unit and before intravenous fluid administration, for quantitative cotinine and creatinine measurement. Maternal tobacco exposure will be assessed using the urinary cotinine concentration, the cotinine-to-creatinine ratio, and maternal self-reported smoking and secondhand smoke exposure. Based on prespecified biomarker thresholds and exposure history, participants will be classified as having active exposure, passive exposure, or no exposure. No experimental intervention will be administered.\n\nNeonatal data will include umbilical cord blood gas parameters, including pH, pCO2, pO2, base excess, bicarbonate, lactate, and fetal carboxyhemoglobin (FCOHb). Birthweight, length, head circumference, Apgar scores, oxygen saturation, heart rate, and blood pressure will also be recorded. Routine laboratory measurements obtained during the early postnatal period will include complete blood count parameters, hematologic and inflammatory indices such as NLR and PLR, albumin, the albumin-to-lactate ratio, HDL, LDL, and other routinely available biochemical markers. Thyroid-stimulating hormone results from the national newborn screening program and newborn hearing screening results will be recorded. Postnatal weight loss and bilirubin measurements from routine follow-up visits will also be collected when available.\n\nThe primary objective is to determine whether increasing maternal urinary cotinine exposure is associated with higher umbilical cord blood lactate and FCOHb levels, indicating greater metabolic stress and impaired fetal oxygenation. Secondary objectives include evaluating associations with cord blood gas parameters, birthweight, early hematologic and biochemical indices, albumin and the albumin-to-lactate ratio, blood pressure, bilirubin levels, thyroid screening results, and hearing screening outcomes.\n\nMaternal, obstetric, and perinatal variables, including maternal age, parity, gestational age, mode of delivery, smoking history, intrapartum factors, and relevant maternal comorbidities, will be recorded for adjusted analyses. Statistical analyses will include comparisons among the three exposure groups and multivariable regression models evaluating urinary cotinine both as a continuous measure and as a categorical exposure variable.\n\nThis study is designed to provide prospectively collected, biomarker-verified evidence regarding the relationship between maternal tobacco exposure and immediate neonatal metabolic, hematologic, and physiologic outcomes using measurements that are feasible within routine clinical care.",[60,61,62,28],"Tobacco Smoke Pollution","Maternal Exposure During Pregnancy","Infant, Newborn",[64,65],"Prenatal Tobacco Exposure","Maternal Smoking","2026-07-18",{"date":68,"type":36},"2026-07-21",{"date":70,"type":21},"2026-08-01",{"date":72,"type":21},"2027-01-01",{"name":74,"class":43},"Haseki Training and Research Hospital",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":44},"100578467","phase-4-the-efficacy-of-dexamethasone-in-combination-with-n-acetylcysteine-in-preventing-neurocognitive-sequelae-due-to-carbon-monoxide-poisoning-100578467","NCT06811675","The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning","Inclusion Criteria:\n\n* History and clinical symptoms consistent with CO poisoning (initial blood carboxyhemoglobin (COHb) levels \\>5%, or \\>10% for smokers).\n\nExclusion Criteria:\n\n* Concurrent use of other potentially lethal toxins. Severe trauma or burns that could be fatal. No spontaneous heartbeat or blood pressure before arrival. Poisoning time exceeding 24 hours before hospital arrival. Minors (under 18 years of age). Pregnant women. Patients or their families refuse to sign the consent form. Contraindications for the use of Dexamethasone or N-acetylcysteine (such as severe allergies) or when the physician assesses the risks outweigh the benefits.","18 Years",{"count":83,"type":21},128,[85],"PHASE4","Background and Aim: Carbon monoxide (CO) poisoning is a significant public health issue that can cause delayed neuropsychological sequelae (DNS). DNS mechanisms involve oxidative stress, inflammation, and immune injury. Although hyperbaric oxygen therapy is widely used, its efficacy in preventing DNS remains inconclusive. Preclinical and retrospective studies suggest that Dexamethasone (anti-inflammatory and immunosuppressive) and N-acetylcysteine (antioxidant) may reduce DNS risk. This study hypothesizes that their combination can effectively prevent DNS.\n\nMethods: This prospective pre-post intervention study will enroll CO poisoning patients into treatment (Dexamethasone + N-acetylcysteine) and control groups. The primary outcome is the incidence of DNS within six weeks post-treatment.\n\nObjective: To determine whether combining Dexamethasone and N-acetylcysteine reduces the incidence of DNS following CO poisoning.",[28,88],"Delayed Neurocognitive Sequelae",[28,90,91,88],"Dexamethasone","N-acetylcysteine","RECRUITING","2025-03-23",{"date":95,"type":36},"2025-03-26",{"date":93,"type":36},{"date":98,"type":21},"2027-09-30",{"name":100,"class":43},"China Medical University Hospital",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":52,"sex":17,"minAge":81,"maxAge":108,"enrollmentInfo":109,"targetDuration":111,"studyType":57,"phases":4,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":44},"100484687","microparticles-blood-level-in-acute-carbon-monoxide-poisoning-100484687","NCT05591300","Microparticles Blood Level in Acute Carbon Monoxide Poisoning","COMPs","Inclusion Criteria:\n\n* Age \\> 18 years\n* Acute carbon monoxide poisoning\n* Need for treatment with hyperbaric oxygen\n\nExclusion Criteria:\n\n* Patient reject to consent","99 Years",{"count":110,"type":21},108,"45 Days","The goal of this pilot, clinical, experimental, biological and prospective study with uso of biological material (venous blood sampling), in patient with acute carbon monoxide (CO) intoxication and in a group of healthy non-intoxicated subject (group of control) is the research of a possible increase of circulating microparticles level in human blood with an acute carbon monoxide intoxication.\n\nThe main question to answer is:\n\nIs there an increase of circulating microparticles levels in subjects with acute carbon monoxide poisoning? Two blood samples will be withdrawn from patients with acute carbon monoxide poisoning, one before and one after hyperbaric oxygen treatment.\n\nResearchers will compare a group of healthy volunteers to see if there is a different in circulating microparticles blood level compared to patients with intoxication.",[28],[115,116,117,118,119,120,121],"Carbon monoxide intoxication","Microparticles","Microvesicles","Carbon monoxide poisoning","CO","Delayed neurological syndrome","Hyperbaric Oxygen","2024-11-13",{"date":124,"type":36},"2024-11-14",{"date":126,"type":36},"2022-11-15",{"date":128,"type":21},"2025-11",{"name":130,"class":43},"Azienda Ospedaliero Universitaria Maggiore della Carita",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":44},"100558323","cardiotoxicity-of-carbon-monoxide-in-patients-treated-with-hyperbaric-oxygen-therapy-100558323","NCT06549621","Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy","COCARDIOTOX","Inclusion Criteria:\n\nPatients treated for CO poisoning with HBOT in the hyperbaric and underwater medicine department of the Brest University hospital from 2015\u002F01\u002F01 to 2021\u002F12\u002F31\n\nExclusion Criteria:\n\n* refusal","100 Years",{"count":140,"type":21},66,"Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome oxidase, resulting in tissue hypoxia and reduced adenosine triphosphate synthesis and ischemia-reperfusion injury.\n\nThis study aims to investigate the early and late cardiologic effects of CO in patients treated with hyperbaric oxygen (HBOT) for CO poisoning",[28],[144,145],"cardiac injury","cardiac toxicity","2024-08-08",{"date":148,"type":36},"2024-08-12",{"date":150,"type":36},"2022-07-25",{"date":152,"type":21},"2024-10-25",{"name":154,"class":43},"University Hospital, Brest",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":163,"conditions":164,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":44},"100400137","carbon-monoxide-intoxication-in-korea-prospective-cohort-care-co-cohort-100400137","NCT04490317","CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)","Inclusion Criteria:\n\n* Acute CO poisoning\n\nExclusion Criteria:\n\n* Declined to enrollment in the study",{"count":162,"type":21},1500,"This prospective cohort study enrolls subjects who experience carbon monoxide (CO) poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments and short and long-term outcomes in CO poisoned patients. In addition, complications of brain and heart susceptible to CO are investigated through various ways and the association between complications and the patient's prognosis is also investigated. All subjects will be regularly monitored by physicians participating in this study.",[28,165,166,167,168,169,170],"Myocardial Injury","Neurologic Deficits","Image, Body","Therapy","Prognostic Factors","Complications","2024-07-22",{"date":173,"type":36},"2024-07-23",{"date":175,"type":36},"2020-07-29",{"date":177,"type":21},"2035-12",{"name":179,"class":43},"Wonju Severance Christian Hospital",{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":17,"minAge":187,"maxAge":4,"enrollmentInfo":188,"targetDuration":190,"studyType":57,"phases":4,"briefSummary":191,"conditions":192,"keywords":193,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":44},"100433528","neurological-sequelae-in-patients-with-acute-carbon-monoxide-poisoning-100433528","NCT04925297","Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning","The Characteristics of Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning","Inclusion Criteria:\n\n* patients present within 12 hours after acute carbon monoxide poisoning;\n* age older than 16 years.\n\nExclusion Criteria:\n\n* pregnant women；\n* patients receive oxygen therapy before presentation;\n* have history of acute carbon monoxide poisoning within 1 year;\n* have been diagnosed any of the following disease: Parkinson disease; cognitive disorder, psychiatric disorders, sequelae of cerebral infarction or hemorrhage, chronic kidney disease and receive hemodialysis, congestive heart failure ( NYHA class III-IV)","16 Years",{"count":189,"type":21},1250,"1 Year","The purpose of this study is to access the clinical characteristics and risk factors for neurological sequelae after acute carbon monoxide poisoning.",[28],[194,195],"carbon monoxide poisoning","neurological sequelae","2021-06-07",{"date":198,"type":36},"2021-06-14",{"date":200,"type":21},"2021-08-01",{"date":202,"type":21},"2027-05-01",{"name":204,"class":43},"The First Hospital of Jilin University"]