[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-rehab\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-rehab":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,80,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100648553","the-effect-of-cardiac-rehabilitation-on-ferroptosis-in-patients-with-coronary-artery-disease-100648553",false,"NCT07722637","The Effect of Cardiac Rehabilitation on Ferroptosis in Patients With Coronary Artery Disease","Evaluation of Ferroptosis-Related Biomarkers in Individuals With Coronary Artery Disease: The Impact of Cardiac Rehabilitation","Inclusion Criteria:\n\nPatients With Coronary Artery Disease (CAD):\n\n* Age between 18 and 75 years.\n* Diagnosis of coronary artery disease within the previous 3 months.\n* Eligible to participate in a cardiac rehabilitation program or voluntarily decline participation in the cardiac rehabilitation program.\n* Peak exercise capacity of ≥5 metabolic equivalents (METs).\n* Able to undergo cardiopulmonary exercise testing (CPET).\n* Able to understand the study procedures and provide written informed consent.\n\nHealthy Controls:\n\n* Age between 18 and 75 years.\n* No history of coronary artery disease or other cardiovascular diseases.\n* No history of chronic systemic diseases, including diabetes mellitus, hypertension, chronic kidney disease, chronic liver disease, inflammatory or autoimmune diseases, or malignancy.\n* Not receiving regular medication.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\nPatients With Coronary Artery Disease (CAD):\n\n* Decompensated heart failure.\n* Unstable angina pectoris.\n* Uncontrolled or complex ventricular arrhythmias.\n* Severe pulmonary hypertension.\n* Neurological, orthopedic, or musculoskeletal disorders limiting exercise performance.\n* Absolute contraindications to cardiopulmonary exercise testing or cardiac rehabilitation according to current clinical guidelines.\n* Chronic kidney failure or chronic liver disease.\n* Active infection.\n* Active inflammatory or autoimmune disease.\n* Active malignancy or history of malignancy.\n* Pregnancy.\n* Cognitive or psychiatric disorders that would interfere with study participation or protocol compliance.\n\nHealthy Controls:\n\n* History of coronary artery disease or other cardiovascular diseases.\n* History of chronic systemic diseases, including diabetes mellitus, hypertension, chronic kidney disease, chronic liver disease, inflammatory or autoimmune diseases, or malignancy.\n* Regular medication use within the previous 6 months.\n* Active infection.\n* Pregnancy.\n* Age younger than 18 years or older than 75 years.",true,"ALL","18 Years","75 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Coronary artery disease (CAD) remains a major global health concern and is the leading cause of cardiovascular mortality worldwide. Cardiac rehabilitation (CR) is a comprehensive, evidence-based intervention that integrates exercise training with optimal medical management and has been shown to improve clinical outcomes in patients with CAD. The primary objective of this study is to investigate the effects of cardiac rehabilitation on ferroptosis, an iron-dependent form of regulated cell death, in patients with coronary artery disease.\n\nA total of 90 participants will be enrolled in the study after providing written informed consent. The study population will consist of three groups: 30 patients with CAD who participate in a cardiac rehabilitation program, 30 patients with CAD who voluntarily decline participation in cardiac rehabilitation, and 30 age- and sex-matched healthy volunteers without any known chronic disease. Peripheral venous blood samples will be collected from patients undergoing cardiac rehabilitation both before the initiation of the rehabilitation program and upon its completion. A single blood sample will be obtained from patients who decline participation in cardiac rehabilitation and from healthy control participants.\n\nTo evaluate ferroptosis-related molecular alterations, the expression levels of the ferroptosis-associated genes GPX4, SLC7A11, ACSL4, FSP1, NRF2, TFRC, and NCOA4 will be analyzed. In addition, serum concentrations of ferroptosis-related biomarkers, including free iron, 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), and GPX4 protein, will be measured. The molecular and biochemical parameters will be compared among the three study groups, and changes in ferroptosis-related biomarkers before and after the cardiac rehabilitation program will be evaluated in patients undergoing cardiac rehabilitation.",[28,29,30],"Coronary Artery Disease (CAD)","Cardiac Rehab","Ferroptosis",[32,33,34],"cardiac rehabilitation","ferroptosis","Coronary artery disease","RECRUITING","2026-07-28",{"date":38,"type":39},"2026-07-29","ACTUAL",{"date":41,"type":39},"2026-01-01",{"date":43,"type":22},"2026-11-15",{"name":45,"class":46},"TC Erciyes University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":47},"100648998","exercise-based-cardiac-rehabilitation-for-patients-with-heart-failure-with-preserved-ejection-fraction-empower-hfpef-100648998","NCT07727096","Exercise-Based Cardiac Rehabilitation for Patients With Heart Failure With Preserved Ejection Fraction (EMPOWER-HFpEF)","Effects of a Supervised Exercise Training Program on Clinical Outcomes, Functional Capacity, and Quality of Life in Patients With Heart Failure With Preserved Ejection Fraction (EMPOWER-HFpEF)","EMPOWER-HFpEF","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Diagnosis of heart failure with preserved ejection fraction (HFpEF) according to current clinical guidelines, defined by: a) signs and\u002For symptoms of heart failure; b) left ventricular ejection fraction ≥50%; c) elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) (≥220 pg\u002FmL); and, d) objective evidence of structural and\u002For functional cardiac abnormalities consistent with HFpEF.\n* High-risk clinical profile, defined by at least one of the following: a) hospitalization for acute or worsening heart failure within the previous 120 days; b) outpatient worsening heart failure within the previous 120 days requiring emergency department evaluation or intensification of oral or intravenous diuretic therapy in a specialized heart failure clinic; c) recent diagnosis of symptomatic HFpEF (≤120 days) with New York Heart Association (NYHA) functional class II-III; or d) stable symptomatic HFpEF (NYHA class II-III) with at least two of the following comorbidities: hypertension, diabetes mellitus, obesity (body mass index ≥30 kg\u002Fm²), chronic kidney disease, dyslipidemia, obstructive sleep apnea, or stable coronary artery disease, together with elevated NT-proBNP (≥220 pg\u002FmL in patients in sinus rhythm or ≥600 pg\u002FmL in patients with atrial fibrillation).\n* Clinically stable at the time of enrollment, with no requirement for intravenous therapy or major changes in heart failure treatment during the previous 2 weeks.\n* Considered by the investigator to be able to participate in a structured exercise-based cardiac rehabilitation program safely.\n* Able and willing to provide written informed consent before any study-specific procedures.\n\nExclusion Criteria:\n\n* Inability to safely participate in a structured exercise-based cardiac rehabilitation program because of severe neurological or musculoskeletal disorders, significant cognitive impairment, or severe psychiatric illness that, in the opinion of the investigator, would interfere with study participation.\n* Clinically unstable heart failure at the time of enrollment, defined by the need for intravenous therapy, recent major changes in heart failure treatment, or ongoing heart failure decompensation.\n* Severe valvular heart disease considered to be the primary cause of the patient's symptoms.\n* Acute coronary syndrome, unstable angina, or coronary revascularization within the previous 2 weeks.\n* Uncontrolled hypertension, defined as resting systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg, or resting heart rate ≥110 beats\u002Fmin despite guideline-directed medical therapy.\n* Severe primary pulmonary disease predominantly limiting functional capacity, including significant pulmonary hypertension, chronic thromboembolic pulmonary disease, or severe chronic obstructive pulmonary disease.\n* Primary cardiomyopathy or known infiltrative heart disease.\n* Severe non-cardiac comorbidity associated with an estimated life expectancy of less than 1 year, in the opinion of the investigator.\n* Inability to provide written informed consent or to comply with study procedures and follow-up requirements.",{"count":57,"type":22},390,[25],"Heart failure with preserved ejection fraction (HFpEF) is a common condition among older adults. It is associated with frequent hospitalizations, impaired functional capacity, reduced quality of life, and high healthcare utilization. Despite recent advances in pharmacological therapy, many patients continue to experience recurrent clinical deterioration and functional decline. Exercise-based cardiac rehabilitation has demonstrated benefits in improving physical performance and quality of life. Still, its effect on long-term clinical outcomes in patients with high-risk HFpEF has not been established.\n\nThe EMPOWER-HFpEF study is a multicenter, randomized, controlled trial designed to evaluate whether an early, individualized, multimodal exercise-based cardiac rehabilitation program improves clinical outcomes compared with usual care in patients with HFpEF. Eligible participants will be randomly assigned in a 1:1 ratio to receive either usual care alone or usual care plus a structured 12-month exercise-based cardiac rehabilitation program. The intervention includes an initial 6-month supervised phase, followed by a 6-month hybrid phase combining supervised sessions with structured home- or community-based exercise to promote long-term adherence and maintenance of physical activity.\n\nThe primary objective is to determine whether this rehabilitation strategy reduces adverse clinical outcomes, including all-cause mortality, heart failure hospitalizations, all-cause hospitalizations, and outpatient heart failure decompensation, while improving functional capacity and health-related quality of life over 12 months. The results of this study will provide evidence on the effectiveness of a long-term multimodal exercise-based cardiac rehabilitation program as part of the comprehensive management of patients with HFpEF.",[61,62,63,64,29],"HF - Heart Failure","HFpEF - Heart Failure With Preserved Ejection Fraction","Readmission Rates","Exercise Training",[66,67,68,69],"Heart Failure with Preserved Ejection Fraction","Cardiac Rehabilitation","Quality of Life","Readmission","NOT_YET_RECRUITING","2026-07-22",{"date":73,"type":39},"2026-07-27",{"date":75,"type":22},"2026-09-01",{"date":77,"type":22},"2031-09-01",{"name":79,"class":46},"Fundación para la Investigación del Hospital Clínico de Valencia",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":88,"targetDuration":90,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":99,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":47},"100600226","the-italian-alliance-for-cardiovascular-rehabilitation-and-prevention-itacare-p-registry-an-observational-study-on-cardiac-rehabilitation-in-patients-with-coronary-disease-or-heart-failure-100600226","NCT07094737","The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) Registry: An Observational Study on Cardiac Rehabilitation in Patients With Coronary Disease or Heart Failure","The ITACARE-P CardioRehab Registry","CardioRehab","Inclusion Criteria:\n\n* Patients with coronary artery disease and\u002For heart failure who meet the current regulatory requirements for appropriateness of referral to cardiac rehabilitation are eligible for enrollment. These patients may be included regardless of whether they are referred to inpatient or outpatient cardiac rehabilitation programs, depending on the clinical setting and care pathway.\n\nExclusion Criteria:\n\n* Explicit refusal to participate in the study by the patient;\n* Planned hospital readmission within six months after completion of the cardiac rehabilitation program.",{"count":89,"type":22},1600,"12 Years","OBSERVATIONAL","ITACARE-P CardioRehab Registry is a nationwide observational study conducted in Italy and coordinated by the Fondazione Don Carlo Gnocchi in Milan. It involves multiple hospitals and rehabilitation centers across the country and aims to better understand how cardiac rehabilitation (CR) is delivered to patients recovering from heart conditions (coronary deseases and\u002For heart failure). CR is a structured program that includes exercise, lifestyle education, and psychological support, and is known to improve recovery, reduce future cardiac events, lower hospital readmissions, and enhance quality of life. Despite strong recommendations from international guidelines, not all eligible patients are referred to CR, and its delivery varies. This study collects real-world data to describe how CR programs are implemented, evaluate patient outcomes, identify subgroups needing tailored care, and support improvements in cardiac care services in Italy. Adults who recently experienced a qualifying heart condition are enrolled and followed during their standard rehabilitation, without any changes to treatment. Data on medical history, risk factors, quality of life, functional improvements, and medication use are collected, with follow-up at 6 and 12 months. Participation involves no added risks, and personal health data is securely managed according to EU GDPR regulations using the REDCap system. The study aims to enhance the quality, consistency, and equity of cardiac rehabilitation across the country.",[29,94,95,96,97,67,98],"Heart Failure","Coronary Disease","Heart Conditions","Rehabilitation","Telerehabilitation",[29,94,100,101,97,102,98],"Coronary disease","Heart conditions","Cardiac rehabilitation","2025-07-23",{"date":105,"type":39},"2025-07-30",{"date":107,"type":39},"2025-05-01",{"date":109,"type":22},"2027-12-31",{"name":111,"class":46},"Fondazione Don Carlo Gnocchi Onlus",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":122,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100563520","a-comparative-pilot-study-on-the-effectiveness-of-nurse-led-and-line-robot-guided-cardiac-rehabilitation-referrals-100563520","NCT06617234","A Comparative Pilot Study on the Effectiveness of Nurse-Led and LINE Robot-Guided Cardiac Rehabilitation Referrals","A Comparative Pilot Study on the Effectiveness of Cardiac Rehabilitation Referral Guided by Nurse-Led and LINE Robot Interventions","Inclusion Criteria:\n\n* Adult ≧18 years old\n* AMI(STEMI or NSTEMI after PCI)\n* Heart failure with New York Heart Association (NYHA) functional class I-III .\n* After coronary artery bypass surgery (CABG)\n* Patients must have a smartphone with internet\n* Able to use the LINE messaging (send and receive messages)\n\nExclusion Criteria:\n\n* Cardiac rehabilitation absolute or relative contraindications.\n* Acute decompensated heart failure, New York Heart Association (NYHA) functional class IV\n* Cognitive impaired\n* Without smartphones\n* Attending physician finds it unsuitable.\n* One patient was enrolled in the same ward","99 Years",{"count":121,"type":22},150,[25],"The goal of this pragmatic randomized trial is to compare the effectiveness of nurse-led versus LINE bot-guided strategies on patient referrals for cardiac rehabilitation in patients with acute myocardial infarction, heart failure, or status post coronary artery bypass surgery, aged 18 years and older. The main questions it aims to answer are:\n\nDoes a nurse-led referral strategy increase cardiac rehabilitation referrals, attendance, and participation compared to routine care? Can a LINE bot-guided system improve cardiac rehabilitation referrals, attendance, and participation? Researchers will compare Intervention Group A (nurse-led face-to-face education), Intervention Group B (LINE bot automated referral system), and a Control Group (routine care) to see if nurse-led or LINE bot strategies are more effective in increasing referrals, attendance, and participation in cardiac rehabilitation programs.\n\nParticipants will:\n\nBe randomly assigned to one of three groups. Participate in either nurse-led education, receive automated LINE bot reminders, or undergo standard care.\n\nHave their cardiac rehabilitation referrals, attendance, and participation tracked for 12 weeks post-discharge through the hospital's medical record system.\n\nThis study seeks to provide healthcare professionals with evidence-based strategies for improving cardiac rehabilitation processes and enhancing patient engagement in rehabilitation programs.",[29,125,126],"Referral","LINE Robot Intervention",[32,128],"automated system or chatbot","2024-09-30",{"date":131,"type":39},"2024-10-02",{"date":133,"type":22},"2025-01-30",{"date":135,"type":22},"2026-01-31",{"name":137,"class":46},"National Taiwan University Hospital"]