[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-surgery":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,105,0,25,[9,44,65,94,119,145,170,195,223,252,281,306,332,356,380,412,441,466,493,522,546,574,595,618,649],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100609979","phase-4-oral-methadone-in-cardiac-surgery-100609979",false,"NCT07221617","Oral Methadone in Cardiac Surgery","Oral Methadone In Cardiac Surgery","OMICS","Inclusion Criteria:\n\n• Undergoing elective cardiac surgery\n\nExclusion Criteria:\n\n* Chronic pain requiring opioid medications as an outpatient\n* Opioid use disorder on medication assistance treatment\n* Prolonged QTc \\>500ms\n* Chronic kidney disease with eGFR \\\u003C 30mL\u002Fmin\n* Documented cirrhosis\n* Intolerance to methadone\n* Admitted inpatient in an intensive care unit (ICU) immediately prior to surgery\n* Pregnancy at the time of surgery\n* Subsequent surgeries after index surgery","ALL","18 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.",[28,29,30],"Pain, Postoperative","Anesthesia","Cardiac Surgery","RECRUITING","2026-08-20",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":35},"2026-01-13",{"date":39,"type":22},"2026-08-31",{"name":41,"class":42},"Mayo Clinic","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":43},"100637024","validation-and-feasibility-of-noninvasive-oxygen-delivery-index-monitoring-in-cardiac-surgery-patients-100637024","NCT07573306","Validation and Feasibility of Noninvasive Oxygen Delivery Index Monitoring in Cardiac Surgery Patients","Inclusion Criteria:\n\n* Adults ≥ 18 years undergoing cardiac surgery\n* Placement of pulmonary artery catheter with continuous cardiac output (CCO) as part of routine clinical care\n* Placement of arterial line with FloTrac as part of routine clinical care\n* Availability of ≥ 3 arterial blood gas samples at specified timepoints\n\nExclusion Criteria:\n\n* Mechanical circulatory support planned or in use (IABP, Impella, ECMO)\n* Patients without BOTH pulmonary artery catheter with CCO and arterial line with FloTrac\n* Patients who are Research Opt-Out",{"count":51,"type":22},150,"OBSERVATIONAL","This study will establish the feasibility and preliminary validity of real-time oxygen delivery index (DO₂i) monitoring using noninvasive hemoglobin (SpHb, Masimo) and minimally invasive cardiac output (FloTrac, Edwards) in cardiac surgery patients.",[30],"NOT_YET_RECRUITING","2026-08-17",{"date":58,"type":35},"2026-08-18",{"date":60,"type":22},"2026-10-15",{"date":62,"type":22},"2027-08-01",{"name":64,"class":42},"University of Minnesota",{"id":66,"slug":67,"hasResults":12,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":23,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100652249","the-effect-of-acupressure-application-on-respiratory-performance-and-pain-levels-in-adult-patients-undergoing-cardiac-surgery-100652249","NCT07771751","The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery","The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 years and older.\n* Undergoing cardiac surgery for the first time.\n* Extubated and hemodynamically stable in the postoperative period.\n* A Glasgow Coma Scale (GCS) score of 15.\n* Absence of arterial or venous catheters, incisions, hematomas, ecchymoses, or any skin lesions\u002Fdeformities at the acupressure application sites.\n* No analgesic medication administered within the last four hours.\n* No known neuromuscular diseases that could affect respiratory muscle strength or performance.\n* Ability to speak Turkish and absence of any communication barriers.\n\nExclusion Criteria:\n\n* Development of postoperative complications (e.g., severe arrhythmia, need for re-intubation, active bleeding).\n* Receiving sedation in the intensive care unit.\n* Presence of chronic pain syndrome or regular use of opioids\u002Fanalgesics.\n* Known psychiatric disorders.",{"count":73,"type":22},114,[75],"NA","The purpose of this randomized controlled trial is to evaluate the effect of acupressure on respiratory performance and pain levels in adult patients who have undergone open-heart surgery. Pulmonary complications and severe pain are common after cardiac surgery, often limiting the effectiveness of standard deep breathing exercises such as incentive spirometry. This study investigates whether applying acupressure-a non-invasive complementary therapy-can help manage postoperative pain and improve respiratory capacity. By potentially reducing pain without the respiratory side effects associated with pharmacological medications, acupressure may enable patients to perform their breathing exercises more effectively and support their overall recovery.",[78,30,79],"Postoperative Pain","Postoperative Complications",[81,82,83,84,85],"Respiratory Performance","Pain Management","Nursing Care","acupressure","cardiac surgery","2026-08-14",{"date":58,"type":35},{"date":89,"type":22},"2026-09-21",{"date":91,"type":22},"2027-09-21",{"name":93,"class":42},"Fenerbahce University",{"id":95,"slug":96,"hasResults":12,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":23,"phases":104,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":43},"100651796","phase-4-discontinuation-or-continuation-of-sglt-2-inhibitors-before-cardiac-surgery-100651796","NCT07766109","Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery","Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery: Impact on Postoperative Cardiovascular Outcomes - DISCO Study","DISCO","Inclusion Criteria:\n\n* Adult patients scheduled to undergo cardiac surgery with cardiopulmonary bypass\n* patients treated with SGLT-2 inhibitors, including combined treatment with metformin, for at least 4 weeks\n* heart failure patients with a left ventricular ejection fraction strictly below 50%\n* patients enrolled in a social security scheme or equivalent\n* patients who have signed the informed consent form\n\nExclusion Criteria:\n\n* Treatment with SGLT-2 inhibitors initiated less than 4 weeks ago and other than empagliflozine or dapagliflozine\n* patients with a contraindication to SGLT-2 inhibitors: hypersensitivity, type 1 diabetes mellitus, and renal impairment with an estimated glomerular filtration rate below 25 mL\u002Fmin\u002F1.73 m²\n* acute conditions likely to call into question the continuation of SGLT2 inhibitor therapy (alone or in combination) at the time of inclusion, including in particular: shock state or acute tissue hypoxia (episode of hyperlactatemia \\> 3 mmol\u002FL within 7 days prior to inclusion); acute kidney injury within the previous 7 days (KDIGO stage ≥2); severe hepatocellular failure (factor V level \\\u003C 50%); acute alcohol intoxication within the previous 7 days or active alcohol use disorder without withdrawal\n* surgery scheduled within less than 3 days\n* surgery for active endocarditis within the last 3 months\n* patients on preoperative mechanical circulatory support\n* heart transplant surgery or implantation of an LVAD (left ventricular assist device)\n* chronic kidney disease patients with a glomerular filtration rate below 25 mL\u002Fmin\u002F1.73m²\n* heart failure patients with a preserved ejection fraction, equal to or greater than 50\n* pregnant or breastfeeding women\n* minors or adults under legal protection (guardianship or conservatorship)\n* patients participating in another interventional study patients who do not understand or speak French.",{"count":103,"type":22},434,[25],"SGLT-2 inhibitors are recommended treatments for managing heart failure patients. In cases of surgery, it is recommended to stop the treatment 3 days before surgery due to the risk of postoperative euglycemic diabetic ketoacidosis. However, several data suggest that it may be beneficial to maintain SGLT-2i treatment given the possibility of improving postoperative cardiovascular outcomes. Investigator team wish to conduct a randomized controlled trial to test the hypothesis that preoperative maintenance of SGLT-2i is superior to discontinuing them 3 days before surgery in improving postoperative cardiovascular outcomes.",[107,30],"Heart Failure",[109,110],"perioperative care","SGLT-2 inhibitor","2026-08-10",{"date":86,"type":35},{"date":114,"type":22},"2026-10",{"date":116,"type":22},"2029-01",{"name":118,"class":42},"University Hospital, Toulouse",{"id":120,"slug":121,"hasResults":12,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":131,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":144},"100651188","randomized-evaluation-of-operating-room-extubation-after-cardiac-surgery-100651188","NCT07757880","Randomized Evaluation of Operating Room Extubation After Cardiac Surgery","Randomized Evaluation of Operating Room Extubation Versus Intensive Care Unit Extubation After Cardiac Surgery","Inclusion Criteria:\n\n* Adults (age 18+) scheduled for elective cardiac surgery requiring cardiopulmonary bypass\n* Low perioperative risk defined as STS Predicted Risk of Mortality (PROM) ≤ 3% based on the latest STS Adult Cardiac Surgery Database (ACSD) Risk Calculator\n* Deemed appropriate for OR extubation preoperatively by the attending cardiac surgeon\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Underlying pulmonary disease requiring use of home supplemental oxygen\n* Pre-capillary pulmonary hypertension (mPAP ≥ 25 mmHg or PVR \\> 2 Wood units) on most recent right heart catheterization for any patient for which there is suspicion for pulmonary hypertension at the time of preoperative evaluation\n* Preoperative right ventricular dysfunction greater than mild on most recent echocardiogram\n* Obstructive sleep apnea with home CPAP or biPAP use or recommended use\n* Neuromuscular disease associated with respiratory muscle weakness including myasthenia gravis, Lambert-Eaton myasthenic syndrome, or muscular dystrophy\n* Airway abnormalities including tracheostomy, history of difficult mask ventilation, history of difficult intubation requiring fiberoptic rescue or multiple (\\>2) attempts, known anatomic abnormalities including limited mouth opening (\\\u003C 3cm), severe micrognathia, tracheal stenosis, or tracheal compression due to mass or goiter\n\nWe will also exclude patients undergoing the following procedures:\n\n* Transplant surgery\n* Pulmonary thromboendarterectomy\n* Implantation of mechanical circulatory support including LVAD, Impella, intra-aortic balloon pump, RVAD, or ECMO",{"count":127,"type":22},120,[75],"We are studying whether waking patients up and removing the breathing tube (also known as \"extubation\") in the operating room after cardiac surgery improves postoperative recovery without causing harm.",[30],[132,133,134],"Extubation","Cardiac surgery","Cardiac surgery recovery","2026-08-06",{"date":137,"type":35},"2026-08-11",{"date":139,"type":22},"2026-08",{"date":141,"type":22},"2027-03",{"name":143,"class":42},"Massachusetts General Hospital",2,{"id":146,"slug":147,"hasResults":12,"nctId":148,"briefTitle":149,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":154,"conditions":155,"keywords":156,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":43},"100577161","evaluation-of-preoperative-anxiety-level-based-on-the-day-of-admission-for-cardiac-surgery-100577161","NCT06794697","Evaluation of Preoperative Anxiety Level Based on the Day of Admission for Cardiac Surgery","ADMITY","Inclusion Criteria:\n\n* Aged over 18 years old\n* Scheduled for cardiac surgery\n* Have received written and oral information about the protocol\n* Admitted to the cardiac and thoracic surgery units\n* Not opposed to participating in the research.\n\nExclusion Criteria:\n\n* Patient undergoing emergency cardiac surgery with no time for reflection\n* Legal adults under legal protection (guardianship, curators, or legal protection)\n* Pregnant or breastfeeding women, minors, individuals unable to express consent\n* Patient on long-term anxiolytic treatment\n* Patient with psychiatric disorders, cognitive impairments, or central neurological disorders.\n* Patient already participating in an ongoing study in the department of Thoracic and Cardiovascular Surgery.",{"count":153,"type":22},400,"Prospective, observational, non-randomized study that evaluates the impact of the admission day (J-1 vs J-0) on preoperative anxiety in cardiac surgery patients.",[30],[157,85,158,159,160],"preoperative anxiety","evaluation of anxiety","admission day","APAIS scale","2026-08-04",{"date":163,"type":35},"2026-08-07",{"date":165,"type":35},"2024-11-12",{"date":167,"type":22},"2027-05",{"name":169,"class":42},"Rennes University Hospital",{"id":171,"slug":172,"hasResults":12,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":12,"sex":18,"minAge":177,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":23,"phases":180,"briefSummary":181,"conditions":182,"keywords":183,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":194},"100624542","phase-4-hydroxyethyl-starch-versus-crystalloid-and-postoperative-major-adverse-kidney-complications-100624542","NCT07410988","Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications","Effect of 130\u002F0.4 Hydroxyethyl Starch vs. Balanced Crystalloid for Intraoperative Fluid Therapy on Major Composite Renal Outcomes After Cardiac Surgery: a Multicenter, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 19 years or older scheduled for coronary artery bypass grafting (CABG), heart valve surgery, and\u002For thoracic aortic surgery\n\nExclusion Criteria:\n\n1. Emergency surgery;\n2. Planned implantation of a durable left ventricular assist device;\n3. History of starch allergy or hypersensitivity;\n4. History of kidney transplantation;\n5. Preoperative end-stage renal disease (ESRD) or requirement for renal replacement therapy (RRT);\n6. Preoperative glomerular filtration rate \\\u003C 30 mL\u002Fmin\u002F1.73 m2;\n7. Planned intraoperative and postoperative RRT;\n8. Preoperative use of mechanical circulatory support devices (e.g., intra-aortic balloon pump, extracorporeal membrane oxygenation, etc.);\n9. Significant clinical coagulopathy (e.g., active bleeding disorder or thrombocytopenia with a platelet count \\\u003C100,000\u002FµL);\n10. Active infective endocarditis.","19 Years",{"count":179,"type":22},1292,[25],"This trial aims to compare two intraoperative fluids, namely hydroxyethyl starch (HES) and balanced crystalloids in terms of major adverse kidney events after cardiac surgery. Indications for the study fluids administarion include preload augmentation and intravascular volume replacement during cardiac surgery.",[30],[184],"hydroxyethyl starch","2026-07-29",{"date":187,"type":35},"2026-07-30",{"date":189,"type":35},"2026-06-22",{"date":191,"type":22},"2029-07-31",{"name":193,"class":42},"Seoul National University Hospital",4,{"id":196,"slug":197,"hasResults":12,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":204,"conditions":205,"keywords":210,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":43},"100617905","impact-of-intraoperative-hemodynamic-instability-on-outcomes-in-cardiac-surgery-100617905","NCT07324694","Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery","Impact of Intraoperative Hemodynamic Instability on Postoperative Major Adverse Events in Cardiac Surgery Patients: A Prospective Cohort Study","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Scheduled for elective cardiac surgery (CABG, Valve replacement\u002Frepair, or combined procedures).\n* Surgery performed under cardiopulmonary bypass (CPB).\n* Preoperative sinus rhythm.\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* Emergency or salvage surgery.\n* Off-pump coronary artery bypass grafting.\n* Preoperative mechanical circulatory support (IABP, ECMO) requirement.\n* Pre-existing chronic renal failure requiring dialysis (HD\u002FPD).\n* Pre-existing cognitive impairment, dementia, or history of psychiatric disorders affecting cooperation.\n* Pregnancy.",{"count":203,"type":22},230,"Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear. This prospective cohort study aims to evaluate the association between intraoperative hemodynamic instability (defined as MAP \\\u003C 65 mmHg or vasopressor requirement) and major postoperative complications (Delirium, Acute Kidney Injury, Stroke, or Mortality) in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass.",[30,206,207,208,209],"Intraoperative Hemodynamic Instability","Postoperative Complication","Acute Kidney Injury","Postoperative Delirium (POD)",[211,212,213,214],"Intraoperative Hypotension","Cardiopulmonary Bypass","Mean Arterial Pressure","Cohort Study","2026-07-28",{"date":185,"type":35},{"date":218,"type":35},"2025-04-26",{"date":220,"type":22},"2026-09-05",{"name":222,"class":42},"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital",{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":12,"sex":18,"minAge":230,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":23,"phases":234,"briefSummary":235,"conditions":236,"keywords":239,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":43},"100648951","impact-of-preoperative-oral-carbohydrate-loading-on-insulin-resistance-in-pediatric-cardiac-surgery-patients-100648951","NCT07729280","Impact of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Pediatric Cardiac Surgery Patients","The Effect of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Pediatric Patients Undergoing Cardiac Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 2-16 years.\n* ASA physical status 2 or 3\n* Good tolerance of enteral feeding\n\nExclusion Criteria:\n\n* History of type 1 diabetes mellitus.\n* History of thyroid insufficiency treated with thyroid medication.\n* History of adrenal insufficiency treated with corticosteroids.\n* History of gastroesophageal reflux disease.\n* Patients receiving preoperative parenteral nutrition.\n* Emergency or urgent cardiac surgery.","2 Years","16 Years",{"count":233,"type":22},44,[75],"Surgical stress and preoperative fasting can induce insulin resistance, characterized by impaired cellular response to insulin and resulting hyperglycemia. In pediatric patients undergoing cardiac surgery, this metabolic stress response may negatively affect postoperative recovery. Although preoperative oral carbohydrate loading, defined as administering a carbohydrate-rich beverage before surgery rather than prolonged fasting, has demonstrated efficacy in reducing postoperative insulin resistance in adults, evidence supporting its use in pediatric cardiac surgery remains limited.\n\nThis randomized controlled trial aims to determine whether preoperative oral carbohydrate loading reduces perioperative insulin resistance, as measured by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), in pediatric patients undergoing cardiac surgery. The study will compare outcomes between children who receive an oral carbohydrate beverage prior to surgery and those who follow standard preoperative fasting protocols.",[30,237,238],"Insulin Resistance","Pediatric Cardiac Surgery",[133,240,241,242],"Carbohydrate loading","Insulin resistance","Glycemic variability","2026-07-24",{"date":245,"type":35},"2026-07-27",{"date":247,"type":22},"2026-08-25",{"date":249,"type":22},"2026-11-01",{"name":251,"class":42},"Rifdhani Fakhrudin Nur",{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":260,"enrollmentInfo":261,"targetDuration":4,"studyType":23,"phases":263,"briefSummary":264,"conditions":265,"keywords":268,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":144},"100535429","fluid-removal-guided-by-vexus-score-with-usual-care-in-patients-with-acute-kidney-injury-after-cardiac-surgery-100535429","NCT06251713","Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery","Feasibility of a Randomised Trial Comparing a Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery: a Pilot Randomised Trial.","VeXUS","Inclusion Criteria:\n\n* Intensive care unit admission within 72 hours of cardiac surgery with extracorporeal circulation\n* Acute kidney injury defined by KDIGO criteria\n* Vasoactive inotropic score \\\u003C45 and capillary refill time \\\u003C3s\n* Informed written consent\n\nExclusion Criteria:\n\n* Hypokalaemia \\\u003C3.5mmol\u002FL\n* Hyponatremia\\\u003C125mmol\u002FL\n* Hypernatremia \\>145mmol\u002FL\n* Metabolic alkalosis with pH \\>7.50\n* Impossibility to measure capillary refill time\n* Chronic liver disease\n* Cirrhosis with portal hypertension\n* Known thrombus of the inferior vena cava\n* Mechanical circulatory assistance (ECMO or mono left ventricular assistance)\n* Severe pre-operative chronic kidney disease (GFR \\\u003C 30mL\u002Fmin\u002F1.73m2)\n* Need for renal replacement therapy anticipated by the attending physician within 24 hours\n* Known hypersensitivity to Furosemide and\u002For hydrochlorothiazide\n* Severe allergy to wheat\n* Patient already included in another interventional study with an exclusion period still in progress\n* Pregnant, breast-feeding or women of childbearing age without suitable contraception\n* Patients under guardianship, curatorship or safeguard of justice\n* Patients under psychiatric care\n* Patients not affiliated to a social security scheme or beneficiaries of a similar scheme","85 Years",{"count":262,"type":22},40,[75],"Acute kidney injury affects more than 30% of patients after cardiac surgery, and is associated with an excess in mortality. There is a clinical continuum between acute kidney injury (transient if \\\u003C48h, persistent if \\>48h), the development of acute kidney and chronic renal failure. Each of these entities characterising renal recovery is associated with an increase in long-term morbidity and mortality. Fluid management in patients with acute kidney injury is challenging, as both hypovolaemia and hypervolaemia are detrimental. Venous congestion (reflecting intravascular hypervolaemia), is a well-established haemodynamic factor contributing to acute kidney injury after cardiac surgery. An ultrasound score, based on the venous doppler pattern explored in intra-abdominal organs, has recently been developed and is a better predictor of acute kidney injury than central venous pressure. Whether using the VeXUS score to guide fluid removal in haemodynamically stabilised patients could promote renal recovery after acute kidney injury remains to be investigated.\n\nBefore designing a large randomised trial to test such a strategy, its feasibility in a pilot randomised trial is assessed.",[208,30,266,267],"Venous Congestion","Hemodynamic Stability",[269,133,266,270,271,272],"Acute kidney injury","VeXUS score","diuretic","fluid removal","2026-07-23",{"date":243,"type":35},{"date":276,"type":35},"2024-07-31",{"date":278,"type":22},"2027-07",{"name":280,"class":42},"Hospices Civils de Lyon",{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":23,"phases":291,"briefSummary":292,"conditions":293,"keywords":295,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":302,"leadSponsor":304,"locationsCount":4},"100645610","exercise-prehabilitation-in-congenital-heart-disease-100645610","NCT07700459","Exercise Prehabilitation in Congenital Heart Disease","A Randomised-controlled Trial to Assess the Impact of Prehabilitation and a Structured Exercise Programme on Cardiorespiratory Performance in Adults Awaiting Elective Surgery for Congenital Heart Disease: The ACE-CHD Trial.","ACE-CHD","Inclusion Criteria:\n\n* Adults with congenital heart disease requiring cardiac surgery via sternotomy or thoracotomy.\n* Capacity to provide informed consent.\n* Ability and willingness to engage in exercise-based interventions.\n* Peak VO2 \\\u003C30ml\u002Fkg\u002Fmin at preoperative exercise assessment.\n* Participant reached peak VO2 in preoperative exercise assessment (RER \\>1.0).\n* Ability to communicate in English.\n\nExclusion Criteria:\n\n* Surgery is scheduled for a date that precludes participation in the programme - surgical date is \\\u003C9 weeks away.\n* Pregnancy of \\\u003C6 months postpartum.\n* History of pneumothorax within the last 3 months.\n* Resting oxygen saturations \\\u003C94%.\n* Uncorrected right-to-left shunt with exercise.\n* Fontan physiology.\n* Pulmonary hypertension.\n* Critical valvular obstruction.\n* Sustained ventricular arrhythmia.\n* Severe aortic dilatation (\\>45mm in Marfan syndrome or hereditary aortopathy, \\>50mm in bicuspid or tricuspid aortic valves).\n\nThe oldest person operated upon by the ACHD service was 78 years old. Upper age is not an exclusion criteria.",{"count":290,"type":22},32,[75],"Around 8-12 in every 1000 babies are born with an abnormal heart, known as a congenital heart defect (CHD).\n\nThanks to major advances in medical and surgical care, most babies born with CHD now live into adulthood.\n\nAs people with CHD get older, many need repeated heart operations. It is known from other areas of medicine that \"prehabilitation\" - a short, structured exercise programme completed before surgery - can improve fitness and help patients cope better with major operations. However, this approach has never been tested in adults with CHD. The investigators are running a randomised controlled trial to find out whether a prehabilitation programme can improve physical fitness before heart surgery in adults with CHD.\n\nParticipants will be randomly assigned to usual care or a prehabilitation group. Those in the prehabilitation group will follow a tailored, supervised exercise plan for several weeks before surgery.\n\nAll patients undergoing cardiac surgery routinely complete a cardiopulmonary exercise test (CPET) as part of their standard pre-operative assessment. CPET is a well-established test that shows how the heart and lungs respond to increasing levels of exercise. During the test, participants exercise on a bike while their breathing, heart rate, and overall physiological response are continuously monitored.\n\nThe results of each participant's routine CPET will be used to guide the individualised exercise programme in the intervention group.\n\nExercise levels prescribed in the study will not exceed the intensity already safely achieved during the routine CPET, ensuring that activity remains within clinically assessed limits.\n\nParticipants in the trial will complete an additional second CPET following the trial period.\n\nThe key question is whether a tailored exercise programme can improve fitness in adults with CHD before heart surgery, and whether this approach is feasible, acceptable and practical to deliver, including successful recruitment and measurable physiological improvements.",[294,30],"Congenital Heart Disease",[296,297,133],"Congenital heart disease","Prehabilitation","2026-07-21",{"date":300,"type":35},"2026-07-22",{"date":111,"type":22},{"date":303,"type":22},"2029-06-01",{"name":305,"class":42},"Liverpool Heart and Chest Hospital NHS Foundation Trust",{"id":307,"slug":308,"hasResults":12,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":23,"phases":316,"briefSummary":317,"conditions":318,"keywords":322,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":325,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":144},"100576555","impact-of-a-technology-platform-based-on-enhanced-recovery-aftereras-surgery-on-length-of-stay-after-coronary-artery-bypass-grafting-timely-project-100576555","NCT06786819","Impact of a Technology Platform Based on Enhanced Recovery After(ERAS) Surgery on Length of Stay After Coronary Artery Bypass Grafting: Timely Project","Estudo Randomizado de Cluster Escalonado Para Avaliar o Impacto de Uma Plataforma tecnológica Baseada no ERAS (Enhanced Recovery After Surgery) no Tempo de permanência após Cirurgia de revascularização miocárdica: Projeto Tempos Certos - REPLICCAR III","REPLICCARIII","Inclusion Criteria:\n\n* Adults over 18 years old\n* Indication for primary isolated CABG (elective or urgent status)\n* Own a personal cell phone\n* Have internet access\n* Knowledgeable in using the device\n* Full understanding and agreement regarding the informed consent form (ICF)\n\nExclusion Criteria:\n\n* Indication for associated surgery\n* Glycosylated hemoglobin level greater than 8%\n* Creatinine clearance less than 30 mL\u002Fmin\n* Pre-operative atrial fibrillation or use of pre-operative anticoagulation\n* Hemoglobin less than 12 g\u002FdL\n* Users of illicit drugs\n* STS score greater than 4%\n* Physical or mental disabilities that prevent adherence to the protocol\n* Refusal by the patient or family member",{"count":315,"type":22},480,[75],"Cardiovascular diseases continue to be the leading cause of death worldwide. Among them, coronary artery disease has the greatest impact, being characterized as one of the main causes of death in Brazil over the last decade. One of the well-established treatments is coronary artery bypass grafting, which is the most performed among cardiac surgeries and, in our scenario, is primarily funded by the Unified Health System (SUS). The information obtained from the Paulista Registry of Cardiovascular Surgeries (REPLICCAR), in partnership with FAPESP, has been important for implementing improvements in the landscape of cardiac surgeries in the state of São Paulo. Although outcomes in cardiac surgery have improved due to the structuring and organization of quality programs, this is still not a reality at the national level. In a situation where data collection and quality initiatives play a central role in continuous improvement, generating value becomes essential for the sustainability of cardiac surgery programs. In this sense, the concept of Enhanced Recovery After Surgery (ERAS) has gained increasing traction. This concept is based on multidisciplinary protocols and scientific evidence, which help prepare patients for rapid recovery, resulting in reduced complications, shorter hospital stays, and, primarily, lower hospital costs. On the other hand, the increase in surgical waiting lists has also led to a rise in home mortality due to cardiac causes. Thus, among the various challenges imposed by the current scenario, the investigators believe that preparing patients for rapid recovery after coronary artery bypass grafting presents an opportunity for the sustainability of the healthcare system. Therefore, the aim of this project is to evaluate the impact of a technology platform based on ERAS on the postoperative recovery time of patients undergoing coronary artery bypass grafting in reference centers in the state of São Paulo, Timely Project - REPLICCAR III.",[319,30,320,321],"ERAS","Cardiac Surgery-CABG","Digital Health",[30,323,324,319,321],"CABG","ERASCS",{"date":273,"type":35},{"date":327,"type":35},"2025-03-10",{"date":329,"type":22},"2026-09-01",{"name":331,"class":42},"University of Sao Paulo General Hospital",{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":12,"sex":18,"minAge":339,"maxAge":340,"enrollmentInfo":341,"targetDuration":4,"studyType":23,"phases":343,"briefSummary":344,"conditions":345,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":354,"locationsCount":43},"100625040","assessment-of-a-multimodal-analgesia-for-enhanced-recovery-after-cardiac-surgery-100625040","NCT07417462","Assessment of a Multimodal Analgesia for Enhanced Recovery After Cardiac Surgery","Assessment of a Multimodal Analgesia for Enhanced Recovery After Cardiac Surgery. A Prospective, Randomized, Study","Inclusion Criteria:\n\n* Age from 40 to 60 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status II-III.\n* Body mass index (BMI) \\\u003C 35 kg\u002Fm2.\n* Underwent cardiac surgery (coronary artery bypass graft surgery with median sternotomy).\n\nExclusion Criteria:\n\n* Valve replacement procedures.\n* Emergency operations.\n* Redo surgeries.\n* Minimally invasive approaches.\n* The presence of psychiatric disorders.\n* Cognitive impairment preventing accurate assessment using the verbal numerical rating scale (NRS).\n* Known hypersensitivity or a history of allergy to local anesthetics.\n* Had severe major organ dysfunction.\n* Left ventricular ejection fraction below 30%.\n* Pregnancy or breastfeeding.","40 Years","60 Years",{"count":342,"type":22},90,[75],"This work aims to assess the analgesic efficacies of transversus thoracic muscle plane block (TTPB) and transversus thoracic muscle plane block (TTPB) for open cardiac surgeries",[346,347,348,30],"Transversus Thoracic Muscle Plane Block","Pecto-intercostal Fascial Block","Enhanced Recovery","2026-07-19",{"date":298,"type":35},{"date":352,"type":35},"2026-02-18",{"date":329,"type":22},{"name":355,"class":42},"Assiut University",{"id":357,"slug":358,"hasResults":12,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":363,"targetDuration":4,"studyType":23,"phases":365,"briefSummary":366,"conditions":367,"keywords":369,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":43},"100648178","aspb-pipb-combination-in-cardiac-surgery-100648178","NCT07716943","ASPB-PIPB Combination in Cardiac Surgery","Effects of Combined Anterior Serratus Plane and Pectoral-Intercostal Plane Blocks on Perioperative Analgesia and Enhanced Recovery After Surgery in Cardiopulmonary Bypass Surgery","Inclusion Criteria:\n\n* Patients undergoing open heart surgery via median sternotomy by the Cardiovascular Surgery Clinic\n* Patients over 18 years of age\n* ASA II-III patients\n\nExclusion Criteria:\n\n* \\- Patients undergoing emergency or recurrent surgery\n* Patients with left ventricular ejection fraction \\\u003C 30\n* Patients who died per-operatively\n* Patients who do not provide informed consent\n* Presence of chronic pain\n* Presence of allergy to local anesthetics\n* Presence of infection in the area where the block will be performed\n* Coagulopathy\n* Pre-existing neurological deficit\n* Mental retardation\n* Anatomical deformity",{"count":364,"type":22},60,[75],"Cardiopulmonary bypass surgery is associated with significant postoperative pain, which may adversely affect respiratory function, delay mobilization, prolong hospital stay, and increase postoperative complications. Within Enhanced Recovery After Surgery (ERAS) protocols, multimodal analgesia and opioid-sparing strategies have become essential components of perioperative care. Ultrasound-guided fascial plane blocks, including the anterior serratus plane block (ASPB) and pectoral-intercostal plane block (PIPB), have emerged as effective and safe regional anesthesia techniques for cardiac surgery, targeting different sensory innervation of the thoracic wall. However, evidence regarding the combined use of these two blocks remains limited. This study aimed to evaluate whether the combination of ASPB and PIPB improves intraoperative and postoperative analgesia, reduces opioid consumption, and enhances postoperative recovery and ERAS outcomes compared with standard analgesic management in patients undergoing cardiopulmonary bypass surgery.",[78,30,212,368],"Median Sternotomy",[212,78,370,371],"Regional Anesthesia","Enhanced Recovery After Surgery","2026-07-16",{"date":298,"type":35},{"date":375,"type":22},"2026-07-01",{"date":377,"type":22},"2027-06-30",{"name":379,"class":42},"Sisli Hamidiye Etfal Training and Research Hospital",{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":390,"conditions":391,"keywords":394,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":43},"100645578","frailty-and-ultrasound-guided-central-venous-catheterization-difficulty-in-adult-cardiac-surgery-patients-100645578","NCT07701538","Frailty and Ultrasound-Guided Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients","Association Between Frailty and Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients: A Prospective Ultrasound-Based Observational Study","FRAILCVC","Inclusion Criteria\n\n* Adults aged 18 years or older.\n* Scheduled for elective cardiac surgery.\n* Planned ultrasound-guided internal jugular vein catheterization as part of routine perioperative care.\n* Able to undergo preoperative frailty assessment using the Clinical Frailty Scale (CFS).\n* Able to perform handgrip strength measurement.\n* Able to undergo ultrasound assessment of the internal jugular vein.\n* Provided written informed consent.\n\nExclusion Criteria\n\nConditions Affecting Neck Anatomy\n\n1. Previous neck surgery.\n2. History of radiotherapy to the neck region.\n3. Presence of a neck mass, infection, or any lesion that may distort neck anatomy.\n4. Known internal jugular vein thrombosis.\n5. Congenital vascular anomalies causing significant alteration of the internal jugular vein or carotid artery anatomy.\n\nClinical Conditions Affecting Catheterization\n\n1. Patients requiring emergency cardiac surgery.\n2. Presence of an existing central venous catheter.\n3. Severe coagulopathy (INR \\> 2.0 or platelet count \\\u003C 50,000\u002Fmm³).\n4. Hemodynamic instability or requirement for active cardiopulmonary resuscitation.\n\nConditions Affecting Frailty and Handgrip Strength Assessment\n\n1. Severe neurological disorders (e.g., advanced dementia or disabling sequelae of stroke).\n2. Orthopedic or neuromuscular disorders affecting upper extremity function.\n3. Inability to perform handgrip strength measurement due to severe arthritis or hand deformity.\n\nConditions Affecting Study Participation\n\n1. Cognitive impairment preventing reliable clinical assessment or informed participation.\n2. Refusal to participate in the study.\n3. Any other condition that, in the investigator's judgment, may compromise patient safety or interfere with study participation.",{"count":389,"type":22},280,"This prospective observational study aims to evaluate the association between preoperative frailty and the procedural difficulty of ultrasound-guided internal jugular vein catheterization in adult patients undergoing elective cardiac surgery.\n\nFrailty will be assessed using the Clinical Frailty Scale and handgrip strength measurements. Preprocedural ultrasound evaluation will include internal jugular vein anatomical characteristics such as anteroposterior and transverse vein diameters, cross-sectional area (CSA), common carotid artery diameter, skin-to-vein distance, overlap status, and sternocleidomastoid muscle thickness Catheterization difficulty will be assessed using the Gaber Procedural Difficulty Index.\n\nThe study seeks to determine whether frailty and ultrasound-derived anatomical parameters can predict difficult internal jugular venous catheterization and improve preprocedural risk assessment without altering routine clinical care.",[392,30,393],"Frailty","Central Venous Catheter",[395,396,397,85,398,399,400,401,402],"frailty","central venous catheterization","ultrasound-guided catheterization","internal jugular vein","difficult catheterization","handgrip strength","venous anatomy","adult patients","2026-07-08",{"date":405,"type":35},"2026-07-14",{"date":407,"type":22},"2026-07-25",{"date":409,"type":22},"2027-06",{"name":411,"class":42},"Ankara City Hospital Bilkent",{"id":413,"slug":414,"hasResults":12,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":418,"eligibilityCriteria":419,"healthyVolunteers":420,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":421,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":423,"conditions":424,"keywords":429,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":437,"leadSponsor":439,"locationsCount":43},"100645912","appropriateness-of-hemostatic-agent-use-in-cardiovascular-surgery-haemovax-100645912","NCT07699016","Appropriateness of Hemostatic Agent Use in Cardiovascular Surgery (HAEMOVAX)","Evaluation of Appropriateness in the Use of Hemostatic Agents in Cardiovascular Surgery: A Mixed-Methods Single-Center Observational Study","HAEMOVAX","Inclusion Criteria:\n\n* Physicians with a surgical role in the Departments of Cardiac Surgery or Vascular Surgery at IRCCS Galeazzi-Sant'Ambrogio, Milan Including attending surgeons, consultant surgeons, and surgical residents\n* Active participation in cardiovascular operative procedures during the study period (or within the preceding 12 months)\n* Employment at the study institution at the time of survey administration Willingness to participate and complete the anonymous structured questionnaire\n\nExclusion Criteria:\n\n* Non-surgical healthcare personnel (e.g., nurses, anesthesiologists, administrative staff, or allied health professionals)\n* Surgeons not involved in operative cardiovascular practice during the study period\n* External collaborators or visiting surgeons without regular clinical activity at the institution\n* Individuals who do not provide informed consent for participation in the anonymous survey\n* Questionnaires with missing or incomplete vignette responses preventing calculation of the KPA-Score",true,{"count":422,"type":22},15,"Hemostatic agents are widely used in cardiac and vascular surgery to support intraoperative bleeding control. Despite their clinical relevance and substantial economic impact, little is known about real-world patterns of use, adherence to evidence-based recommendations, and the alignment between clinicians' perceived knowledge and actual decision-making.\n\nHAEMOVAX is a single-center mixed-methods observational study conducted at IRCCS Galeazzi-Sant'Ambrogio Hospital, Milan, Italy. The study combines an anonymous survey of cardiovascular surgeons with a retrospective audit of institutional hemostatic agent consumption. The primary objective is to evaluate the appropriateness of hemostatic agent selection using a Knowledge-Practice Alignment Score (KPA-Score) derived from standardized clinical vignettes based on current EACTS and ESA recommendations. Secondary objectives include assessment of usage patterns, barriers to appropriate use, concordance between declared practice and real-world consumption, and opportunities for evidence-based standardization.",[425,426,427,30,428],"Hemostasis","Perioperative Bleeding","Cardiovascular Surgery","Vascular Surgery",[430,431,432,426],"Hemostatic Agents","Surgical Hemostasis","Topical Hemostatic Agents","2026-07-07",{"date":435,"type":35},"2026-07-13",{"date":375,"type":22},{"date":438,"type":22},"2026-08-15",{"name":440,"class":42},"University of Milan",{"id":442,"slug":443,"hasResults":12,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":448,"enrollmentInfo":449,"targetDuration":4,"studyType":23,"phases":451,"briefSummary":452,"conditions":453,"keywords":455,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":43},"100605604","serratus-posterior-superior-plane-block-for-postoperative-pain-in-cardiac-surgery-100605604","NCT07164677","Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery","Efficacy of the Serratus Posterior Superior Intercostal Plane Block for Postoperative Acute Pain Management in Open-Heart Surgery","Inclusion Criteria:\n\n* Patients aged 18-80 undergoing elective on-pump open-heart surgery via median sternotomy.\n* American Society of Anesthesiologists (ASA) classification II-III patients.\n* Patients who can use PCA.\n* Patients who will sign the informed consent form.\n\nExclusion Criteria:\n\n* History of opioid use for more than four weeks\n* Chronic pain syndromes\n* Patients with a history of local anesthetic or opioid allergy, hypersensitivity\n* Alcohol and drug addiction\n* Conditions where regional anesthesia is contraindicated\n* Failure in the dermatomal examination performed after the block\n* Emergency surgeries and redo surgeries.\n* Individuals with obstructive sleep apnea.\n* Left ventricular ejection fraction less than 30%.\n* Patients with severe psychiatric illnesses (such as psychosis, dementia) that limit cooperation with verbal numerical pain scales.\n* Pregnant and breastfeeding patients.\n* Hematological disorders.\n* Significant impairment in the function of a major organ (e.g., severe hepatic or renal disease). • Patients who cannot be extubated within the first 6 hours postoperatively.","80 Years",{"count":450,"type":22},50,[75],"The aim of this study is to investigate the efficacy of bilateral serratus posterior superior intercostal plane (SPSIP) block on postoperative acute pain and opioid consumption in patients undergoing on-pump open-heart surgery. Postoperative outcomes including pain scores, cumulative morphine use, quality of recovery, and opioid-related side effects will be evaluated within the first 24 hours after surgery.",[30,454],"Post Operative Pain, Acute",[133,456],"Serratus Posterior Superior Plane Block","2026-06-30",{"date":459,"type":35},"2026-07-02",{"date":461,"type":35},"2025-09-13",{"date":463,"type":22},"2027-02-01",{"name":465,"class":42},"Ondokuz Mayıs University",{"id":467,"slug":468,"hasResults":12,"nctId":469,"briefTitle":470,"officialTitle":470,"acronym":471,"eligibilityCriteria":472,"healthyVolunteers":12,"sex":18,"minAge":473,"maxAge":4,"enrollmentInfo":474,"targetDuration":4,"studyType":23,"phases":476,"briefSummary":477,"conditions":478,"keywords":480,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":485,"lastUpdatePostDateStruct":486,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":491,"locationsCount":43},"100644894","sage-heart--senior-assessment-fragility-and-post-operative-qalys-1-year-after-emergency-heart-surgery-for-patients-aged-75-and-older-100644894","NCT07677319","SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older","SAGE-Heart","Inclusion Criteria:\n\n* Patients aged ≥ 75 years who are affiliated with or beneficiaries of a social security scheme and undergoing emergency cardiac surgery under cardiopulmonary bypass, either immediate or urgent (relative) :\n\n  * Immediate emergency surgery: intervention performed before the start of the next working day following the decision to operate,\n  * Urgent (relative) emergency surgery: patients not admitted electively for surgery but requiring an intervention during the current hospital stay for medical reasons, and who cannot be discharged without undergoing a definitive procedure\n\nExclusion Criteria:\n\n* Patients requiring preoperative cardiopulmonary resuscitation\n* Scheduled (elective) surgery\n* Lack of informed consent\n* Impaired consciousness at the time of inclusion (defined by a Glasgow Coma Scale score \\\u003C 15)\n* Individuals under legal guardianship or judicial protection\n* Individuals participating in another interventional research protocol","75 Years",{"count":475,"type":22},265,[75],"The hypothesis is that the preoperative Clinical Frailty Score (CFS) is a predictive factor for a loss in quality-adjusted life years (QALYs) one year after emergency cardiac surgery under cardiopulmonary bypass (CPB) in patients aged 75 years and older.",[392,30,479],"QALYs",[392,481,30,482,479,483,484],"Elderly","Cardio-pulmonary Bypass","Clinical Frailty Scale","EuroQol, postoperative","2026-06-29",{"date":457,"type":35},{"date":488,"type":35},"2025-12-03",{"date":490,"type":22},"2028-12-03",{"name":492,"class":42},"University Hospital, Bordeaux",{"id":494,"slug":495,"hasResults":12,"nctId":496,"briefTitle":497,"officialTitle":498,"acronym":499,"eligibilityCriteria":500,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":501,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":503,"conditions":504,"keywords":507,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":519,"leadSponsor":520,"locationsCount":43},"100646912","hemo-integra-integrated-intraoperative-hemodynamic-monitoring-during-cardiac-surgery-with-cardiopulmonary-bypass---a-pilot-study-100646912","NCT07683299","HEMO-INTEGRA: Integrated Intraoperative Hemodynamic Monitoring During Cardiac Surgery With Cardiopulmonary Bypass - A Pilot Study","HEMO-INTEGRA: Feasibility and Description of an Integrated Intraoperative Hemodynamic Monitoring System for Cardiac Surgery With Cardiopulmonary Bypass - A Pilot Observational Study","HEMO-INTEGRA","Inclusion Criteria:\n\n* \\- Adult patients 18 years or older scheduled for elective cardiac surgery with cardiopulmonary bypass\n* Standard intraoperative TEE and arterial line monitoring in place\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* \\- Emergency surgery\n* Off-pump cardiac surgery (OPCAB)\n* Inability to obtain adequate TEE window\n* Refusal to participate",{"count":502,"type":22},30,"HEMO-INTEGRA is a software system that integrates four domains of intraoperative hemodynamic monitoring in a single dashboard during cardiac surgery with cardiopulmonary bypass (CPB): (1) ventricular-arterial coupling (VAC) analysis using the Balan 2026 method; (2) tissue perfusion and oxygen delivery (EPOC module with Q10 temperature correction); (3) neuromonitoring (NIRS\u002FBIS); and (4) systemic venous congestion assessment via VExUS-TEE (Waldron 2024 method).\n\nThis pilot observational study evaluates the feasibility and completeness of data capture using HEMO-INTEGRA across five perioperative time points (T0: pre-CPB; T1: early CPB; T2: mid-CPB; T3: rewarming; T4: post-CPB) in adult patients undergoing elective cardiac surgery at Clinica Medellin Sede Occidente, Medellin, Colombia.\n\nThe system operates in parallel with standard monitoring and does not modify clinical management. No additional procedures are performed on participants beyond standard of care.",[30,212,505,506],"Hemodynamic Monitoring","Ventricular-Arterial Coupling",[499,508,509,510,511,512,513],"VExUS","Oxygen Delivery","NIRS","Deep Hypothermia","Transesophageal Echocardiography","Clinical Decision Support","2026-06-27",{"date":516,"type":35},"2026-07-06",{"date":518,"type":35},"2026-05-27",{"date":141,"type":22},{"name":521,"class":42},"Hernán Darío Castro Arias",{"id":523,"slug":524,"hasResults":12,"nctId":525,"briefTitle":526,"officialTitle":527,"acronym":528,"eligibilityCriteria":529,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":448,"enrollmentInfo":530,"targetDuration":4,"studyType":23,"phases":531,"briefSummary":532,"conditions":533,"keywords":536,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":540,"startDateStruct":541,"completionDateStruct":542,"leadSponsor":544,"locationsCount":43},"100644856","anti-bloating-patch-for-postoperative-gastric-distension-after-cardiac-surgery-100644856","NCT07677423","Anti-Bloating Patch for Postoperative Gastric Distension After Cardiac Surgery","Efficacy of an Anti-Bloating Patch for Postoperative Gastric Distension After Cardiac Surgery: A Randomized Controlled Trial Using Quantitative Gastric Bubble Imaging Analysis","ABP-CS","Inclusion Criteria:\n\n* Age ≥18 years\n* Undergoing elective cardiac surgery\n* Postoperative chest radiographs available for gastric bubble area assessment\n* Able to provide written informed consent or have consent provided by a legally authorized representative\n* Expected postoperative intensive care unit admission\n\nExclusion Criteria:\n\n* Previous major gastrointestinal surgery affecting gastric anatomy or motility\n* Known gastrointestinal obstruction, perforation, or severe gastrointestinal disease\n* Severe hepatic or renal dysfunction judged unsuitable by the investigators\n* Known allergy or hypersensitivity to components of the anti-bloating patch\n* Participation in another interventional clinical trial within the previous 30 days\n* Pregnancy or lactation\n* Inability to complete study assessments or follow study procedures",{"count":51,"type":22},[75],"Postoperative gastric distension is a common gastrointestinal complication after cardiac surgery and may delay recovery, prolong intensive care unit (ICU) stay, and reduce patient comfort. Anti-bloating patches are widely used in clinical practice to promote gastrointestinal function recovery; however, high-quality evidence regarding their effectiveness in cardiac surgical patients remains limited.\n\nThis randomized controlled trial aims to evaluate the efficacy and safety of an anti-bloating patch in reducing postoperative gastric distension after cardiac surgery. Adult patients undergoing cardiac surgery will be randomly assigned to receive either standard perioperative care alone or standard perioperative care plus anti-bloating patch therapy. Gastric bubble area will be quantitatively measured using chest radiographs and image analysis software.\n\nThe primary outcome is the change in gastric bubble area on postoperative day 1 compared with baseline. Secondary outcomes include gastric bubble area on postoperative day 1, percentage change in gastric bubble area, abdominal distension score, time to first flatus, time to first bowel movement, gastric drainage volume, time to oral feeding, ICU length of stay, postoperative hospital length of stay, and patch-related adverse events.\n\nThe results of this study may provide evidence for the use of anti-bloating patches as an adjunctive intervention to enhance postoperative gastrointestinal recovery in patients undergoing cardiac surgery.",[534,535,30],"Postoperative Gastric Distension","Postoperative Gastrointestinal Dysfunction",[537,534,538,30,539],"Anti-Bloating Patch","Gastric Bubble Area","Gastrointestinal Dysfunction",{"date":457,"type":35},{"date":375,"type":22},{"date":543,"type":22},"2027-07-01",{"name":545,"class":42},"Southeast University, China",{"id":547,"slug":548,"hasResults":12,"nctId":549,"briefTitle":550,"officialTitle":551,"acronym":552,"eligibilityCriteria":553,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":554,"targetDuration":4,"studyType":23,"phases":556,"briefSummary":557,"conditions":558,"keywords":561,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":572,"locationsCount":43},"100644603","personalized-blood-transfusion-protocol-for-cardiac-patients-100644603","NCT07671469","Personalized Blood Transfusion Protocol for Cardiac Patients","Personalized (Demand-Informed) Blood Transfusion Protocol for Cardiac Patients","PerP","Inclusion Criteria:\n\n* Adults 18 years or older scheduled for cardiac surgery using the heart-lung machine (cardiopulmonary bypass), such as bypass, valve, or combined procedures\n* Moderate-to-high surgical risk (e.g., EuroSCORE II ≥ 3% or equivalent)\n* Allogeneic red blood cell transfusion is considered likely\n* Able to provide informed consent and understand randomization to different transfusion thresholds\n* Willing to receive blood products and follow study transfusion thresholds from anesthesia induction until hospital discharge or day 28, whichever comes first\n\nExclusion Criteria:\n\n* Refusal of or contraindication to allogeneic blood (e.g., Jehovah's Witness or formal directive against transfusion), or enrollment in a preoperative autologous donation program\n* Emergency or salvage procedures where protocol triggers are impractical (e.g., active arrest, aortic dissection with collapse)\n* Heart transplantation, durable ventricular assist device implantation, or surgery solely for VAD insertion\n* Off-pump bypass or other procedures not using cardiopulmonary bypass\n* Severe preoperative anemia (e.g., hemoglobin \\\u003C 8 g\u002FdL) or chronic transfusion-dependent anemia\n* Conditions preventing protocol adherence (e.g., anticipated massive hemorrhage, known bleeding disorder, very low platelets, uninterruptible dual antiplatelet\u002Fanticoagulant therapy)\n* Chronic dialysis dependence or established end-stage renal disease (eGFR \\\u003C 15 mL\u002Fmin\u002F1.73m² or on maintenance renal replacement therapy) prior to surgery.\n* Pregnancy or lactation\n* Enrollment in another interventional trial affecting transfusion practice or hemoglobin thresholds\n* Unable to provide informed consent (e.g., severe cognitive impairment without a legally authorized representative)",{"count":555,"type":22},900,[75],"This study compares two accepted ways of deciding when adults recovering from open-heart surgery should receive a blood transfusion in the intensive care unit. One approach gives a transfusion when the blood count (hemoglobin) falls below a fixed level that is the same for everyone. The other approach adds each patient's own physiology - such as oxygen levels and lactate - to help decide whether a transfusion is truly needed, within a safe range. The investigators want to learn whether the personalized approach is as safe as the standard approach for major outcomes after heart surgery, while reducing the amount of blood transfused. Participants may also choose to give blood and stool samples to a research biobank for future studies on recovery after cardiac surgery.",[30,559,560,212],"Blood Transfusion","Anemia",[562,563,564,85,565],"restrictive transfusion","hemoglobin trhreshold","oxygen delivery","ICU","2026-06-26",{"date":457,"type":35},{"date":569,"type":22},"2026-09-14",{"date":571,"type":22},"2030-03-15",{"name":573,"class":42},"Yan Mia Min",{"id":575,"slug":576,"hasResults":12,"nctId":577,"briefTitle":578,"officialTitle":578,"acronym":4,"eligibilityCriteria":579,"healthyVolunteers":12,"sex":18,"minAge":580,"maxAge":581,"enrollmentInfo":582,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":583,"conditions":584,"keywords":586,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":588,"startDateStruct":589,"completionDateStruct":591,"leadSponsor":593,"locationsCount":43},"100430068","assessing-the-burden-of-perioperative-atrial-fibrillation-in-patients-undergoing-cardiac-surgery-100430068","NCT04880265","Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Elective open heart surgery\n* Age \\> 20 years\n\nExclusion Criteria:\n\n* Refusal to participate (patient or health care proxy)\n* Participation in other pharmacological trials\n* Lack of data or poor data quality which cannot be analyzed for any heart rhythm in 80% of the postoperative study period.","20 Years","90 Years",{"count":51,"type":22},"Background and Significance:\n\nIn the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimated at 30 - 60 %, and therefore presents the most common adverse event after cardiac surgery. Multiple complications may be associated with AF: Patients are usually subject to an increased length-of-stay in the intensive care unit and in the hospital. Furthermore, the risk for stroke and development of long-term AF is elevated, while further anticoagulation is required putting the patient at risk for bleeding. On average, an additional $10,000 - $20,000 is spent for each patient with AF. However, the exact burden of postoperative AF still remains unknown.\n\nSpecific Aims of Research Project:\n\n1. To collect data from an electrocardiogram (EKG) monitoring patch, we aim to accurately determine the prevalence of atrial fibrillation in patients undergoing cardiac surgery at our center.\n2. To collect data on epidemiological characteristics to investigate risk factors for developing perioperative atrial fibrillation in patients undergoing cardiac surgery. This will allow us to create robust risk prediction models.",[585,30],"Atrial Fibrillation",[587],"Wearable Device",{"date":457,"type":35},{"date":590,"type":35},"2021-09-14",{"date":592,"type":22},"2030-05",{"name":594,"class":42},"Brigham and Women's Hospital",{"id":596,"slug":597,"hasResults":12,"nctId":598,"briefTitle":599,"officialTitle":599,"acronym":600,"eligibilityCriteria":601,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":602,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":603,"conditions":604,"keywords":606,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":617,"locationsCount":43},"100580671","impact-of-variation-of-oxydo-reduction-potential-in-cardiac-surgery-on-post-operative-outcome-100580671","NCT06840327","Impact of VARIation of OXYdo-reduction Potential in Cardiac Surgery on Post-operative Outcome","VARIOXY","Inclusion Criteria:\n\nPatients over 18 years of age Scheduled cardiac surgery patients undergoing bypass surgery with saphenous vein harvesting.\n\nPatients able to understand the protocol; Patients able to express non-opposition to participating in the study Patients affiliated to a social security system or equivalent.\n\nExclusion Criteria:\n\nEmergency surgery patients. Pregnant or breast-feeding women. Patients deprived of their freedom or under legal protective measures.",{"count":127,"type":22},"Observational, prospective, monocentric study conducted in the cardiac surgery department about biological markers to predict the short-term outcome of heart surgery patients.",[30,605],"Extracorporeal Circulation",[607,85,608,609,610],"extracorporeal circulation","biological markers","Redox balance","post-operative outcome","2026-06-24",{"date":485,"type":35},{"date":614,"type":35},"2025-10-07",{"date":616,"type":22},"2027-10",{"name":118,"class":42},{"id":619,"slug":620,"hasResults":12,"nctId":621,"briefTitle":622,"officialTitle":622,"acronym":623,"eligibilityCriteria":624,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":625,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":627,"conditions":628,"keywords":640,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":642,"lastUpdatePostDateStruct":643,"startDateStruct":645,"completionDateStruct":646,"leadSponsor":647,"locationsCount":43},"100642312","risk-factors-of-atrial-fibrillation-after-cardiac-surgery-100642312","NCT07625033","Risk Factors of Atrial Fibrillation After Cardiac Surgery","PFAS","Inclusion Criteria:\n\n* age \\>18\n* having undergone a scheduled cardiac surgery in the study center\n* having agreed to the reuse of their hospital care data\n\nExclusion Criteria:\n\n* Atrial fibrillation at the admission in hospital.",{"count":626,"type":22},918,"Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death. Preventing the occurrence of these arrhythmias is a major challenge. This study aims to investigate risk factors and protective factors regarding atrial fibrillation and other iatrogenic cardiac arrhythmias after cardiac surgery, particularly innovative anesthetic strategies such as stellar ganglion blockade which have been recently implemented in our center.",[30,629,630,212,631,632,633,634,635,636,637,371,29,638,639],"Peri Operative Medicine","Thoracic Surgery","Coronary Artery Bypass","Heart Valve Prosthesis Implantation","Aortic Valve Replacement","Perioperative Medicine","Preoperative Care","Intraoperative Care","Postoperative Care","Cardiac Anesthesia","Intensive Care Unit",[641],"Stellar Ganglion Blockade, SGB, cardiac surgery","2026-06-23",{"date":644,"type":35},"2026-06-25",{"date":375,"type":22},{"date":375,"type":22},{"name":648,"class":42},"Centre Hospitalier Régional Metz-Thionville",{"id":650,"slug":651,"hasResults":12,"nctId":652,"briefTitle":653,"officialTitle":654,"acronym":4,"eligibilityCriteria":655,"healthyVolunteers":12,"sex":18,"minAge":177,"maxAge":4,"enrollmentInfo":656,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":657,"conditions":658,"keywords":659,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":642,"lastUpdatePostDateStruct":661,"startDateStruct":662,"completionDateStruct":663,"leadSponsor":665,"locationsCount":43},"100622557","perioperative-continuous-glucose-monitoring-accuracy-in-cardiac-surgery-100622557","NCT07385170","Perioperative Continuous Glucose Monitoring Accuracy in Cardiac Surgery","Evaluation of Perioperative Continuous Glucose Monitoring Accuracy in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Patients aged 19 years or older scheduled for cardiac surgery\n\nExclusion Criteria:\n\n* Skin disease at the sensor application site (proximal arm)",{"count":21,"type":22},"The goal of this clinical trial is to evaluate accuracy of continuous glucose monitoring device called 'Dexcom G7' in patients undergoing cardiac surgery.",[30],[660],"continuous glucose monitoring",{"date":566,"type":35},{"date":518,"type":35},{"date":664,"type":22},"2028-05-31",{"name":193,"class":42}]