[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardio-respiratory-fitness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardio-respiratory-fitness":81},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100648901","cardiorespiratory-fitness-and-acute-high-intensity-exercise-effects-on-brain-and-cognitive-function-in-older-adults-100648901",false,"NCT07727577","Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults","ExBrain","Inclusion Criteria:\n\n* Physical active in the last three months (\\>3x\u002Fweek of 30 minutes of moderate exercise)\n* To participate in the study, participants must answer \"no\" to all the Physical Activity Readiness questionnaire (PAR-Q) questions and have no signs and symptoms of cardiovascular, metabolic, and kidney diseases following the decision tree of the American College of Sports Medicine screening procedure.\n* Agree to have their data stored in a human performance database for future use. Agree to have their data stored in a repository per the requirement of peer-reviewed scientific journals, which may require data to be stored in a repository as a condition for publication. Such repositories are online databases, in which coded data is linked (no link to participants personally) to the journal article citation. Must read, understand, and sign the informed consent form.\n\nExclusion Criteria:\n\n* Use of illicit drugs, excessive alcohol, and\u002For performance-enhancing drugs.\n* Have any current orthopedic injury.\n* Have implanted medical devices.\n* Serious medical conditions limiting the ability to safety participate in either the PA interventions; these include dementia, symptomatic heart or vascular disease, severe hypertension, recent myocardial infarction, stroke, severe insulin-dependent diabetes mellitus, psychiatric disease, renal disease, liver disease or active cancer\n* Mini-mental examination score \\\u003C 23",true,"ALL","55 Years","79 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether a single session of high-intensity interval exercise (HIIT) affects cognitive performance and brain activity in older adults, and whether cardiorespiratory fitness influences these effects. The main questions it aims to answer are:\n\n* Does a single HIIT session change performance on a task-switching test of cognitive flexibility?\n* Does a single HIIT session change prefrontal brain activity during cognitive testing, as measured by functional near-infrared spectroscopy (fNIRS)?\n* Do older adults with higher cardiorespiratory fitness show greater cognitive and brain changes in response to HIIT than those with lower fitness?\n\nParticipants will:\n\n* Visit the laboratory on two separate days\n* Complete a sub-maximal graded exercise test during the first visit to measure cardiorespiratory fitness\n* Complete a single \\~30-minute HIIT cycling session during the second visit\n* Complete a task-switching cognitive test before and after the HIIT session\n* Have their brain activity monitored with fNIRS while completing the cognitive tests",[28,29,30,31],"Healthy Aging","Cognitive Benefits","Cardio Respiratory Fitness","Brain Activity",[33,34,35,36],"Cognitive Flexibility","Prefrontal Cortex Activation","Aging","Acute effects of high-intensity interval exercise on cognitive flexibility and prefrontal brain activity in healthy older adults","NOT_YET_RECRUITING","2026-08-11",{"date":40,"type":41},"2026-08-12","ACTUAL",{"date":43,"type":22},"2026-09-01",{"date":45,"type":22},"2028-08-01",{"name":47,"class":48},"Colby-Sawyer College","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":49},"100644833","evaluate-the-effect-of-remote-exercise-intervention-on-blood-glucose-control-and-physical-fitness-in-t2dm-patients-100644833","NCT07676773","Evaluate the Effect of Remote Exercise Intervention on Blood Glucose Control and Physical Fitness in T2DM Patients","A 12 Weeks Clinical Trail to Evaluate the Effect of Remote Exercise Intervention on Blood Glucose Control and Physical Fitness in T2DM Patients","Inclusion Criteria:\n\n(1) Both gender, age from 40 to 69 years old. (2) Meeting the diagnostic criteria for type 2 diabetes in China. (3) HbA1c is within 6.5%-7 .0% and no medication is taken. (4) Newly diagnosed with diabetes or the duration of the disease is no more than 5 years. (5) Possessing general exercise capacity and no obvious diseases in the muscle and osteoarticular systems. (6) The exercise risk is evaluated as medium or low risk through the PAR-Q+ questionnaire. (7) No contraindications to exercise tests. (8) Willing to adopt intensifed lifestyle intervention and complete the entire research process.\n\nExclusion Criteria:\n\n(1) T1DM patients, autoimmune diabetes and special types of diabetes, including hypercortisolism, growth hormone tumor, glucagonoma and some special types of diabetes caused by genetic factors; (2) pregnant or lactating women; (3) regular use of antidiabetic drugs or insulin in the past three months; (4) fasting blood glucose level \\> 16.7 mmol\u002FL; (5) recurrent hypoglycemia; (6) a history of acute diabetic complications, including diabetic ketoacidosis, hyperosmolar hyperglycemia, and lactic acidosis; (7) a history of severe chronic microvascular or macrovascular complications; (8) diseases that may be exacerbated by exercise or impair exercise efciency, such as uncontrolled hypertension, hyperthyroidism, osteoarthritis or hypokalemia; (9) unable to use smart phones or wearable smart devices independently; (10) communication or motor dysfunction; (11) Patients with severe chronic diseases could not participate in the study.","18 Years","69 Years",{"count":60,"type":22},80,[25],"The intervention group received 12 weeks of continuous remote intervention combined with health education. The control group only received 12 weeks of continuous health education, and the content and frequency were the same as those of the management group. Both groups received instruction at the beginning of the intervention. The intervention group was given priority to continuous walking\u002Frunning combined with aerobic exercise and swimming. Five to seven sessions per week for 45 minutes each session. Acclimatizations were performed at an intensity of 40%-49% reserve oxygen uptake (VO2R) from weeks 1 to 4, and exercise was performed at an intensity of 50%-59% VO2R from weeks 5 to 12. 5 minutes each of preparation and grooming activities (including joint movement and stretching) for each exercise. Combined with incremental load resistance exercise 2-3 times a week, 8 movements, 2-3 groups each time, repeated 8-10 times\u002Fgroup, with a 2-min rest between groups. The heart rate, RPE (12-13, \"fairly easy\" to \"somewhat laborious\") and exercise bracelet were used to monitor the intensity and amount of exercise. The exercise intervention was usually delivered 1-2 h after a meal. The daily medical supervision in the process of management implementation was carried out by trained sports managers through the doctor terminal of \"exercise assistant\" to collect and monitor the data of the study subjects.",[64,30],"Diabete Type 2",[66,67,68,69,70],"Type 2 diabetes mellitus","Integration of sports and healthcare","Randomized controlled trial","Exercise prescription","Remote exercise intervention","RECRUITING","2026-06-24",{"date":74,"type":41},"2026-06-30",{"date":76,"type":41},"2026-06-01",{"date":78,"type":22},"2026-12-31",{"name":80,"class":48},"Sichuan Academy of Medical Sciences","Cardio-respiratory Fitness"]