[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiometabolic-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiometabolic-health":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,44,73,112,143,180,208,233,270,295,319,345,374,399],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100610584","potatoes-type-2-diabetes-and-cardiometabolic-health-100610584",false,"NCT07229482","Potatoes, Type 2 Diabetes, and Cardiometabolic Health","Cardiometabolic Effects of a Potato-rich Diet in Older Adults at Increased Risk of Developing Type 2 Diabetes: A Randomized Controlled Feeding Study","Inclusion Criteria:\n\n* Age 50-70 years\n* Weight stable for previous 3 months (±5% body weight)\n* Sedentary to recreationally active\n* ADA-Risk Screener questionnaire score of at least 5\n* No plans to gain or lose weight or change physical activity level\n* Willing to pick up food daily and consume foods provided for a 14-week period\n* Verbal and written informed consent\n* Estrogen or testosterone use, lipid-lowering or blood pressure medication and thyroid replacement medication is acceptable, if on stable dose for \\>6 months\n\nExclusion Criteria:\n\n* Body mass index \\>40 m2\u002Fkg\n* Diabetes or diabetes medication\n* Weight loss medication or medication influencing glucose metabolism\n* Antibiotic, prebiotic or probiotic use in prior 3 months\n* TCHOL \\>6.2 mmol\u002FL; TG \\>4.5 mmol\u002FL\n* Blood pressure (BP) \\> 159\u002F99 mmHg\n* Diagnosed inflammatory bowel disease\n* Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease\n* Vegetarian or vegan\n* Pregnant or plans to become pregnant\n* Food allergies or aversions to diet foods provided\n* Estrogen or testosterone usage, lipid-lowering medication, blood pressure medication usage \\\u003C6 months",true,"ALL","50 Years","70 Years",{"count":21,"type":22},42,"ESTIMATED","INTERVENTIONAL",[25],"NA","Type 2 diabetes (T2D) is a major chronic health condition which increases risk of coronary artery disease, frailty, cognitive decline, and mortality. Additionally, hypertension is a major comorbidity for individuals with T2D, further increasing the risk of adverse cardiovascular outcomes. The prevalence of both conditions increases with advancing age. There is an urgent need to identify new approaches to prevent the development of T2D and improve cardiometabolic health in older adults 50-70 years of age.\n\nWhole white potatoes are an unprocessed food rich in essential nutrients often under-consumed by Americans, including potassium, fiber, magnesium, vitamins C and B6, and phytochemicals. Each of these nutrients individually are associated with cardiometabolic health benefits. Potatoes account for a significant amount of the intake of these nutrients in the US diet and are well-positioned to be a foundational element of a healthy dietary pattern. However, there are few interventional studies evaluating the effect of potatoes on cardiometabolic health, and the evidence from observational studies is mixed, leaving a significant gap in knowledge regarding the potential for potatoes to be included in healthy dietary patterns.\n\nThe results of our proposed study will provide foundational data that inform future dietary guidelines regarding the inclusion of white potatoes as part of a healthy US dietary pattern.",[28,29,30],"T2D","Blood Pressure","Cardiometabolic Health","RECRUITING","2026-07-31",{"date":34,"type":35},"2026-08-04","ACTUAL",{"date":37,"type":22},"2026-08",{"date":39,"type":22},"2029-03",{"name":41,"class":42},"Virginia Polytechnic Institute and State University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100650011","reset-in-all-2-a-randomized-controlled-pilot-trial-testing-an-optimized-multi-component-mobile-health-intervention-to-reduce-sedentary-time-in-early-adolescents-and-young-adults-eayas-with-all-during-maintenance-therapy-100650011","NCT07742891","ReSeT in ALL 2: A Randomized, Controlled Pilot Trial Testing an Optimized, Multi-component Mobile Health Intervention to Reduce Sedentary Time in Early Adolescents and Young Adults (eAYAs) With ALL During Maintenance Therapy","Inclusion Criteria:\n\n* Age 13-22 years at the time of enrollment.\n* Diagnosis of lymphoblastic leukemia or lymphoma treated with Children's Oncology Group (COG)-based maintenance chemotherapy (B-ALL, T-ALL, MPAL).\n* Patients with a history of relapsed disease are eligible if currently in second (or greater) remission and receiving COG-based maintenance therapy.\n* Completed at least 1 month of maintenance therapy (through maintenance cycle 1, day 29) and have at least one maintenance cycle (approximately 3 months) remaining.\n* Patients receiving nelarabine-containing maintenance cycles are eligible.\n* Self-reported sedentary lifestyle with an average of 4 or more leisure-time hours per day spent sedentary.\n* Willing to reduce sedentary time.\n* Parent\u002Flegal guardian available for consent (if applicable) and participant available for assent\u002Fconsent as applicable.\n* Access to the internet and a smartphone compatible with Fitbit and GroupMe (participant's or parent\u002Fguardian's device).\n* Ability to participate in virtual sessions with study staff.\n* Fluent in English. (Parents\u002Fguardians do not need to be English-speaking if consent can be completed in their primary language.)\n\nExclusion Criteria:\n\n* Evidence of recurrent or metastatic disease.\n* Inability to obtain informed consent\u002Fassent.\n* Medical contraindication to daily standing and light physical activity (\\>1.5 METs).\n* Intellectual disability or developmental delay that limits the ability to fully participate in the study intervention.\n* Unable to obtain study laboratory tests\n* Unable to independently complete quality-of-life surveys accurately.\n* Unable to complete study-related surveys.\n* Pregnancy.\n* Current imprisonment.","13 Years","22 Years",{"count":53,"type":22},50,[25],"The goal of this clinical trial is to learn whether an optimized, multi-component mobile health intervention (ReSeT2) can reduce sedentary behavior in adolescents and young adults with acute lymphoblastic leukemia (ALL) who are receiving maintenance therapy. The participant population includes English-speaking adolescents and young adults aged 13-22 years with ALL or related lymphoid malignancies being treated at Children's Hospital Los Angeles.\n\nThe main questions it aims to answer are:\n\n* Does the ReSeT2 intervention reduce device-measured total sedentary time (minutes\u002Fday) from baseline to Week 12 compared with usual care?\n* Does the ReSeT2 intervention improve other sedentary behavior measures, feasibility and acceptability outcomes, and exploratory health outcomes such as cardiometabolic health, quality of life, and self-efficacy?\n\nResearchers will compare participants receiving the ReSeT2 intervention with participants receiving usual care to see if the intervention leads to greater reductions in sedentary time and improvements in related health outcomes.\n\nParticipants will:\n\n* Complete baseline and Week 12 assessments, including questionnaires, clinical measurements, laboratory tests, and 7-day accelerometer wear periods.\n* Be randomized to either the ReSeT2 intervention group or usual care.\n* If assigned to the intervention group:\n\nUse a Fitbit activity tracker with inactivity prompts for 10 weeks. Receive home activity equipment and goal-based incentives. Participate in individualized coaching sessions. Participate in a peer support GroupMe chat and optional in-person group sessions.\n\nIf assigned to the usual care group, continue standard clinical care and complete study assessments.",[57,58,30],"Acute Lymphoblastic Leukemia (ALL)","Sedentary Behavior \u002F Physical Inactivity",[60,57,61,62],"Sedentary Behavior","Mobile Health (mHealth) Intervention","Adolescents and Young Adults (AYA)","NOT_YET_RECRUITING","2026-07-29",{"date":66,"type":35},"2026-08-03",{"date":68,"type":22},"2026-09-01",{"date":70,"type":22},"2028-12-23",{"name":72,"class":42},"Children's Hospital Los Angeles",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":43},"100648882","advancing-precision-medicine-for-cardiovascular-disease-and-diabetes-in-asian-populations-digital-intervention-cohort-100648882","NCT07728799","Advancing Precision Medicine for Cardiovascular Disease and Diabetes in Asian Populations: Digital Intervention Cohort","Advancing Precision Medicine for Cardiovascular Disease and Diabetes in Asian Populations: Digital Intervention Cohort (COBRA+)","COBRA+","Inclusion Criteria:\n\n* are currently enrolled in the Singapore Population Health Studies - Multi-Ethnic Cohort Phase 3 (MEC3) or Second Follow-up (F2),\n* are of Chinese, Malay, or Indian ethnicity,\n* are 21 to 69 years old, and\n* can read and write English,\n* own or use a smartphone (iOS ≥ 12.4 or Android ≥ 8 with at least 5 GB of free storage, and data plan and internet access),\n* are able and willing to download and use study smartphone apps,\n* are able and willing to wear the smartwatch provided throughout the study period, and\n* can walk independently.\n\nExclusion Criteria:\n\n* have a history or current condition of stroke, heart attack, kidney failure, diabetes mellitus, thyroid disease, or cancer, or have had a vascular bypass surgery or angioplasty procedure (either stent or balloon) performed, or\n* a serious mental health condition including schizophrenia, psychotic depression, or severe dementia, or\n* are currently pregnant or planning to get pregnant during the study period, or\n* are participating or planning to participate in other lifestyle intervention studies.\n* have a known sensitivity to medical-grade adhesives or a bleeding disorder will be \\[applicable to continuous glucose monitoring component only\\]\n* with contraindications specified by the blood pressure monitoring device manufacturer \\[applicable to continuous blood pressure monitoring component only\\]\n* participated in the pilot study \\[applicable to main trial only\\].","21 Years","69 Years",{"count":84,"type":22},600,[25],"The overarching aim is to improve cardiometabolic health and promote healthy ageing by supporting adults to adopt favourable lifestyle patterns identified through our observational research. The trial will recruit n=600 to be involved in Phase I (referred to as the \"Optimisation Phase\") of a two-phase project (Phase II trial registration will be submitted separately). All participants will complete a baseline study visit where, after consent taking, will complete a baseline questionnaire, receive a smartwatch each and additional wearables if applicable, and download the study app for the receiving and testing of interventions and completion of short form surveys. Participants will be involved in the continual evaluation and optimisation of ecological momentary interventions (EMIs) in adaptive, factorial, micro-randomised trials over 12 months. Consenting participants may also be contacted to participate in interviews to be involved in the co-design of interventions, or to provide insights to the feasibility and process evaluation of the trial.",[88,89,90,30,91],"Physical Activity","Diet Quality","Sleep","Digital Intervention",[93,94,95,96,97,98,99,100,101,102],"smartphone","smartwatch","ecological momentary assessment","EMA","ecological momentary intervention","EMI","microrandomised trial","mHealth","digital health","intervention","2026-07-23",{"date":105,"type":35},"2026-07-27",{"date":107,"type":22},"2026-07-20",{"date":109,"type":22},"2031-06-30",{"name":111,"class":42},"National University of Singapore",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":16,"sex":17,"minAge":119,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":124,"conditions":125,"keywords":127,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":43},"100648046","exercise-snacking-and-cardiometabolic-health-100648046","NCT07718113","Exercise Snacking and Cardiometabolic Health","Influence of Exercise Snacking on Cardiometabolic Health, Physical Activity, and Psychological Well-Being","Inclusion Criteria:\n\n* Age 18-60 years.\n* Body mass index (BMI) ≥18.5 kg\u002Fm².\n* Insufficiently physically active, defined as generally not meeting current physical activity guidelines for moderate-to-vigorous physical activity.\n* Able to safely participate in moderate-to-vigorous physical activity as determined by study screening procedures, including completion of the Physical - Activity Readiness Questionnaire (PAR-Q+) and health history review.\n* Willing and able to provide written informed consent.\n* Willing to complete all study visits, wear activity monitors, and comply with study procedures.\n\nExclusion Criteria:\n\n* Known cardiovascular, pulmonary, metabolic, neurological, orthopedic, or other medical conditions that would make participation in moderate-to-vigorous physical activity unsafe.\n* Resting heart rate \\>100 beats\u002Fminute at screening.\n* Resting blood pressure \\>160\u002F100 mmHg at screening.\n* Clinically significant electrocardiogram (ECG) abnormalities identified during screening that require medical evaluation.\n* Current participation in regular structured physical activity that meets or exceeds recommended physical activity guidelines.\n* Physical limitations or injuries that preclude safe participation in the intervention or fitness testing.\n* Moderate-to-severe psychological distress or other mental health concerns identified during screening that require referral or would make study participation inappropriate.\n* Pregnancy or any other condition judged by the investigators to make participation unsafe or interfere with completion of study procedures.","18 Years","60 Years",{"count":122,"type":22},60,[25],"Regular physical activity is associated with numerous health benefits, yet many young adults do not achieve recommended levels of physical activity. Exercise snacking, which involves performing brief bouts of physical activity throughout the day, may provide a practical alternative to traditional exercise programs by making physical activity easier to incorporate into daily routines.\n\nThis randomized controlled trial will evaluate whether a 12-week exercise snacking intervention improves physical activity levels, aerobic fitness, cardiometabolic health, and psychological well-being in insufficiently active young adults. Participants will be randomly assigned to either an exercise snacking intervention or a usual behavior control group. Assessments will be completed at baseline, after the 12-week intervention, and after an additional 12-week follow-up period to determine whether any changes are maintained after the intervention ends.\n\nThe study will measure physical activity using wearable activity monitors and assess aerobic fitness, body composition, blood pressure, blood lipids, glucose, exercise motivation, affective responses to exercise, and mental well-being. The findings will help determine whether exercise snacking is an effective and sustainable strategy for improving health in young adults and may inform future physical activity recommendations and interventions",[126,60,30],"Physical Inactivity",[128,129,130,131,132,133,134],"exercise snacking","physical activity","aerobic fitness","behavioral intervention","exercise motivation","physical activity maintenance","randomized controlled trial","2026-07-21",{"date":103,"type":35},{"date":138,"type":22},"2026-08-01",{"date":140,"type":22},"2027-12-31",{"name":142,"class":42},"University of Wisconsin, River Falls",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":16,"sex":17,"minAge":149,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":159,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":176,"leadSponsor":178,"locationsCount":43},"100640391","assessing-the-influence-of-habitual-beef-intake-on-key-molecular-markers-of-brain-health-100640391","NCT07623785","Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health","Inclusion Criteria:\n\nAdults aged 65 years and older.\n\nGenerally healthy with no acute illnesses.\n\nFluent in English.\n\nWilling to consume lean beef and dairy products (cottage cheese and whey protein) daily during the intervention phases.\n\nWilling to maintain current, habitual diet, physical activity levels, and body weight throughout the study.\n\nWilling to fast for 12 hours prior to clinical visits and provide blood, urine, stool, and saliva samples.\n\nExclusion Criteria:\n\nDiagnosed with Alzheimer's disease, Parkinson's disease, or other severe cognitive disorders.\n\nHistory of gastrointestinal diseases (e.g., Crohn's disease, celiac disease) or major gastrointestinal surgery.\n\nUncontrolled diabetes, severe liver or kidney disease, or a recent cardiovascular event (within the past 6 months).\n\nAllergies or severe intolerances to beef or dairy, or adherence to a strict vegetarian or vegan diet.\n\nBody weight fluctuation of \\>5% within the past 3 months.\n\nUse of systemic antibiotics within the 2 months prior to baseline.\n\nCurrent heavy smoking or excessive alcohol consumption.","65 Years",{"count":151,"type":22},20,[25],"his study investigates whether eating lean beef every day can help support brain health and healthy aging in older adults. As people age, protecting memory and cognitive function becomes increasingly important. Lean beef is a rich source of essential nutrients-such as vitamin B12, iron, zinc, and creatine-that are known to support brain function. However, the direct biological effects of a beef-rich diet on brain health markers are not fully understood.\n\nIn this study, researchers will recruit 20 generally healthy older adults (aged 65 and older) to participate in a dietary feeding trial. Participants will complete two separate 2-week dietary phases. During one phase, participants will consume 5.5 ounces (156 grams) of provided lean beef daily. During the other phase, they will consume an iso-caloric, protein-matched, non-beef control food daily. A two-week \"washout\" period, where participants return to their normal diets, will separate the two phases to ensure there are no overlapping effects.\n\nResearchers will collect blood, urine, stool, and saliva samples at the beginning and end of each 2-week dietary phase. These samples will be analyzed to see if the lean beef diet improves specific biological markers in the blood related to memory, nerve protection, and overall brain aging. Ultimately, the findings from this study will help determine if incorporating lean beef into a regular diet can be a natural, food-based strategy to help preserve neurological health in older adults.",[155,156,30,157,158],"Healthy Aging","Brain Health","Normal Aging","Cognitive Decline Prevention in Robust Older Adults",[160,161,162,163,164,165,166,167,168,169,170,171],"lean beef","red meat","dietary intervention","brain biomarkers","p-tau217","amyloid beta","bdnf","lipidomics","older adults","neuroprotection","nutrition","metabolomics","2026-05-28",{"date":174,"type":35},"2026-06-03",{"date":174,"type":22},{"date":177,"type":22},"2027-07-31",{"name":179,"class":42},"South Dakota State University",{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":17,"minAge":186,"maxAge":120,"enrollmentInfo":187,"targetDuration":4,"studyType":23,"phases":189,"briefSummary":190,"conditions":191,"keywords":193,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":43},"100615668","postprandial-effect-of-isocaloric-challenge-meals-enriched-with-indigenous-fruits-and-vegetables-on-glucose-metabolism-in-individuals-with-type-2-diabetes-in-wakiso-district-uganda-100615668","NCT07295600","Postprandial Effect of Isocaloric Challenge Meals Enriched With Indigenous Fruits and Vegetables on Glucose Metabolism in Individuals With Type 2 Diabetes in Wakiso District, Uganda","Inclusion Criteria:\n\n* Fasting blood sugar \\>= \\[7 mmol\u002FL\\](based on medical records)\n* Diabetic regimen for at least 6 months\n* Type 2 diabetes\n* Plans to continue staying in the same location for the next 6 months\n\nExclusion Criteria:\n\n* Taking dietary supplements\n* Type 1 diabetes\n* Tuberculosis co-infection\n* Renal failure\n* Liver cirrhosis\n* Chronic pancreatitis\n* Pregnancy and Lactation\n* Regular sports activity\n* Parallel participation in another clinical trial\n* On treatment for dyslipidaemia,\n* On treatment for hypertension\n* Very low blood pressure (\\\u003C 90\u002F50 mmHg)\n* Allergic reactions to test products","30 Years",{"count":188,"type":22},8,[25],"The goal of this clinical trial is to evaluate changes in glucose and lipid levels after consuming challenge meals enriched with selected indigenous fruits and vegetables in people living with type 2 diabetes in Wakiso district.\n\nThe main question to answer is:\n\nDoes the consumption of challenge meals enriched with indigenous fruits and vegetables improve glucose and lipid levels among people living with type 2 diabetes? Researchers will compare the effects of different challenge meals on glucose and lipid levels to identify the indigenous fruit and vegetable with the strongest glucose- and lipid-lowering effects.\n\nParticipants will:\n\nConsume five challenge meals over 5 weeks. Visit the study site after a 5-7 day rest period to consume the challenge meal and complete the tests.",[192,30],"Type 2 Diabetes",[194,195,196,197,198],"Type 2 diabetes","Challenge meals","Postprandial","Glucose metabolism","Indigenous fruits and Vegetables","2026-05-19",{"date":201,"type":35},"2026-05-22",{"date":203,"type":35},"2026-05-18",{"date":205,"type":22},"2026-08-30",{"name":207,"class":42},"KU Leuven",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":16,"sex":17,"minAge":119,"maxAge":149,"enrollmentInfo":215,"targetDuration":4,"studyType":23,"phases":216,"briefSummary":217,"conditions":218,"keywords":219,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":229,"leadSponsor":231,"locationsCount":43},"100602246","how-animal-and-plant-protein-shakes-change-the-bodys-nutrient-and-health-responses-100602246","NCT07121010","How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses","Randomized Crossover Trial of Protein Source and Leucine Supplementation on Metabolic and Immune Signaling Pathways","Inclusion Criteria:\n\n1. Age 18-65 years\n2. BMI 18.5-29.9 kg\u002Fm²\n3. Generally healthy, without known chronic illness and\u002For treatment with chronic medications\n4. Willing to comply with dietary restrictions and study procedures\n5. Not currently following a prescribed or restrictive diet (for example, vegan, ketogenic or high-protein regimen) or regularly taking high-protein supplements\n\nExclusion Criteria:\n\n1. History of cardiovascular disease, diabetes, or autoimmune disorders\n2. Active use of anti-inflammatory, immunomodulatory, or lipid-lowering medications\n3. Renal or hepatic dysfunction\n4. Pregnancy or breastfeeding\n5. Allergies or intolerances to components of study meals. A list of the smoothie ingredients will be sent to the potential participant with the mailing of the consent form\n6. Participation in another interventional study within the last 30 days",{"count":151,"type":22},[25],"The goal of this clinical trial is to learn how different protein types affect the body's metabolism and immune system in healthy adults. The main questions it aims to answer are:\n\nDoes drinking smoothies with animal-based or plant-based protein change the level of amino acids like leucine in the blood?\n\nDoes adding leucine to a plant-based smoothie make the body respond like it does to an animal-based smoothie?\n\nParticipants will:\n\nCome to the research clinic for 3 study visits\n\nDrink a high-protein smoothie at each visit (one with animal protein, one with plant protein, and one with plant protein + leucine)\n\nGive blood samples before and 1 and 3 hours after each smoothie\n\nResearchers will look at how the body's metabolism and immune system respond. They are especially interested in a pathway called mTOR, which helps control how cells use nutrients and may be involved in heart disease like atherosclerosis.\n\nAll smoothies are prepared to meet Halal and Kosher dietary guidelines.",[30],[220,221,222,223,224],"mTOR Signaling","Dietary Protein","Cardiometabolic Disease","Atherosclerosis","Nutrient Signaling","2026-03-24",{"date":227,"type":35},"2026-03-25",{"date":225,"type":35},{"date":230,"type":22},"2026-10",{"name":232,"class":42},"University of Pittsburgh",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":239,"minAge":240,"maxAge":241,"enrollmentInfo":242,"targetDuration":4,"studyType":23,"phases":244,"briefSummary":245,"conditions":246,"keywords":250,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":43},"100628354","improving-health-among-disadvantaged-girls-to-slow-pubertal-onset-and-reduce-long-term-health-risks-100628354","NCT07460544","Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks","Inclusion Criteria:\n\n1. Child female biological sex\n2. Child BMI percentile in the overweight\u002Fobese range (BMI percentile ≥85th for age and sex)\n3. Low child household income based on local income requirements for subsidized housing\n4. At least 50% enrollment of child Black or Latina or 'multiple' race or ethnicity identification (self- or mother-identified)\n5. Child between ages 6.5 and 8.0 years at screening\n6. Participation of child with mother who identifies as a primary caregiver\n7. Confirmed child prepubertal status by mother-report on the indicated pubertal staging scale\n8. Child and mother speak English\n9. Successful completion of the 'run-in' protocol, which includes screening and the baseline assessment\n\nExclusion Criteria:\n\n1. Child has medical contraindications to participate in a weight loss program (e.g., chromosomal abnormality, phenylketonuria, syndromal cause of obesity, type 1 diabetes) as determined by child's pediatrician or study pediatrician\n2. Mother has major medical or psychiatric conditions likely to interfere with participation (e.g., dementia, schizophrenia, terminal illness with life expectancy \\\u003C12 months)\n3. Family lives in temporary or group housing or has plans to relocate outside the Seattle metropolitan area in the next 12 months","FEMALE","6 Years","8 Years",{"count":243,"type":22},240,[25],"This study is testing whether improving health in girls during the prepubertal period may slow the onset of puberty. This study will focus on prepubertal girls who have a high weight status (at or above the 85th percentile for body mass index). Half of the girls who join the study will participate in a treatment program to reduce weight and improve lifestyle behaviors, and half of the girls will participate in a control condition. The frequency of pubertal onset will be compared across the groups. This research is important because girls who experience puberty at an earlier age are at risk for poor psychological and physical health.\n\nGirls in the treatment condition will participate in the Family Based Treatment (FBT) program, an established treatment for children who are overweight or obese. Families attend 20 weekly sessions (30 minutes each) over a 5-month period. Sessions are led by a trained interventionist and focus on healthy eating and physical activity behaviors.\n\nGirls in the control condition will receive their usual medical care through their pediatric care doctor or other care provider. Families will also receive educational handouts about 1 time per month, addressing topics related to healthy eating and physical activity behaviors.\n\nFamilies in both the treatment and control conditions will participate in assessments conducted at baseline and approximately 6-, 12-, 18-, 24-, 30-, and 36 months follow-up. These assessments are led by a data collector and include the measurement of height and weight, pubertal status, and health behaviors.",[247,248,249,30],"Overweight\u002FObesity","Puberty","Health Behavior",[251,252,253,254,255,131,256,257,258,259,260],"obesity","overweight","puberty","pubertal onset","pubertal development","family-based treatment","cardiometabolic health","health behaviors","health behavior change","weight loss","2026-03-03",{"date":263,"type":35},"2026-03-10",{"date":265,"type":22},"2026-05",{"date":267,"type":22},"2030-06",{"name":269,"class":42},"University of Washington",{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":239,"minAge":119,"maxAge":19,"enrollmentInfo":278,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":294},"100542839","project-womens-insomnia-sleep-health-equity-study-wishes-100542839","NCT06348082","Project Women's Insomnia Sleep Health Equity Study (WISHES)","Implementing Mindfulness Practice to Advance Sleep Health Equity Among Black Women","Project WISHES","Inclusion Criteria:\n\n* self-identified Black women\n* English speaking\n* meet ICSD3 diagnostic criteria for insomnia disorders, defined as difficulty initiating or maintaining sleep that occurs despite adequate opportunity to sleep with at least one associated daytime impairment symptom (ISI \\> 7)\n* additional quantitative insomnia criteria based on research recommendations and the new ICSD3: (a) severity of sleep onset latency or wake time after sleep onset of ≥31 min, (b) occurring ≥3 nights a week, and (c) for ≥ 3 months.\n\nExclusion Criteria:\n\n* Psychosis or unstable\u002Fsignificant depression, anxiety, or substance abuse under active care (more than 1 monthly mental healthcare visit or requiring more than 1 psychotropic medicine daily)\n* significant current practice of any form of meditation (\\>15min per day)\n* obstructive sleep apnea (OSA), restless legs syndrome (RLS), or circadian rhythm related condition (shift worker, use of medication that influence circadian rhythm, e.g., Parkinson's disease)\n* active or terminal cancer.",{"count":279,"type":22},340,[25],"The purpose of this study is to achieve health and healthcare equity by implementing an equity-focused, mindfulness-based sleep intervention to reduce stress and sleep deficiency-related cardiometabolic disease burden in Black women.",[283,284,30],"Insomnia","Sleep Health","2026-02-18",{"date":287,"type":35},"2026-02-19",{"date":289,"type":35},"2026-01-06",{"date":291,"type":22},"2028-08-31",{"name":293,"class":42},"Yale University",2,{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":16,"sex":17,"minAge":119,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":304,"phases":4,"briefSummary":305,"conditions":306,"keywords":308,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":317,"locationsCount":294},"100589158","the-neighborhood--health-study-100589158","NCT06950775","The Neighborhood & Health Study","A Naturalistic Study of Residents of an Agriculturally Integrated Community","N&HS","Inclusion Criteria:\n\nIndigo Neighborhood Participants:\n\n* 18 years or older\n* Lived in the Indigo Neighborhood as their primary and permanent residence for less than 3 months or intend to move to the Indigo Neighborhood as their primary and permanent residence.\n* Pregnant women will not be excluded from participation and may be coincidentally included\n\nElyson Neighborhood Participants:\n\n* 18 years or older\n* Live in the Elyson Neighborhood as their primary and permanent residence (the comparison neighborhood group).\n* Pregnant women will not be excluded from participation and may be coincidentally included\n\nExclusion Criteria:\n\nIndigo Neighborhood Participants:\n\n• None.\n\nElyson Neighborhood Participants:\n\n• None.",{"count":84,"type":22},"OBSERVATIONAL","The objective of The Neighborhood \\& Health Study is to use a quasi-experimental mixed-methods approach to assess the impact of living in an agrihood-an agriculturally integrated community. This study follows a longitudinal cohort of residents of a newly developed neighborhood (the Indigo Neighborhood) and a geographically and socio-demographically matched neighborhood (the Elyson Neighborhood), both located in Fort Bend County, Texas, providing a unique opportunity for a natural experiment.",[307,30],"Healthy Eating",[309,88,307,310],"Agrihood","Social Connectedness","2025-12-05",{"date":313,"type":35},"2025-12-09",{"date":315,"type":35},"2025-05-09",{"date":138,"type":22},{"name":318,"class":42},"Texas A&M University",{"id":320,"slug":321,"hasResults":11,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":16,"sex":17,"minAge":119,"maxAge":18,"enrollmentInfo":327,"targetDuration":4,"studyType":23,"phases":329,"briefSummary":330,"conditions":331,"keywords":335,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":43},"100557212","the-influence-of-sleep-on-cardiovascular-outcomes-100557212","NCT06535178","The Influence of Sleep on Cardiovascular Outcomes","Determining the Influence of Sleep on Cardiovascular Outcomes","DISCO","Inclusion Criteria:\n\n* Ostensibly healthy men and women Subgroup study (chronic pain)\n* Satisfies diagnostic criteria for fibromyalgia according to the Widespread Pain Index - Symptom Severity (WPI-SS) scale with the following three conditions being met:\n\n  1. Widespread pain index (WPI) ≥7 and symptom severity (SS) scale score ≥5 or WPI 3-6 and SS scale score ≥9.\n  2. Symptoms have been present at a similar level for at least 3 months.\n  3. The patient does not have a disorder that would otherwise explain the pain.\n\nExclusion Criteria:\n\n* No history of drug or alcohol dependency.\n* Must be current non-smokers, and are required to have a history of less than 5 pack years of smoking.\n* No history of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study. In addition to this, individuals must not have traveled across more than 1 time zone during the 3 months prior to the study.\n* Chronobiologic and sleep disorders.\n* Diseases of the cardiovascular system.\n* Hypertension. Individuals will be allowed to be normotensive (resting systolic blood pressure of \\\u003C140\u002F90 mmHg, measured on more than one occasion) or uncomplicated stage 1 hypertension (systolic BP between 140 and 159 mmHg or a diastolic BP between 90 and 99 mmHg).\n* Disorders of the respiratory system.\n* Pre-diabetes\u002FDiabetes. For participants who have self-reported pre-diabetes\u002Fdiabetes.\n* Disorders of the kidney and urinary tract.\n* Infectious diseases.\n* Disorders of the gastrointestinal system.\n* Disorders of the immune system.\n* Disorders of the hematopoietic system.\n* Neoplastic diseases.\n* Endocrine and metabolic diseases.\n* Neurologic disorders.\n* Must not be participating in another research study that would influence their safe participation in the study.",{"count":328,"type":22},30,[25],"The goal of this study is to identify the effects of sleep regularity on cardiovascular regulatory mechanisms. The investigators are hoping to discover if improving the regularity of sleep timing will improve metabolic and vascular health markers. The protocol is a 12-week prospective cohort study that includes both field and in-laboratory data collection in ostensibly healthy male and female adults, aged 18-40years. We will also have a sub-group of individuals with chronic pain to examine the effects of sleep regularity on pain outcomes.",[332,30,333,334],"Circadian Rhythm","Vascular Health","Pain",[332,30,333,334],"2025-11-05",{"date":338,"type":35},"2025-11-10",{"date":340,"type":35},"2024-07-01",{"date":342,"type":22},"2026-09-30",{"name":344,"class":42},"Oregon Health and Science University",{"id":346,"slug":347,"hasResults":11,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":16,"sex":17,"minAge":149,"maxAge":352,"enrollmentInfo":353,"targetDuration":4,"studyType":23,"phases":355,"briefSummary":356,"conditions":357,"keywords":359,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":43},"100494443","hepa-pm25-and-cardiometabolic-health-100494443","NCT05718245","HEPA, PM2.5, and Cardiometabolic Health","Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals","Inclusion Criteria:\n\n* Age between 65 and 84 years old;\n* Nonsmoker for at least 1 year;\n* History of BMI ≥ 25 kg\u002Fm2 in the past based on EMR information;\n* Either an English or Spanish speaker;\n* Live in the Los Angeles County.\n\nExclusion Criteria:\n\n* History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);\n* Currently have active cancer treatment;\n* The residential house has already had HEPA filters;\n* Participants will move out of the current house in the next 2 years;\n* Participants will spend more than one month living outside the primary home;\n* Have any health conditions that prohibit collecting health and covariate data and biospecimen;\n* The residential houses are not feasible for setting up air purifiers and air pollutants monitors;\n* Have high blood glucose from finger stick test (\\> 200 mg\u002FdL).","84 Years",{"count":354,"type":22},52,[25],"The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.",[358,30],"Air Pollution",[360,361,362,363,364],"Air pollution","Particulate matter","Air purifier","HEPA filter","Cardiometabolic health","2025-07-29",{"date":367,"type":35},"2025-08-01",{"date":369,"type":35},"2023-03-15",{"date":371,"type":22},"2026-12-31",{"name":373,"class":42},"University of Southern California",{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":17,"minAge":240,"maxAge":381,"enrollmentInfo":382,"targetDuration":4,"studyType":23,"phases":384,"briefSummary":385,"conditions":386,"keywords":388,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":43},"100559943","evaluating-the-impact-of-a-school-based-fruit-and-vegetable-co-op-on-cardiometabolic-child-and-parents-health-in-a-persistent-poverty-area-100559943","NCT06570707","Evaluating the Impact of a School-based Fruit and Vegetable Co-op on Cardiometabolic Child and Parents Health in a Persistent Poverty Area","Cluster-Randomized Controlled Trial (RCT) to Evaluate the Impact of a School-based Fruit and Vegetable Co-op on Cardiometabolic Health of Children and Parents in a Persistent Poverty Area","Inclusion Criteria:\n\n* enrollment of 100 1st, 2nd, and 3rd grade students\n* high proportion of children participating in the free and reduced lunch (FRL) program (\\>70%)\n* willingness to implement a coordinated school health (CSH) program\n\nExclusion Criteria:\n\n* Prior participation in BB in the previous school year\n* children or parents identified as special needs per school; or having any physical, cognitive, or psychological disability that would prevent participation in evaluation measures","9 Years",{"count":383,"type":22},720,[25],"The purpose of this study is to examine the effects of the (Brighter Bites (BB) intervention compared to a wait-list control group 9 months after the intervention on changes in primary child outcomes (HbA1c, and vegetable intake), on changes in secondary outcomes (household food security status, parent and child dietary behaviors, and home access\u002Favailability of fruits and vegetables (FV)), and the mediational influence of changes in food security status, parent outcomes, and home environment measures on changes in child outcomes.",[387,30],"Child Obesity",[389],"Brighter Bites","2025-07-02",{"date":392,"type":35},"2025-07-08",{"date":394,"type":35},"2024-08-08",{"date":396,"type":22},"2027-06-30",{"name":398,"class":42},"The University of Texas Health Science Center, Houston",{"id":400,"slug":401,"hasResults":11,"nctId":402,"briefTitle":403,"officialTitle":404,"acronym":405,"eligibilityCriteria":406,"healthyVolunteers":16,"sex":239,"minAge":119,"maxAge":407,"enrollmentInfo":408,"targetDuration":4,"studyType":304,"phases":4,"briefSummary":410,"conditions":411,"keywords":416,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":435},"100505052","cardiometabolic-health-in-first-time-pregnancy-100505052","NCT05856318","Cardiometabolic Health in First Time Pregnancy","Preconception to pOst-partum Study of Cardiometabolic Health in Primigravid PregnancY","POPPY","Pregnancy Arm Inclusion Criteria:\n\nTo be included in the trial the participant must:\n\n* Nulliparous (no previous pregnancy beyond 20 weeks' gestation)\n* Actively considering pregnancy within approximately 12 months\n* Aged between 18 and 45 years\n* Ability to consent and willing to participate\n\nPregnancy Arm Exclusion Criteria:\n\nThe presence of any of the following will preclude participant inclusion:\n\n* Currently pregnant\n* Established infertility\n* Planning or actively using fertility treatments (e.g. IVF, ICSI, FET, IUI)\n* Assigned male sex at birth\n* Autoimmune disease (e.g. rheumatoid arthritis, lupus)\n* Thrombophilia\n* Type 1 diabetes\n* Known advanced chronic kidney disease (stages 4-5)\n* Malignant hypertension\n* Clinically manifest CVD (e.g. previous myocardial infarction, stroke)\n* Active cancer\u002Fbeing treated for cancer currently (other than skin cancer)\n* Any other condition preventing full participation in the study\n\nNon-Pregnancy Arm Inclusion criteria\n\nTo be included in the trial the participant must:\n\n* Nulliparous (no previous pregnancy beyond 20 weeks' gestation)\n* Not planning to conceive during next 18 months\n* Aged between 18 and 45 years\n* Ability to consent and willing to participate\n\nNon-Pregnancy Exclusion Criteria\n\nThe presence of any of the following will preclude participant inclusion:\n\n* Currently pregnant\n* Planning or actively using fertility treatments (e.g. IVF, ICSI, FET, IUI)\n* Assigned male sex at birth\n* Autoimmune disease (e.g. rheumatoid arthritis, lupus)\n* Thrombophilia\n* Type 1 diabetes\n* Known advanced chronic kidney disease (stages 4-5)\n* Malignant hypertension\n* Clinically manifest CVD (e.g. previous myocardial infarction, stroke)\n* Active cancer\u002Fbeing treated for cancer currently (other than skin cancer)\n* Any other condition preventing full participation in the study","45 Years",{"count":409,"type":22},3500,"Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth restriction (baby being small) have twice the risk of developing heart disease and diabetes later in life, compared to women who have a healthy pregnancy.\n\nThis study aims to assess risk factors for heart disease and diabetes in women who are actively trying to conceive, before and during their pregnancy, and 9-12 months after delivery of their baby, to see whether placental syndromes make a difference to their heart health. This will allow us to understand, if, and how, placental syndromes increase the risk of heart disease and diabetes, and, therefore, how best to reduce this risk and potentially prevent placental syndromes in the future. The investigators will also recruit women who are NOT planning pregnancy, as a control group.",[30,412,413,414,415],"Pregnancy Related","Diabetes","Placental; Syndrome, Dysfunction","Heart Diseases",[417,418,419,420,421,422,423,424,425],"cardiometabolic","pregnancy","diabetes","childbirth","placental syndrome","heart disease","nulliparous","CVD risk","cardiovascular","2024-04-05",{"date":428,"type":35},"2024-04-09",{"date":430,"type":35},"2023-05-24",{"date":432,"type":22},"2052-12",{"name":434,"class":42},"Cambridge University Hospitals NHS Foundation Trust",7]