[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cataract-post-operative-cataract-surgery-follow-up\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cataract-post-operative-cataract-surgery-follow-up":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,83,104,133,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100649088","postoperative-cct-in-fecd-vs-non-fecd-100649088",false,"NCT07731945","Postoperative CCT in FECD vs. Non-FECD","Central Corneal Thickness After Cataract Surgery in Eyes With Fuchs Endothelial Corneal Dystrophy (FECD) Compared With Non-FECD Eyes: A Prospective, Controlled, Non-interventional Observational Clinical Study","Inclusion Criteria:\n\n1. Signed written informed consent for participation and for use of routine clinical data in pseudonymised form.\n2. Age ≥50 years at the time of cataract surgery.\n3. Scheduled cataract surgery (unilateral\u002Fbilateral cataract).\n4. No evidence of other ophthalmic diseases (e.g. macular pathology)\n\n   Cohort-specific inclusion:\n5. FECD cohort: Clinical diagnosis of FECD based on slit-lamp findings, graded accord-ing to Krachmer et al. (1978) as documented in routine care.\n6. Control cohort: No clinical evidence of corneal endothelial disease at baseline (no signs consistent with FECD or other endothelial pathology) as documented in routine care.\n\nExclusion Criteria:\n\n1. Corneal scars\n2. Pseudoexfoliation (PEX) syndrome\n3. Glaucoma\n4. Uveitis\n5. Diabetic retinopathy\n6. Other relevant ophthalmic disorders (e.g. retinal degeneration, macular or corneal pa-thologies)\n7. Previous intraocular surgery (including laser procedures)\n8. Ocular trauma (within the past 6 months)\n9. Pregnancy (if applicable, pregnancy must be excluded by a β-hCG test)\n10. CCT \\> 625μm",true,"ALL","50 Years",{"count":20,"type":21},98,"ESTIMATED","OBSERVATIONAL","This single-centre, prospective, controlled, non-interventional observational clinical study aims to characterize early postoperative corneal thickness behaviour after routine phacoemulsification cataract surgery in eyes with Fuchs endothelial corneal dystrophy (FECD) compared with non-FECD controls, using exclusively standard-of-care perioperative assessments. To compare central corneal thickness (CCT) six weeks postoperatively between FECD and non-FECD eyes, adjusting for baseline (preoperative) CCT.\n\nAll participants undergo routine phacoemulsification cataract surgery and routine perioperative assessments. Data are collected from the standard-of-care documentation at the following time points:\n\n1. Preoperative baseline visit (routine cataract work-up)\n2. Study specific postoperative follow-up at approximately 6 weeks. Each participant will attend a study-specific follow-up visit at 6 weeks postoperatively and contributes study-specific follow-up data up to this time point.\n\nThe routine clinical parameters assessed (as available per standard practice) include:\n\n(A) Medical history \u002F baseline characteristics and documentation of ocular\u002Fsystemic comorbidities and topical medication.\n\n(B) Best-corrected visual acuity (BCVA) (logMAR).\n\n(C) Intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT).\n\n(D) Slit-lamp examination (including assessment of corneal clarity\u002Fedema and anterior segment findings) with fundoscopy as routinely documented.\n\n(E) Central corneal thickness (CCT) measurement using routine clinical devices. All measurements will be performed at a consistent time of day for each patient.\n\n(F) Anterior segment optical coherence tomography (AS-OCT) using Casia2.\n\n(G) Anterior segment Scheimpflug tomography (Pentacam Oculus AXL).\n\n(H) Endothelial cell assessment or Endothelial Cell Count (ECC) examined with NIDEK® CEM-530 Specular Microscope:\n\n* Cell Density (CD) or Cell Count. Expressed as Cells\u002Fmm²\n* Coefficient of Variation (CV), represents the degree of variation in cell size (Polymegethism)\n* Percentage (%) of six-sided (hexagon) cells (HEX)\n* Standard Deviation (SD) of the average cell area.",[25,26],"Fuchs Endothelial Corneal Dystrophy","Cataract (Post-operative Cataract Surgery Follow-up)",[28,25,29,30,31],"Postoperative CCT","FECD","CCT in FECD","Cataract Surgery FECD","NOT_YET_RECRUITING","2026-08-05",{"date":35,"type":36},"2026-08-10","ACTUAL",{"date":38,"type":21},"2026-07-20",{"date":40,"type":21},"2027-08",{"name":42,"class":43},"Vienna Hospital Association","OTHER_GOV",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100647921","randomized-controlled-trial-of-the-stein-protocol-a-neuroplastic-pain-education-and-guided-breathing-intervention-during-awake-cataract-surgery-100647921","NCT07715591","Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery","SLin","Inclusion Criteria:\n\nAdults undergoing elective cataract surgery under topical anesthesia who are able to provide informed consent and complete study procedures.\n\nExclusion Criteria:\n\nInability to provide informed consent Inability to comply with study procedures Complex or combined cataract surgery General anesthesia Medical, neurologic, psychiatric, or respiratory conditions interfering with study participation Requirement for modified anesthetic protocols Inability to complete postoperative breathing exercises or follow-up assessments",{"count":52,"type":21},300,"INTERVENTIONAL",[55],"NA","This randomized controlled trial evaluates whether a standardized perioperative neuroplastic intervention: the STEIN Protocol (Strategies and Techniques for Enhancing Integration and Neuroplasticity), consisting of pain neuroscience education, guided imagery, and paced breathing, reduces intraoperative analgesic and anxiolytic requirements.\n\nSecondary outcomes include patient-reported pain, anxiety, satisfaction, and postoperative recovery following cataract surgery.\n\nReduced intraoperative sedative and analgesic requirements may reflect improved patient comfort and autonomic regulation while minimizing medication-related adverse effects.",[58,26],"Cataract",[60,61,62,63,64,65,66,67,68,69,70],"Cataract Surgery","Pain Neuroscience Education","Guided Imagery","Guided Breathing","Perioperative Care","Anxiety","Patient Satisfaction","Mind-Body Medicine","Meditation","Breathwrok","Pain","RECRUITING","2026-07-21",{"date":74,"type":36},"2026-07-23",{"date":76,"type":36},"2026-06-10",{"date":78,"type":21},"2026-09-01",{"name":80,"class":81},"University of California, Los Angeles","OTHER",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":53,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":82},"100646213","evaluation-of-visual-outcomes-complications-and-neuroadaptation-following-bilateral-implantation-of-envista-envy-trifocal-intraocular-lenses-100646213","NCT07696130","Evaluation of Visual Outcomes, Complications, and Neuroadaptation Following Bilateral Implantation of enVista Envy Trifocal Intraocular Lenses","Inclusion Criteria:\n\n* Bilateral cataract or refractive lens exchange candidates.\n* Presbyopia and\u002For hyperopia.\n* Preoperative corneal astigmatism less than 1.00 diopter (D).\n* Absence of ocular diseases other than cataract.\n* High motivation to achieve spectacle independence.\n* Patients willing to accept the possibility of mild photic phenomena, such as glare and halos.\n\nExclusion Criteria:\n\n* Ocular Conditions:\n\n  * Glaucoma.\n  * Amblyopia.\n  * Macular diseases (including macular degeneration and other macular pathology).\n  * Angle kappa greater than 0.5 mm.\n  * Dry eye disease.\n  * Corneal disorders.\n  * Pupil abnormalities.\n  * Irregular astigmatism.\n  * Ocular motility disorders or strabismus.\n  * Pupil diameter \\\u003C 2.5 mm under photopic conditions or \\> 6.0 mm under mesopic conditions.\n  * Abnormalities of the capsular bag or zonular apparatus, including pseudoexfoliation syndrome (PEX).\n* Lifestyle Factors:\n\n  * Patients with unrealistic expectations regarding postoperative visual outcomes.\n  * Individuals whose professions require highly precise visual performance, such as pilots, professional drivers, architects, or similar occupations.\n  * Patients satisfied with using spectacles for near vision.\n  * Age greater than 75 years (due to potential difficulties with neuroadaptation to new visual conditions).\n* Psychological and Personality Factors:\n\n  * Patients with psychiatric disorders that may interfere with study participation or outcome assessment.\n  * Patients dissatisfied with progressive addition lenses (progressive spectacles).\n  * Patients with dyslexia or a history of stroke.\n  * Type A personality traits (perfectionists).\n* Patients will also be excluded if the calculated IOL power falls outside the available range of +6.00 D to +34.00 D or if they have a history of laser vision correction surgery.","75 Years",{"count":91,"type":21},20,[55],"The enVista Envy intraocular lens (IOL) manufactured by Bausch + Lomb is a new multifocal intraocular lens based on diffractive optics. It was registered with the Polish Office for Registration of Medicinal Products, Medical Devices and Biocidal Products in September 2025. The lens also bears the CE mark, indicating that it is approved for marketing and use within the European Union.\n\nIts innovative design is based on a smooth, continuous transition between diffractive rings, allowing patients to achieve excellent visual quality at far, intermediate, and near distances while reducing the incidence and severity of unwanted photic phenomena such as glare and halos. Thanks to this technology, patients may achieve better uncorrected visual acuity, reduced dependence on spectacles, and faster neuroadaptation.\n\nThe Second Department of Ophthalmology is the first center in Poland to be offered participation in a clinical study evaluating the safety and effectiveness of the enVista Envy IOL. The planned study will provide the first clinical experience with this lens in Poland and contribute to expanding knowledge regarding modern intraocular lens technologies.\n\nTwenty patients will be selected according to predefined inclusion and exclusion criteria. Preoperative assessment will include a comprehensive ophthalmic examination and IOL power calculation. Cataract surgery will be performed using bimanual MICS (Micro-Incision Cataract Surgery) phacoemulsification. Surgery in the fellow eye will be performed one month after the first procedure.\n\nBefore surgery and during follow-up visits at 1, 3, and 6 months postoperatively, the following assessments will be performed: routine ophthalmic examination, intraocular pressure (IOP) measurement, visual evoked potentials (VEP), monocular and binocular uncorrected distance visual acuity (UDVA), distance best-corrected visual acuity (DBCVA) at 4 meters, intermediate visual acuity (66 cm) and near visual acuity (40 cm), both corrected and uncorrected, monocularly and binocularly (logMAR charts), binocular contrast sensitivity testing, and defocus curve assessment.\n\nIntraoperative and postoperative complications, quality of vision (using the standardized Quality of Vision Questionnaire \\[QoV\\] and the Near Activity Vision Questionnaire \\[NAVQ\\]), speed of neuroadaptation, spectacle independence, and the occurrence of photic phenomena such as glare and halos will also be analyzed.",[58,26],"2026-07-08",{"date":97,"type":36},"2026-07-10",{"date":99,"type":36},"2026-02-01",{"date":101,"type":21},"2029-02",{"name":103,"class":81},"Pomeranian Medical University Szczecin",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":53,"phases":116,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100637703","can-tailored-surgical-incisions-reduce-refractive-error-and-dependence-on-glasses-after-cataract-surgery-100637703","NCT07623317","Can Tailored Surgical Incisions Reduce Refractive Error and Dependence on Glasses After Cataract Surgery?","A Prospective Randomized Controlled Study of How Construction and Placement of Surgical Corneal Incisions May Influence Refractive Errors and Spectacle Dependence After Cataract Surgery","AST-2","Inclusion Criteria:\n\n* Visually disturbing cataract\n* Corneal and refractive astigmatismus more than 1 dioptre\n* Able and willing to undergo study procedures and measurements 3 weeks and 12 weeks after cataract surgery.\n\nExclusion Criteria:\n\n* Declining to participate\n* concomitant disease that prevents detailed objective and subjective investigations (e.g. dementia, serious ocular comorbidity limiting expected postoperative visual acuity to below 20\u002F40)\n* condition damaging structural integrity of cornea (surgical complications, infection, trauma, previous corneal disease)","40 Years","90 Years",{"count":115,"type":21},100,[55],"Astigmatism is a common cause of continued dependence on glasses after cataract surgery and may lead to patient dissatisfaction with surgical outcomes. As the corneal curvature is the main source for astigmatism after cataract surgery, our aim is to investigate whether postoperative astigmatism can be reduced by tailoring the location of surgical incisions according to the curvature of the cornea. We also wish to investigate whether this in turn reduces the need for glasses following cataract surgery.\n\nIn the planned study, one group of patients with cataracts and concurrent corneal astigmatism will undergo surgery using customized incision placement, while a control group will be operated on using standard incision placement without consideration of corneal astigmatism. Astigmatism will be measured before surgery and again at 3 and 12 weeks postoperatively. We will also assess how tailored incisions affect corneal biomechanics and shape, as well as measure visual quality and the need for glasses during daily activities before and after surgery.\n\nApproximately 160,000 cataract procedures are performed annually in Sweden. Around 40% of these patients (64,000 individuals) have astigmatism greater than 1 diopter and could potentially achieve improved surgical outcomes based on the results of this study. The method is cost-effective and associated with a low risk of complications compared to other approaches for reducing astigmatism.",[26,119],"Refraction Error",[58,121,122,123],"Micro-Incision Cataract Surgery","Astigmatismus","Spectacle dependence","2026-05-28",{"date":126,"type":36},"2026-06-03",{"date":128,"type":21},"2026-09-15",{"date":130,"type":21},"2027-09-30",{"name":132,"class":43},"Linkoeping University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":4},"100633334","effect-of-dry-eye-disease-on-accuracy-of-intraocular-lens-power-calculation-before-phacoemulsification-100633334","NCT07525336","Effect of Dry Eye Disease on Accuracy of Intraocular Lens Power Calculation Before Phacoemulsification","Inclusion Criteria:\n\n* Age equals to or above 40 years old\n* cataract patient\n* suitable for phacoemulsification\n* clear corneal media\n\nExclusion Criteria:\n\n* previous corneal surgery\n* advanced glaucoma\n* corneal pathology (keratoconus, scarring)\n* retinal disease affecting vision\n* irregular astigmatism\n* contact lens use within the last 2 weeks",{"count":115,"type":21},"This study aims to determine the effect of dry eye disease on intraocular lens power calculation and the postoperative refractive outcome.",[142,26],"Dry Eye Disease (DED)",[144,145,146,147],"dry eye disease","biometry","refractive surprise","phacoemulsification","2026-04-07",{"date":150,"type":36},"2026-04-13",{"date":152,"type":21},"2026-04-30",{"date":154,"type":21},"2029-04-30",{"name":156,"class":81},"Assiut University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":53,"phases":166,"briefSummary":167,"conditions":168,"keywords":169,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":4},"100632416","vision-center-determinants-of-cataract-follow-up-in-rural-india-100632416","NCT07513402","Vision Center Determinants of Cataract Follow-Up in Rural India","Facility-Level Determinants of Post-Operative Cataract Follow-Up Compliance: A Phased Mixed-Methods Implementation Study of Vision Center-Based Follow-Up Systems in Rural and Semi-Rural India.","Inclusion Criteria:\n\n* Age ≥40 years\n* All cataract surgery types (e.g., SICS, phacoemulsification)\n* Advised Vision Center follow-up at discharge\n* Complete HMIS-VCMIS linkage\n\nExclusion Criteria:\n\n* Age \\\u003C40 years\n* Non-cataract surgeries\n* No advised Vision Center follow-up",{"count":165,"type":21},150,[55],"Cataract remains the leading cause of avoidable blindness in India despite substantial expansion of surgical services over the past two decades. While surgical coverage has improved, optimal visual outcomes depend on effective post-operative follow-up, which remains inconsistent across decentralized Vision Center-based systems, particularly in rural and semi-urban settings. Routine program data show wide variation in post-operative cataract follow-up compliance among Vision Centers operating within similar organizational and geographic contexts, suggesting the influence of facility-level determinants.\n\nThis phased mixed-methods implementation study aims to identify facility-level factors influencing post-operative cataract follow-up compliance and to develop an evidence-based framework to strengthen follow-up systems. Phase 1 will involve retrospective analysis of three years of integrated Health Management Information System- Vision Centre Management Information System (HMIS-VCMIS) data from approximately 120 Vision Centers to establish empirical benchmarks and classify centers as high- or low-performing. Structured facility assessments and qualitative interviews with Vision Center staff, program managers, and post-operative patients will be conducted to identify operational practices, workflows, and contextual factors associated with follow-up performance.\n\nPhase 2 will focus on co-design, pilot testing, and early implementation of a Follow-Up Strengthening Intervention Framework in selected low-performing Vision Centers. The intervention will include standardized counselling workflows, follow-up tracking and reminder systems, role clarification, supervisory feedback mechanisms, and peer-learning support from high-performing centers. Changes in follow-up compliance will be monitored using routine data over a 12-month implementation period, alongside process evaluation to assess feasibility, fidelity, and acceptability.\n\nFindings from this study will generate practical evidence to strengthen post-operative cataract follow-up systems and inform scalable quality improvement strategies within decentralized Vision Center networks.",[26],[170,171,172,173,174],"Cataract surgery","Community-based eye care","Continuity of care","Facility-level determinant","Follow-up compliance","2026-04-02",{"date":148,"type":36},{"date":178,"type":21},"2026-05",{"date":180,"type":21},"2028-03",{"name":182,"class":81},"Seva Canada Society"]