[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"catheter-obstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:catheter-obstruction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100657076","efficacy-and-safety-of-peripherally-inserted-central-venous-catheters-100657076",false,"NCT07834996","Efficacy and Safety of Peripherally Inserted Central Venous Catheters","Peripherally Inserted Central Venous Catheter: Efficacy and Safety","Inclusion Criteria:\n\n* Adult patients aged ≥ 18 years admitted to the Intensive Care Unit (ICU)\n* Clinical requirement for central venous access via a peripherally inserted central catheter (PICC) (e.g., difficult peripheral venous access, parenteral nutrition, prolonged intravenous antibiotic therapy ≥ 5 days, or infusion of vesicant\u002Fvasoactive medications)\n* Anticipated need for central venous access or ICU stay of at least 5 to 7 days\n* Patient or legal representative willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Age below 18 years\n* Known hypersensitivity or allergy to catheter material (polyurethane or silicone)\n* Local skin infection, cellulitis, or active thrombosis at the intended insertion site\n* Documented ipsilateral upper-extremity or superior vena cava venous obstruction\u002Fstenosis precluding catheter passage\n* Presence of an arteriovenous fistula or graft in the intended limb\n* Severe, uncorrectable coagulopathy considered an absolute contraindication to catheter insertion\n* Refusal of patient or legal guardian to provide informed consent","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","Central venous access is critical for administering intravenous medications, parenteral nutrition, and fluid therapy in intensive care units (ICUs). Peripherally inserted central catheters (PICCs) provide an alternative to traditional centrally placed catheters, but they can be associated with complications such as blood clots (thrombosis), catheter-related infections, and mechanical blockages. The primary purpose of this study is to assess the procedural efficacy, functional lifespan, and complication rates of ultrasound-guided PICCs in critically ill adult patients.\n\nIn this prospective observational study, 60 adult ICU patients who require central venous access for at least 5 to 7 days will undergo bedside PICC placement by radiology staff using real-time ultrasound guidance and the modified Seldinger technique. Proper positioning of the catheter tip will be verified by a portable chest radiograph immediately after insertion.\n\nParticipants will be monitored daily while the catheter remains in place until line removal, ICU discharge, or death. Surveillance includes daily clinical site inspections, structured laboratory assessments, and scheduled compression Doppler ultrasound scans to check for blood clots in the cannulated arm. If an infection or blockage is suspected, appropriate blood cultures and diagnostic work-ups will be conducted. The gathered data will determine the insertion success rate, functional patency rate, and the overall incidence of complications per 1,000 catheter-days to establish evidence-based guidelines for vascular access in critical care.",[24,25,26,27],"Critical Illness","Catheter-Related Infections","Upper Extremity Deep Vein Thrombosis","Catheter Obstruction",[29,30,31,32,33,34,35],"Peripherally Inserted Central Catheter","PICC","Bedside Ultrasound Guidance","Catheter-Related Bloodstream Infection","Catheter-Related Thrombosis","Central Venous Access","Intensive Care Unit","NOT_YET_RECRUITING","2026-09-17",{"date":39,"type":40},"2026-09-22","ACTUAL",{"date":42,"type":20},"2026-10",{"date":44,"type":20},"2027-11",{"name":46,"class":47},"Assiut University","OTHER"]