[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-palsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-palsy":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,170,0,25,[9,45,73,100,128,156,187,206,236,260,282,306,334,362,384,403,436,459,482,502,522,543,574,598,622],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":4,"leadSponsor":41,"locationsCount":44},"100196174","cerebral-palsy-and-the-study-of-brain-activity-during-motor-tasks-100196174",false,"NCT01829724","Cerebral Palsy and the Study of Brain Activity During Motor Tasks","Near-infrared Spectroscopy and Electroencephalography to Assess and Train Cortical Activation During Motor Tasks","* INCLUSION CRITERIA\n* Age 5 years and older\n* Surgery free for six months in either the upper or lower extremities.\n* Free from botulinum toxin injections within four months in either the upper or lower extremities.\n* Either a healthy volunteer or have a diagnosis of a childhood-onset (before 13 years of age) brain injury resulting in motor impairment of one arm and one leg on the same side of the body or motor impairment of both legs or have a diagnosis of childhood-onset (before 13 years of age) peripheral injury resulting in sensory or motor impairment of any limb or multiple limbs.\n* Able to understand and follow simple directions that include how to perform a repetitive task and when to start and stop doing the task, based on parent report if the subject is a child and physician observation during history and physical examination.\n* Able to walk at least 20 feet without stopping with or without a walking aid\n* Able to provide informed consent (Guardian or parent of child participants) or verbal\u002Fwritten assent as appropriate (for child participant).\n* Agreement to not drink caffeine or alcohol for 24 hours before each assessment session because both agents can modify brain activity and may confound outcome measures. This restriction does not apply to the training sessions in Objective 3.\n\nEXCLUSION CRITERIA:\n\n* Any neurological, musculoskeletal or cardiorespiratory injury, health condition, or diagnosis other than childhood-onset brain or peripheral injury that would affect the ability to mentally concentrate or move a body part repetitively for short periods of time. Examples of this include, but are not limited to, congestive heart failure, end stage cardiac disease, or fractures that have not completely healed.\n* Uncontrolled seizures.\n* Concurrent use of medicines for muscle tone (e.g., baclofen, trihexyphenedyl, dantrolene sodium, tizanidine, or carbidopa\u002Flevodopa). If patients are taking these medications daily, the treating physician will be contacted by the MAI to determine if it is acceptable for the subject to temporarily discontinue the medication(s) for 24 hours prior to participating in testing for this study for each of the first 2 objectives. If that is not deemed to be safe, the subject will be excluded. Subjects who are on these medications will not be allowed to participate in Objective 3.\n* Pregnancy: Childbearing potential will be determined during the history and physical exam and urine pregnancy test may be required\n* Adult who can t consent for themselves.\n\nTo participate in Objective 1, it is preferable that all subjects be willing and able to have, or have previously had, a structural MRI to aid in the interpretation of results. Inability or refusal to complete an MRI, or to provide access to a previous structural MRI scan, will not constitute an exclusion criterion for this study.\n\nAdditional exclusion criteria for MRI\n\n* Inability to lie flat on the back for up to 45 minutes without sedation.\n* Discomfort being in small spaces for up to 45 minutes.\n* Cardiac pacemakers, implanted medication pumps, intracardiac lines, or acute, unstable cardiac disease, with intracranial implants (e.g. aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth that cannot be safely removed.\n\nAdditional exclusion criteria for EEG\n\n-History of allergic reaction to water-based electrode gel",true,"ALL","5 Years","100 Years",{"count":22,"type":23},320,"ESTIMATED","OBSERVATIONAL","Background:\n\n\\- Two ways to study the brain while people are moving are near-infrared spectroscopy (NIRS) and electroencephalography (EEG). NIRS uses light to look at blood flow in the brain when it is active. EEG records electrical activity in the brain. Both have been used safely for many years, even in very young children. NIRS or EEG can be used while a person is moving to show which parts of the brain are the most active. Researchers want to use NIRS and EEG to study brain activity during movement in people with cerebral palsy and healthy volunteers. Learning more about how people with and without cerebral palsy use their brain to control their muscles may lead to new ways of training people with cerebral palsy to move better.\n\nObjectives:\n\n\\- To study how the brain controls body movement in people with and without cerebral palsy.\n\nEligibility:\n\n* Individuals at least 5 years of age who have cerebral palsy.\n* Healthy volunteers at least 5 years of age.\n\nDesign:\n\n* This study has three parts. People with cerebral palsy will be selected for all three. Healthy volunteers will be asked to do only two of them. Everyone who participates will have NIRS and\u002For EEG exams during movement. People with cerebral palsy may also have biofeedback sessions to train coordination of movement and brain activity.\n* Participants will be screened with a physical exam and medical history. Urine samples may be collected.\n* All participants will have at least one session of NIRS and\u002For EEG imaging studies. Sessions may also include the following tests:\n* Magnetic resonance imaging to look at the brain\n* Electromyography to measure electrical activity of the muscles\n* Motion analysis of specific body parts\n* Ultrasound to measure activity of the muscles\n* Motorized, robotic, and electrical stimulation of the muscles\n* Other clinical tests of muscle movement as needed.\n* Participants with cerebral palsy will have biofeedback sessions. These sessions will help them learn to coordinate muscle movement and brain activity.",[27,28],"Cerebral Palsy","Children",[30,27,31,32,33],"Functional Brain Imaging","Motion Analysis","Macro-EMG","Natural History","RECRUITING","2026-08-15",{"date":37,"type":38},"2026-08-18","ACTUAL",{"date":40,"type":38},"2013-08-22",{"name":42,"class":43},"National Institutes of Health Clinical Center (CC)","NIH",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":18,"minAge":52,"maxAge":19,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":44},"100651226","effect-of-sunlight-exposure-on-vitamin-d-levels-in-children-with-cerebral-palsy-100651226","NCT07757477","Effect of Sunlight Exposure on Vitamin D Levels in Children With Cerebral Palsy","The Effect of Sunlight Exposure on Vitamin D Levels in Children With Cerebral Palsy at Cipto Mangunkusumo National Referral General Hospital (RSCM)","Inclusion Criteria:\n\n* Children aged 1-5 years.\n* Diagnosed with cerebral palsy, with the diagnosis clinically confirmed by a pediatrician.\n* Parents or legal guardians provide written informed consent to participate in the study.\n* Covered by the Indonesian National Health Insurance or other insurance.\n\nExclusion Criteria:\n\n* Children with chronic liver disease or chronic kidney disease.\n* Children with contraindications to direct sunlight exposure, such as allergies, hypersensitivity, or skin disorders.\n* Children with severe malnutrition.\n* Children with vitamin D deficiency (baseline serum vitamin D level \\\u003C 20 ng\u002FmL).","1 Year",{"count":54,"type":23},60,"INTERVENTIONAL",[57],"NA","The goal of this clinical trial is to learn the effect of sunlight exposure on serum vitamin D levels in children aged 1-5 years with cerebral palsy. This study also aims to assess the effect of sunlight exposure on the incidence of acute respiratory tract infections and to evaluate the safety of the intervention.\n\nThe main questions it aims to answer are:\n\n* Does sunlight exposure increase vitamin D levels in children with cerebral palsy?\n* Does sunlight exposure influence the incidence of acute respiratory tract infections in children with cerebral palsy?\n* Does sunlight exposure cause acute adverse effects in children with cerebral palsy?\n\nParticipants will:\n\n* Be randomly assigned to either the sunlight exposure group or the control group.\n* Undergo baseline assessments, including vitamin D levels measurement, anthropometric measurements, dietary assessment, and Fitzpatrick skin phototype assessment before randomization.\n* Receive sunlight exposure for 10 minutes, three times per week between 11:00 AM and 1:00 PM for 8 weeks (intervention group), while participants in the control group will continue their usual sunlight exposure habits.\n* Have caregivers record daily sunlight exposure (intervention group), acute respiratory tract infection episodes, adverse events, and dietary intake during the study period.\n* Undergo repeat vitamin D levels measurement and evaluation of dietary intake, acute respiratory tract infections incidence, and adverse events at the end of the 8-week intervention.",[27],[27,61,28,62],"Vitamin D","Sun Exposure","2026-08-11",{"date":65,"type":38},"2026-08-13",{"date":67,"type":38},"2026-06-30",{"date":69,"type":23},"2026-08",{"name":71,"class":72},"Indonesia University","OTHER",{"id":74,"slug":75,"hasResults":12,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":12,"sex":18,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":55,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":44},"100647785","dorsal-root-electrical-stimulation-in-children-with-cerebral-palsy-100647785","NCT07715006","Dorsal Root Electrical Stimulation in Children With Cerebral Palsy","Dorsal Root Electrical Stimulation to Suppress Spastic Muscle Activation in Children With Cerebral Palsy","Inclusion Criteria:\n\n* Children ages 3 to 14\n* Diagnosis of Cerebral Palsy\n* Require an SDR as determined by the multidisciplinary movement disorders team\n* Confirmation that subjects' terms of insurance coverage for their standard of care procedure will not be altered by study enrollment.\n\nExclusion Criteria:\n\n* No exclusion criteria","3 Years","14 Years",{"count":83,"type":23},15,[57],"The goal of this clinical trial is to evaluate whether dorsal root electrical stimulation could reduce spasticity in children with cerebral palsy (CP).",[87,27,88,89],"Cerebral Palsy (CP)","Spasticity","Spasticity Due to Cerebral Palsy",[91],"Dorsal root electrical stimulation","2026-08-10",{"date":63,"type":38},{"date":95,"type":38},"2026-07-16",{"date":97,"type":23},"2029-12",{"name":99,"class":72},"Martin Piazza",{"id":101,"slug":102,"hasResults":12,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":12,"sex":18,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":55,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":44},"100650989","motus-nova-foot-device-for-patients-with-hemiplegia-100650989","NCT07754773","Motus Nova Foot Device for Patients With Hemiplegia","Evaluating Gait After Use of The Motus Nova Foot Device for Patients With Hemiplegia","Inclusion Criteria:\n\n* Age 12-20 years.\n* Diagnosis consistent with hemiplegia and gait\u002Fbalance impairments involving ankle\u002Ffoot control (e.g., reduced heel strike).\n* Able to ambulate and safely participate in laboratory walking and balance testing.\n* Able to follow instructions and use the Motus Nova Foot system at home with family support as needed.\n* Willingness to refrain from standard clinic-based PT during the study period.\n\nExclusion Criteria:\n\n* Skin integrity issues or hypersensitivity preventing safe use of straps\u002Fpads.\n* Medical\u002Forthopedic conditions making walking or balance testing unsafe (e.g., unstable seizures, recent surgery, acute injury).\n* Inability to safely use the device as determined during fitting\u002Ftraining.\n* Planned participation in standard clinic-based PT during the study period.\n* Electrical stimulation device to lower extremity within 6 months of study start, or planned use of electrical stimulation to lower extremity during study period.\n* Heart conditions that prevent physical activity.\n* Pregnancy.","12 Years","20 Years",{"count":110,"type":23},5,[57],"Individuals with hemiplegia commonly demonstrate gait deviations such as difficulties with heel strike at initial contact, foot drop in swing, asymmetrical limb loading, muscle activation, and balance impairments. This study evaluates whether a therapeutic device (Motus Nova Foot; FDA approved) used in the home setting can increase heel strike, decrease limp, improve foot clearance in swing phase, improve quality of active muscle contraction of the affected limb, and improve balance. The Motus Nova Foot moves the ankle\u002Ffoot and uses guided computer\u002Fvideo activities to encourage active participation while automatically recording device use and duration.",[114,27,115],"Hemiplegia","Hemiplegic Cerebral Palsy",[117,118,27,114],"Motus Nova Foot","Gait Analysis","NOT_YET_RECRUITING","2026-08-04",{"date":92,"type":38},{"date":123,"type":23},"2026-09",{"date":125,"type":23},"2027-12",{"name":127,"class":72},"MultiCare Health System Research Institute",{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":12,"sex":18,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":55,"phases":139,"briefSummary":140,"conditions":141,"keywords":142,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":4},"100650388","strength-training-combined-with-blood-flow-restriction-and-cerebral-palsy-100650388","NCT07748052","Strength Training Combined With Blood Flow Restriction and Cerebral Palsy","Effect of Strength Training Combined With Blood Flow Restriction on Deltoid Muscle Thickness and Upper Limb Functions in Children With Hemiplegic Cerebral Palsy","Inclusion Criteria:\n\n1. A diagnosis of spastic hemiplegic CP\n2. Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)\n3. The age of the selected children will range from 4 to 6 years old.\n4. Children are levels II and III according to GMFCS\n\nExclusion Criteria:\n\n1- Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).","4 Years","10 Years",{"count":138,"type":23},26,[57],"load resistance exercises are performed while partially restricting venous blood flow to the exercising limb using a pneumatic cuff. In children with hemiplegic cerebral palsy, this intervention has been proposed to enhance muscle strength and hypertrophy while minimizing mechanical stress on joints and soft tissues. Previous studies suggest that BFR training may improve muscle thickness, muscle strength, functional mobility, gait performance, and overall physical function compared with conventional low-intensity strength training alone. However, careful monitoring of cuff pressure, exercise intensity, and safety considerations is essential when applying this technique in pediatric populations.",[27],[143,144,145,146],"cerebral palsy","progressive resistive exercise","low load resistive training","blood flow restriction","2026-08-03",{"date":149,"type":38},"2026-08-05",{"date":151,"type":23},"2026-08-06",{"date":153,"type":23},"2027-07-11",{"name":155,"class":72},"Cairo University",{"id":157,"slug":158,"hasResults":12,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":12,"sex":18,"minAge":80,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":55,"phases":165,"briefSummary":166,"conditions":167,"keywords":168,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":180,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":44},"100649100","effects-of-lokomat-robot-assisted-gait-training-on-gross-motor-function-in-children-and-young-adults-with-cerebral-palsy-100649100","NCT07732205","Effects of Lokomat-Robot Assisted Gait Training on Gross Motor Function in Children and Young Adults With Cerebral Palsy","Inclusion Criteria:\n\n* Children and young adult with cerebral palsy (GMFCS II-IV)\n* Age between 3-23 years, of both genders\n* Minimum length of femur: 21 centimeters\n* Hip X-ray not older than 3 months\n* Orthopedic specialist opinion and recommendation for robotic therapy treatment not older than one month\n* Valid medical referral for robotic therapy treatment\n* Signed consent form from the parent\u002Fcustodian\n\nExclusion Criteria:\n\n* Gross motor function classification GMFCS I or GMFCS V\n* Participation in robotic therapy at another location during the control group\n* The safety regulations and contraindications specified by the manufacturer are fully taken into account when using the Lokomat® robotic-assisted gait training system used in the study\n* The main contraindications for the use of Lokomat® include:\n* significant bone mineral density loss (osteopenia, osteoporosis) and increased fracture risk;\n* unhealed or unstable bone fractures; fixed joint contractures that significantly limit the range of motion;\n* medical conditions that prevent active rehabilitation participation (e.g. acute infection, severe respiratory or cardiovascular condition, significant cognitive or neuropsychological impairment);\n* anatomical or body size differences that prevent safe use of the device;\n* skin or soft tissue lesions that pose a risk of injury during use of the orthosis or suspension system.","23 Years",{"count":164,"type":23},96,[57],"This single-center, controlled, delayed-intervention, quasi-experimental study evaluates the effectiveness of Lokomat®-assisted robotic gait training on gross motor function and health-related quality of life in children and young adults with cerebral palsy.\n\nAlthough previous studies have reported improvements in walking ability, gross motor function, and lower limb performance following Lokomat-assisted gait training, uncertainty remains regarding the optimal treatment intensity and dosing schedule, particularly across different age groups and levels of functional impairment.\n\nThe primary objective of this study is to evaluate the effect of a 20-session (8 week) Lokomat-assisted gait training program on standing and walking function, assessed using Dimensions D and E of the Gross Motor Function Measure (GMFM-88). Secondary objectives include evaluation of lower limb muscle strength, walking speed, health-related quality of life, individualized rehabilitation goal attainment, and objective gait training parameters recorded by the Lokomat® system.\n\nThe study employs a controlled, delayed-intervention, quasi-experimental design conducted over three consecutive study periods. During each study period, one intervention group receives Lokomat-assisted gait training in addition to usual rehabilitation, whereas a concurrent control group receives usual rehabilitation alone. As standard (usual) rehabilitation participants receive nationally approved standard-of-care rehabilitation, which may include neurorehabilitation, physiotherapy, and\u002For educational (pedagogical) rehabilitation, as appropriate to their individual clinical needs and routine care.\n\nAfter completion of the control period and post-intervention assessment, participants in the control group receive the same 20-session Lokomat-assisted gait training program and physiotherapy program during the subsequent study period. Participants allocated to the control group during the final study period receive the intervention after completion of the formal study period.",[27],[169,143,170,171,172,173,174,175,176,177,178,179],"rehabilitation","robot-assisted therapy","conductive education","lokomat","robot-assisted gait training","pediatric neurorehabilitation","gross motor function","walking function","health-related quality of life","gross motor function measure","goal attainment scaling",{"date":120,"type":38},{"date":182,"type":23},"2026-08-31",{"date":184,"type":23},"2027-08-31",{"name":186,"class":72},"Semmelweis University",{"id":188,"slug":189,"hasResults":12,"nctId":190,"briefTitle":191,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":193,"enrollmentInfo":4,"targetDuration":4,"studyType":194,"phases":4,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":201,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":202,"startDateStruct":4,"completionDateStruct":4,"leadSponsor":203,"locationsCount":205},"100310906","expanded-access-protocol-umbilical-cord-blood-infusions-for-children-with-brain-injuries-100310906","NCT03327467","Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain Injuries","Under this protocol, participants may be eligible for infusion of autologous, sibling, and\u002For unrelated donor CB cells (Duke only). Some eligibility criteria vary based on CB source. For all participants, eligibility is dependent on the availability of a qualifying CB unit To be eligible, patients must:\n\nInclusion Criteria:\n\n1. Age at Consent:\n\n   1. Autologous: 0-26 years\n   2. Sibling: 6 months - 26 years\n   3. Unrelated Donor (Duke only): 6 months - 26 years\n2. Diagnosis\n\n   1. Autologous and Sibling: Cerebral palsy, Hypoxic brain injury, Stroke, Hydrocephalus, Apraxia (without autism), Other brain injury\n   2. Unrelated Donor (Duke only): Motor impairment secondary to: Hypoxic brain injury, Periventricular leukomalacia, Stroke\u002Fbleed, Congenital hydrocephalus\n3. Functional Status:\n\n   1. Autologous and Sibling: See exclusion criteria\n   2. Unrelated Donor (Duke only): GMFCS level I-IV (age ≥2)\n4. No clinically significant abnormalities in blood counts and basic chemistries for age.\n5. Absolute Lymphocyte Count:\n\n   * 1200 for African American participants\n   * 1500 for all other participants\n6. Availability of a qualified autologous or Sibling CB Unit\n\n   1. Autologous or Sibling: available\n   2. Unrelated Donor (Duke only): N\u002FA\n7. Written informed consent obtained from the parent or legal guardian.\n\nExclusion Criteria:\n\n1. Documented HIV or Hepatitis or other disease transmittable through the blood.\n2. A cord blood unit that fails to meet specifications\n3. Refusal of consent\n4. Uncontrolled seizure disorder\n5. Uncontrolled infection\n6. Diagnosed with a genetic or metabolic disorder related to the neurologic condition\n7. History of an immune deficiency\n8. History of treatment with chemo or immunosuppressive therapy\n9. History of previous allogeneic cell therapy outside of participation in a Duke clinical trial\n10. Need for mechanical ventilation or chronic O2 support\n11. Unstable airway\n12. Eligible for an active clinical trial of cellular therapy at Duke. If previously enrolled on another Duke cell therapy protocol the participant may still be considered for enrollment on this study after the follow-up period for the clinical trial is completed.\n13. Cerebral palsy secondary to infection, congenital or otherwise, without another known cause\n14. Pregnant or breastfeeding\n15. Treated with autologous cellular therapy through a non-intravenous route (ie. intrathecally) within one year prior to enrollment.\n\nUmbilical Cord Blood Criteria\n\nParticipant enrollment is dependent on the availability of a banked unit of autologous or sibling CB that has been stored at a private or public bank, or, if enrolling at Duke, availability of a publicly banked unrelated donor unit. Units must meet the following criteria:\n\nPrecryopreservation:\n\n1. TNCC ≥2x107\u002Fkg\n2. Sterility cultures performed and negative\n3. Viability ≥70%\n4. At least haploidentical HLA match for sibling units and at least a 4\u002F6 HLA match for unrelated donor units\n5. Donor screening testing performed and negative\n\nCBU Test sample\n\n1. Segment or test vial available\n2. Identity confirmed via HLA typing of test sample and donor\n3. Viability testing recommended, but not required","26 Years","EXPANDED_ACCESS","This protocol is designed to enable access to intravenous infusions of banked umbilical cord blood (CB), that is thawed and not more than minimally manipulated, for children with various brain disorders. Children with cerebral palsy, congenital hydrocephalus, apraxia, stroke, hypoxic brain injury and related conditions will be eligible if they have normal immune function and do not qualify for, have previously participated in, or are unable to participate in an active cell therapy clinical trial at Duke Medicine. For the purpose of this protocol the term children refers to patients less than 26 years of age. Cord blood is administered as a cellular infusion without prior treatment with chemotherapy or immunosuppression. The mechanism of action is through paracrine signaling of cord blood monocytes inducing endogenous cells to repair existing damage.",[27,197,198,199,200],"Hydrocephalus","Apraxia of Speech","Hypoxia Ischemia, Cerebral","Drowning; Anoxia","AVAILABLE",{"date":149,"type":38},{"name":204,"class":72},"Joanne Kurtzberg, MD",2,{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":12,"sex":18,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":55,"phases":217,"briefSummary":218,"conditions":219,"keywords":220,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":44},"100575199","how-much-virtual-reality-intervention-improve-the-balance-of-patients-with-cerebral-palsy-100575199","NCT06769178","How Much Virtual Reality Intervention Improve the Balance of Patients With Cerebral Palsy","Effect of Virtual Reality-Based Interventions on Clinical and Neuroplasticity, Brain Functional Resting State Networks in Cerebral Palsy Rehabilitation","Inclusion Criteria:\n\nBeing diagnosed with unilateral spastic type cerebral palsy (hemiplegic type) \u002F Being between the ages of 18-30 \u002F Being able to walk independently (GMFCS I-II) \u002F Not having Botox application in the last six months \u002F Not using any medication that will affect the study process\n\nExclusion Criteria:\n\nHaving a history of epileptic attacks \u002F Having \\>2 spasticity in any joint according to the modified Ashworth scale \u002F Having severe depression according to the Beck Depression Inventory \u002FHaving hearing-vision problems","18 Years","30 Years",{"count":216,"type":23},24,[57],"The purpose of this clinical study is to investigate how effective virtual reality applications are in adult cerebral palsy rehabilitation.\n\nThe main questions it aims to answer are:\n\nDo virtual reality interventions (of Becure Balance and Becure Wesense Systems) improve balance and is this improvement reflected in the clinic? Is there a change in brain functional resting state networks after virtual reality interventions?",[27],[221,222,223,224,225,226],"adult cerebral palsy","functional magnetic reasonance imaging","virtual reality","becure systems","balance","resting state functional magnetic reasonance imaging","2026-07-28",{"date":229,"type":38},"2026-07-30",{"date":231,"type":38},"2026-01-23",{"date":233,"type":23},"2027-07",{"name":235,"class":72},"Yeditepe University",{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":12,"sex":18,"minAge":243,"maxAge":107,"enrollmentInfo":244,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":246,"conditions":247,"keywords":249,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":44},"100649149","smartphone-accelerometry-for-gait-analysis-in-children-with-unilateral-spastic-cerebral-palsy-100649149","NCT07730086","Smartphone Accelerometry for Gait Analysis in Children With Unilateral Spastic Cerebral Palsy","Concurrent Validity and Test-Retest Reliability of Smartphone-Embedded Accelerometry for Spatiotemporal Gait Analysis in Children With Unilateral Spastic Cerebral Palsy","Inclusion criteria:\n\n1. Clinical diagnosis of unilateral spastic cerebral palsy.\n2. Chronological age ranging from 6 to 12 years.\n3. Gross Motor Function Classification System (GMFCS) Level I or II (capable of walking 10 meters independently without physical support or handheld mobility aids).\n4. Ability to comprehend and execute simple verbal instructions during clinical evaluation.\n\nExclusion criteria:\n\n1. History of lower extremity corrective orthopedic surgery or joint casting within the preceding 12 months.\n2. Botulinum Toxin Type A injections administered to the lower limbs within the past 6 months.\n3. Fixed structural bony deformities or rigid joint contractures in the lower extremities.\n4. Severe, uncorrected visual or auditory deficits that threaten safety or test execution","6 Years",{"count":245,"type":23},35,"This observational study will evaluate whether a smartphone's built-in accelerometer can provide accurate and repeatable measurements of walking in children with unilateral spastic cerebral palsy.\n\nThirty-five children aged 6 to 12 years will complete two walking trials along a 10-meter indoor walkway at their usual comfortable speed. During each trial, a smartphone will be secured over the lower back at the L4-L5 level to record body acceleration using the Phyphox application. At the same time, a video camera will record the child's walking for analysis using Kinovea software.\n\nMeasurements obtained from the smartphone will be compared with measurements obtained from video analysis. The study will assess walking velocity, cadence, stride timing, and gait asymmetry. The two repeated walking trials will also be used to determine whether the smartphone measurements are consistent when the test is repeated during the same session.\n\nThe study does not involve any treatment or change to the child's usual medical or physical therapy care. The purpose is to determine whether smartphone-based gait assessment may be a practical, low-cost method for evaluating walking in children with unilateral spastic cerebral palsy.",[27,248],"Unilateral Spastic Cerebral Palsy",[250,118,251,248,115],"Smartphone Accelerometry","Spatiotemporal Gait Parameters","2026-07-24",{"date":227,"type":38},{"date":255,"type":38},"2026-07-01",{"date":257,"type":23},"2026-12-01",{"name":259,"class":72},"Deraya University",{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":107,"enrollmentInfo":267,"targetDuration":4,"studyType":55,"phases":268,"briefSummary":269,"conditions":270,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":279,"locationsCount":281},"100369906","evaluation-of-effectiveness-of-child-oriented-goal-setting-in-paediatric-rehabilitation-the-engage-approach-100369906","NCT04096430","Evaluation of Effectiveness of Child-oriented Goal-setting in Paediatric Rehabilitation (the ENGAGE Approach)","Evaluation of Effectiveness of Child-oriented Goal-setting in Paediatric Rehabilitation (the ENGAGE Approach): A Pragmatic Cluster Randomized Controlled Trial and Economic Analysis","Inclusion criteria are children with a diagnosed disability who:\n\n1. are between the ages of 5-12 years\n2. are able to engage in the goal-setting process (determined by therapists)\n3. are referred to PT and\u002For OT for a period of direct treatment\n4. speak English.\n\nChildren will be excluded from the trial if:\n\n1. the parent or guardian who attends therapy does not speak English\n2. the child has a diagnosis that suggests developmental regression\n3. the child has uncontrolled seizures (i.e., seizure within the past 2 months).",{"count":164,"type":23},[57],"Children with disabilities often access rehabilitation services to improve their abilities to participate in everyday activities. Goal-directed therapy is considered an important therapeutic strategy to achieve outcomes that are meaningful to families. Not a lot is known about the effects of goal setting on rehabilitation outcomes. Strategies to help children participate in the goal-setting process are rarely used in clinical practice. The aim of this project is to test the effects of a child-focussed goal setting approach, Enhancing Child Engagement in Goal Setting (ENGAGE), on therapy outcomes. Service use and the cost vs. benefits of the ENGAGE approach compared to usual practice will also be examined. Children with neurodevelopmental disabilities aged 5-12 years old (n=96) who access paediatric rehabilitation services at six rehabilitation sites will participate. Therapists (n=24) at participating sites in Alberta, Canada will be randomized into 1) the ENGAGE intervention group or 2) the usual therapy practice control group. Children will participate in the ENGAGE approach to goal setting or usual practice based on the allocation of their therapist. This study will determine if the ENGAGE approach to goal setting affects child goal performance, satisfaction with goal performance, functional abilities, participation, and parent and child quality of life. The investigators will also evaluate differences in parent and child quality of life in relation to parent costs (e.g., absenteeism, presenteeism, travel costs) and compare amount of therapy time between the two groups to see which approach is more cost-effective and efficient. After the study, children, parents and therapists will be asked to discuss aspects that influenced effective implementation of the ENGAGE approach. This study could provide evidence to improve meaningful child and family outcomes in paediatric rehabilitation and improve efficiency of paediatric rehabilitation services.",[271,272,27],"Autism Spectrum Disorder","Neurodevelopmental Disorders","2026-07-14",{"date":275,"type":38},"2026-07-15",{"date":277,"type":38},"2022-03-01",{"date":182,"type":23},{"name":280,"class":72},"University of Alberta",6,{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":12,"sex":18,"minAge":243,"maxAge":136,"enrollmentInfo":288,"targetDuration":4,"studyType":55,"phases":290,"briefSummary":291,"conditions":292,"keywords":293,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":4},"100645719","effect-of-nordic-walking-versus-treadmill-training-on-gait-asymmetry-in-children-with-unilateral-cerebral-palsy-100645719","NCT07702786","Effect of Nordic Walking Versus Treadmill Training on Gait Asymmetry in Children With Unilateral Cerebral Palsy","Inclusion Criteria:\n\n* Their age will range from 6-10 years, from both sexes.\n* Level I, II and III of gross motor functional classification system\n* Grade 1 and 1+ spasticity according to the Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Uncontrolled epilepsy.\n* Mental retardation or autistic features.\n* Significant visual or auditory problems according to medical reports (audio-vestibular and ophthalmic examination),",{"count":289,"type":23},30,[57],"Children with hemiparesis show characteristic walking pattern resulting from weakness and spasticity on one side of the body. Nordic walking (NW) engages both the upper and lower body, which can help improve coordination and balance.",[27],[294,295,296,297,298],"Cerebral palsy","gait","spatio-temporal gait parameters","Nordic walking","walking poles","2026-07-13",{"date":273,"type":38},{"date":302,"type":23},"2026-08-01",{"date":304,"type":23},"2027-01-30",{"name":155,"class":72},{"id":307,"slug":308,"hasResults":12,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":12,"sex":18,"minAge":314,"maxAge":315,"enrollmentInfo":316,"targetDuration":4,"studyType":55,"phases":318,"briefSummary":319,"conditions":320,"keywords":323,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":328,"startDateStruct":329,"completionDateStruct":330,"leadSponsor":332,"locationsCount":44},"100629043","coaching-learning-empowerment-in-cerebral-palsy---a-6-week-integrated-ptot-caregiver-primer-bootcamp-for-infants-diagnosed-with-or-at-high-risk-for-cerebral-palsy-100629043","NCT07469514","Coaching, Learning, Empowerment in Cerebral Palsy - a 6-Week Integrated PT\u002FOT Caregiver \"Primer\" Bootcamp for Infants Diagnosed With or at High Risk for Cerebral Palsy","CIRCLE-CP Study: Coaching, Learning, Empowerment in Cerebral Palsy - a 6-Week Integrated PT\u002FOT Caregiver \"Primer\" Bootcamp for Infants Diagnosed With or at High Risk for Cerebral Palsy","CIRCLE-CP","Inclusion Criteria:\n\n* Infants 3-15 months corrected age at enrollment\n* Diagnosed with CP or at high possibility of CP\n* Not yet independently walking at baseline\n* Medically stable for therapeutic handling and group play\n* Primary caregiver (\\>=18years) able to attend all weekly group sessions\n* English-speaking only\n\nExclusion Criteria:\n\n* Unstable medical condition (eg, frequent desaturations, emeses, uncontrolled seizures) or acute restrictions incompatible with participation\n* Concurrent enrollment in another intensive motor program\n* Profound sensory impairments that preclude group program participation","3 Months","15 Months",{"count":317,"type":23},32,[57],"This study focuses on the caregiver's knowledge, comfort, and confidence in interacting with and supporting their infant with Cerebral Palsy (CP) or at high risk for Cerebral Palsy. Four caregivers with their infants will be in one cohort to assess the benefits of group intervention. The intervention is delivered in a group, bootcamp-style educational format led by clinical team including pediatric physiatrist, physical therapist and occupational therapist.",[27,87,321,322],"Cerebral Palsy Infantile","Infant",[324,325,326,327],"physical therapy","occupational therapy","caregivers","caregiver",{"date":273,"type":38},{"date":123,"type":23},{"date":331,"type":23},"2027-04",{"name":333,"class":72},"University of California, San Francisco",{"id":335,"slug":336,"hasResults":12,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":340,"eligibilityCriteria":341,"healthyVolunteers":12,"sex":18,"minAge":243,"maxAge":107,"enrollmentInfo":342,"targetDuration":4,"studyType":55,"phases":344,"briefSummary":345,"conditions":346,"keywords":348,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":44},"100645805","effects-of-proprioceptive-neuromuscular-facilitation-and-task-oriented-training-on-upper-extremity-function-in-children-with-spastic-diplegic-cerebral-palsy-100645805","NCT07694804","Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy","Isolated Versus Combined Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy","PNF-TOT-CP","Inclusion Criteria:\n\n* Children aged 6 to 12 years.\n* Clinical diagnosis of spastic diplegic cerebral palsy.\n* Gross Motor Function Classification System (GMFCS) Levels I-III.\n* Ability to understand and follow simple verbal instructions.\n* Medically stable and able to participate in physiotherapy sessions.\n* Parent or legal guardian willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Orthopedic surgery involving the upper or lower extremities within the previous 6 months.\n* Botulinum toxin injections administered within the previous 6 months.\n* Severe visual, hearing, or cognitive impairments that would interfere with assessment or treatment.\n* Uncontrolled epilepsy or other unstable neurological or medical conditions.\n* Fixed upper extremity contractures or musculoskeletal deformities preventing participation in the intervention.\n* Participation in another structured upper extremity rehabilitation program during the study period.\n* Failure to obtain informed consent from a parent or legal guardian.",{"count":343,"type":23},63,[57],"Children with spastic diplegic cerebral palsy often experience upper extremity impairments, including reduced coordination, muscle control, and functional hand use, which limit independence in daily activities. Proprioceptive Neuromuscular Facilitation (PNF) and Task-Oriented Training (TOT) are commonly used rehabilitation approaches to improve motor function; however, evidence comparing their individual and combined effects on upper extremity function remains limited.\n\nThis randomized controlled trial aims to compare the effects of PNF alone, TOT alone, and a combined PNF plus TOT intervention on upper extremity function in children with spastic diplegic cerebral palsy. Sixty-three children aged 6 to 12 years with Gross Motor Function Classification System (GMFCS) levels I to III will be randomly assigned to one of three intervention groups. Each group will receive supervised 45-minute treatment sessions, three times per week for six weeks.\n\nUpper extremity function, functional independence, and joint range of motion will be assessed at baseline, mid-intervention (3 weeks), and post-intervention (6 weeks) using the Melbourne Assessment of Unilateral Upper Limb Function (MA2), Pediatric Evaluation of Disability Inventory-Functional Skills Scale (PEDI-FSS), and goniometric measurements. The findings of this study are expected to provide evidence regarding the most effective rehabilitation approach for improving upper extremity function in children with spastic diplegic cerebral palsy.",[27,347],"Spastic Diplegia",[349,350,351,352,353],"Spastic diplegic cerebral palsy","Proprioceptive neuromuscular facilitation","Task-oriented training","Motor function","Functional independence","2026-07-10",{"date":299,"type":38},{"date":357,"type":38},"2026-02-17",{"date":359,"type":23},"2026-07-08",{"name":361,"class":72},"Ibadat International University, Islamabad",{"id":363,"slug":364,"hasResults":12,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":4,"eligibilityCriteria":368,"healthyVolunteers":12,"sex":18,"minAge":135,"maxAge":369,"enrollmentInfo":370,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":371,"conditions":372,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":44},"100471324","influence-of-hawthorne-effect-and-dual-tasks-on-gait-in-cp-100471324","NCT05417399","Influence of Hawthorne Effect and Dual-tasks on Gait in CP","Ecological Validity of Clinical Gait Analysis in Children With Cerebral Palsy: Influence of the Hawthorne Effect and Dual-tasks. A Pilot Study","Inclusion Criteria:\n\n* Cerebral palsy, bilateral spastic, GMFCS classification I-III\n* Age \\\u003C16 years\n* Use of bilateral AFO's (rigid or ground reaction AFO's) to improve knee extension in stance\n\nExclusion Criteria:\n\n* Behavioural issues or poor instructability which might affect participation in the protocol\n* Significant visual disorders\n* Other diagnoses influencing gait\n* Not willing to sign informed consent before inclusion","16 Years",{"count":83,"type":23},"It is the clinical experience of the authors that some children with cerebral palsy who walk in crouch gait show sufficient knee extension during the clinical gait analysis, but walk in considerable knee flexion when they leave the gait laboratory. Possible differences between walking in a gait lab and walking in daily life may be caused by the effect of observational awareness in the lab (also known as the Hawthorne effect), and the lack of dual-tasks (DT) during the analysis (which are common during daily life walking). Since so far there is no technique to reliably measure gait kinematics in children with CP outside of the laboratory, the researchers aim to objectify the influence of both the Hawthorne effect and dual-tasks by introducing different conditions during a standard clinical 3D gait analysis.",[27,373,374,375,376],"Gait Disorders, Neurologic","Hawthorne Effect","Dual-tasks","Kinematics",{"date":299,"type":38},{"date":379,"type":38},"2022-09-01",{"date":381,"type":23},"2028-12-01",{"name":383,"class":72},"Roessingh Research and Development",{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":17,"sex":18,"minAge":243,"maxAge":213,"enrollmentInfo":391,"targetDuration":4,"studyType":55,"phases":393,"briefSummary":394,"conditions":395,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":396,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":44},"100550675","robot-assisted-training-in-children-with-cp-100550675","NCT06450158","Robot-assisted Training in Children With CP","Robot-assisted Hand Training to Induce Manual Functional Change and Cerebral Neural Plasticity in Children With Cerebral Palsy","Inclusion Criteria:\n\n* An evaluation by a pediatric neurologist, Physical Medicine and Rehabilitation (PMNR) physicians (physiatrists), neonatal developmental specialist, or neonatologist with a diagnosis of CP.\n* Classified as high-functioning (I or II) at the Gross Motor Function Classification System (GMFCS)\n* Participants in the control group should have no history of neurological disorder or brain injury\n\nExclusion Criteria:\n\n* Psychoactive or myorelaxant medication during study procedures\n* Genetic syndrome diagnosis\n* History of trauma or brain operation\n* Inability to sit still\n* Metal implants\n* Baclofen pump\n* Inability or unwillingness of patient or parent\u002Flegally authorized representative to give written informed consent",{"count":392,"type":23},80,[57],"Cerebral palsy (CP) is the most common physical disability in early childhood causing serious motor and sensory impairments. Effective interventions for the recovery of motor functions are of profound significance to children with CP, their families, caregivers, and health professionals. Robot-assisted rehabilitation represents a frontier with potential to improve motor functions and induce brain reorganization in children with CP.",[27],{"date":354,"type":38},{"date":398,"type":38},"2021-09-25",{"date":400,"type":23},"2029-12-31",{"name":402,"class":72},"Cook Children's Health Care System",{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":12,"sex":18,"minAge":411,"maxAge":412,"enrollmentInfo":413,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":415,"conditions":416,"keywords":417,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":4},"100646929","retrospective-study-of-intensive-therapy-pathways-in-children-with-cerebral-palsy-pti-parcours-100646929","NCT07683455","Retrospective Study of Intensive Therapy Pathways in Children With Cerebral Palsy (P'TI-PARCOURS)","Retrospective Study of Intensive Therapy Pathways (COLHEMI and Mini-COLHEMI Programs) in Children With Unilateral Cerebral Palsy: Care Trajectories, Bimanual Performance, and Goal Attainment","P'TI-PARCOURS","INCLUSION CRITERIA\n\n* Minor patient (age \\\u003C 18 years)\n* Unilateral upper limb involvement due to Cerebral Palsy (hemiplegia)\n* Having participated in at least one intensive therapy program (COLHEMI and\u002For Mini-COLHEMI) since program launch in January 2010\n* Participation before June 30, 2026\n* Followed at the CMCR des Massues\n\nNON-INCLUSION CRITERIA\n\n* Parental opposition to medical data processing for research purposes\n* Incomplete medical record","2 Years","17 Years",{"count":414,"type":23},75,"This retrospective single-center study aims to describe the care pathways of children with unilateral cerebral palsy (hemiplegia) who participated in intensive therapy programs (COLHEMI and\u002For Mini-COLHEMI) at the Centre des Massues since January 2010. The COLHEMI program (launched in 2010, for children aged 6-12) provides 70 hours of intensive motor learning-based therapy over 2 weeks, while the Mini-COLHEMI program (launched in 2020, for children from age 2) provides 30 hours over 2 weeks. The study will describe the immediate and medium-term impact of these programs on bimanual performance (Assisting Hand Assessment, AHA) and individualized goal attainment (Goal Attainment Scaling, GAS), analyze their impact on bimanual developmental trajectories using all available AHA scores, identify characteristics of good responders, and describe parent satisfaction. Approximately 75 patients will be included. Data are collected retrospectively from electronic and paper medical records by an occupational therapist.",[27,114],[27,418,114,419,420,421,422,423,424,425,426],"Unilateral cerebral palsy","Intensive therapy","Constraint-induced movement therapy","Bimanual training","HABIT","Assisting Hand Assessment","Goal Attainment Scaling","Pediatric rehabilitation","Care pathway","2026-07-02",{"date":429,"type":38},"2026-07-06",{"date":431,"type":23},"2026-09-01",{"date":433,"type":23},"2027-06-01",{"name":435,"class":72},"Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française",{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":442,"eligibilityCriteria":443,"healthyVolunteers":12,"sex":18,"minAge":243,"maxAge":213,"enrollmentInfo":444,"targetDuration":4,"studyType":55,"phases":446,"briefSummary":447,"conditions":448,"keywords":449,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":454,"startDateStruct":455,"completionDateStruct":456,"leadSponsor":458,"locationsCount":44},"100645260","a-gamified-breathing-and-postural-awareness-education-model-for-children-with-cerebral-palsy-100645260","NCT07681947","A Gamified Breathing and Postural Awareness Education Model for Children With Cerebral Palsy","N.E.F.E.S.-CP (Qualified Education for Awareness, Accessible Breathing: Cerebral Palsy) A Gamified Breathing and Postural Awareness Education Model","NEFES-CP","Inclusion Criteria:\n\n* Diagnosed with cerebral palsy.\n* Classified as Level I-III according to the Gross Motor Function Classification System (GMFCS).\n* Aged between 6 and 18 years.\n* Having a cognitive level sufficient to understand and follow simple instructions (for active participation in gamified training).\n\nExclusion Criteria:\n\n* Presence of uncontrolled medical conditions or systemic limitations.\n* Use of medications affecting respiratory function.\n* Presence of musculoskeletal problems (other than CP diagnosis) that may affect walking ability, and\u002For the presence of cognitive and mental impairment that may affect participation and\u002For motivation.\n* Visual or hearing loss that severely restricts participation in digital game and video-based applications (if appropriate adaptation cannot be provided).",{"count":445,"type":23},40,[57],"This project aims to develop an accessible, learning-oriented model based on gamified breathing and posture training that emphasizes active participation for children with cerebral palsy (CP), their families, and educators. Since current practices are largely clinic-centered, there is a growing need for game-based, motivational and widely discernible programs. In this context, the project aims to provide an inclusive model that enhances breathing and postural awareness through digital technology, thereby increasing motivation and adherence.",[27],[450,143,451,452,453],"awareness","gamification","posture","respiration",{"date":427,"type":38},{"date":354,"type":23},{"date":457,"type":23},"2026-11-30",{"name":235,"class":72},{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":464,"acronym":4,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":18,"minAge":136,"maxAge":466,"enrollmentInfo":467,"targetDuration":4,"studyType":55,"phases":468,"briefSummary":469,"conditions":470,"keywords":472,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":478,"completionDateStruct":480,"leadSponsor":481,"locationsCount":44},"100647023","comparing-mixed-reality-and-physical-therapy-to-improve-balance-and-coordination-in-adolescents-with-spastic-diplegic-cerebral-palsy-100647023","NCT07685327","Comparing Mixed Reality and Physical Therapy to Improve Balance and Coordination in Adolescents With Spastic Diplegic Cerebral Palsy","Effect Of Fully Immersive Mixed Reality Versus Standard Physical Therapy For Improving Balance And Coordination In Adolescent With Spastic Diplegic Cerebral Palsy\" A Randomized Controlled Trial","Inclusion Criteria:\n\n* Male and female participants.\n* Adolescents aged 10 to 19 years.\n* Clinically diagnosed with spastic diplegic cerebral palsy.\n* Gross Motor Function Classification System (GMFCS) Levels I, II, or III.\n* Pediatric Balance Scale (PBS) score greater than 35.\n* Willing to participate in the study and provide written informed consent\u002Fassent with parental or legal guardian consent where applicable.\n\nExclusion Criteria:\n\n* Cognitive impairment (MMSE score \\\u003C24).\n* History of seizure disorders.\n* Visual or hearing impairment that interferes with participation.\n* Diagnosed psychological or psychiatric disorders.\n* Any other medical condition that would prevent safe participation in the study.","19 Years",{"count":445,"type":23},[57],"This randomized controlled trial aims to compare the effectiveness of fully immersive Mixed Reality (MR) combined with standard physical therapy versus standard physical therapy alone in improving balance and coordination among adolescents with spastic diplegic cerebral palsy. A total of 40 participants aged 10 to 19 years will be randomly assigned to one of two treatment groups. The intervention will be provided three times per week for eight weeks. Balance and coordination will be assessed before treatment, at four weeks, and after completion of the intervention using validated clinical outcome measures. The findings of this study may help determine whether immersive Mixed Reality can enhance rehabilitation outcomes in adolescents with cerebral palsy.",[27,471],"Spastic Diplegic Cerebral Palsy",[27,473,474,475],"Mixed Reality","Fully Immersive Mixed Reality","Pediatric Rehabilitation","2026-06-29",{"date":429,"type":38},{"date":479,"type":38},"2026-01-12",{"date":302,"type":23},{"name":361,"class":72},{"id":483,"slug":484,"hasResults":12,"nctId":485,"briefTitle":486,"officialTitle":487,"acronym":4,"eligibilityCriteria":488,"healthyVolunteers":12,"sex":18,"minAge":243,"maxAge":136,"enrollmentInfo":489,"targetDuration":4,"studyType":55,"phases":490,"briefSummary":491,"conditions":492,"keywords":493,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":498,"completionDateStruct":499,"leadSponsor":501,"locationsCount":4},"100644847","functional-progressive-resistive-training-and-cerebral-palsy-100644847","NCT07675343","Functional Progressive Resistive Training and Cerebral Palsy","Effect of Functional Progressive Resistance Training on Bone Mineral Density and Balance in Children With Cerebral Palsy","Inclusion Criteria:\n\n1. A diagnosis of spastic diplegic CP\n2. Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)\n3. The age of the selected children will range from 6 to 10 years old.\n4. Children are levels II and III according to GMFCS\n\nExclusion Criteria:\n\n1 - Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).",{"count":54,"type":23},[57],"Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance. It involves performing task-oriented exercises, such as sit-to-stand, stair climbing, and walking-related activities, while gradually increasing the load to enhance muscle strength, endurance, and functional performance. FPRE is widely used in rehabilitation programs to improve mobility and the ability to perform activities of daily living in various populations, including children with neurological and musculoskeletal disorders.",[27],[143,494,495,225],"functional progressive resistive exercise","bone mineral density","2026-06-26",{"date":67,"type":38},{"date":255,"type":23},{"date":500,"type":23},"2026-11-09",{"name":155,"class":72},{"id":503,"slug":504,"hasResults":12,"nctId":505,"briefTitle":506,"officialTitle":506,"acronym":4,"eligibilityCriteria":507,"healthyVolunteers":17,"sex":18,"minAge":508,"maxAge":4,"enrollmentInfo":509,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":511,"conditions":512,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":514,"startDateStruct":515,"completionDateStruct":517,"leadSponsor":519,"locationsCount":521},"100454469","anatomical-and-functional-imaging-correlates-of-chronic-pain-in-cerebral-palsy-100454469","NCT05197946","Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy","Participants with CP (Survey-only):\n\nInclusion Criteria:\n\n* Individual 8+ years of age\n* Diagnosis of cerebral palsy\n\nExclusion Criteria:\n\n-None\n\nNeurotypical participants: (Survey-only):\n\nInclusion Criteria:\n\n* Individual 8+ years of age\n* Adult subject able to indicate understanding and affirmative consent OR Adult\u002Fchild subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents\n\nExclusion Criteria:\n\n-Clinically-significant neurologic or developmental diagnosis\n\nParticipants with CP (Survey and MRI):\n\nInclusion Criteria:\n\n* Individual 8+ years of age\n* Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents\n* Diagnosis of cerebral palsy\n* Clinical imaging demonstrating isolated periventricular white matter injury\n* Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury\n* Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI\n\nExclusion Criteria:\n\n-None\n\nNeurotypical participants (Survey and MRI):\n\nInclusion Criteria:\n\n* Individual 8+ years of age\n* Adult subject able to indicate understanding and affirmative consent\n* Able to lie still in scanner for 1.5 hours and be able to have MRI\n\nExclusion Criteria:\n\n-Clinically-significant neurologic or developmental diagnosis","8 Years",{"count":510,"type":23},300,"The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.",[27,513],"Chronic Pain",{"date":476,"type":38},{"date":516,"type":38},"2018-12-04",{"date":518,"type":23},"2028-12",{"name":520,"class":72},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.",4,{"id":523,"slug":524,"hasResults":12,"nctId":525,"briefTitle":526,"officialTitle":527,"acronym":4,"eligibilityCriteria":528,"healthyVolunteers":12,"sex":18,"minAge":508,"maxAge":529,"enrollmentInfo":530,"targetDuration":4,"studyType":55,"phases":531,"briefSummary":532,"conditions":533,"keywords":534,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":541,"locationsCount":44},"100644666","comparative-effect-of-cimt-and-pnftechnique-on-hands-dexterity-in-cerebral-palsy-100644666","NCT07673289","Comparative Effect of CIMT and PNFTechnique on Hands Dexterity in Cerebral Palsy","Comparative Effect of Constraint Induced Movement Therapy and Proprioceptive Neuromuscular Facilitation Technique on Hands Dexterity in Cerebral Palsy","Inclusion Criteria:\n\n* 8 to 13 years of age\n* Both male and female\n* Children with moderate level of mental retardation who are able to follow commands\n\nExclusion Criteria:\n\n* Children with other musculoskeletal and neurological issues.\n* Children who have complications such as epilepsy, congenital heart condition","13 Years",{"count":138,"type":23},[57],"Cerebral Palsy (CP) is a group of permanent disorders of the development of movement and posture, causing activity limitations that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The primary motor impairments in CP often include issues with muscle tone, reflexes, and coordination. Among the various motor disorders associated with CP, impairment of the upper extremities is particularly common and functionally debilitating. Specifically, reduced hand dexterity the ability to perform coordinated, fine motor tasks significantly impacts a child's independence in daily activities such as feeding, dressing, and school-related tasks like writing. Therefore, improving hand function is a critical goal in physiotherapy for this population The objective of this study was to compare the effectiveness of a constraint induced movement therapy ( CIMT ) and Proprioceptive neuromuscular facilitation technique on dexterous movement of hands in cerebral palsy .The study design will be Randomized Controlled Trail. The study setting will be Pediatric Rehabilitation Center or Physiotherapy Department. The duration of study will be 10 months after approval of synopsis. The sample size will be 20 which is calculated by epitools. The sampling technique will be Non-probability convenient sampling . Children who are diagnosed with cerebral palsy will be included. Children with other musculoskeletal and neurological issues will be excluded. Data Collection Tools will be Box and Block test and Pediatric Evaluation of Disability Inventory.. The data will be analyzed using SPSS 23.\n\nKeyword Cerebral Palsy, Constraint induced movement therapy (CIMT), dexterous movement, Proprioceptive neuromuscular facilitation",[27],[27,535],"Constraint induced movement therapy","2026-06-23",{"date":476,"type":38},{"date":539,"type":38},"2026-01-11",{"date":255,"type":23},{"name":542,"class":72},"Riphah International University",{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":12,"sex":18,"minAge":135,"maxAge":369,"enrollmentInfo":551,"targetDuration":4,"studyType":55,"phases":553,"briefSummary":555,"conditions":556,"keywords":562,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":567,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":572,"locationsCount":44},"100644540","phase-3-tranexamic-acid-to-reduce-blood-loss-after-varus-derotation-osteotomy-100644540","NCT07672158","Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy","Postoperative Continuous Intravenous Tranexamic Acid Infusion to Reduce Blood Loss in Non-Ambulatory Children With Cerebral Palsy Following Bilateral Bony Hip Reconstructive Surgery: A Phase III Parallel-Group Randomised Placebo-Controlled Trial","TABLO","Inclusion Criteria:\n\n* Children (aged 4 to 16 years)\n* Diagnosis of cerebral palsy (CP). CP is an umbrella term under which many specific diagnoses are captured, and the clinical team at the study institution operates a comprehensive referral network to ensure patients with any relevant diagnoses are included.\n* Gross Motor Function Classification System (GMFCS) levels IV and V, with substantial hip displacement (\\>40% migration percentage per Australian Hip Surveillance Guidelines (Wynter M, Gibson N, Kentish M, Love S, Thomason P, Willoughby K, et al. Australian hip surveillance guidelines for children with cerebral palsy 2014. Australian Academy of Cerebral Palsy and Developmental Medicine. 2014.)), who are on the waitlist for bilateral proximal femoral varus derotational osteotomy (VDRO) +\u002F- unilateral or bilateral pelvic osteotomy.\n\nExclusion Criteria:\n\n* Haematological disorder (defined as an active genetic or acquired bleeding disorder)\n* Known hypersensitivity to tranexamic acid (TXA)\n* Children with promyelocytic leukaemia being treated with oral tretinoin will be excluded from the trial because combination with TXA has resulted in fatal thrombotic complications\n* Known coagulation defect\n* Known renal disorder (moderate to severe as per study institution guidelines)",{"count":552,"type":23},52,[554],"PHASE3","TABLO (Tranexamic Acid to reduce Blood Loss after varus derotation Osteotomy) is a clinical trial of postoperative tranexamic acid vs placebo in non-ambulatory children with cerebral palsy (CP) undergoing reconstructive hip surgery.\n\nImproving surgical outcomes is a high priority in this patient population given the high risk of bleeding and the diminished capacity for these children to withstand substantial blood loss. Preliminary data from the study institution indicates that approximately one third of these patients receive transfusion of blood products in the postoperative period. There is growing evidence that hidden blood loss occurring in the postoperative period is substantial and can potentially be attenuated with the administration of Tranexamic Acid (TXA). However, trials on postoperative TXA have been carried out exclusively in adult surgical populations.",[27,557,558,559,560,561],"Hip Surgery Corrective","Tranexamic Acid Use","Blood Loss, Surgical","Paediatrics","Orthopedics",[27,563,564,565,566],"Hip surgery","Tranexamic Acid","Blood Loss","Orthopaedics",{"date":496,"type":38},{"date":569,"type":23},"2026-07",{"date":571,"type":23},"2029-04",{"name":573,"class":72},"Murdoch Childrens Research Institute",{"id":575,"slug":576,"hasResults":12,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":4,"eligibilityCriteria":580,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":581,"enrollmentInfo":582,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":583,"conditions":584,"keywords":585,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":591,"lastUpdatePostDateStruct":592,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":44},"100554400","investigating-new-methods-to-study-movement-in-children-and-young-adults-with-movement-disorders-100554400","NCT06498596","Investigating New Methods to Study Movement in Children and Young Adults With Movement Disorders.","A Natural History Study Evaluating the Use of Multimodal Signal Acquisition Techniques to Characterize Movement in Children and Young Adults With Movement Disorders","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet criteria 1-4 and 5a as given below. If they also meet 5b, 5c or 6, they will perform the tasks related to the respective joint(s) for which criteria are met, and\u002For walking.:\n\n1. Provision of signed and dated separate informed consent and assent forms for screening purposes. Upon inclusion in the protocol, provision of signed and dated informed consent and assent forms to begin participation in the study will be necessary.\n2. Stated willingness to comply with all study procedures and availability for the duration of the study, or alternatively, ability to do so based on parent report and physician observation during history and physical examination.\n3. Age 5 to 25 years old.\n4. Group A: Have a gait pathology arising from a diagnosis of cerebral palsy.\n\n   Group B: Healthy volunteers who are age and sex matched to individuals recruited in Group A.\n5. Sufficient range of motion to perform the target acquisition task, specifically:\n\n   1. Knee joint range of motion of at least 50 degrees in the sagittal plane (knee extension\u002Fflexion) assessed with hip extended in supine position. Limited hamstring flexibility as assessed by straight leg raising test does not limit ability to participate in the study.\n   2. Ankle joint range of motion of at least 40 degrees in the sagittal plane (dorsiplantar- flexion) with the foot in neutral alignment.\n   3. Wrist joint range of motion of at least 50 degrees in the frontal plane (wrist extension\u002Fflexion) assessed with hip extended in standing position.\n6. Able to walk at least 1 minute on a treadmill without stopping with or without holding onto side or front support rails. This assessment will be completed by the physician during the medical history and physical exam.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Any neurological, musculoskeletal or cardiorespiratory injury, health condition, or diagnosis other than cerebral palsy that would affect the ability to move the required joints through the necessary range of motion or walk as directed on a treadmill.\n2. A history of multiple seizures that have occurred in the past year that are not controlled by medication.\n3. Pregnancy.","25 Years",{"count":289,"type":23},"Background:\n\nCerebral palsy (CP) is the most common motor disorder that affects children. People with CP have weak muscles; they may have trouble controlling the movements of their arms and legs. Researchers have been developing braces called robotic exoskeletons for people with CP. These devices can adapt to the person s movements and help them move better. This natural history study will explore new technologies that may tell us more about how people with CP move and improve how these exoskeletons work.\n\nObjective:\n\nTo test new technologies to measure people s movements and brain function while they move with and without a robotic exoskeleton.\n\nEligibility:\n\nPeople aged 5 to 25 years with CP. Healthy volunteers are also needed.\n\nDesign:\n\nParticipants will have 3 to 5 clinic visits in 2 months.\n\nParticipants will be fitted with an exoskeleton that will be worn on one of their legs.\n\nAt each visit, participants will be asked to move their wrist, ankle, and knee while the following measurements are taken:\n\nUltrasound. A bar will be placed against the skin. It will send soundwaves into the body to take pictures of the muscles.\n\nElectroencephalography (EEG). Participants will wear a cap with sensors. Their brain waves will be recorded.\n\nElectromyography (EMG). Small metal discs will be taped to the skin. They will measure electrical activity of muscle.\n\nParticipants will flex and extend each joint (wrist, ankle, or knee) on one side of their body. These movements will be done on their own and while assisted by two devices:\n\nFunctional electrical stimulation (FES). Small adhesive pads will be placed on the skin and electric. Pulses will stimulate muscles to help move the limb. This will be done for the wrist, ankle and knee.\n\nRobotic Exoskeleton. A leg brace will be placed on one limb with a motor that will help move the knee. The exoskeleton can be used with or without FES.\n\nParticipants will also walk on a treadmill at their own pace.\n\nPhotographs and videos will record how they move.",[27],[27,586,587,588,589,590],"Ultrasound","EEG","Exoskeleton","Functional Electrical Stimulation","Walking","2026-06-19",{"date":536,"type":38},{"date":594,"type":38},"2025-02-20",{"date":596,"type":23},"2027-12-31",{"name":42,"class":43},{"id":599,"slug":600,"hasResults":12,"nctId":601,"briefTitle":602,"officialTitle":602,"acronym":603,"eligibilityCriteria":604,"healthyVolunteers":12,"sex":18,"minAge":605,"maxAge":81,"enrollmentInfo":606,"targetDuration":4,"studyType":55,"phases":607,"briefSummary":608,"conditions":609,"keywords":610,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":615,"lastUpdatePostDateStruct":616,"startDateStruct":618,"completionDateStruct":619,"leadSponsor":621,"locationsCount":4},"100641296","pilot-study-on-the-validity-tolerability-and-impact-of-a-walking-rehabilitation-intervention-using-cruro-malleolar-cast-in-children-with-cerebral-palsy-100641296","NCT07650370","Pilot Study on the Validity, Tolerability, and Impact of a Walking Rehabilitation Intervention Using Cruro-Malleolar Cast in Children With Cerebral Palsy","RCMs","INCLUSION CRITERIA\n\n* Children aged 7 to 14 years\n* Pubertal development at Tanner stage 1 or 2\n* Bilateral cerebral palsy (diplegia or quadriplegia)\n* Ambulatory with or without assistive device (GMFCS levels I, II, or III)\n* Clinical indication for walking training\n* Ability to use an adapted visual analogue scale to rate perceived pain\n* No botulinum toxin injection in the 4 months preceding study entry\n* Affiliated to or beneficiary of a French social security scheme\n* Not currently enrolled in another biomedical research study (not in an exclusion period from the national registry)\n\nEXCLUSION CRITERIA\n\n* Pubertal development at Tanner stage greater than 2\n* Refusal to wear cruro-malleolar casts (CMCs)\n* Inability to walk on a treadmill\n* Refusal to participate in the repeated assessment sessions required by the study protocol\n* Refusal to delay the next scheduled botulinum toxin injection series until after completion of study participation","7 Years",{"count":281,"type":23},[57],"This pilot study investigates whether walking training using cruro-malleolar casts (CMCs) - rigid leg splints extending from the thigh to the ankle - can safely improve gait quality in children with bilateral cerebral palsy (CP). CMCs are already used in routine clinical care at our center, but their biomechanical effects and therapeutic value have never been formally studied.Children aged 7 to 14 with bilateral spastic CP (diplegia or quadriplegia, GMFCS levels I-III) will participate in a 4-week treadmill walking program wearing CMCs, preceded by a 1-month observation baseline and followed by a 6-month follow-up. The investigators will use motion capture technology and surface electromyography to measure how the CMCs immediately change the way children walk - particularly at the hip and pelvis - and whether the training program leads to lasting improvements in walking speed, quality, and endurance.The study also carefully monitors pain and effort perceived by children during each training session, so that tolerance of the intervention can be rigorously assessed. Six participants will be enrolled. The study uses a Single-Case Experimental Design (SCED), which allows rigorous conclusions to be drawn from a small number of patients through repeated measurements over time.",[27],[27,611,612,613,614],"Gait rehabilitation","Knee-extension orthosis","Treadmill training","Single-case experimental design","2026-06-18",{"date":617,"type":38},"2026-06-22",{"date":431,"type":23},{"date":620,"type":23},"2028-09",{"name":435,"class":72},{"id":623,"slug":624,"hasResults":12,"nctId":625,"briefTitle":626,"officialTitle":627,"acronym":628,"eligibilityCriteria":629,"healthyVolunteers":12,"sex":18,"minAge":243,"maxAge":107,"enrollmentInfo":630,"targetDuration":4,"studyType":55,"phases":632,"briefSummary":633,"conditions":634,"keywords":636,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":640,"lastUpdatePostDateStruct":641,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":44},"100612459","effects-of-hand-and-arm-bimanual-intensive-therapy-including-lower-extremity-in-spastic-cerebral-palsy-100612459","NCT07253857","Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy","Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity on Motor Function and Cognition in Children With Spastic Cerebral Palsy","HABIT-ILE","Inclusion Criteria:\n\n* Diagnosed with diplegic cerebral palsy\n* CP children with manual ability level 1-3 on manual ability classification system\n* Participants with gross motor function classification system level ranging from 1-3 will be included in the study.\n* With an ability to grasp light objects and lift the more affected arm 15 cm above a table surface.\n* Base line cognition level should be 20 or above assessed through mini mental state exam for children (MMC).\n\nExclusion Criteria:\n\n* Uncontrolled seizures\n* Recent or planned botulinum toxin injections within 6 months\n* Any recent orthopedic interventions that may affect motor function\n* Visual impairments impeding with treatment protocol",{"count":631,"type":23},42,[57],"Cerebral palsy (CP), particularly the spastic diplegic subtype, is characterized by motor impairments such as spasticity and mobility limitations. In addition to motor dysfunction, children with CP often experience cognitive impairments affecting decision-making, problem-solving, working memory, selective attention, and inhibitory control. These non-motor challenges contribute to reduced social interaction and quality of life.\n\nHand-Arm Bimanual Intensive Therapy Including Lower Extremity (HABIT-ILE) has demonstrated improvements in gross motor function among children with spastic CP. However, evidence regarding its impact on cognitive outcomes remains limited. This randomized controlled trial (RCT) aims to evaluate the effects of HABIT-ILE compared with conventional therapy on both motor and cognitive functions in children with spastic diplegic CP. By addressing both upper and lower limb the research seeks to provide a comprehensive therapeutic approach that may yield more significant developmental benefits. Ultimately, the findings could inform the interventions for improving outcomes in pediatric populations affected by diplegic cerebral palsy.\n\nParticipants will receive 90 hours of intervention, with assessments conducted at baseline, mid-intervention, and post-intervention. The study will investigate outcomes across motor domains and cognitive functions such as inhibitory control and working memory. Findings are expected to inform comprehensive therapeutic approaches to improve developmental outcomes and quality of life in pediatric populations affected by spastic diplegic CP.",[27,635],"Cerebral Palsy, Spastic",[628,637,27,638,639],"Intensive motor therapy","diplegic cerebral palsy with spasticity","Spastic cerebral palsy","2026-06-17",{"date":615,"type":38},{"date":643,"type":38},"2025-12-20",{"date":645,"type":23},"2026-06",{"name":647,"class":72},"Lahore University of Biological and Applied Sciences"]