[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-visual-impairment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-visual-impairment":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,79,110,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100570005","in-person-and-telehealth-visual-rehabilitation-for-children-with-low-vision-100570005",false,"NCT06701617","In-person and Telehealth Visual Rehabilitation for Children With Low Vision","The Effectiveness of In-person and Telehealth Visual Rehabilitation for Children With Low Vision","Passive visual stimulation group\n\nInclusion Criteria:\n\n1. Children aged less than or equal to 18 years old.\n2. The causes of visual disorder in children are unlimited.\n3. The acuity of the children's better eye was ≤ 0.2.\n4. Children with multiple disabilities and visual disorders typically exhibit developmental levels ranging from moderate to severe or below.\n5. The parents of these children exhibit a positive attitude and are willing to cooperate with visual learning programs.\n6. Infants under 1 year old with low vision without other developmental issues , under or equal to moderate developmental issues.\n\nExclusion Criteria:\n\n1. Significant refractive errors that affect acuity but are unable to cooperate with wearing corrective glasses in two training sessions.\n2. Requires patching for monocular vision rehabilitation but is unable to cooperate with patching in two training sessions.\n3. The individual is unable to adapt to the training environment and cooperate with visual learning in two sessions due to unstable emotions or difficulty adapting to the environment.\n\nPerceptual learning group Inclusion Criteria\n\n(1)Children aged less than or equal to 12 years old. (2)No restrictions on the causes of visual impairment in children. (3)The acuity of the children's better eye was ≤ 0.5 (4)If children have additional developmental issues, their disability severity should primarily be mild or moderate.\n\n(5)The primary caregiver demonstrates a positive attitude and is willing to cooperate with the visual training program.\n\n(6)The child is capable of completing calibration with an eye-tracking device. Exclusion Criteria\n\n1. Significant refractive errors that severely affect vision, where the child cannot adapt to wearing corrective glasses within two training sessions.\n2. Requires occlusion therapy for monocular visual rehabilitation but cannot cooperate with occlusion within two training sessions.\n3. Inability to adapt to the training environment or cooperate with visual training due to emotional instability or difficulty adjusting within two training sessions.\n4. Unstable physiological conditions (e.g., epilepsy, sleep disturbances) that prevent consistent participation in visual training.","ALL","1 Month","18 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","Restorative visual rehabilitation is frequently used to enhance the visual development and function of children with low vision. An important strategy within this field is visual stimulation, which is particularly used for infants and toddlers with low vision, as well as for children who have both developmental disabilities and low vision.This study has two primary objectives.The first objective is to examine the effect of using intensive, specific, and flickering black-and-white checkerboard patterns to enhance visual function in children with mild to moderate low vision. The second objective is to develop a visual stimulation program tailored for children with severe or profound multiple disabilities and visual impairments, and to evaluate its effectiveness. For both objectives, the visual stimulation intervention will be provided through either in-person or remote delivery",[27,28,29,30,31],"Visual Rehabilitation","Oddball Design","Cerebral Visual Impairment","Passive Visual Stimulation","Perceptual Learning",[33,34,35],"visual rehabilitation","visual stimulation","perceptual learning","RECRUITING","2026-08-12",{"date":39,"type":40},"2026-08-14","ACTUAL",{"date":42,"type":40},"2024-11-25",{"date":44,"type":21},"2028-06-14",{"name":46,"class":47},"National Taiwan University Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":18,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100649920","body-image-identity-development-and-social-media-use-among-youth-with-visual-impairment-a-single-case-intervention-study-100649920","NCT07741500","Body Image, Identity Development, and Social Media Use Among Youth With Visual Impairment: A Single Case Intervention Study","VIPPSTAR_G3KUL","Inclusion Criteria:\n\n* Children with (C)VI\n* Participants should be aged between 10-18 years old\n* Participants should be able to understand Dutch sufficiently\n* Participants should be cognitively able to comprehend the questions\n* A completed ICF by the parent if the participant is under 18 years of age and a completed assent form by the participant\n\nExclusion Criteria:\n\n* Intellectual disability of such severity that they are unable to respond to the questions (as indicated by parents)\n* Non-Dutch Speaking (as indicated by parents)","10 Years",{"count":58,"type":21},15,[24],"1\\. Introduction\n\nThis 3-week single case intervention study is funded by the Horizon Europe Research Program and is part of the VIPPSTAR project (Project 101156763 - VIPPSTAR \"Visually Impaired children and adolescents: bridging the gap with Personalized Prevention Strategies, Tools, Approaches, and Resources). Within this project, the Belgian consortium will focus on the development of body image in relation to the social media use of children (10-11 years old) and adolescents (12-18 years old) with visual impairment (VI). This intervention study builds upon the insights done in earlier studies within the project, a focus group study and daily diary study. In the intervention study, children and adolescents with visual impairment will complete digital body image exercises through the first version of VIPPSTAR app. It is important to note that the data collection for this particular study will be limited to Flanders, Belgium, and will not extend to the other countries involved in the VIPPSTAR project. Furthermore, the ethical approval obtained for this study is specifically for collecting data from Flemish participants only, ensuring compliance with local ethical guidelines and regulations.",[62,29,63],"Visual Impairment","Visual Impairments",[65,66,67],"Visual impairment","Cerebral visual impairment","Digital intervention","NOT_YET_RECRUITING","2026-07-29",{"date":71,"type":40},"2026-08-03",{"date":73,"type":21},"2027-05-01",{"date":75,"type":21},"2028-12-31",{"name":77,"class":47},"Universitaire Ziekenhuizen KU Leuven",2,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":5},"100648078","vippstar-g1-digital-early-intervention-for-visual-impairment-100648078","NCT07717671","VIPPSTAR-G1 Digital Early Intervention for Visual Impairment","VIPPSTAR-G1: A Multicenter Randomized Controlled Trial Evaluating a Caregiver-mediated Digital Intervention to Promote Visual Function and Neurodevelopment in Infants at Risk of\u002FWith Visual Impairment","VIPPSTAR-G1","Inclusion Criteria: Study Sample 1 - Infants at Risk of Visual Impairment\n\n* Gestational age ≤32 weeks OR full-term\u002Fnewborns\\>32 weeks of age with neonatal distress (Apgar ≤5 at 10 minutes)\n* NAVEG score ≥3\n* At least one neurological or neuroimaging abnormality:\n\n  * 3 abnormal signs at ATNAT neurological examination OR Abnormal cranial ultrasound findings OR Abnormal MRI findings\n\nExclusion Criteria: Study Sample 1 - Infants at Risk of Visual Impairment\n\n* Epileptic encephalopathy\n* Parents unable to understand local language\n\nInclusion Criteria: Study Sample 2 - Infants\u002FToddlers With Visual Impairment\n\n* Age ≤42 months\n* Diagnosis of peripheral or cerebral visual impairment\n* Moderate or severe visual impairment documented by standardized visual acuity testing Exclusion Criteria: Study Sample 2 - Infants\u002FToddlers With Visual Impairment\n* Age \\>42 months\n* Refractory epilepsy or epileptic encephalopathy\n* Participation in another interventional study within previous 12 months\n* Parents unable to understand local language","1 Day","42 Months",{"count":90,"type":21},150,[24],"Visual impairment in infancy is associated with significant risks for neurodevelopmental impairment. Early intervention based on enriched visual and multisensory experiences may promote neuroplasticity and improve developmental outcomes, but implementation of intensive interventions in routine clinical practice remains challenging. The VIPPSTAR-G1 study evaluates a caregiver-mediated digital intervention delivered through a dedicated platform designed to support visual and neurodevelopmental functions in infants at risk of or with visual impairment, within a framework that promotes and strengthens the parent-child\u002Fcaregiver-child relationship.\n\nThis multicenter, multinational, single-blind randomized controlled trial will enroll 102 newborns at risk of visual impairment and an additional exploratory pilot subgroup of 48 infants and toddlers with established visual impairment. Participants will be randomized to receive either the VIPPSTAR digital intervention plus standard care or standard care alone. Outcomes include visual acuity, smooth pursuit, additional neuro-ophthalmological functions, neurodevelopmental measures, adaptive functioning, language development, parental stress, quality of life, and feasibility of the digital intervention.",[62,29,94,95],"Neurodevelopmental Disorders","Prematurity",[97,98,99,100],"visual impairment","early intervention","digital health","prematurity","2026-07-16",{"date":103,"type":40},"2026-07-21",{"date":105,"type":21},"2026-07-01",{"date":107,"type":21},"2028-06-30",{"name":109,"class":47},"Università degli Studi di Brescia",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":48},"100645665","promoting-psychophysical-well-being-in-children-and-adolescents-with-visual-impairment-100645665","NCT07703150","Promoting Psychophysical Well-being in Children and Adolescents With Visual Impairment","Promoting the Psychophysical Well-Being of Children and Adolescents With Visual Impairment","VIPPSTAR_UNITN","Inclusion Criteria:\n\n* Aged 10 to 17 years.\n* Diagnosis of Visual Impairment (VI), defined as a congenital or acquired impairment of visual functioning that cannot be corrected solely through the use of glasses or contact lenses.\n* Ability to participate in the exercise protocol, with adapted instructions or support where necessary.\n\nExclusion Criteria:\n\n* Presence of severe neurological, orthopaedic, or cardiac conditions that contraindicate moderate physical exercise.\n* Current pregnancy.\n* Conditions preventing the safe use of wearable devices, such as severe skin allergies or incompatible medical devices.","17 Years",{"count":120,"type":21},20,[24],"Visual impairment (VI) has significant implications not only for visual functioning, but also for the motor development, psychological well-being, and social participation of children and adolescents. Despite the fundamental role of physical activity in promoting health, autonomy, and quality of life, young people with VI still participate to a limited extent in structured physical activity programmes, owing to the lack of adapted interventions supported by robust scientific evidence. The European VIPPSTAR project (Horizon Europe 2024), conducted at the University of Trento, aims to address this gap through the development and validation of an integrated system of educational and rehabilitation interventions designed to promote the motor, physiological, and psychosocial competences of children and adolescents with VI.\n\nThis study marks the transition from the validation of the exercise battery in a controlled setting, carried out during the first phase of the VIPPSTAR project, to its implementation in participants' everyday environments. The aim is to assess its effectiveness, sustainability, and impact on psychophysical and relational well-being.\n\nThe study has a longitudinal, non-profit experimental design and will involve 20 children and adolescents with VI aged 10-17 years (50% female and 50% male), recruited through lower- and upper-secondary schools in the Autonomous Province of Trento participating in the project.\n\nThe intervention programme lasts 12 weeks and is divided into two blocks. During Block 1 (8 weeks), participants will complete the motor exercise battery twice weekly in the school setting, under the supervision of Abilnova educators. Sessions will take place twice a week, last approximately 45-60 minutes, and will be accompanied by fortnightly group meetings with classmates aimed at promoting social inclusion. During Block 2 (4 weeks), participants will perform the exercises at home, with the aim of consolidating the skills acquired and promoting autonomy in carrying out physical activity exercises, while continuing the fortnightly peer sessions at school.\n\nThe effectiveness of the programme will be evaluated using a pre-post design (T0-T1), with an intermediate assessment at the end of Block 1 (T0.5). An integrated assessment system will be used, including ComfTech® wearable devices for continuous monitoring of physiological parameters, such as heart rate, respiratory rate, body temperature, SpO₂, and ECG; video systems for the assessment of motor and postural performance; standardised questionnaires assessing quality of life and social participation; and structured observation grids during peer sessions. Data will be transmitted to the AVATAR system, a conversational system developed within the project, which processes physiological and kinematic information in real time. AVATAR does not operate autonomously and does not make medical decisions.\n\nThe results will contribute to validating an adapted, sustainable, and transferable exercise battery, laying the foundations for large-scale applications in clinical, educational, and rehabilitation settings, with potentially significant benefits for the quality of life and autonomy of young people with VI.",[62,29,63],[125,62,126,127,128],"Physical Activity","Psychophysical Well-being","Physiological Monitoring","Social Inclusion","2026-07-08",{"date":131,"type":40},"2026-07-14",{"date":133,"type":21},"2027-01-01",{"date":135,"type":21},"2028-08-31",{"name":137,"class":47},"Università degli Studi di Trento",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":149,"phases":4,"briefSummary":150,"conditions":151,"keywords":155,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":48},"100625829","retinopathy-of-prematurity---visual-function-and-retinal-structure-100625829","NCT07427719","Retinopathy of Prematurity - Visual Function and Retinal Structure","Children Treated for Retinopathy of Prematurity - Study of Visual Function and Retinal Structure","Inclusion criteria:\n\n* Patients treated for ROP with either laser or injection of A-VEGF.\n* Patients previously diagnosed with ROP but not treated for the condition.\n\nExclusion criteria:\n\n* Age below six years at date of examination.\n* A developmental level not compatible with performing the study examinations.\n* Patients born or treated outside Norway\n* Known ocular or systemic disease that can give structural or functional changes in the retina.","6 Years","20 Years",{"count":148,"type":21},140,"OBSERVATIONAL","Children born prematurely may develop a characteristic retinal disease named retinopathy of prematurity (ROP). This disease could lead to retinal detachment and blindness. ROP was traditionally treated with laser, but injection with a medication (A-VEGF) has become more common.\n\nIn this study, the researchers will explore whether treatment of ROP affects visual function and retinal development. To explore this, the study group will examine children with ROP (but not treated) with children treated with either laser or injection. The researchers will compare the children's visual functions (e.g. visual acuity and visual field) and their retinas (e.g. central and peripheral retina).",[152,153,29,154],"Retinopathy of Prematurity (ROP)","Prematurity Complications","Visual Field Defect",[156,157,158,159,160,66,161,95],"Retinopathy of Prematurity","Treatment","Laser","anti-vascular endothelial growth factor","Visual field defect","Refractive errors","2026-02-16",{"date":164,"type":40},"2026-02-23",{"date":166,"type":21},"2026-04-01",{"date":168,"type":21},"2029-06-01",{"name":170,"class":47},"Oslo University Hospital"]