[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-degenerative-disc-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-degenerative-disc-disease":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,38,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100545596","post-market-data-collection-to-evaluate-the-performance-of-the-synergy-disc-100545596",false,"NCT06383962","Post-Market Data Collection to Evaluate the Performance of the Synergy Disc®","A Single Site Post-Market Data Collection Protocol to Evaluate the Performance of Synergy Spine Solutions Synergy Disc®","Inclusion Criteria:\n\nAge 21 or above at the time of the surgery. Have had (retrospective cohort) or the decision has been made to have (prospective cohort) the Synergy Disc implanted Skeletally mature patients for reconstruction of the disc from C3-C7 following a single or multiple level discectomy for intractable radiculopathy\n\nIntractable radiculopathy and\u002For myelopathy with at least one of the following producing symptomatic nerve root and\u002For spinal cord compression:\n\nherniated disc and\u002For osteophyte formation Symptomatic nerve root and\u002For spinal cord compression documented by patient history (arm or neck pain and\u002For neurologic deficit) and imaging (CT, MRI, x-rays, etc.) Failed a minimum of 6 weeks conservative treatment Written informed consent given by subject.\n\nExclusion Criteria:\n\nExclusion Criteria: All answers must be NO to be eligible for the study. Moderate to advanced spondylosis Diagnosis of osteoporosis Active systemic infection or infection at the operative site Pregnancy Marked cervical instability on lateral, coronal, or flexion\u002Fextension radiographs Cervical spine condition other than symptomatic cervical disc disease requiring surgical treatment at the involved level Severe pathology of the facet joints of the involved vertebral bodies Previous diagnosis of osteopenia or osteomalacia More than one immobile vertebral level between C1 and T1 from any cause Morbid obesity Vulnerable person (pregnant patients, emergency cases, children, prisoners and people without mental capacity)","ALL","21 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts. The study will examine the safety and effectiveness of the Synergy cervical disc system in patients with degenerative cervical disc disease.",[24],"Cervical Degenerative Disc Disease","RECRUITING","2026-04-30",{"date":28,"type":29},"2026-05-01","ACTUAL",{"date":31,"type":29},"2025-03-17",{"date":33,"type":20},"2034-12",{"name":35,"class":36},"Synergy Spine Solutions","INDUSTRY",2,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":45,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":4},"100626017","screw-integrated-vs-traditional-cervical-cages-in-acdf-for-degenerative-disc-disease-100626017","NCT07430163","Screw-Integrated vs Traditional Cervical Cages in ACDF for Degenerative Disc Disease","Comparative Study Between Cervical Cage With Screws and Traditional Cage in Anterior Cervical Discectomy and Fusion (ACDF) for Treatment of Cervical Degenerative Disc Disease (CDDD)","Inclusion Criteria:\n\n* Patients aged above 18 years old.\n* Clinical diagnosis of cervical degenerative disc disease (CDDD).\n* Single or double level cervical degenerative disc disease (CDDD) confirmed by MRI\n* Failure of conservative treatment for at least 6 weeks.\n* Patients indicated for Anterior Cervical Discectomy and Fusion (ACDF).\n* Availability of complete preoperative and postoperative clinical and radiological data.\n* Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Previous cervical spine surgery.\n* Mutli-level (more than double level) cervical degenerative disc disease (CDDD).\n* Significant cervical instability requiring additional posterior fixation\n* Cervical trauma, fracture, or spinal infection.\n* Cervical tumors or inflammatory spinal disease.\n* Severe cervical deformity (fixed kyphosis)\n* Osteoporosis or metabolic bone disease.\n* Pregnancy\n* Psychiatric illness or substance abuse that would compromise follow-up","19 Years",{"count":47,"type":20},40,"INTERVENTIONAL",[50],"NA","This study is a prospective, comparative clinical trial conducted at Assiut University Hospitals to evaluate the effectiveness of two different interbody fusion devices in patients with Cervical Degenerative Disc Disease (CDDD). The primary objective is to compare cervical cages with integrated screws against traditional stand-alone cervical cages during single or double-level Anterior Cervical Discectomy and Fusion (ACDF). While ACDF is the gold standard for CDDD, traditional cages can sometimes lead to complications like subsidence or incomplete fusion; integrated screw designs aim to provide immediate stability and reduce these risks.\n\nInvestigators will assess 40 patients over a 12-month follow-up period, focusing on primary outcomes of radiological interbody fusion using the Daniel Riew grading system.\n\nSecondary outcomes include the maintenance of cervical alignment (Ishihara Index), change in segmental angles (Cobb's method), disc height restoration, and clinical improvements in pain and function measured by the Visual Analog Scale (VAS) and Neck Disability Index (NDI). The study's rationale is to provide clearer evidence on whether screw-integrated cages offer superior radiological and clinical outcomes to help guide future surgical preferences",[53,24,54],"Cervical Cage With Screw","Anterior Cervical Discectomy and Fusion (ACDF)","NOT_YET_RECRUITING","2026-02-18",{"date":58,"type":29},"2026-02-24",{"date":60,"type":20},"2026-03-15",{"date":62,"type":20},"2027-12-30",{"name":64,"class":65},"Assiut University","OTHER",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":14,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":73,"keywords":74,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},"100545595","real-world-data-collection-on-the-synergy-disc-100545595","NCT06383949","Real World Data Collection on the Synergy Disc","Inclusion Criteria:\n\nAge 21 or above at the time of the surgery. Have had (retrospective cohort) or the decision has been made to have (prospective cohort) the Synergy Disc implanted Skeletally mature patients for reconstruction of the disc from C3-C7 following a single or multiple level discectomy for intractable radiculopathy\n\nIntractable radiculopathy and\u002For myelopathy with at least one of the following producing symptomatic nerve root and\u002For spinal cord compression:\n\nherniated disc and\u002For osteophyte formation Symptomatic nerve root and\u002For spinal cord compression documented by patient history (arm or neck pain and\u002For neurologic deficit) and imaging (CT, MRI, x-rays, etc.) Failed a minimum of 6 weeks conservative treatment Written informed consent given by subject.\n\nExclusion Criteria:\n\nModerate to advanced spondylosis Diagnosis of osteoporosis Active systemic infection or infection at the operative site Pregnancy Marked cervical instability on lateral, coronal, or flexion\u002Fextension radiographs Cervical spine condition other than symptomatic cervical disc disease requiring surgical treatment at the involved level Severe pathology of the facet joints of the involved vertebral bodies Previous diagnosis of osteopenia or osteomalacia More than one immobile vertebral level between C1 and T1 from any cause Morbid obesity Vulnerable person (pregnant patients, emergency cases, children, prisoners and people without mental capacity)-",{"count":19,"type":20},[24],[75,76,77,78],"radiculopathy","myelopathy","disc replacement","motion preservation","2026-01-08",{"date":81,"type":29},"2026-01-09",{"date":83,"type":29},"2024-08-06",{"date":85,"type":20},"2033-02-23",{"name":35,"class":36},1]