[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-plexus-block\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-plexus-block":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,60],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100649774","phase-4-the-effect-of-bilateral-intermediate-cervical-plexus-block-on-the-surgical-stress-response-following-total-thyroidectomy-100649774",false,"NCT07740460","The Effect of Bilateral Intermediate Cervical Plexus Block on the Surgical Stress Response Following Total Thyroidectomy","The Effect of Ultrasound-guided Bilateral Intermediate Cervical Plexus Block on Serum Biomarkers of the Surgical Stress Response Following Total Thyroidectomy","Inclusion Criteria:\n\n* ASA I or ASA II\n* euthyroid status\n* signed informed consent\n\nExclusion Criteria:\n\n* patients who refuse to sign the informed consent form\n* infection at the block injection site\n* hypersensitivity or contraindications to the medication used in the study\n* hypo\u002Fhyperthyroidism at the time of surgery\n* presence of substernal goiter\n* additional surgical interventions during the procedure\n* history of previous neck surgery or radiation\n* coagulopathy\n* uncontroled respiratory disease\n* diabetes mellitus\n* autoimune disease\n* chronic corticosteroid therapy\n* smokers\n* pregnant women","ALL","18 Years",{"count":19,"type":20},48,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Total thyroidectomy triggers a systemic surgical stress response involving neuroendocrine and inflammatory pathways. Ultrasound-guided bilateral intermediate cervical plexus block (BICPB) is commonly utilized for postoperative analgesia, however, its specific impact on modulating the systemic stress biomarker response remains to be fully elucidated.\n\nTo evaluate the effect of an ultrasound-guided BICPB on the perioperative surgical stress response by comparing changes in specific serum inflammatory and metabolic biomarkers between patients receiving BICPB and those receiving total intravenous anesthesia (TIVA) alone.\n\nIn this prospective, randomized, controlled study, a total of 48 eligible patients scheduled for elective total thyroidectomy will be randomly assigned to two groups of 24 participants each:\n\n* BICPB Group: TIVA combined with an ultrasound-guided bilateral intermediate cervical plexus block.\n* Control Group: TIVA alone.\n\nVenous blood samples will be collected at predefined intervals: preoperatively (baseline), immediately postoperatively, 24 hours and 48 hours post-surgery.\n\nIt is hypothesized that integrating an ultrasound-guided bilateral intermediate cervical plexus block with total intravenous anesthesia (TIVA) will significantly attenuate the surgical stress response, as evidenced by a reduction in specific serum biomarker concentrations (interleukin-6, C-reactive protein, total leukocyte count,cortisol, alpha-amylase, and glucose), compared to utilizing TIVA alone during total thyroidectomy.\n\nTesting this hypothesis aims to provide scientific evidence regarding the routine integration of the bilateral intermediate cervical plexus block into standard anesthetic protocols for total thyroidectomy, with the objective of evaluating its potential to minimize perioperative stress and support postoperative patient recovery.",[26,27,28],"Thyroidectomy","Cervical Plexus Block","Surgical Stress Response","NOT_YET_RECRUITING","2026-08-04",{"date":32,"type":33},"2026-08-07","ACTUAL",{"date":35,"type":20},"2026-08-15",{"date":37,"type":20},"2027-04-15",{"name":39,"class":40},"University Hospital Dubrava","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":47,"briefSummary":48,"conditions":49,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":4},"100648424","phase-4-the-association-between-bilateral-intermediate-cervical-plexus-block-and-salivary-biomarkers-of-surgical-stress-response-following-total-thyroidectomy-100648424","NCT07721818","The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary Biomarkers of Surgical Stress Response Following Total Thyroidectomy",{"count":19,"type":20},[23],"The aim of this study is to evaluate how an ultrasound-guided bilateral intermediate cervical plexus block affects the surgical stress response in individuals undergoing total thyroidectomy. The primary objective is to quantify this physiological response through the analysis of specific stress and inflammatory biomarkers collected from the participants' saliva.\n\nThe clinical trial will encompass a total of 48 patients, randomized equally into two distinct cohorts of 24 participants each. The control group will undergo standard total intravenous anesthesia (TIVA), whereas the experimental group will receive the bilateral intermediate cervical plexus block in combination with the TIVA protocol.\n\nIt is hypothesized that integrating this regional nerve block with total intravenous anesthesia will significantly attenuate the surgical stress response, evidenced by a reduction in salivary biomarker concentration, compared to utilizing TIVA alone during thyroid surgery.\n\nValidating this hypothesis would offer robust scientific evidence to advocate for the routine integration of the bilateral intermediate cervical plexus block into standard anesthetic practices for total thyroidectomy. Ultimately, this approach aims to minimize perioperative stress and facilitate a more rapid postoperative recovery for patients.",[28,50,51,27],"Total Thyroidectomy","Saliva Collection","2026-07-20",{"date":54,"type":33},"2026-07-23",{"date":56,"type":20},"2026-08-01",{"date":58,"type":20},"2027-04",{"name":39,"class":40},{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":21,"phases":70,"briefSummary":72,"conditions":73,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100638700","effects-of-two-anesthesa-technques-on-inflammatory-response-and-amno-acd-metabolsm-n-thyrod-surgery-100638700","NCT07592832","EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY","THE EFFECT OF TWO DİFFERENT ANESTHESİA APPROACHES ON PERİOPERATİVE INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY","Inclusion Criteria:\n\n* This includes patients aged 18-70 years\n* classified as ASA I-III\n* who have undergone elective thyroidectomy.\n\nExclusion Criteria:\n\n* Patients who did not wish to participate in the study voluntarily\n* patients for whom superficial cervical block was contraindicated\n* pregnant and breastfeeding women\n* patients in ASA IV-V groups were excluded from the study.","70 Years",{"count":69,"type":20},60,[71],"NA","The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and amino acid metabolism in patients undergoing thyroidectomy.",[74,27,75],"General Anesthesia","Thyroid Surgery","2026-05-15",{"date":78,"type":33},"2026-05-18",{"date":80,"type":20},"2026-07-30",{"date":82,"type":20},"2027-02-20",{"name":84,"class":40},"Harran University"]