[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ceserean-section\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ceserean-section":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100649737","phase-4-routine-antiemetic-prophylaxis-for-nonfasted-parturients-undergoing-cesarean-sections-under-spinal-anesthesia-100649737",false,"NCT07740577","Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia","Comparative Effectiveness of Routine Antiemetic Prophylaxis in Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women scheduled for emergency cesarean delivery under spinal anesthesia\n* Non-fasted (full-stomach) parturients\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Age ≥ 18 years\n* Singleton pregnancy\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* ASA physical status III or higher\n* Refusal to participate\n* Elective cesarean delivery (non-emergency cases)\n* Preoperative antiemetic use within 24 hours before surgery\n* Known allergy or contraindication to study drugs (ondansetron or metoclopramide)\n* Pre-existing gastrointestinal disorders (e.g., severe GERD, gastroparesis, bowel obstruction)\n* Psychiatric illness or current use of psychotropic medications\n* Preoperative anemia (as defined by institutional threshold, e.g., Hb \\\u003C 10 g\u002FdL)\n* Intraoperative conversion to general anesthesia\n* Massive intraoperative hemorrhage (\\>1000-1500 mL or requiring transfusion, depending on your protocol definition)\n* Intraoperative administration of additional sedative or antiemetic agents outside study protocol\n* Multiple gestation pregnancies","FEMALE","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The aim of this prospective randomized double-blind study is to compare the effectiveness of routine antiemetic prophylaxis for the prevention of intraoperative nausea and vomiting (IONV) in non-fasted parturients undergoing emergency cesarean section under spinal anesthesia.\n\nNausea and vomiting are common complications during cesarean delivery performed under spinal anesthesia and may negatively affect maternal comfort and perioperative safety. The incidence of these symptoms may be particularly increased in emergency cesarean sections involving non-fasted (full-stomach) parturients. This study compares two commonly used antiemetic strategies, namely 5-hydroxytryptamine-3 (5-HT3) receptor antagonists and dopamine receptor antagonists, to determine their relative effectiveness in preventing IONV during surgery.\n\nThe findings are expected to contribute to optimization of antiemetic prophylaxis protocols, improvement of maternal comfort, and reduction of perioperative complications associated with nausea and vomiting during emergency cesarean delivery.",[26,27,28,29,30,31],"Intraoperative Nausea-retching-vomiting Episodes","Spinal Aneshtesia","Ceserean Section","Antiemetic Therapy","Ondansetron","Metoclopramide",[33,34,35,36,37,38,39,40,41],"Cesarean Section","Emergency Cesarean Delivery","Non-fasted Parturients","Full Stomach","Spinal Anesthesia","Antiemetic Prophylaxis","Intraoperative Nausea and Vomiting","Obstetric Anesthesia","Maternal Outcomes","RECRUITING","2026-08-16",{"date":45,"type":46},"2026-08-18","ACTUAL",{"date":48,"type":46},"2026-07-30",{"date":50,"type":20},"2027-01-02",{"name":52,"class":53},"Sanliurfa Education and Research Hospital","OTHER_GOV",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":62,"minAge":4,"maxAge":4,"enrollmentInfo":63,"targetDuration":65,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":54},"100642614","infection-prevention-for-bellwether-surgery-in-ethiopia-100642614","NCT07647796","Infection Prevention for \"Bellwether\" Surgery in Ethiopia","Infection Prevention for \"Bellwether\" Surgery in Ethiopia: Efficacy, Antimicrobial Resistance, Long-term Patient Outcomes, and Cost-effectiveness","Inclusion Criteria:\n\n* Emergency Caesarean section.\n* Open tibia\u002Ffemur fractures.\n* Treated at participating Ethiopian hospitals.\n\nExclusion Criteria:\n\n* Elective or non-bellwether surgeries.\n* Inability to provide informed consent.\n* Lost to follow-up for 24-month assessment.","ALL",{"count":64,"type":20},1000,"24 Months","OBSERVATIONAL","The study examines surgical site infections and antimicrobial resistance following life-saving surgeries like C-sections and leg fracture repairs in Ethiopia. It does not include healthy volunteers because it specifically focuses on patients who require these urgent operations due to medical necessity. Eligible participants are those undergoing these specific procedures at Tikur Anbessa Specialized Hospital or other participating public hospitals. While the birth-related portion is for females, the trauma portion includes both men and women, generally of reproductive or working age with no upper age limit. People are excluded if they are having elective surgeries, cannot provide consent, or cannot be reached for the two-year follow-up period. The researchers use a mixed intervention based on the \"Clean Cut\" safety bundle, which includes staff training, surgical checklists, and regular audits. The main goals are to measure infection rates within 30 days of surgery and track how well patients can function in their daily lives using the WHODAS scale up to 24 months later.",[28,69,70],"Lower Limb Fractures","Surgical Site Infection (SSI)",[72,73,74,75,76,77],"Surgical Site Infections","Global Surgery","Ethiopia","Multidrug resistance","Antimicrobial resistance","Subsahara Africa","NOT_YET_RECRUITING","2026-06-09",{"date":81,"type":46},"2026-06-15",{"date":83,"type":20},"2026-09-01",{"date":85,"type":20},"2030-08-01",{"name":87,"class":88},"Karolinska Institutet","OTHER"]