[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chemotherapy-induced-toxicity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chemotherapy-induced-toxicity":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100657331","integrating-geriatric-8-g8-screening-and-cancer-and-age-research-group-carg-toxicity-assessment-score-into-routine-care-for-older-adults-with-cancer-100657331",false,"NCT07837505","Integrating Geriatric 8 (G8) Screening and Cancer and Age Research Group (CARG) Toxicity Assessment Score Into Routine Care for Older Adults With Cancer","Integrating Geriatric 8 (G8) Screening and Cancer and Age Research Group (CARG) Toxicity Assessment Score Into Routine Oncology Care for Older Adults With Cancer","Inclusion Criteria:\n\n* Age 65 years or older\n* Confirmed diagnosis of any solid malignancy\n* Scheduled to initiate cytotoxic chemotherapy\n\nExclusion Criteria:\n\n* Hematological malignancies (e.g., leukemia, lymphoma)\n* Treatment plans consisting exclusively of non-chemotherapy modalities (e.g., endocrine therapy, immunotherapy monotherapy, or radiotherapy alone)\n* Incomplete or missing medical records (applicable to the retrospective historical control cohort)","ALL","65 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","This study evaluates whether using specialized geriatric screening and toxicity prediction tools can help oncologists personalize chemotherapy dosing and reduce severe side effects in older adults with solid cancers.\n\nOlder adults with cancer have diverse levels of physical resilience and functional reserve that standard oncologic performance scores often miss. Consequently, uniform standard chemotherapy dosing can lead to severe, life-threatening toxicities, unplanned hospitalizations, or early treatment discontinuation.\n\nIn this prospective-retrospective comparative study, patients aged 65 years and older who are starting chemotherapy are prospectively evaluated using the Geriatric 8 (G8) screening tool. Patients identified as vulnerable (G8 score ≤ 14) undergo a Comprehensive Geriatric Assessment (CGA) across functional, nutritional, cognitive, and psychological domains. In addition, all prospective participants are evaluated using the Cancer and Age Research Group (CARG) toxicity tool to calculate their risk of severe side effects. Chemotherapy doses are risk-adapted based on CARG scores:\n\n* Low Risk: Standard chemotherapy dose\n* Intermediate Risk: 20% dose reduction\n* High Risk: 50% dose reduction\n\nParticipants are followed every 3 months for 1 year to evaluate treatment tolerance, adherence, tumor response, and survival. These outcomes will be compared against a historical retrospective cohort of older patients with solid tumors who received standard-dose chemotherapy without G8 screening or CARG toxicity risk stratification.",[24,25,26],"Solid Neoplasms","Solid Tumors","Chemotherapy-Induced Toxicity",[28,29,30,31,32,33,34,35],"Geriatric Oncology","G8 Screening Tool","CARG Score","Comprehensive Geriatric Assessment","Chemotherapy Toxicity","Dose Reduction","Older Adults With Cancer","Frailty","NOT_YET_RECRUITING","2026-09-18",{"date":39,"type":40},"2026-09-23","ACTUAL",{"date":42,"type":20},"2026-10",{"date":44,"type":20},"2027-11",{"name":46,"class":47},"Assiut University","OTHER"]