[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chest-trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chest-trauma":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,72,94,121,142,167],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100652427","serum-srage-cc16-and-syndecan-1-as-predictors-of-ards-and-mortality-after-severe-chest-trauma-100652427",false,"NCT07774338","Serum sRAGE, CC16, and Syndecan-1 as Predictors of ARDS and Mortality After Severe Chest Trauma","Early Admission Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), Club Cell Protein-16 (CC16), and Syndecan-1 as Independent Predictors of Acute Respiratory Distress Syndrome and In-Hospital Mortality Following Severe Isolated Chest Trauma: A Prospective Cohort Study.","Inclusion Criteria:\n\n* Adult patients aged 18 - 60 years old.\n\n  * Patients with blunt or penetrating severe chest trauma.\n  * Chest Abbreviated Injury Scale (Chest AIS ≥3).\n  * Admission within 24 hours of injury.\n  * Patients admitted to the Trauma Unit or Trauma ICU.\n  * Written informed consent obtained from the patient or legally authorized representative.\n\nExclusion Criteria:\n\n* h. Age below 18 years or above 60 years old (to ensure a homogeneous adult study population and avoid age- related physiological differences).\n\n  * i. Hospital admission more than 24 hours after injury (to ensure early biomarker measurement before secondary inflammatory changes occur).\n  * j. Previous diagnosis of acute respiratory distress syndrome before admission (to ensure that ARDS outcomes are attributable to the index chest trauma).\n  * k. Pre-existing chronic interstitial lung disease (to avoid baseline pulmonary abnormalities that may influence biomarker levels and respiratory outcomes).\n  * l. Acute exacerbation of chronic obstructive pulmonary disease requiring hospitalization (to minimize confounding from pre-existing acute pulmonary inflammation).\n  * m. Active pulmonary infection before trauma (to exclude pre-existing pulmonary inflammation that may alter biomarker levels and increase the risk of ARDS independently of trauma).\n  * n. End-stage chronic liver disease (to avoid altered inflammatory responses and poor clinical outcomes unrelated to chest trauma).\n  * o. End-stage renal disease requiring dialysis (to avoid altered clearance of circulating biomarkers and independently increased mortality risk).\n  * p. Active malignancy receiving chemotherapy or radiotherapy (to exclude patients with cancer-related systemic inflammation and immunosuppression that may affect biomarker levels and outcomes).\n  * q. Pregnancy (because physiological changes during pregnancy may influence biomarker levels and respiratory function).\n  * r. Patients transferred from another hospital more than 24 hours after injury (to ensure standardized early clinical assessment and biomarker sampling within the predefined study period).\n  * s. Refusal to participate in the study (because informed consent is required for study enrollment).\n  * t. Connective tissue diseases\n  * u. Severe burns and major inhalational injury v. Immunosuppressive therapy\n  * w. Chronic systemic inflammatory diseases\n  * x. Severe obesity ( BMI\\>40), if relevant.\n  * y. Poly trauma with AIS\\> or = 3 outside the chest.","ALL","18 Years","60 Years",{"count":20,"type":21},85,"ESTIMATED","OBSERVATIONAL","This prospective cohort study aims to evaluate whether blood levels of soluble receptor for advanced glycation end products (sRAGE), Club Cell Protein-16 (CC16), and Syndecan-1 measured early after severe chest trauma can predict the development of acute respiratory distress syndrome (ARDS) and in-hospital mortality. Adult patients aged 18 years or older admitted with severe blunt or penetrating chest trauma will be enrolled. Clinical data, injury severity, laboratory findings, imaging results, and clinical outcomes will be recorded. Patients will be followed daily during the first 7 days after admission for the development of ARDS, and in-hospital mortality will be recorded until discharge or death. The findings may help identify patients at high risk of respiratory complications and poor outcomes after severe chest trauma.",[25,26],"Acute Respiratory Distress Syndrome","Chest Trauma",[28,29,30,31,32,33],"Severe chest trauma","Acute respiratory distress syndrome","sRANGE","CC16","Syndecan-1","Trauma biomarker","NOT_YET_RECRUITING","2026-08-17",{"date":37,"type":38},"2026-08-19","ACTUAL",{"date":40,"type":21},"2026-10",{"date":42,"type":21},"2028-12",{"name":44,"class":45},"Assiut University","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100572520","validation-of-the-stumbl-score-for-blunt-thoracic-trauma-100572520","NCT06734338","Validation of the STUMBL Score for Blunt Thoracic Trauma","Validation of the STUMBL Score for Risk Stratification in Emergency Department Patients With Blunt Thoracic Trauma: A Prospective Observational Study in Iraq","STUMBL","Inclusion Criteria:\n\n* Patients presenting to the emergency department with blunt thoracic trauma (e.g., motor vehicle accidents, falls, or direct impacts to the chest).\n* Patients who present within 4 hours of sustaining the injury.\n* Patients or their legal guardians must provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with penetrating chest trauma (e.g., stab wounds, gunshot wounds).\n* Patients with other life-threatening injuries that overshadow the thoracic trauma (e.g., head or abdominal trauma).\n* Pregnant women due to potential risks related to radiation or certain diagnostic procedures.\n* Pediatric patients under 18 years of age.\n* Patients with a history of major thoracic surgery (e.g., prior lung or heart surgery) that may interfere with the assessment of trauma severity.",{"count":55,"type":21},188,"This prospective observational study aims to validate the STUMBL score for risk stratification in emergency department patients with blunt thoracic trauma in Iraq. The main questions it seeks to answer are:\n\nHow accurately does the STUMBL score predict mortality and critical outcomes such as ICU admission or advanced interventions? How well does the score stratify patients by injury severity in a resource-limited setting? Are there demographic or clinical factors that influence the score's predictive performance?\n\nParticipants will:\n\nBe assessed using the STUMBL score upon arrival at the emergency department to predict risk levels.\n\nHave demographic and clinical data, including age, gender, injury mechanism, comorbidities, and length of hospital stay, collected to explore potential associations with outcomes.",[26],[52,59,60],"Trauma","Chest","RECRUITING","2026-03-03",{"date":64,"type":38},"2026-03-04",{"date":66,"type":38},"2025-04-20",{"date":68,"type":21},"2026-12-20",{"name":70,"class":45},"Al-Nahrain University",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":89,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":93,"locationsCount":71},"100570453","thorax-vs-trauma-injury-severity-scores-as-outcome-predictors-in-chest-trauma-100570453","NCT06707441","Thorax vs. Trauma Injury Severity Scores as Outcome Predictors in Chest Trauma","Which Score Best Predicts Outcomes in Chest Trauma? A Prospective Comparison of Thorax and Trauma Injury Severity Scores","TTSS\u002FTRISS\u002FER","Inclusion Criteria:\n\n* Patients with chest injuries that require clinical assessment using the Thorax Trauma Severity Score (TTSS) and the Trauma Injury Severity Score (TISS) within 6 hours of admission.\n* Patients (or their legal guardians) must provide informed consent for participation in the study. This ensures ethical standards are maintained.\n* Patients presenting with thoracic injuries, including rib fractures, pulmonary contusions, pneumothorax, hemothorax, and other chest-related injuries. This will include both isolated chest trauma and trauma with multiple injuries\n\nExclusion Criteria:\n\n* Patients younger than 16 years.\n* Patients with chest injuries caused by conditions unrelated to trauma, such as spontaneous pneumothorax, infections, or other medical conditions (e.g., non-traumatic rib fractures or cancer).\n* Patients with severe co-morbidities (e.g., terminal illnesses, advanced stages of cancer, or end-stage organ failure) that would significantly affect outcomes unrelated to the chest trauma.\n* Patients with pre-existing severe neurological conditions or other comorbidities that would interfere with trauma assessment and clinical management (e.g., severe brain injury, vegetative state).\n* Patients or their legal representatives who refuse consent for participation in the study.\n* Pregnant women due to potential risks associated with trauma and interventions during pregnancy.","16 Years",{"count":82,"type":21},150,"The goal of this observational study is to compare the predictive utility of the Thorax Trauma Severity Score (TTSS) and the Trauma and Injury Severity Score (TRISS) in determining outcomes among patients presenting with chest trauma to the emergency room. The main questions it aims to answer are:\n\nDoes the TTSS provide a more accurate prediction of patient outcomes (e.g., mortality, ICU admission) than the TRISS? Are there specific patient subgroups where one score is more effective than the other?\n\nParticipants will:\n\nHave their chest trauma severity assessed using both TTSS and TRISS during their emergency room admission.\n\nHave their clinical outcomes (e.g., mortality, ICU admission, length of hospital stay) monitored throughout their hospital stay.",[26],[86,87,88],"TTSS","ER","TRISS",{"date":64,"type":38},{"date":91,"type":38},"2025-01-20",{"date":68,"type":21},{"name":70,"class":45},{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":120},"100502882","hfnc-compared-with-facial-mask-in-patients-with-chest-trauma-patients-100502882","NCT05828030","HFNC Compared With Facial Mask in Patients With Chest Trauma Patients","Noninvasive Ventilation With High Flow Nasal Cannula Compared With Facial Mask in Patients With Chest Trauma: a Randomized Controlled Study","Inclusion Criteria:\n\nPatients who have the following condition within 72 hours of chest trauma despite receiving standard nasal cannula oxygen therapy \\[≥10 L\u002Fmin\\], are eligible for inclusion.\n\n* severe hypoxemic respiratory failure \\[Arterial partial pressure of oxygen (PaO2)\u002Ffraction of inspired oxygen fraction(FiO2) \\\u003C300 mmHg\\]\n* with a respiratory rate \\>25 breaths\u002Fminute and difficulty breathing, or respiratory distress\n* PaCO2 of 45 mmHg or higher (if the patient requires emergency surgery with endotracheal intubation and mechanical ventilation, the time of inclusion will be the start of the post-extubation period. (Note: For patients who receive emergency trauma surgery with endotracheal intubation and mechanical ventilation, the time of inclusion assessment will be 72 hours after extubation.)\n\nExclusion Criteria:\n\n1. Patients with a Glasgow Coma Scale less than 8 or severe brain injury.\n2. Patients with any contraindications to non-invasive ventilation, including acute gastrointestinal bleeding, upper airway obstruction, or hemodynamic instability.\n3. Facial trauma involving skull base fractures, facial bone fractures, or orbital floor fractures.\n4. Severe injuries involving the nasal sinuses.\n5. Patients with cervical spine injuries.\n6. Patients with increased intracranial pressure.\n7. Patients with facial, nasal, or airway structural abnormalities or surgery that prevents the use of appropriate nasal cannula.\n8. Patients after upper airway surgery.\n9. Patients who are unable to clearly express their willingness to sign informed consent.","20 Years","99 Years",{"count":104,"type":21},100,"INTERVENTIONAL",[107],"NA","Guidelines for noninvasive ventilation (NIV) recommend continuous positive airway pressure in patients with thoracic trauma who remain hypoxic . However, no any suggestion was applied for high flow nasal cannula (HFNC). Therefore, Our aim was to determine whether HFNC reduces intubation in severe trauma-related hypoxemia.",[26,110],"Hypoxia","2025-09-01",{"date":113,"type":38},"2025-09-08",{"date":115,"type":38},"2023-04-26",{"date":117,"type":21},"2027-12-31",{"name":119,"class":45},"National Taiwan University Hospital",2,{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":131,"conditions":132,"keywords":133,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":71},"100573336","thorax-trauma-severity-score-in-chest-trauma-a-study-in-iraq-100573336","NCT06744959","Thorax Trauma Severity Score in Chest Trauma: A Study in Iraq","Reliability of Thoracic Trauma Severity Scores in Predicting Outcomes Among Chest Trauma Patients in Low-Resource Settings: A Prospective Cohort Study From Iraq","TTSS-Iraq","Inclusion Criteria:\n\n* patients above 16 years of age.\n* Patients presenting to the emergency department with thoracic trauma.\n* Patients or their legal guardians must provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with incomplete clinical data or those discharged before scoring can be performed.\n* Pregnant patients (due to specific physiological considerations not accounted for by the scoring system).\n* Patients who succumb to their injuries before scoring or baseline data collection.\n* chronic respiratory diseases\n* malignancy and end-organ failure\n* Patients with severe head injury (having extradural, subdural, subarachnoid, or intraparenchymal hemorrhage and skull bone fracture) or those requiring prior neurosurgical intervention\n* patients with severe abdominal injury requiring surgical intervention like laparotomy",{"count":130,"type":21},166,"This prospective observational study aims to evaluate the predictive utility of the Thorax Trauma Severity Score (TTSS) in determining morbidity and mortality in patients presenting with chest trauma at a tertiary hospital in Iraq. The primary objectives of the study are:\n\nTo assess the accuracy of TTSS in predicting mortality and critical outcomes such as ICU admission and the need for advanced interventions.\n\nTo evaluate the utility of TTSS in stratifying patients based on injury severity in a resource-constrained setting.\n\nTo identify demographic and clinical factors influencing the predictive performance of TTSS.\n\nParticipants will:\n\nBe assessed using the TTSS upon arrival at the emergency department to establish risk stratification.\n\nProvide demographic and clinical data, including age, gender, mechanism of injury, comorbidities, and length of hospital stay, for analyzing associations with clinical outcomes.",[26],[86,60,59],"2025-08-06",{"date":136,"type":38},"2025-08-07",{"date":138,"type":38},"2025-07-22",{"date":140,"type":21},"2026-05-10",{"name":70,"class":45},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":105,"phases":151,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100595849","phased-array-versus-curvilinear-probe-for-fast-ultrasonography-100595849","NCT07037797","Phased-Array Versus Curvilinear Probe for FAST Ultrasonography","PAC-FAST","Inclusion Criteria:\n\n* Trauma patients attending emergency departments in investigating centers\n* Age ≥ 18 years\n* Indication retained for FAST-ultrasound by the emergency physician in charge of the patient\n* Patient affiliated to the French Social Security system or equivalent\n\nExclusion Criteria:\n\n* Patients undergoing treatment limitation or discontinuation\n* Pregnant, parturient or breast-feeding women\n* Patients deprived of liberty by judicial or administrative decision",{"count":150,"type":21},2660,[107],"Background:\n\nFAST ultrasound is a crucial technique in emergency medicine, enabling rapid assessment of trauma patients.\n\nBy allowing visualization of an effusion in a trauma patient in a far more sensitive and specific way than clinical examination, it enables informed decisions to be made on therapeutics, technical gestures, but also the potential receiving service.\n\nArbitrarily, FAST ultrasound is taught with the cardiac probe (phased-array) and the abdominal probe (curvilinear). The difference in use of these two probes varies according to operator and team, with no figures available.\n\nNo recent study has been conducted on the possibility of better diagnostic performance of FAST with a curvilinear versus phased-array probe.\n\nObjective:\n\nThe main objective of this project is to evaluate and compare the diagnostic performance of FAST ultrasound using a phased-array probe versus a curvilinear probe in the detection of effusions in trauma patients (FAST protocol).\n\nMaterials and methods:\n\nProspective, interventional, multicenter, randomized study.\n\nHypothesis tested:\n\nFAST-ultrasound with a curvilinear probe improves diagnostic performance compared with FAST-ultrasound with a phased-array probe.",[26,154],"Abdominal Trauma",[156,157],"chest trauma","abdominal trauma","2025-06-17",{"date":160,"type":38},"2025-06-26",{"date":162,"type":21},"2025-07-01",{"date":164,"type":21},"2027-05-02",{"name":166,"class":45},"Centre Hospitalier Memorial France Etats-Unis",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":71},"100522104","senstivity-and-specificity-of-lung-ultrasound-for-early-detection-of-ards-in-patients-with-chest-trauma-100522104","NCT06078254","Senstivity and Specificity of Lung Ultrasound for Early Detection of ARDS in Patients With Chest Trauma","Accuracy, Senstivity and Specificity of Lung Ultrasound in Comparison to CT Chest for Early Detection of ARDS and Pneumonia in Patients With Chest Trauma","Inclusion Criteria:\n\n* All ICU patients who got admitted to critical care department with chest trauma.\n\nExclusion Criteria:\n\n* Pediatric patients aged less than 18 years old.\n* Any patients have previous lung disease like (IPF, lung cancer, respiratory failure and pulmonary hypertension).\n* Pregnant females at any gestational age",{"count":175,"type":21},30,"The aim of this study is to evaluate the accuracy, sensitivity and specificity of lung ultrasound in early detection of ARDS and Pneumonia in comparison to CT chest in patients with chest trauma. Also, we aim at finding any pulmonary complications and its correlation to development of ARDS and pneumonia in patients with chest trauma.",[26],"2025-05-22",{"date":180,"type":38},"2025-05-28",{"date":182,"type":38},"2023-10-30",{"date":184,"type":21},"2025-10-30",{"name":186,"class":45},"Ain Shams University"]