[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-edema\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-edema":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100647294","boosted-compression-for-lower-limb-chronic-edema-100647294",false,"NCT07708662","Boosted Compression for Lower Limb Chronic Edema","Effectiveness of BoostEd COMpresson for the Treatment of Lower Limb Chronic Edema (BECOME): a Pragmatic Multi-centric Randomized Trial","BECOME","Inclusion criteria:\n\n* Patients suffering from chronic edema ( \\> 3 months) of the lower extremity with a positive pitting sign and a conservative treatment is prescribed.\n\n  -≥ 18 years old\n* BMI is \\\u003C36\n* Able to understand and follow instructions in Dutch\n\nExclusion criteria:\n\n* All treatable causes of chronic edema, such as hormonal disturbances (e.g. thyroid dysfunction), protein abnormalities (especially Albumin), cardiac insufficiency, nephrological conditions, drug-induced edema or peripheral arterial disease.\n* Peripheral arterial disease (ABI \\\u003C 0.55)\n* The patient is allergic for one of the products we use during the treatment, and no alternative is available\n* The patient has wounds at the level of the treated edema zone.\n* The patient is currently receiving treatment within the convention \"lymfoedeem\" according to the Belgian Health insurance (RIZIV-INAMI).\n* The patient is not able to give written consent.","ALL","18 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","Patients:\n\nPatients targeted in this proposal comprise individuals afflicted by chronic edema\u002Flymphedema of the lower limbs.\n\nIntervention:\n\nThe intervention entails the incorporation of boosted compression alongside standard care during the intensive treatment phase. Boosted compression involves thrice-daily re-application of a multicomponent short stretch compression bandage, aimed at enhancing the efficacy of compression therapy within edema treatment.\n\nComparison:\n\nComparison will be made between the experimental intervention (boosted compression) and the prevailing standard edema treatment, which adheres to the complex decongestive therapy as stipulated by healthcare services, utilizing a single daily application of compression bandage.\n\nStandard care is administered under the supervision of trained physical therapists, specialized in edema treatment.\n\nOutcome:\n\nPrimary outcomes encompass the determination of:\n\n1. the requisite number of treatment days to attain a non-pitting edema state during the intensive phase of edema treatment; and\n2. the non-inferiority of boosted compression in maintaining reduced edema volume during the maintenance phase assessed at 1y of follow-up.\n\nSecondary outcomes encompass assessments of:\n\nQuality of Life, acceptance, and adherence to boosted compression, alongside evaluations of time and cost-effectiveness associated with its implementation.",[27,28],"Chronic Edema","Lymphedema",[30,31,27,32,28,33],"RCT","Pragmatic","Lower Limb","compression therapy","RECRUITING","2026-07-13",{"date":37,"type":38},"2026-07-16","ACTUAL",{"date":40,"type":21},"2026-06",{"date":42,"type":21},"2029-12-31",{"name":44,"class":45},"Universiteit Antwerpen","OTHER",4,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":5},"100629274","impact-of-virtual-reality-vr-based-exercises-on-lower-limb-lymphedema-outcomes-lelo-100629274","NCT07472543","Impact of Virtual Reality (VR) Based Exercises on Lower Limb Lymphedema Outcomes (LELO)","The Effect of Virtual Reality-Assisted Exercises on Gait Parameters, Function, Quality of Life, and Edema Level in Patients With Lower Extremity Lymphedema","VR-LELO","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Diagnosis of unilateral lower extremity lymphedema following gynecological and\u002For oncological surgery\n* Stage 2 or 3 lymphedema\n\nExclusion Criteria:\n\n* Decompensated heart, lung, or kidney failure\n* Uncontrolled hypertension\n* Presence of systemic infection\n* Local infections in the lower extremity such as erysipelas or cellulitis\n* Venous insufficiency (e.g., deep vein thrombosis)\n* Any neuromuscular or orthopedic disease affecting lower extremity walking\n* Presence of balance disorders\n* Bilateral lymphedema\n* Presence of lipolymphedema\n* Fracture in the lower extremity\n* Active metastasis\n* Speech or language problems\n* Pregnancy\n* Inability to continue treatment (5 days a week for a total of 4 weeks)","65 Years",{"count":57,"type":21},40,[24],"This randomized controlled study aims to investigate the effects of virtual reality (VR)-assisted gait training, in addition to Complex Decongestive Therapy (CDT), on gait parameters, physical function, quality of life, and edema levels in patients with lower extremity lymphedema. Lymphedema is a progressive condition characterized by the accumulation of protein-rich fluid due to lymphatic drainage insufficiency, leading to chronic inflammation and fibrosis. It impairs gait patterns and reduces functional mobility. VR technologies, such as the RehaWalk system, provide interactive, personalized rehabilitation environments that enhance motor learning, motivation, and adherence to treatment. The study evaluates spatiotemporal gait parameters, three-zone foot analysis (heel, midfoot, forefoot), limb circumferences, ultrasound measurements (dermis, epidermis, subcutaneous fat thickness), and patient-reported outcomes. VR-based training offers a novel, engaging approach to improve physical rehabilitation outcomes in patients with lower limb lymphedema. No significant risks are expected in this study.",[28,61,62,27],"Gait Dysfunction","Physical Rehabilitation",[64,65,66,67,68,69],"lymphedema","virtual reality exercises","ultrasonography","Gait Analysis","Spatiotemporal Parameters","Complex Decongestive Therapy (CDT)","2026-03-13",{"date":72,"type":38},"2026-03-16",{"date":74,"type":38},"2025-09-01",{"date":76,"type":21},"2026-10-01",{"name":78,"class":45},"Gaziler Physical Medicine and Rehabilitation Education and Research Hospital"]