[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-kidney-disease-associated-pruritus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-kidney-disease-associated-pruritus":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100651913","phase-4-efficacy-of-nalfurafine-for-chronic-kidney-disease-associated-pruritus-in-twice-weekly-hemodialysis-patients-a-randomized-controlled-trial-100651913",false,"NCT07769073","Efficacy of Nalfurafine for Chronic Kidney Disease-Associated Pruritus in Twice-Weekly Hemodialysis Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with chronic kidney disease-associated pruritus (CKD-aP) undergoing maintenance hemodialysis twice weekly for more than 6 months and in a hemodynamically stable condition.\n* Aged 18 to 65 years old and willing to participate in the study.\n* Received standard therapy for at least 2 weeks and met the moderate to severe pruritus criteria based on Visual Analog Scale (VAS) score and 5-D Pruritus Scale.\n* Able to understand and comply with the study instructions\u002Fprotocol.\n\nExclusion Criteria:\n\n* Patients with active malignancy or active infection.\n* Patients with primary skin diseases, such as allergic dermatitis, irritant contact dermatitis, neurodermatitis, or psoriasis.\n* Patients with chronic liver disease or cholestatic disease.\n* Received phototherapy or acupuncture therapy within the last 1 week prior to study enrollment.","ALL","18 Years","65 Years",{"count":19,"type":20},36,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","This study evaluates the efficacy and safety of nalfurafine as a treatment for chronic kidney disease-associated pruritus (CKD-aP) in patients undergoing maintenance hemodialysis twice weekly.\n\nPruritus (severe itching) is a common and distressing symptom in patients with end-stage renal disease receiving hemodialysis, significantly impairing their quality of life. Nalfurafine is a selective kappa-opioid receptor agonist designed to reduce itching.\n\nThe main objective of this clinical trial is to evaluate whether nalfurafine effectively reduces itch intensity and improves symptom control compared to control, while monitoring for any adverse effects.",[26,27],"Chronic Kidney Disease Associated Pruritus","End Stage Renal Disease on Dialysis","NOT_YET_RECRUITING","2026-08-12",{"date":31,"type":32},"2026-08-17","ACTUAL",{"date":31,"type":20},{"date":35,"type":20},"2026-10-13",{"name":37,"class":38},"Indonesia University","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":63},"100616999","effect-of-hand-massage-on-chronic-kidney-disease-associated-pruritus-in-patients-receiving-hemodialysis-100616999","NCT07312916","Effect of Hand Massage on Chronic Kidney Disease Associated Pruritus in Patients Receiving Hemodialysis","Effect of Hand Massage on Chronic Kidney Disease Associated Pruritus in Patients Receiving Hemodialysis: a Mixed Methods Study","MADRID","Inclusion Criteria:\n\n* Adults ≥18 years\n* on hemodialysis ≥ three months\n* able to communicate in French\n* diagnosed with CKD-aP based on VAS\n* signed informed consent\n\nExclusion Criteria:\n\n* Participants with cognitive impairment -\n* participants who have been prescribed CKD-aP medications after enrollment in study.",{"count":48,"type":20},54,[50],"NA","Chronic Kidney Disease-Associated Pruritus (CKD-aP) affects about 25% of Swiss hemodialysis patients, most with moderate to severe itching. It negatively impacts sleep, quality of life, and survival. This mixed-methods study will investigate the effect hand massage delivered by nurses on the itch severity, health-related quality of life and sleep compared to usual care in patients on hemodialysis. Fifty-four patients will be randomized to receive either hand massage or verbal attention over three months. Quantitative data (NRS, 5D Itch Scale, KDQOL-SFv1.2) will be collected at baseline, one, and three months. Qualitative interviews with 12 participants who received the hand massage intervention, will explore their experiences. The intervention is safe, non-invasive, and may offer valuable insights into CKD-aP management and pathogenesis.",[26],"RECRUITING","2026-03-12",{"date":56,"type":32},"2026-03-16",{"date":58,"type":32},"2025-12-17",{"date":60,"type":20},"2027-06-30",{"name":62,"class":38},"University of Applied Sciences of Western Switzerland",4,"Chronic Kidney Disease-associated Pruritus"]