[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-lower-back-pain-clbp\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-lower-back-pain-clbp":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100658093","phase-1-mechanistic-evaluation-of-polypharmacy-effects-for-pain-100658093",false,"NCT07846020","Mechanistic Evaluation of Polypharmacy Effects for Pain","Mechanistic Evaluation of Gabapentin and Opioid Polypharmacy","PAT","Inclusion Criteria:\n\n* 18-65 years old\n* Lifetime history of opioid use\n* Medically cleared to take study medications\n* Chronic Lower Back Pain\n* Agree to use effective form of contraception throughout enrollment\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding\n* Have evidence of physical dependence on or current use of any central nervous system depressants including but not limited to alcohol, benzodiazepines, opioids, gabapentinoids, or barbiturates\n* Past 30-day use of certain pain medications\n* Evidence of past 7-day nonmedical drug use\n* Known hypersensitvity, allergy to, or history of adverse reactions to study medications\n* Are currently taking a medication or have a condition that is contraindicated with either study medication\n* Have evidence of current or past significant medical\u002Fpsychiatric illness\n* Have a history of clinically significant cardiac arrhythmias or vasospastic disease\n* Have evidence of renal or hepatic impairment\n* Current suicidal ideation or behavior, or a history of a suicide attempt within the past 2 years\n* Have any condition that may increases the risk for respiratory depression","ALL","18 Years","65 Years",{"count":21,"type":22},110,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","This is a single-group, within-subject, double-blind, double-dummy, placebo-controlled study evaluating whether gabapentin (Neurontin) changes the analgesic, safety, and subjective effects of the opioid hydromorphone (Dilaudid) when the two are combined.",[29],"Chronic Lower Back Pain (CLBP)","NOT_YET_RECRUITING","2026-09-22",{"date":33,"type":34},"2026-09-29","ACTUAL",{"date":36,"type":22},"2027-01-15",{"date":38,"type":22},"2032-04-01",{"name":40,"class":41},"University of Maryland, Baltimore","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100646261","lumbar-facet-platelet-rich-plasma-injection-versus-medial-branch-radiofrequency-ablation-for-chronic-lumbar-facet-mediated-pain-100646261","NCT07692737","Lumbar Facet Platelet-Rich Plasma Injection Versus Medial Branch Radiofrequency Ablation for Chronic Lumbar Facet-Mediated Pain","A Randomized Controlled Trial Comparing Intra-Periarticular Lumbar Facet Platelet-Rich Plasma Injection Versus Medial Branch Radiofrequency Ablation for Chronic Lumbar Facet-Mediated Pain","Inclusion Criteria:\n\n* Adults with chronic lumbar back pain suspected to be facet-mediated\n* ≥80% pain relief following two diagnostic medial branch blocks\n* Ability to provide informed consent\n* Ability to complete patient-reported outcome measures\n\nExclusion Criteria:\n\n* Active radiculopathy or alternate dominant spinal pain generator\n* Prior lumbar fusion at target level\n* Active systemic infection or local infection at injection site\n* Thrombocytopenia, less than 100,000\u002FuL\n* Anemia, Hemoglobin less than 10 g\u002FdL\n* Pregnancy\n* Inability to complete follow-up assessments",{"count":51,"type":22},30,[53],"NA","The first clinical research effort under this initiative is a pilot randomized controlled trial comparing intra-periarticular lumbar facet platelet-rich plasma (PRP) injection to standard-of-care medial branch radiofrequency ablation (RFA) for chronic lumbar facet-mediated pain.\n\nThe study is designed to:\n\n* Use contemporary best-practice techniques for both treatment arms\n* Minimize incremental risk beyond standard care\n* Generate feasibility, safety, and preliminary comparative effectiveness data\n* Inform future definitive trials and potential program expansion",[29,56],"Lumbar Facet Joint Pain",[58,59,60,61,62,63],"Platelet-Rich Plasma","PRP","Radiofrequency Ablation","Lumbar Facet Joint","Medial Branch Neurotomy","Spine Injection","2026-07-07",{"date":66,"type":34},"2026-07-09",{"date":68,"type":22},"2026-06",{"date":70,"type":22},"2028-06",{"name":72,"class":41},"The New England Baptist Hospital"]