[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-nausea-and-vomiting-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-nausea-and-vomiting-syndrome":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100614164","brain-stomach-circuits-in-chronic-nausea-100614164",false,"NCT07276035","Brain-Stomach Circuits in Chronic Nausea","TMS Neuromodulation of Brain-to-Stomach Circuits in Chronic Nausea","Inclusion Criteria:\n\n* Adults between ages 21-60 years old, with and without CNVS diagnosis per self-report.\n\nExclusion Criteria:\n\n* body mass index (BMI) \\> 30\n* pregnancy or intention to become pregnant\n* past or present chemotherapy\n* diagnosis of gastric (stomach) cancer\n* any kind of gastric (stomach) surgery\n* current use of GLP-1 receptor agonists (e.g. Ozempic, Trulicity)\n* medications which significantly lower seizure thresholds (e.g. bupropion (Wellbutrin), fluoxetine (Prozac), or tramadol (Ultram))\n* implantable devices, such as a pacemakers or nerve stimulators\n* history of head injury that required hospitalization, metal in the skull, or neurologic disease such as stroke, history of seizures or history of syncope (fainting or passing out)\n* neurodegenerative disease (Multiple Sclerosis, Parkinson's or Alzheimer's Disease)\n* ongoing psychosis or altered cognitive status status (e.g. hearing sounds or seeing visions that are not there, or feeling confused or suffering from memory lapses)\n* history of cardiovascular (i.e., heart attack), pulmonary (i.e., need for supplemental oxygen), or endocrine disease (e.g. diabetes)\n* current enrollment in another study using Transcranial Magnetic Stimulation (TMS)\n* current use of drugs such as amphetamines, methamphetamine, Ecstasy, Ketamine, Angel Dust\u002FPCP, cocaine, or drinking 3 or more alcoholic drinks per day\n* For healthy subjects only: chronic history of gastrointestinal symptoms (e.g., nausea, indigestion, bloating, abdominal pain)\n* For CNVS subjects only: diagnosis of gastric motility disorder (e.g. gastroparesis\u002Fslow stomach emptying) or history of bowel obstruction (i.e., chronic partial small bowel obstruction)",true,"ALL","21 Years","60 Years",{"count":21,"type":22},219,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are:\n\n* What are the best brain sites to influence the stomach?\n* What are the effects of different stimulation patterns on stomach activity?\n* Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea?\n\nResearchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen.\n\nParticipants will:\n\n* Visit the clinic at least once, and for up to 9 times more over the course of several months.\n* Receive TMS while sitting in a chair similar to a dentist's chair.\n* Drink water or consume a test meal during each study visit.",[28],"Chronic Nausea and Vomiting Syndrome",[30],"Chronic unexplained nausea and vomiting","RECRUITING","2026-07-22",{"date":34,"type":35},"2026-07-24","ACTUAL",{"date":37,"type":35},"2026-01-28",{"date":39,"type":22},"2031-07",{"name":41,"class":42},"David Levinthal","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":43},"100648256","evaluating-whether-a-nausea-band-reduces-symptoms-in-those-with-chronic-nausea-vomiting-100648256","NCT07720323","Evaluating Whether a Nausea Band Reduces Symptoms in Those With Chronic Nausea Vomiting","Evaluating the Effect of a WearIng a TENS-device in NausEa Relief (The WINNER Study)","WINNER","Inclusion Criteria:\n\n* Nausea present for more than 2 months. Age 18 years or older. Able to understand English. Receiving care at The Ohio State University. Able to complete online surveys using a smartphone or computer\n\nExclusion Criteria:\n\n* Active treatment for cancer Current treatment for inflammatory bowel disease Cirrhosis End-stage renal disease Prior use of a wearable TENS unit for nausea Abdominal surgery within the previous 3 months Pregnancy (self-reported at enrollment) Current carpal tunnel syndrome Any contraindication to use of the EmeTerm device Inflammation, irritation, infection, ulceration, bleeding, open wounds, or other skin conditions near the wrist where the device is applied Presence of metallic implants in the body Head or facial injury within the previous 3 months Known brain tumor, meningitis, or stroke within the previous 3 months Cardiac pacemaker, implanted defibrillator, or other implanted metallic or electronic device History of seizures","18 Years",{"count":54,"type":22},120,[25],"The goal of this clinical trial is to learn whether a wearable transcutaneous electrical nerve stimulation (TENS) device called EmeTerm can help reduce nausea in adults who have had nausea for 2 months or longer and who receive care at The Ohio State University. The study will also evaluate whether use of the device affects other symptoms and aspects of wellbeing, including vomiting, abdominal pain, bloating, constipation, appetite, sleep, mood, stress, fatigue, quality of life, and hope. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\]\n\nThe main questions it aims to answer are:\n\nDoes using the EmeTerm device reduce the average weekly frequency of moderate to severe nausea compared with symptoms during a baseline observation period? \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Does using the EmeTerm device reduce the duration of nausea, frequency of vomiting, and use of anti-nausea medications, and improve other gastrointestinal symptoms, wellbeing, and quality of life? \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\]\n\nThis is a single-arm study. Participants will serve as their own comparison by comparing symptoms during device use with symptoms recorded during the baseline period before using the device. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\]\n\nParticipants will:\n\nComplete a screening survey and provide electronic informed consent if eligible. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Complete baseline questionnaires and record daily gastrointestinal symptoms for a 2-week baseline period. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Receive an EmeTerm wearable TENS device and instructions for its use. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Use the EmeTerm device for 12 weeks while continuing to record nausea and other gastrointestinal symptoms. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Complete weekly and monthly surveys about symptoms, stress, sleep, appetite, fatigue, quality of life, anxiety, depression, autonomic symptoms, device experience, and any adverse events.",[58,28],"Chronic Nausea",[60,61,62,63,64,65,66,67,68,69],"chronic nausea","TENS","wearable device","median nerve stimulation","nausea and vomiting","gastroparesis","neuromodulation","quality of life","vomiting","appetite","2026-07-17",{"date":32,"type":35},{"date":73,"type":35},"2023-02-01",{"date":75,"type":22},"2028-06-30",{"name":77,"class":42},"Ohio State University"]