[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-nausea\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-nausea":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100648280","aroma-nt-essential-oils-and-wearable-tens-device-for-chronic-nausea-100648280",false,"NCT07720336","AROMA-NT: Essential Oils and Wearable TENS Device for Chronic Nausea","AROMA-NT: Assessment of the Mechanisms of Action of Inhaled Essential Oils and Wearable TENS Unit Device on Nausea","AROMA-NT","Inclusion Criteria:\n\nAge 18 years or older. Chronic nausea for more than 6 months. Nausea on 3 or more days during the previous week. Severe or very severe nausea. At least moderate anxiety as defined by a Generalized Anxiety Disorder-7 (GAD-7) score of 10 or greater.\n\nAble to read and understand English. Willing and able to complete study procedures and questionnaires\n\nExclusion Criteria:\n\nCurrently receiving treatment for cancer. Decompensated cirrhosis, including cirrhosis with ascites, variceal bleeding, or hepatic encephalopathy.\n\nCurrently receiving dialysis. Gastrointestinal surgery within the previous 3 months. Stroke within the previous 3 months. Currently pregnant (self-reported). Symptoms consistent with carpal tunnel syndrome based on the Kamath-Stothard questionnaire.\n\nInflammation, irritation, infection, or other significant skin disease near the wrist at the intended site of ReliefBand application.\n\nLatex allergy, due to natural rubber latex contained in the ReliefBand wrist strap","ALL","18 Years",{"count":20,"type":21},250,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will investigate how two inhaled essential oil products (QueaseEASE and STILL) and a wearable transcutaneous electrical nerve stimulation (TENS) device (ReliefBand) affect chronic nausea and anxiety in adults with longstanding nausea. The goal is to better understand the mechanisms by which these non-prescription therapies may influence nausea, anxiety, sleep, pain, autonomic symptoms, and bowel-related symptoms.\n\nParticipants will first complete a 2-week baseline period during which nausea and other symptoms are assessed through questionnaires. Participants will then use the inhaled essential oil products as needed for 12 weeks while completing symptom surveys. Afterward, participants will use the ReliefBand wearable TENS device as needed for an additional 12 weeks and continue completing surveys. Researchers will compare symptom changes during the intervention periods with baseline measurements to better understand factors that contribute to chronic nausea and how these therapies may provide relief. Up to 250 participants may be enrolled to achieve approximately 100 participants completing both intervention phases",[27,28],"Chronic Nausea","Anxiety",[30,31,32,33,34,35,36,37,38,39,40,41,42],"chronic nausea","anxiety","aromatherapy","essential oil","inhaled essential oil","transcutaneous Electrical Nerve Stimulation","mechanism of action","autonomic dysfunction","sleep disturbance","stress","pain","bowel symptoms","quality of life","RECRUITING","2026-07-17",{"date":46,"type":47},"2026-07-22","ACTUAL",{"date":49,"type":47},"2024-05-17",{"date":51,"type":21},"2027-12-31",{"name":53,"class":54},"Ohio State University","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":79,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":55},"100648256","evaluating-whether-a-nausea-band-reduces-symptoms-in-those-with-chronic-nausea-vomiting-100648256","NCT07720323","Evaluating Whether a Nausea Band Reduces Symptoms in Those With Chronic Nausea Vomiting","Evaluating the Effect of a WearIng a TENS-device in NausEa Relief (The WINNER Study)","WINNER","Inclusion Criteria:\n\n* Nausea present for more than 2 months. Age 18 years or older. Able to understand English. Receiving care at The Ohio State University. Able to complete online surveys using a smartphone or computer\n\nExclusion Criteria:\n\n* Active treatment for cancer Current treatment for inflammatory bowel disease Cirrhosis End-stage renal disease Prior use of a wearable TENS unit for nausea Abdominal surgery within the previous 3 months Pregnancy (self-reported at enrollment) Current carpal tunnel syndrome Any contraindication to use of the EmeTerm device Inflammation, irritation, infection, ulceration, bleeding, open wounds, or other skin conditions near the wrist where the device is applied Presence of metallic implants in the body Head or facial injury within the previous 3 months Known brain tumor, meningitis, or stroke within the previous 3 months Cardiac pacemaker, implanted defibrillator, or other implanted metallic or electronic device History of seizures",{"count":65,"type":21},120,[24],"The goal of this clinical trial is to learn whether a wearable transcutaneous electrical nerve stimulation (TENS) device called EmeTerm can help reduce nausea in adults who have had nausea for 2 months or longer and who receive care at The Ohio State University. The study will also evaluate whether use of the device affects other symptoms and aspects of wellbeing, including vomiting, abdominal pain, bloating, constipation, appetite, sleep, mood, stress, fatigue, quality of life, and hope. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\]\n\nThe main questions it aims to answer are:\n\nDoes using the EmeTerm device reduce the average weekly frequency of moderate to severe nausea compared with symptoms during a baseline observation period? \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Does using the EmeTerm device reduce the duration of nausea, frequency of vomiting, and use of anti-nausea medications, and improve other gastrointestinal symptoms, wellbeing, and quality of life? \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\]\n\nThis is a single-arm study. Participants will serve as their own comparison by comparing symptoms during device use with symptoms recorded during the baseline period before using the device. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\]\n\nParticipants will:\n\nComplete a screening survey and provide electronic informed consent if eligible. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Complete baseline questionnaires and record daily gastrointestinal symptoms for a 2-week baseline period. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Receive an EmeTerm wearable TENS device and instructions for its use. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Use the EmeTerm device for 12 weeks while continuing to record nausea and other gastrointestinal symptoms. \\[34\\_Emeterm...rotocol\\_v3 \\| Word\\] Complete weekly and monthly surveys about symptoms, stress, sleep, appetite, fatigue, quality of life, anxiety, depression, autonomic symptoms, device experience, and any adverse events.",[27,69],"Chronic Nausea and Vomiting Syndrome",[30,71,72,73,74,75,76,42,77,78],"TENS","wearable device","median nerve stimulation","nausea and vomiting","gastroparesis","neuromodulation","vomiting","appetite",{"date":46,"type":47},{"date":81,"type":47},"2023-02-01",{"date":83,"type":21},"2028-06-30",{"name":53,"class":54}]