[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-neck-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-neck-pain":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,38,0,25,[9,53,85,114,145,167,206,227,256,287,309,329,359,382,407,431,453,478,505,532,552,574,603,631,660],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100652615","physical-profile-of-cervicogenic-headache-comparison-with-neck-pain-and-healthy-controls-100652615",false,"NCT07776275","Physical Profile of Cervicogenic Headache: Comparison With Neck Pain and Healthy Controls","A Multidimensional Physical Profile of Cervicogenic Headache: A Cross-Sectional Comparison With Nonspecific Neck Pain and Healthy Controls","* Inclusion Criteria:\n* Aged 25 to 60 years\n* Able to provide written informed consent\n* Meeting the criteria for one of the following groups:\n* Cervicogenic headache: physician diagnosis according to the International Classification of Headache Disorders, 3rd edition, with symptoms lasting at least 3 months\n* Chronic nonspecific neck pain: neck pain lasting at least 6 months without headache\n* Healthy control: no neck pain or headache\n\nExclusion Criteria:\n\n* Receipt of physiotherapy for headache or neck pain during the previous 6 months\n* Diagnosis of a headache disorder other than cervicogenic headache, including migraine or tension-type headache, or a diagnosis of trigeminal neuralgia\n* History of cervical spine surgery or significant cervical trauma\n* Current or previous diagnosis of a tumor or cancer\n* Serious cardiovascular, cerebrovascular, hematological, metabolic, neurological, or psychiatric disorder\n* Rheumatoid arthritis\n* Congenital cervical abnormality\n* Cervical spondylolisthesis or cervical instability\n* Active infection\n* Temporomandibular joint dysfunction\n* Dizziness or visual disturbance accompanying headache\n* Any clinical red flag suggesting serious cervical pathology\n* Pregnancy or breastfeeding\n* Upper-extremity injury, surgery, or another condition affecting handgrip strength\n* Serious musculoskeletal disorder affecting cervical posture or muscle measurements\n* Inability to complete the questionnaire-based or instrument-based assessments",true,"ALL","25 Years","60 Years",{"count":22,"type":23},135,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to compare physical findings across three adult groups. Cervicogenic headache (CGH) is a headache linked to a problem in the neck. Neck pain may affect posture, muscle function, grip strength, and sensitivity to pressure. Researchers do not know whether CGH has a distinct pattern of these findings.\n\nThe main questions are:\n\n* Do posture, grip strength, muscle stiffness, elasticity, and pressure sensitivity differ among the groups?\n* Are any differences more closely associated with CGH than with neck pain?\n\nResearchers will compare adults ages 25 through 60. One group will include people with CGH lasting at least three months. Another group will include people with neck pain lasting at least six months. People in the neck pain group will have no headaches. Healthy participants will have no neck pain or headaches.\n\nResearchers will not provide treatment or change participants' usual care. Each participant will complete one study visit lasting about 15 minutes. Participants will:\n\n* Answer short questions about their health and pain\n* Stand while researchers measure their head and neck posture\n* Squeeze a device that measures grip strength\n* Complete brief tests of neck muscle stiffness and elasticity\n* Tell researchers when applied pressure first becomes painful\n\nResearchers will compare results across the three groups. The findings may guide future CGH assessment and treatment research.",[27,28],"Cervicogenic Headache","Chronic Neck Pain",[30,31,32,33,34,35,36,37,38,39],"physical profile","myotonometry","upper trapezius","muscle stiffness","logarithmic decrement","pressure pain threshold","handgrip strength","craniovertebral angle","tragus to wall distance","cross-sectional study","RECRUITING","2026-08-20",{"date":43,"type":44},"2026-08-21","ACTUAL",{"date":46,"type":44},"2026-04-21",{"date":48,"type":23},"2026-10-01",{"name":50,"class":51},"Istanbul Medipol University Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":12,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":52},"100643683","prospective-case-series-evaluating-6-month-and-12-month-outcomes-after-cryoneurolysis-for-chronic-pain-100643683","NCT07639060","Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain","Inclusion Criteria:\n\n* Diagnosis of chronic pain (generally pain duration of at least 3-6 months) localized to an anatomical region appropriate for cryoneurolysis as determined by the treating physician.\n* Planned cryoneurolysis procedure as part of standard clinical care.\n* Ability to provide written informed consent.\n* Ability and willingness to complete baseline and follow-up questionnaires.\n\nExclusion Criteria:\n\n* Cryoneurolysis performed as part of a separate investigational trial in which data sharing is not permitted.\n* Active infection or other clinical contraindication to the procedure as determined by the treating clinician.\n* Life expectancy of less than 12 months in the judgment of the treating clinician.\n* Any condition that, in the investigator's opinion, would interfere with study participation or completion of follow-up, such as severe psychiatric instability or active substance use that precludes reliable follow-up","18 Years",{"count":61,"type":23},80,"To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.",[64,65,66,67,68,69,70,71,72,73,74,75,76,28],"Chronic Pain","PERIPHERAL NEUROPATHY","Occipital Neuralgia","Chronic Hip Pain","Hip Osteoarthritis","Knee Osteoarthritis","Spasticity","Chronic Low Back Pain","Lumbar Spondylosis","Cervical Spondylosis","Shoulder Arthritis","Causalgia","Chronic Pain Syndrome","2026-08-19",{"date":43,"type":44},{"date":80,"type":44},"2026-06-20",{"date":82,"type":23},"2028-07",{"name":84,"class":51},"Yale University",{"id":86,"slug":87,"hasResults":12,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":100,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":52},"100652079","effects-of-the-timing-of-vagus-nerve-stimulation-combined-with-exercise-in-chronic-neck-pain-100652079","NCT07769034","Effects of the Timing of Vagus Nerve Stimulation Combined With Exercise in Chronic Neck Pain","Does Timing Matter? Effects of Transcutaneous Auricular Vagus Nerve Stimulation Before and After Exercise in Chronic Neck Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of chronic neck pain confirmed by a physical medicine and rehabilitation physician.\n* Age between 18 and 65 years.\n* Neck pain persisting or recurring for at least 3 months.\n* Ability to participate in the exercise program included in the study protocol.\n* No contraindication to transcutaneous auricular vagus nerve stimulation.\n* Willingness to provide written informed consent.\n* Willingness to participate regularly in the planned exercise and assessment sessions.\n\nExclusion Criteria:\n\n* Cervical radiculopathy or specific neurological findings.\n* Previous cervical spine surgery.\n* Serious cardiovascular disease.\n* Serious neurological or systemic disease.\n* Pregnancy.\n* Orthopedic or musculoskeletal conditions preventing participation in exercise.\n* Cognitive or communication problems that prevent completion of the assessment instruments.\n* Inability or unwillingness to comply with the study protocol or attend scheduled sessions.","65 Years",{"count":94,"type":23},81,"INTERVENTIONAL",[97],"NA","This randomized controlled trial aims to investigate whether the timing of transcutaneous auricular vagus nerve stimulation (taVNS) relative to exercise influences clinical and autonomic outcomes in individuals with chronic neck pain.\n\nParticipants will be randomly allocated to one of three groups: taVNS applied before exercise, taVNS applied after exercise, or exercise alone. All groups will receive a standardized exercise program designed for chronic neck pain. The intervention will be conducted over a 6- to 8-week period.\n\nThe effects of the interventions will be evaluated using pain intensity, neck-related disability, sleep quality, heart rate variability, and exercise adherence. The study will determine whether applying taVNS before or after exercise provides additional benefits compared with exercise alone and whether the timing of stimulation influences treatment outcomes.",[28],[101,102,103],"CHRONIC PAIN","VAGAL NERVE STIMULATION","EXERCISE","NOT_YET_RECRUITING","2026-08-12",{"date":107,"type":44},"2026-08-17",{"date":109,"type":23},"2026-09-14",{"date":111,"type":23},"2027-09-15",{"name":113,"class":51},"Kutahya Health Sciences University",{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":122,"targetDuration":4,"studyType":95,"phases":124,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":52},"100651403","diaphragmatic-myofascial-release-added-to-neck-exercises-for-chronic-neck-pain-100651403","NCT07761793","Diaphragmatic Myofascial Release Added to Neck Exercises for Chronic Neck Pain","Effect of Adding Diaphragmatic Myofascial Release to a Neck Exercise Program on Pain, Disability, Fatigue, and Kinesiophobia Among Patients With Chronic Neck Pain in the Gaza Strip: A Randomized Controlled Trial","DMR-CNP","Inclusion Criteria:\n\n* Men and women aged 25-60 years.\n* Diagnosis of chronic neck pain lasting longer than 3 months.\n* Ability to understand and follow instructions.\n\nExclusion Criteria:\n\n* Previous cervical spine surgery.\n* Cervical radiculopathy or myelopathy.\n* History of fracture, inflammatory disease, malignancy, or neurological disorder.\n* Respiratory diseases such as chronic obstructive pulmonary disease (COPD) or severe asthma.\n* Current vestibular disorder.\n* Pregnancy.\n* Receipt of physical therapy or manual therapy during the previous 3 months.",{"count":123,"type":23},60,[97],"Chronic neck pain can affect daily activities and may be associated with pain, disability, fear of movement, and fatigue. Exercise is commonly used to manage chronic neck pain, but some people continue to experience symptoms despite exercise treatment.\n\nThis study will investigate whether adding diaphragmatic myofascial release, a hands-on manual therapy directed toward the diaphragm and surrounding tissues, to a neck exercise program provides greater benefits than neck exercises alone in adults with chronic neck pain.\n\nSixty adults aged 25 to 60 years with chronic neck pain lasting more than three months will be randomly assigned to one of two groups. The control group will receive a supervised neck exercise program, while the intervention group will receive the same neck exercise program combined with diaphragmatic myofascial release and related diaphragmatic manual therapy. Both groups will receive treatment for six weeks, with three supervised sessions per week.\n\nPain, neck-related disability, fear of movement, and fatigue will be assessed before treatment, immediately after the six-week intervention, and four weeks after completion of treatment. The study will examine whether adding diaphragmatic myofascial release to neck exercises leads to greater improvements in these outcomes compared with neck exercises alone.",[28],[28,128,129,130,131,132,133,134,135,136],"Diaphragmatic Myofascial Release","Neck Exercise","Manual Therapy","Physical Therapy","Kinesiophobia","Fatigue","Neck Disability","Pain Intensity","Diaphragmatic Breathing","2026-08-08",{"date":105,"type":44},{"date":140,"type":23},"2026-10",{"date":142,"type":23},"2027-01",{"name":144,"class":51},"Abdelrahman Alghoul",{"id":146,"slug":147,"hasResults":12,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":95,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":52},"100651121","clinical-and-brain-activity-assessment-before-and-after-physiotherapy-in-people-with-chronic-non-specific-neck-pain-100651121","NCT07756229","Clinical and Brain Activity Assessment Before and After Physiotherapy in People With Chronic Non-specific Neck Pain","Predictors of Response After Physiotherapy Treatment in People With Chronic Non-specific Neck Pain","Inclusion Criteria:\n\n* Chronic non-specific neck pain (\\>3 months duration)\n* Willing and able to sign informed consent for study participation\n\nExclusion Criteria:\n\n* Concomitant neurological or psychiatric disease apart from depression (especially severe mental disorder or psychopathology)\n* Regular (daily) intake of benzodiazepines\n* Signs of severe disease, cervical myelopathy, tumour, rheumatic diseases or a neurological pathology of central origin\n* Neck pain of traumatic origin or as a result of whiplash\n* Previous surgical intervention of the cervical spine",{"count":153,"type":23},100,[97],"The goal of this clinical trial is to investigate whether electroencephalographic features are associated with the multidimensional clinical characteristics of adults with chronic non-specific neck pain and whether clinical and brain function measures change following physiotherapy. Participants with chronic non-specific neck pain will receive six weekly treatment sessions consisting of a manual physiotherapy and neck-specific exercise programme, including a home exercise programme. Clinical, psychophysical, and 64-channel electroencephalographic assessments will be performed at baseline and approximately one week after completion of the intervention. Clinical outcomes will also be reassessed 12 weeks after the last treatment session. Electroencephalographic recordings will be obtained while participants are seated comfortably and instructed to remain relaxed. EEG-derived measures will be examined in relation to pain intensity, neck-related disability, psychological and cognitive-affective factors, sleep quality, and psychophysical pain responses. Healthy participants without chronic neck pain will undergo a comparable baseline assessment to provide reference data for the interpretation of brain function in the clinical group.",[157,28],"Neck Pain Musculoskeletal","2026-08-05",{"date":160,"type":44},"2026-08-10",{"date":162,"type":44},"2024-03-21",{"date":164,"type":23},"2027-12",{"name":166,"class":51},"Ander Cervantes Benítez",{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":95,"phases":177,"briefSummary":178,"conditions":179,"keywords":184,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":4},"100650268","virtual-pain-education-for-spinal-cord-stimulation-patients-100650268","NCT07743905","Virtual Pain Education for Spinal Cord Stimulation Patients","Virtual Pain Neuroscience Education for Patients Undergoing Spinal Cord Stimulation: A Hybrid Effectiveness-Implementation Pilot Trial","SCS-PNE","Inclusion Criteria (pilot study Aim 3):\n\n1. presence of a scheduled spinal cord stimulator trial surgery date within the EPIC workbench report,\n2. age greater than or equal to 18 years,\n3. ability to speak, read, and understand English to complete study surveys and participate in educational sessions,\n4. consistent access to an internet-enabled device (smartphone, tablet, or computer) equipped with a working camera and microphone compatible with the virtual intervention delivery,\n5. willingness and ability to participate in virtual video visits per the SCS-PNE intervention (i.e. through Doximity, Zoom, or EPIC MyChart).\n\nExclusion Criteria (pilot study):\n\n1. diagnosis of a severe cognitive impairment, advanced dementia, or active psychosis,\n2. prior formal exposure to structured PNE program within the past 12 months, 3) current involvement in active, unresolved litigation related to their chronic pain condition (i.e., ongoing legal or worker's compensation claim).",{"count":176,"type":23},50,[97],"Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy. SCS uses an implanted device to send mild electrical currents to the spine to block pain signals before they reach the brain. However, long-term success is often limited by how a patient's nervous system and brain process chronic pain, as well as psychological factors like anxiety and excessive worrying about pain, also known as catastrophizing.\n\nTo improve outcomes, this study combines SCS therapy with Pain Neuroscience Education (PNE). PNE is an educational approach that teaches patients how the brain and nervous system handle pain signals, reframing pain as a process that can be changed rather than just ongoing tissue damage. The goal of this pilot trial is to test the feasibility of using virtual, remote PNE sessions to help patients reduce pain catastrophizing and anxiety, while building overall psychological resilience. Additionally, the study explores an innovative, objective way to monitor pain levels by analyzing short voice recordings. Researchers want to see if specific vocal features change when a person's pain is well-controlled versus when it is uncontrolled.\n\nParticipants enrolled in this study will receive either 1) standard spinal cord stimulation or 2) spinal cord stimulation plus the intervention--a virtual, multi-session PNE delivered remotely over a secure telehealth platform. Throughout the study, participants will complete standard clinical surveys to measure their physical function, anxiety, pain catastrophizing, and emotional resilience using standardized tools. Participants will also provide short voice recordings, such as holding a sustained \"\u002Fah\u002F\" vowel sound, during their virtual assessments. This allows researchers to safely evaluate the direct relationship between subtle voice patterns and reported clinical pain levels.",[64,180,181,182,183,28],"Chronic Pain Due to Injury","Failed Back Syndrome","Persistent Spinal Pain Syndrome","Chronic Leg Pain",[185,186,187,188,189,190,191,192,193,194,195,196],"spinal cord stimulation","neuromodulation","pain neuroscience education","pain science education","telehealth","virtual behavioral health","acoustic biomarker","voice analysis","pain catastrophizing","psychological resilence","anxiety and depression","physical therapy","2026-07-31",{"date":199,"type":44},"2026-08-04",{"date":201,"type":23},"2026-07-27",{"date":203,"type":23},"2028-06-30",{"name":205,"class":51},"University of Arkansas",{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":92,"enrollmentInfo":213,"targetDuration":4,"studyType":95,"phases":215,"briefSummary":216,"conditions":217,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":52},"100649970","electroacupuncture-on-neck-muscle-stiffness-in-chronic-neck-pain-100649970","NCT07741227","Electroacupuncture on Neck Muscle Stiffness in Chronic Neck Pain","The Immediate Effect of Electroacupuncture on Neck Muscle Stiffness in Individuals With Chronic Neck Pain","Inclusion Criteria:\n\n1. Aged 18-65 years\n2. Chronic non-specific neck pain persisting for ≥3 months\n3. Average pain intensity ≥3 on a 0-10 Numeric Rating Scale over the past week\n4. Pain primarily located in the posterior cervical region, which may radiate to the upper trapezius muscles\n5. Able to provide informed consent and sufficient language proficiency to complete questionnaires\n\nExclusion Criteria:\n\n1. Specific pathological causes for neck pain (cervical radiculopathy or myelopathy, fracture, infection, tumour, systemic rheumatic disease)\n2. History of neck or shoulder surgery\n3. Contraindications to acupuncture (severe needle phobia, bleeding disorders, pregnancy)\n4. Received acupuncture or other physical therapy for neck pain within the past 6 months",{"count":214,"type":23},66,[97],"This randomized, single-blind, placebo-controlled clinical trial aims to investigate the immediate physiological effects of a single session of electroacupuncture (EA) on neck muscle stiffness in individuals with chronic neck pain. While acupuncture is a widely used complementary therapy for musculoskeletal pain, high-quality, objective evidence demonstrating its immediate effects on muscle biomechanics remains limited. This study will utilize Shear Wave Elastography (SWE)-a non-invasive, objective ultrasound-based technology-to measure these changes.\n\nAdult participants aged 18 to 65 with non-specific chronic neck pain (lasting\n\n≥ 3 months) will be randomly allocated into one of two groups:\n\n1. True Electroacupuncture (EA) Group: Participants will receive a 20-minute session of active electroacupuncture with comfortable electrical stimulation at specific neck and tender points.\n2. Sham Acupuncture (Placebo) Group: Participants will receive a 20-minute session of non-penetrating sham acupuncture with a deactivated electroacupuncture device to ensure participant blinding.\n\nThe primary objective is to evaluate immediate changes in the stiffness of the upper trapezius muscle, measured objectively via SWE (as Young's Modulus in kPa) before and immediately after the intervention. Secondary objectives include assessing immediate post-treatment changes in subjective pain and stiffness (Visual Analogue Scale), Pressure Pain Threshold (PPT), and active Cervical Range of Motion (CROM), alongside a 7-day post-intervention follow-up questionnaire on neck function.",[28],"2026-07-28",{"date":220,"type":44},"2026-08-03",{"date":222,"type":44},"2026-05-01",{"date":224,"type":23},"2026-10-30",{"name":226,"class":51},"The Hong Kong Polytechnic University",{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":17,"sex":18,"minAge":234,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":238,"conditions":239,"keywords":241,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":52},"100647743","association-between-periodontal-disease-and-chronic-neck-pain-100647743","NCT07711431","Association Between Periodontal Disease and Chronic Neck Pain","Evaluation of the Association Between Periodontal Diseases and Chronic Non-Specific Neck Pain and Functional Disability: A Cross-Sectional Study","Inclusion Criteria:\n\n* Aged between 30 and 55 years\n* Willing to participate and provide written informed consent\n* Able to undergo periodontal examination and complete self-report questionnaires\n\nExclusion Criteria:\n\n* Neck pain attributable to a specific identifiable cause (e.g., trauma, cervical disc herniation, spinal deformity, tumor, fracture)\n* Systemic inflammatory or autoimmune disease\n* Neurological disease affecting the cervical region\n* Pregnancy\n* Regular use of analgesic or anti-inflammatory medication\n* Fewer than 20 remaining natural teeth\n* History of periodontal treatment within the past 6 months","30 Years","55 Years",{"count":237,"type":23},123,"This study investigates whether there is an association between periodontal disease (gum disease) and chronic neck pain and related functional disability. Participants aged 30-55 years will be grouped based on their periodontal health status (healthy, gingivitis, or periodontitis). Neck pain intensity will be assessed using the Visual Analog Scale (VAS), and functional disability will be measured using the Neck Disability Index (NDI). The study aims to determine whether periodontal disease severity is linked to the severity of neck pain and disability, which may help clarify a potential connection between oral health and musculoskeletal health.",[240,28],"Periodontal Disease",[240,242,243,244,134,245,246],"Gingivitis","Periodontitis","Neck Pain","Oral Health","Musculoskeletal Pain","2026-07-14",{"date":249,"type":44},"2026-07-17",{"date":251,"type":44},"2026-07-11",{"date":253,"type":23},"2026-09-15",{"name":255,"class":51},"Nigde Omer Halisdemir University",{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":262,"eligibilityCriteria":263,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":95,"phases":267,"briefSummary":268,"conditions":269,"keywords":273,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":282,"completionDateStruct":283,"leadSponsor":285,"locationsCount":52},"100645479","effects-of-different-myofascial-release-techniques-on-function-in-chronic-non-specific-neck-pain-100645479","NCT07694882","Effects of Different Myofascial Release Techniques on Function in Chronic Non-Specific Neck Pain","Investigation of the Effects of Different Myofascial Release Techniques on Functional Outcomes in Individuals With Chronic Non-Specific Neck Pain","MFR \u002F CNNP","Inclusion Criteria:\n\n* Neck pain persisting for at least 3 months and diagnosed as chronic non-specific neck pain by a specialist physician\n* Aged between 18 and 45 years\n* Perceived pain affecting daily living activities (VAS at least 3)\n* Presence of myofascial trigger points in the upper-quarter muscles\n\nExclusion Criteria:\n\n* Specific serious cervical spine pathology (radiculopathy, myelopathy, severe nerve root compression, spondylosis, and similar)\n* History of rheumatologic, neurologic, or systemic disease (for example, acute inflammation, multiple sclerosis, Parkinson's disease, rheumatoid arthritis, fibromyalgia, or cancer)\n* History of trauma, fracture, or surgery involving the neck, shoulder, or upper extremity\n* Pregnancy or breastfeeding\n* Any diagnosed psychiatric disorder (for example, major depression or anxiety disorder) or regular use of psychopharmacological medication\n* Use of systemic analgesics, NSAIDs, or muscle relaxants within the last 7 days for pain control\n* Any physiotherapy, manual therapy, or injection treatment to the neck region within the last 3 months","45 Years",{"count":266,"type":23},84,[97],"This single-center, three-arm randomized controlled trial compares the effects of different myofascial release techniques, combined with a structured exercise program, on functional outcomes in individuals with chronic non-specific neck pain (CNNP).\n\nEligible participants (aged 18 to 45 years, neck pain for at least 3 months, pain intensity VAS at least 3, and myofascial trigger points in the upper-quarter muscles) are allocated by simple randomization into three groups:\n\n* Conventional Therapy Group: hot pack, conventional TENS, and a structured exercise program.\n* Manual Myofascial Release Group: conventional therapy plus therapist-applied manual myofascial release.\n* Self-Myofascial Release Group: conventional therapy plus supervised self-applied myofascial release using a duo-ball, balls, and a massage stick\u002Fcane.\n\nAll interventions are delivered 3 days per week for 6 weeks. The primary outcome is pain intensity. Secondary outcomes include pressure pain threshold and tolerance, cervical range of motion, muscle stiffness, craniovertebral angle, cervical proprioception, muscle strength and endurance, disability, neck awareness, multidimensional biopsychosocial status, sleep quality, quality of life, and kinesiophobia. The aim is to determine whether manual or self-applied myofascial release, added to exercise, produces greater functional improvement in people with chronic non-specific neck pain.",[28,270,271,272],"Non-specific Neck Pain","Myofascial Trigger Points","Myofascial Pain Syndrome - Neck",[274,275,276,277,278,279],"chronic non-specific neck pain","myofascial release","manual therapy","trigger points","therapeutic exercise","physiotherapy","2026-07-13",{"date":247,"type":44},{"date":247,"type":44},{"date":284,"type":23},"2026-12-31",{"name":286,"class":51},"Eastern Mediterranean University",{"id":288,"slug":289,"hasResults":12,"nctId":290,"briefTitle":291,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":293,"enrollmentInfo":294,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":296,"conditions":297,"keywords":298,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":52},"100645784","the-correlation-between-central-conduction-time-and-central-pain-syndrome-in-chronic-neck-pain-100645784","NCT07698691","The Correlation Between Central Conduction Time and Central Pain Syndrome in Chronic Neck Pain","Inclusion Criteria:\n\n* Participants aged 18-35 years.\n* Normal Body Mass Index (BMI) less than 25 kg\u002Fm2.\n* Both genders were included.\n* having chronic neck pain lasting for more than three months.\n\nExclusion Criteria:\n\n* signs of serious pathology (e.g., malignancy, inflammatory disorders, infection).\n* history of cervical spine surgery.\n* history of trauma or fractures in the cervical spine.\n* presence of vascular syndromes such as vertebrobasilar insufficiency.","35 Years",{"count":295,"type":23},120,"To investigate the neurophysiological relationship between Central Conduction Time measured via Somatosensory evoked potentials and pain intensity in individuals suffering from chronic neck pain",[28],[299,300,28],"Central Conduction Time","Central Pain Syndrome","2026-07-07",{"date":280,"type":44},{"date":304,"type":23},"2026-07-10",{"date":306,"type":23},"2026-09-01",{"name":308,"class":51},"Cairo University",{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":92,"enrollmentInfo":316,"targetDuration":4,"studyType":95,"phases":318,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":327,"locationsCount":52},"100630462","acute-effects-of-motor-imagery-and-motor-control-exercises-in-individuals-with-chronic-neck-pain-100630462","NCT07487987","Acute Effects of Motor Imagery and Motor Control Exercises in Individuals With Chronic Neck Pain","Comparison of the Acute Effects of Motor Imagery and Motor Control Exercises in Individuals With Chronic Neck Pain","Inclusion Criteria:\n\n* Neck pain lasting at least 12 weeks,\n* VAS score of at least 3 cm,\n* Standardized Mini Mental Test score of at least 24.\n\nExclusion Criteria:\n\n* History of cervical surgery,\n* neurological deficit,\n* malignancy,\n* rheumatic diseases,\n* having received physical therapy for the neck region within the last 3 months",{"count":317,"type":23},40,[97],"The aim of this study is to compare the effects of single-session motor imagery and motor control exercises on pain, pressure pain threshold, cervical proprioception, and motor imagery in individuals with chronic neck pain.",[28],"2026-07-01",{"date":323,"type":44},"2026-07-02",{"date":325,"type":44},"2026-03-10",{"date":109,"type":23},{"name":328,"class":51},"KTO Karatay University",{"id":330,"slug":331,"hasResults":12,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":20,"enrollmentInfo":336,"targetDuration":4,"studyType":95,"phases":338,"briefSummary":339,"conditions":340,"keywords":341,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":52},"100641610","longitudinal-stripping-massage-vs-percussion-device-for-neck-pain-ultrasound-study-100641610","NCT07630142","Longitudinal Stripping Massage vs. Percussion Device for Neck Pain: Ultrasound Study.","The Effect of Percussion Therapy on Neck Functional Disability, Pain and Upper Trapezius Muscle Properties Assessed by Elastography and Doppler Ultrasound in Patients With Neck Pain.","Inclusion Criteria:\n\n* Age: 18-60 years\n* Neck pain persisting for at least 3 months\n* Visual Analog Scale (VAS) score between 3 and 7\n* Neck Disability Index (NDI) between 30% and 48%\n\nExclusion Criteria:\n\n* Pregnancy and postpartum period\n* History of cervical spine or shoulder surgery\n* Diagnosed fibromyalgia, radiculopathy, or myelopathy\n* Myofascial therapy within the last 3 months\n* Use of analgesic medication within 48 hours before assessment\n* Venous diseases",{"count":337,"type":23},35,[97],"This study evaluates whether a single session of percussion therapy can reduce muscle tension and increase blood flow in the transverse cervical artery in individuals with neck pain. The investigators will evaluate muscle stiffness using ultrasound elastography, and assess blood flow in the transverse cervical artery via Doppler imaging before and after treatment. The primary objective is to determine how this therapy affects neck muscle relaxation and vascular responses, specifically within the upper trapezius region.",[28],[342,343,344,345,346,347,348,349],"neck pain","longitudinal stripping massage","percussion massage","trapezius","elastography","shear wave","Doppler ultrasound","cervical pain","2026-06-14",{"date":352,"type":44},"2026-06-17",{"date":354,"type":23},"2026-06-01",{"date":356,"type":23},"2029-06-01",{"name":358,"class":51},"Poznan University of Physical Education",{"id":360,"slug":361,"hasResults":12,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":365,"eligibilityCriteria":366,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":367,"targetDuration":4,"studyType":95,"phases":369,"briefSummary":370,"conditions":371,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":380,"locationsCount":52},"100637894","cervical-medial-branch-block-versus-ipsilateral-cervical-erector-spinae-plane-block-100637894","NCT07595406","Cervical Medial Branch Block Versus Ipsilateral Cervical Erector Spinae Plane Block","Ultrasound-Guided Cervical Medial Branch Block Versus Ipsilateral Cervical Erector Spinae Plane Block in Cervical Facetogenic Pain: A Prospective Randomized Controlled Study","CERVESP","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Chronic neck pain lasting at least 3 months\n* Clinical findings suggestive of cervical facetogenic pain\n* Numeric Rating Scale pain score ≥4\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Cervical radiculopathy or myelopathy\n* Major neurological deficit\n* Infection at the injection site\n* Coagulopathy or anticoagulant therapy contraindicating intervention\n* Allergy to local anesthetics\n* Pregnancy\n* Previous cervical interventional pain procedure within the last 3 months\n* Severe psychiatric disease",{"count":368,"type":23},130,[97],"This prospective randomized controlled study aims to compare the analgesic effectiveness of ultrasound-guided cervical medial branch block and ipsilateral cervical erector spinae plane block in patients with cervical facetogenic pain.\n\nPatients with chronic cervical facet-mediated pain will be randomized into two intervention groups. Pain intensity, functional status, meaningful pain response rates, analgesic consumption, and patient satisfaction will be evaluated during follow-up.\n\nThe primary objective is to determine whether cervical erector spinae plane block provides comparable short-term pain relief to cervical medial branch block.",[372,28,373],"Cervical Facetogenic Pain","Cervical Facet Joint Syndrome","2026-05-12",{"date":376,"type":44},"2026-05-19",{"date":378,"type":23},"2026-05-31",{"date":284,"type":23},{"name":381,"class":51},"Ankara City Hospital Bilkent",{"id":383,"slug":384,"hasResults":12,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":4,"enrollmentInfo":389,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":391,"conditions":392,"keywords":393,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":405,"locationsCount":52},"100633351","kinesiophobia-pain-and-disability-in-chronic-neck-pain-100633351","NCT07525557","Kinesiophobia, Pain and Disability in Chronic Neck Pain","Kinesiophobia As A Mediator Of The Association Between Pain Intensity And Disability In Chronic Neck Pain","Inclusion Criteria:\n\n* Individuals aged 18 years or older\n* Presence of chronic neck pain lasting at least 3 months\n* Ability to understand and complete questionnaires\n* Voluntary participation\n\nExclusion Criteria:\n\n* Acute neck pain (\\\u003C 3 months)\n* History of cervical spine surgery\n* Neurological disease or cervical radiculopathy\n* Inflammatory, neoplastic, or traumatic conditions affecting the neck\n* Cognitive impairment preventing questionnaire completion",{"count":390,"type":23},250,"This study aims to investigate the mediating role of kinesiophobia in the relationship between pain intensity and disability in individuals with chronic neck pain. Chronic neck pain is a multidimensional clinical condition influenced not only by biological factors but also by psychological components such as fear of movement. Understanding the mechanisms underlying disability may contribute to more targeted rehabilitation strategies. Participants with chronic neck pain lasting at least three months will be assessed using validated self-report questionnaires measuring pain intensity, kinesiophobia, disability, and physical activity levels.",[28],[132,64,246,394,395,396,397,398],"Disability Evaluation","Pain Measurement","Fear Avoidance","Neck Disability Index","Tampa Scale of Kinesiophobia","2026-05-07",{"date":401,"type":44},"2026-05-11",{"date":403,"type":44},"2026-04-10",{"date":321,"type":23},{"name":406,"class":51},"Ondokuz Mayıs University",{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":92,"enrollmentInfo":414,"targetDuration":4,"studyType":95,"phases":416,"briefSummary":417,"conditions":418,"keywords":419,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":428,"leadSponsor":429,"locationsCount":4},"100639288","mindfulness-plus-supervised-rehabilitation-vs-supervised-rehabilitation-alone-for-chronic-neck-pain-in-office-workers-100639288","NCT07576556","Mindfulness Plus Supervised Rehabilitation vs Supervised Rehabilitation Alone for Chronic Neck Pain in Office Workers","Effect of Mindfulness Combined With Supervised Rehabilitation Versus Supervised Rehabilitation Alone in Office Workers With Chronic Neck Pain: Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* Office workers aged 18 years or older\n* diagnosed with chronic neck pain for more the three months\n\nExclusion Criteria:\n\n* history of neck surgery\n* history of cervical trauma\n* history of neurological disorders affecting the neck or upper extremities\n* currently receiving other treatments for neck pain, such as injections or surgical interventions\n* Participants with significant psychiatric disorders that could interfere with study participation or adherence to the intervention",{"count":415,"type":23},48,[97],"The goal of this clinical trial is to learn if adding mindfulness to supervised rehabilitation exercises improves outcomes in office workers with chronic neck pain. It will also evaluate the impact of this combined approach on psychosocial factors and quality of life. The main questions it aims to answer are:\n\nDoes mindfulness combined with supervised exercises reduce neck pain intensity more than supervised exercises alone? Does the combined intervention improve neck-related disability, psychosocial outcomes, and quality of life?\n\nResearchers will compare a mindfulness-based intervention plus supervised rehabilitation exercises to supervised rehabilitation exercises alone to determine whether the combined approach provides additional benefit.\n\nParticipants will:\n\nBe randomly assigned to receive either mindfulness plus supervised exercises or supervised exercises alone for 8 weeks Attend weekly 60-minute mindfulness sessions (experimental group only) and twice-weekly supervised exercise sessions Undergo assessments at the beginning and at the end of the intervention period",[28],[420,421,342,422,423],"office workers","supervised exercise","stress","mindfulness","2026-05-02",{"date":426,"type":44},"2026-05-08",{"date":222,"type":23},{"date":284,"type":23},{"name":430,"class":51},"University of Monastir",{"id":432,"slug":433,"hasResults":12,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":293,"enrollmentInfo":438,"targetDuration":4,"studyType":95,"phases":439,"briefSummary":440,"conditions":441,"keywords":442,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":450,"leadSponsor":452,"locationsCount":52},"100633811","respiratory-exercises-versus-deep-neck-flexor-training-in-chronic-mechanical-neck-pain-100633811","NCT07531537","Respiratory Exercises Versus Deep Neck Flexor Training in Chronic Mechanical Neck Pain","Effect of Respiratory Muscle Exercises Versus Deep Neck Flexor Training on Pain, Function and Neck Muscle Endurance in Patients With Chronic Mechanical Neck Pain","Inclusion Criteria:\n\n1. Patients have mechanical neck pain lasting longer than three months.\n2. The ages of patients range from 18 to 35 years.\n3. Patients are lifetime non-smoker and non-alcoholic.\n\nExclusion Criteria:\n\n1. History of trauma or cervical spine fractures.\n2. Previous spinal surgery.\n3. Any inflammatory pathology.\n4. Any cervical disc pathology and neurological signs.\n5. Malignancy.\n6. Cervical radiculopathy.\n7. Rheumatoid arthritis.\n8. Pregnant female.\n9. Currently using muscle relaxation medication.\n10. History of respiratory and cardiovascular illness",{"count":214,"type":23},[97],"This study will be conducted to compare the effect of adding respiratory exercises versus deep neck flexor training to conventional program on pain, cervical ROM, cervical muscle endurance, function, and chest expansion in patients with chronic mechanical neck pain. Sixty-six (66) of both genders ranging in age from 18 to 35 years old, with a history of mechanical neck pain longer than 3 months (chronic neck pain) will be invited to participate in this study. Participants will be randomly assigned into one of the three experimental groups as follow:\n\nGroup A will receive respiratory exercises in form of diaphragmatic breathing \\& respiratory muscle stretch gymnastics plus conventional program.\n\nGroup B will receive deep neck flexor training in the form of low-load craniocervical flexion using feedback from an air-filled pressure sensor placed behind the neck plus conventional program.\n\nGroup C (control group) will receive conventional program in form of TENS, infrared, isometric neck strengthening exercises and stretching exercises.",[28],[443,444,445],"chronic neck pain","deep neck flexor training","respiratory exercises","2026-04-20",{"date":448,"type":44},"2026-04-22",{"date":325,"type":44},{"date":451,"type":23},"2026-12",{"name":308,"class":51},{"id":454,"slug":455,"hasResults":12,"nctId":456,"briefTitle":457,"officialTitle":458,"acronym":4,"eligibilityCriteria":459,"healthyVolunteers":17,"sex":18,"minAge":59,"maxAge":264,"enrollmentInfo":460,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":462,"conditions":463,"keywords":466,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":470,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":52},"100628987","masseter-muscle-thickness-in-individuals-with-chronic-neck-pain-100628987","NCT07468786","Masseter Muscle Thickness in Individuals With Chronic Neck Pain","Comparison of Masseter Muscle Thickness Measured by Ultrasonography in Individuals With Chronic Neck Pain Compared to Healthy Individuals","Inclusion Criteria:\n\n* Be between the ages of 18 and 45\n* Have neck pain that has persisted for at least 3 months\n* Agree to participate in the study voluntarily and provide written informed consent\n\nExclusion Criteria:\n\n* History of cervical spine surgery or severe trauma\n* Diagnosis of cervical radiculopathy, myelopathy, or neurological disease\n* Rheumatic, inflammatory, or systemic musculoskeletal diseases\n* Diagnosed temporomandibular joint disorder (TMD)\n* Diagnosis of bruxism or a pronounced habit of teeth clenching\u002Fgrinding\n* History of manual therapy, injection, or surgical intervention in the face, jaw, or neck region within the last 6 months\n* Currently undergoing orthodontic treatment or history of orthodontic treatment within the last 6 months\n* Cognitive impairment or conditions that prevent understanding and responding to questionnaires",{"count":461,"type":23},90,"The primary objective of our study is to compare the thickness of the masseter muscle, measured by ultrasound, in individuals with chronic neck pain to that of healthy individuals. The secondary objective of the study is to examine the relationships between masseter muscle thickness and pain intensity, neck disability level, pain catastrophizing level, and clinical diagnostic criteria in individuals with chronic neck pain.",[464,465,28],"Masseter Muscle","Ultrasonographic",[443,467,468],"Ultrasonographic measurement","Masseter muscle","2026-03-09",{"date":471,"type":44},"2026-03-13",{"date":473,"type":23},"2026-03-20",{"date":475,"type":23},"2026-05-20",{"name":477,"class":51},"Hasan Kalyoncu University",{"id":479,"slug":480,"hasResults":12,"nctId":481,"briefTitle":482,"officialTitle":482,"acronym":4,"eligibilityCriteria":483,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":484,"enrollmentInfo":485,"targetDuration":4,"studyType":95,"phases":487,"briefSummary":488,"conditions":489,"keywords":491,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":52},"100618532","symmetrical-scapula-pelvis-proprioceptive-neuromuscular-facilitation-and-superficial-back-line-in-chronic-neck-pain-with-hamstring-tightness-100618532","NCT07332845","Symmetrical Scapula-pelvis Proprioceptive Neuromuscular Facilitation and Superficial Back Line in Chronic Neck Pain With Hamstring Tightness","Inclusion Criteria:\n\n* Individual with both male and female gender\n* Individuals with chronic neck pain (pain for \\> 3 month) with hamstring tightness\n\nExclusion Criteria:\n\n* Any history related to spinal surgery\n* Previous administration of epidural injections\n* Neck pain due to specific pathology\n* Patients with radiculopathy or myelopathy\n* Traumatic spinal cord injury\n* Neck pain associated with progressive neurological deficit or loss of strength","40 Years",{"count":486,"type":23},156,[97],"A research study will be conducted at Physiotherapy department of the Sindh Institute of Physical Medicine and Rehabilitation, Karachi, Pakistan. Overall 156 patients with 18-40 years old individuals with neck pain will be eligible and they will be included through non-probability, purposive sampling technique. The written informed consent will be taken from all the patients. They will be divided through Simple random sampling (computer generated software) method into two groups, 78 in each group. Group A (experimental group) will receive PNF Symmetrical Scapula-Pelvis Patterns (PNF-SSPP), group B (control group) will receive sub occipital muscle inhibition technique (SMI) and static stretching (SS) of hamstring muscle. All participants will be assessed using assessment form. Outcome measures will be Pain, disability, disability, neck range of motions, hamstring tightness, head posture, and levator scapulae index. An independent assessor blinded to the treatment will assess all the patients for treatment outcome assessment at baseline, after first session and post treatment. Treatment sessions will be given thrice a week for 6 weeks.",[28,490,244],"Hamstring Muscle Tightness",[492,493,494,495,496],"neck ache","Exercise","Muscle Stretching","Muscle Inhibition","PNF","2026-03-08",{"date":325,"type":44},{"date":500,"type":44},"2026-01-16",{"date":502,"type":23},"2026-11-26",{"name":504,"class":51},"University of Karachi",{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":12,"sex":18,"minAge":512,"maxAge":92,"enrollmentInfo":513,"targetDuration":4,"studyType":95,"phases":515,"briefSummary":516,"conditions":517,"keywords":518,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":52},"100626191","effects-of-different-exercise-protocols-on-physical-and-cognitive-changes-in-people-with-chronic-neck-pain-100626191","NCT07432425","Effects of Different Exercise Protocols on Physical and Cognitive Changes in People With Chronic Neck Pain","Effects of Different Exercise Protocols on Physical Status, Cognitive Functions, Brain Structure, and Blood Biomarkers in People With Chronic Neck Pain","Inclusion Criteria:\n\n* Participants aged 20-65\n* Having neck pain at least 3 months and rated as 3 or more according to the Numeric Rating Scale\n* Having a score of 10 or more according to the Neck Disability Index\n* Having a score of 24 or above according to the Mini Mental State Examination\n* Right hand dominancy according to Edinburgh Handedness Inventory\n* Having at least a primary school graduate\n\nExclusion Criteria:\n\n* Having neuropsychiatric, neurologic, metabolic, cardiovascular, and inflammatory disease(s)\n* Participating in a rehabilitation program for neck pain in the last 6 months\n* Having an exercise or sports history of 6 months or more\n* Presence of brain parenchymal lesion on MRI\n* Presence of materials in the body such as jewelry, metal, hearing aid, pacemaker, lead that cannot be removed and are not suitable for MRI\n* History of neck or shoulder surgery\n* Being pregnant or having given birth within the last year","20 Years",{"count":514,"type":23},21,[97],"This study aims to investigate the effects of different exercise approaches on physical status, cognitive functions, brain structures, and blood biomarkers in individuals with chronic neck pain.",[244,28],[244,493,519,520,521,522],"Cognition","Neuropsychological test","Neuroimaging","Enzyme-linked immunosorbent assay","2026-02-19",{"date":525,"type":44},"2026-02-25",{"date":527,"type":44},"2025-05-01",{"date":529,"type":23},"2026-03-30",{"name":531,"class":51},"Hacettepe University",{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":4,"eligibilityCriteria":538,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":92,"enrollmentInfo":539,"targetDuration":4,"studyType":95,"phases":540,"briefSummary":541,"conditions":542,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":543,"lastUpdatePostDateStruct":544,"startDateStruct":546,"completionDateStruct":548,"leadSponsor":550,"locationsCount":52},"100625130","kinematic-training-in-patients-with-neck-pain-based-on-machine-learning-classification-approach-100625130","NCT07418632","Kinematic Training in Patients With Neck Pain Based on Machine Learning Classification Approach","What is the Ability of Datamining Approaches to Cluster Patients With Idiopathic Neck Pain and Can Machine Learning Algorithms Provide More Efficient Rehabilitation and Less Recurrence Based on Kinaesthetic Training Protocols","Inclusion Criteria:\n\n* presence of neck pain\n* pain level minimum 3 of 10 on VAS\n* did not receive conventional physiotherapy in last 6 months\n\nExclusion Criteria:\n\n* any upper extremity pain within last 2 years\n* any neurological or vestibular dissorders\n* type 2 diabetes\n* diagnosed psychiatric dissorders\n* medication or alcohol consumptin in last 30 hours",{"count":5,"type":23},[97],"The goal of this clinical trial is to study if kinematic training based on novel kinematic assessment clasification approach can decrease chronic neck pain and prevent its reoccurance better than conventional kinematic training in adults. The main question\\[s\\] it aims to answer \\[is\u002Fare\\]:\n\nDoes clustering patients with neck pain based on head and neck movement characteristics lead to more efficient kinematic rehabilitation training and improved clinical outcomes\n\nResearchers will compare effects of cluster specific kinematic training to see if it effects pain levels and its reoccurance.\n\nParticipants will \\[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\\].",[28],"2026-02-13",{"date":545,"type":44},"2026-02-18",{"date":547,"type":23},"2026-03-18",{"date":549,"type":23},"2026-09-20",{"name":551,"class":51},"University of Ljubljana",{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":556,"acronym":557,"eligibilityCriteria":558,"healthyVolunteers":12,"sex":18,"minAge":59,"maxAge":559,"enrollmentInfo":560,"targetDuration":4,"studyType":95,"phases":562,"briefSummary":563,"conditions":564,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":566,"lastUpdatePostDateStruct":567,"startDateStruct":569,"completionDateStruct":571,"leadSponsor":572,"locationsCount":4},"100623313","the-effectiveness-of-dynamic-neuromuscular-stabilization-dns-exercises-compared-to-localized-exercises-and-standard-care-on-pain-intensity-neck-dysfunction-and-upper-cervical-range-of-motion-in-patients-with-chronic-neck-pain-a-pilot-randomized-controlled-trial-rct-100623313","NCT07395011","The Effectiveness of Dynamic Neuromuscular Stabilization (DNS) Exercises Compared to Localized Exercises and Standard Care on Pain Intensity, Neck Dysfunction, and Upper Cervical Range of Motion in Patients With Chronic Neck Pain: A Pilot Randomized Controlled Trial (RCT)","DYNEX","Inclusion Criteria:\n\n* between 18 and 50 years of age. This ensures a homogeneous population that in-cludes both young adults and middle-aged individuals.\n* have suffered from neck pain continuously for at least 12 weeks, as described by the International Association for the Study of Pain (IASP)\n* have current neck pain greater than 40 on the Numeric Rating Scale (NRS) (on a scale of 0 to 100).\n* have an NDI score of over 10 points.\n\nExclusion Criteria: -\n\n* Cancer\n* Patients with existing or previous fractures in the cervical spine\n* Patients who have undergone surgery on the cervical spine\n* Patients who, in addition to neck pain, also have or have had dizziness or balance disorders\n* People with osteoporosis\n* Fibromyalgia\n* People with diagnosed rheumatoid arthritis\n* People with red flags identified during a thorough physical examination\n* Patients with neurological deficits identified during a thorough physical examination\n* Participants who have undergone physiotherapy within the last 3 months.","50 Years",{"count":561,"type":23},45,[97],"Many people experience long-lasting neck pain, which can affect daily life, work, and overall well-being. This study aims to find out which type of exercise program is most effective in reducing neck pain, improving neck movement, and making daily activities easier.\n\nWhat Is Being Studied?:\n\nThe study compares three different types of treatment:\n\nDNS Exercises (Dynamic Neuromuscular Stabilization):\n\nWhole-body exercises focusing on posture, breathing, and core stability.\n\nLocalized Neck Exercises:\n\nTargeted exercises for the neck and shoulder muscles.\n\nStandard Care:\n\nUsual physiotherapy treatment commonly provided in clinical practice.\n\nStudy Procedures:\n\nParticipants are randomly assigned to one of the three groups. Each participant receives individual exercise instruction from a physiotherapist.\n\nParticipants are also given simple home exercises to perform on their own. The study lasts for about 12 weeks.\n\nWhat Will Be Measured?:\n\nAt the beginning, during, and at the end of the study, the following will be assessed:\n\nNeck pain intensity (pain scale) Neck range of motion How much the pain affects daily life and activities\n\nPossible Benefits:\n\nParticipants may experience:\n\nLess neck pain Improved neck mobility Better overall body awareness Even if not every participant notices improvement, taking part will help researchers improve future treatment options for chronic neck pain.\n\nRisks:\n\nNo major risks are expected. All exercises are supervised by qualified physiotherapists and adjusted to each participant's abilities.\n\nParticipation can be stopped at any time if discomfort or pain occurs.\n\nVoluntary Participation and Data Privacy:\n\nParticipation is completely voluntary. All personal data will be kept confidential and analyzed anonymously for research purposes only.\n\nParticipants may withdraw from the study at any time without any disadvantages.",[244,157,28,565,134],"Neck Disease","2026-01-31",{"date":568,"type":44},"2026-02-09",{"date":570,"type":23},"2026-02-02",{"date":284,"type":23},{"name":573,"class":51},"Hochschule Osnabruck",{"id":575,"slug":576,"hasResults":12,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":580,"eligibilityCriteria":581,"healthyVolunteers":12,"sex":18,"minAge":512,"maxAge":264,"enrollmentInfo":582,"targetDuration":4,"studyType":95,"phases":583,"briefSummary":584,"conditions":585,"keywords":586,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":594,"lastUpdatePostDateStruct":595,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":601,"locationsCount":52},"100586681","progressive-muscle-relaxation-vs-muscle-energy-technique-on-nonspecific-neck-pain-in-prolonged-computer-users-100586681","NCT06918535","Progressive Muscle Relaxation Vs Muscle Energy Technique on Nonspecific Neck Pain in Prolonged Computer Users.","Progressive Muscle Relaxation Vs Muscle Energy Technique on Nonspecific Neck Pain in Prolonged Computer Users. A Randomized Controlled Trial","RCT","Inclusion Criteria:\n\n* Persons using computer more than 6 hours throughout the day, intermittently both genders.\n* Age between 20-45.\n* Hypertonicity of trapezius muscle and SCM muscle. Specifically, those workers have neck pain and stiffness (including trouble tilting or turning head). Patients who reported small tightening and spasm at the posterior aspect of their neck are included, also associated with more diffuse neck pain patterns that included the following: headache, (upper back, neck and shoulder pain) numbness\u002F tingling in the hand\u002Farm.\n* Pain intensity of 2 on the NRS and presence of at least one latent trigger point in a taut band in the neck region.\n\nExclusion Criteria:\n\n* Recent trauma to the cervical region\n* Exclusion criteria based on with any serious pathology such as specific neck pain due to disc prolapsed, tumor of cervical spine, whiplash injury, cervical fractures, Cervicogenic headache, and any neurological signs consistent with nerve root compression",{"count":123,"type":23},[97],"The objective of this randomized controlled trial is to assess the potential effectiveness of Progressive muscle relaxation technique (PMRT) vs Muscle energy technique (MET) as an intervention for releasing trigger points in SCM and upper trapezius in prolonged computer users. The study will be conducted in a workplace setting, where desk-type computer users are expected to regularly engage in their professional activities for ≥ 6 hours throughout the day, intermittently. This study will be conducted at the Outpatient Physiotherapy department of Sindh Institute of Physical Medicine and Rehabilitation, Karachi among 60 patients with nonspecific chronic neck pain on the basis of non-probability purposive sample technique. After taking informed consent, all participants will be randomly allocated into two groups through a investigator (blinded) the same investigator will be screening the individuals, doing baseline assessment, and post treatment assessment while another investigator will be providing intervention. Group 1 will receive Progressive muscle relaxation technique while Group 2 will receive Muscle Energy Technique on sternocleidomastoid and upper trapezius bilaterally. Patients will also be blinded. A total of 12 sessions will be provided. Outcomes will be assessed at baseline and post treatment after 2 weeks intervention.",[244,28],[587,588,589,590,342,443,591,592,593],"chronic pain","Computer user","Muscle relaxation","Progressive muscle relaxation,","Sternocleidomastoid muscle","Trapezius","neck pain musculoskeletal","2026-01-06",{"date":596,"type":44},"2026-01-08",{"date":598,"type":44},"2025-04-22",{"date":600,"type":23},"2026-04-30",{"name":602,"class":51},"IQRA University",{"id":604,"slug":605,"hasResults":12,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":4,"eligibilityCriteria":609,"healthyVolunteers":12,"sex":18,"minAge":610,"maxAge":611,"enrollmentInfo":612,"targetDuration":4,"studyType":95,"phases":613,"briefSummary":614,"conditions":615,"keywords":616,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":625,"completionDateStruct":627,"leadSponsor":629,"locationsCount":52},"100618179","effects-of-post-isometric-relaxation-as-compared-to-post-isometric-stretching-muscle-energy-technique-in-the-management-of-neck-pain-a-randomized-controlled-trial-100618179","NCT07328256","Effects of Post Isometric Relaxation as Compared to Post Isometric Stretching Muscle Energy Technique in the Management of Neck Pain: a Randomized Controlled Trial","Effects of Post Isometric Relaxation as Compared to Post Isometric Stretching Muscle Energy Technique in the Management of Neck Pain","Inclusion Criteria: • Age ranging from 19-44 years old\n\n* Both gender\n* With sub-acute or chronic neck pain for at least 4 to 12 weeks\n* Pain intensity on NPRS ranging 4-8\n* Limitation on neck movement\n\nExclusion Criteria:\n\n* • Positive history of fracture\n\n  * Surgery in the cervical region\n  * Any sort of physical trauma in the cervical region in the last 12 months\n  * Thoracic Outlet syndrome\n  * Cervical radiculopathy\n  * Cervical myelopathy\n  * Cervical spondylosis\n  * Cervical syringomyelia\n  * Any systemic disorder including malignancy or inflammatory and rheumatic disorders\n  * Infection\n  * Vascular syndromes such as vertebrobasilar insufficiency (VBI).","19 Years","44 Years",{"count":317,"type":23},[97],"This study aims to compare the effects of post-isometric relaxation (PIR) and post isometric stretching (PIS) techniques on reducing neck pain, improving range of motion, and decreasing neck disability in individuals with neck pain. A randomized controlled trial will be conducted with 50 participants, who will be randomly assigned to one of two groups: one receiving PIR and the other receiving PIS. A single-blind method will be used, meaning the participants will not know which group they belong to. Participants will be selected based on specific criteria related to neck pain and will then be randomly allocated to the PIR or PIS group. Initially, all participants will receive two standard treatments: Transcutaneous Electrical Nerve Stimulation (TENS) and hot pack application. After these treatments, one group will undergo post-isometric relaxation (PIR), which involves 3-5 repetitions of muscle contraction and relaxation, conducted over five consecutive sessions. The other group will receive post-isometric stretching (PIS), which involves stretching after muscle contraction and relaxation, also administered over five consecutive sessions. At the end of the intervention, pain, range of motion, and neck disability will be measured. Pain will be assessed using a standardised pain scale, range of motion will be measured with a goniometer or other appropriate tools, and neck disability will be evaluated using the Neck Disability Index (NDI). Statistical analysis will be performed to compare the effectiveness of PIR and PIS in terms of pain reduction, range of motion improvement, and decreased neck disability.",[28],[617,618,28,619,620,621],"Subacute neck pain","Neck Muscles","Pain Management","Muscle Relaxation","Isometric Contraction","2025-12-26",{"date":624,"type":44},"2026-01-09",{"date":626,"type":44},"2025-01-15",{"date":628,"type":23},"2026-12-15",{"name":630,"class":51},"Foundation University Islamabad",{"id":632,"slug":633,"hasResults":12,"nctId":634,"briefTitle":635,"officialTitle":636,"acronym":637,"eligibilityCriteria":638,"healthyVolunteers":12,"sex":18,"minAge":639,"maxAge":640,"enrollmentInfo":641,"targetDuration":4,"studyType":95,"phases":642,"briefSummary":643,"conditions":644,"keywords":645,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":651,"lastUpdatePostDateStruct":652,"startDateStruct":654,"completionDateStruct":656,"leadSponsor":658,"locationsCount":52},"100602219","vacuum-massage-vs-tactile-massage-for-the-treatment-of-chronic-neck-pain-100602219","NCT07120659","Vacuum Massage vs Tactile Massage for the Treatment of Chronic Neck Pain","Vacuum Massage vs Tactile Massage for the Treatment of Chronic Neck Pain: A Randomized Controlled Pilot Study Investigating Pain Mechanisms.","MeCNeck","Inclusion Criteria:\n\n* suffer from non-specific neck pain persisting at least 3 months\n* mean pain intensity ≥ 50 on a 0-100 mm visual analogue scale (NRS) with \"0\" meaning \"no pain\" and \"100\" meaning \"worst pain imaginable\"\n\nExclusion Criteria:\n\n* neurological symptoms\n* having had a vertebral column surgery less than 12 months prior to the study,\n* have received TENS, acupuncture, osteopathy, or a chiropractic maneuver or infiltration at the area within 4 weeks prior to the inclusion in the study\n* suffer from a congenital deformation of the spine.","21 Years","75 Years",{"count":123,"type":23},[97],"Chronic pain significantly impacts individuals and society, with about 30% of Norwegian adults affected, making it the leading cause of long-term sick leave and disability benefits. Concerns over addiction to pain medications highlight the need for non-pharmacological treatments, though many such therapies, often complementary or alternative, are not widely available in conventional healthcare. Unclear biomechanisms of these therapies pose challenges for clinical trials and acceptance.\n\nThis pilot study aims to explore the effects of two types of massage-cupping massage (CM, intense) and tactile massage (TM, soft)-on chronic neck pain, focusing on their mechanisms of action. Quantitative sensory testing (QST) will be used as a biomarker to assess changes in the pain pathway. A previous feasibility study on CM and QST conducted in Germany informs this research.\n\nThe study will recruit 60 patients with chronic neck pain, randomized to CM or TM, with six weekly treatment sessions. QST will be measured before and after treatment to understand therapy-induced changes in the pain pathway. Findings will help tailor massage therapies to individual needs, improve clinical trial quality, and promote the integration of non-pharmacological treatments into conventional care, benefiting a large population in need.",[28],[443,646,647,648,649,650],"massage","soft touch massage","vacuum massage","cupping","quantitative sensory testing QST","2025-12-10",{"date":653,"type":44},"2025-12-11",{"date":655,"type":44},"2025-10-27",{"date":657,"type":23},"2030-12-31",{"name":659,"class":51},"University of Tromso",{"id":661,"slug":662,"hasResults":12,"nctId":663,"briefTitle":664,"officialTitle":665,"acronym":666,"eligibilityCriteria":667,"healthyVolunteers":17,"sex":18,"minAge":512,"maxAge":559,"enrollmentInfo":668,"targetDuration":4,"studyType":95,"phases":670,"briefSummary":671,"conditions":672,"keywords":674,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":676,"lastUpdatePostDateStruct":677,"startDateStruct":679,"completionDateStruct":681,"leadSponsor":683,"locationsCount":52},"100580308","effects-of-schroth-based-exercise-on-kyphosis-angle-muscle-strength-balance-pain-and-quality-of-life-in-hyperkyphosis-with-chronic-neck-pain-100580308","NCT06835608","Effects of Schroth-Based Exercise on Kyphosis Angle, Muscle Strength, Balance, Pain, and Quality of Life in Hyperkyphosis With Chronic Neck Pain","Effects of Schroth-Based Three-Dimensional Exercise Program on Angle of Kyphosis, Muscle Strength, Balance, Pain, and Quality of Life in Patients With Postural Hyperkyphosis With Chronic Neck Pain","Kyphosis","Inclusion Criteria:\n\n* Thoracic kyphosis angle \\> 45 degrees,\n* Aged between 20 and 50 years,\n* Have neck pain for more than 3 months,\n* Neck pain visual analogue scale \\> 3,\n* Not being treated for postural kyphosis in the last 6 months,\n* Has no systemic disease\n\nExclusion Criteria:\n\n* History of trauma or surgery on spinal joints,\n* Participants with rheumatological and metabolic disorders,\n* Participants with congenital postural deformity and scoliosis",{"count":669,"type":23},52,[97],"The normal thoracic kyphosis angle of the spine is 20-40°, however, an angle of more than 40° is referred to as postural kyphosis, increased kyphosis or hyperkyphosis. Although postural kyphosis negatively affects individuals' general health status, physical performance, and quality of life, there is still no standardized protocol for correcting the thoracic kyphosis angle. Conservative treatment approaches such as postural training and exercises, manual therapy, postural corrective kinesiotaping, and orthotic use have been recommended for managing increased thoracic kyphosis. While numerous studies have demonstrated the effectiveness of three-dimensional exercise programs in the treatment of scoliosis, research examining their impact on kyphosis remains considerably limited.Nevertheless, the potential of these exercises to promote neuromuscular reorganization suggests that they may be similarly effective in individuals with thoracic kyphosis. This randomized controlled trial aims to evaluate the effects of a Schroth-based three-dimensional exercise program on kyphosis angle, trunk muscle strength, balance, pain, and quality of life in individuals with postural hyperkyphosis and chronic neck pain.",[673,28],"Postural Kyphosis",[675,443],"postural hyperkyphosis","2025-12-02",{"date":678,"type":44},"2025-12-03",{"date":680,"type":44},"2025-02-25",{"date":682,"type":23},"2026-08-23",{"name":684,"class":51},"Baskent University"]