[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-otitis-media\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-otitis-media":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100659428","outcomes-of-cartilage-tympanoplasty-in-children-100659428",false,"NCT07866222","Outcomes of Cartilage Tympanoplasty in Children","Inclusion Criteria:\n\n* Children aged 8-18 years\n* Large, subtotal central tympanic membrane perforation or persistent same-size central perforation for 6 months before surgery\n* Dry perforation for 6 months duration\n* Conductive hearing loss attributable to tympanic membrane perforation\n* Patients able to undergo preoperative and postoperative audiological assessment\n* Written informed consent obtained from the parent\u002Flegal guardian and assent from the child when appropriate\n\nExclusion Criteria:\n\n* Cholesteatoma\n* Active ear infection at the time of surgery\n* Sensorineural hearing loss unrelated to the tympanic membrane perforation\n* Conductive gap \\> 40 dB (suggestive of ossicular chain pathology)\n* Congenital middle-ear abnormalities affecting the surgical outcome","ALL","8 Years","18 Years",{"count":19,"type":20},35,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study evaluates the anatomical and hearing outcomes of cartilage tympanoplasty in pediatric patients with chronic tympanic membrane perforations.\n\nA perforation (hole) in the eardrum in children can lead to recurrent ear discharge, chronic middle-ear infections, and conductive hearing loss. Cartilage tympanoplasty is a surgical technique that uses autologous cartilage (the patient's own cartilage tissue) to reconstruct and seal the eardrum. Cartilage is known for its rigidity and resistance to retraction, which may offer advantages in children who frequently experience middle-ear pressure and ventilation issues.\n\nChildren aged 8 to 18 years presenting with large, subtotal, or persistent dry central perforations will undergo cartilage tympanoplasty at Assiut University Hospitals. All participants will undergo standardized pre-surgical and post-surgical evaluations, including otological microscopic examinations and pure-tone audiometry tests.\n\nThe main objectives are to evaluate the graft success rate (complete anatomical closure and stability of the eardrum) and to measure functional hearing restoration, specifically changes in air-conduction thresholds and the air-bone gap (ABG).",[26,27,28],"Tympanic Membrane Perforation","Conductive Hearing Loss","Chronic Otitis Media",[30,31,32,33,34,35],"Cartilage tympanoplasty","Pediatric tympanoplasty","Myringoplasty","Tympanic membrane repair","Air-bone gap","Graft take rate","NOT_YET_RECRUITING","2026-10-04",{"date":39,"type":40},"2026-10-08","ACTUAL",{"date":42,"type":20},"2026-11",{"date":44,"type":20},"2027-12",{"name":46,"class":47},"Assiut University","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100656516","boomerang-shaped-cartilage-graft-in-endoscopic-tympanoplasty-100656516","NCT07823894","Boomerang-Shaped Cartilage Graft in Endoscopic Tympanoplasty","Boomerang-Shaped Cartilage\u002FPerichondrial Graft in Endoscopic Tympanoplasty for Anterior or Subtotal Tympanic Membrane Perforations","Inclusion Criteria:\n\n* Age 18 years or older\n* Anterior or subtotal tympanic membrane perforation\n* Dry ear for at least 3 months prior to surgery\n* Intact and mobile ossicular chain on clinical and intraoperative assessment\n* Aerated middle ear with healthy or near-normal middle ear mucosa\n* No evidence of cholesteatoma\n* Ability to attend all scheduled postoperative follow-up visits\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Active ear discharge at the time of surgery\n* Presence of cholesteatoma\n* Marginal or attic perforation associated with pathology requiring mastoid surgery\n* Ossicular discontinuity or erosion requiring ossiculoplasty\n* Significant adhesive otitis media\n* Previous failed tympanoplasty in the same ear\n* Severe Eustachian tube dysfunction associated with adhesive disease\n* Craniofacial anomalies affecting the ear\n* Uncontrolled systemic disease contraindicating surgery\n* Narrow external auditory canal precluding endoscopic access\n* Inability to complete the planned follow-up period",{"count":56,"type":20},50,[23],"This study evaluates the anatomical and functional outcomes of using a boomerang-shaped chondroperichondrial graft in endoscopic Type I tympanoplasty for repairing anterior or subtotal tympanic membrane perforations.\n\nAnterior and subtotal eardrum perforations represent challenging surgical scenarios due to limited visualization, lack of anterior graft support, and higher risks of graft retraction, medialization, or residual perforation. The boomerang-shaped cartilage and perichondrium graft provides a sturdy cartilage framework along the anterior border to secure structural support, while maintaining a thin perichondrial layer over the functional vibratory area to facilitate acoustic transmission.\n\nAll enrolled participants undergo endoscopic Type I tympanoplasty using this autologous grafting technique. Follow-up assessments are conducted at 1, 3, and 6 months after surgery to determine successful graft uptake, evaluate hearing improvement (via pure-tone audiometry and air-bone gap closure), and monitor for complications such as blunting, retraction, lateralization, or infection.",[26,28],[61,62,63,64,30,65,66,67],"Endoscopic tympanoplasty","Type 1 tympanoplasty","Boomerang-shaped graft","Chondroperichondrial graft","Anterior perforation","Subtotal perforation","Graft uptake","2026-09-11",{"date":70,"type":40},"2026-09-17",{"date":72,"type":20},"2026-10",{"date":74,"type":20},"2027-11",{"name":46,"class":47}]