[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-pain-due-to-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-pain-due-to-injury":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,58,97,126,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":4},"100650268","virtual-pain-education-for-spinal-cord-stimulation-patients-100650268",false,"NCT07743905","Virtual Pain Education for Spinal Cord Stimulation Patients","Virtual Pain Neuroscience Education for Patients Undergoing Spinal Cord Stimulation: A Hybrid Effectiveness-Implementation Pilot Trial","SCS-PNE","Inclusion Criteria (pilot study Aim 3):\n\n1. presence of a scheduled spinal cord stimulator trial surgery date within the EPIC workbench report,\n2. age greater than or equal to 18 years,\n3. ability to speak, read, and understand English to complete study surveys and participate in educational sessions,\n4. consistent access to an internet-enabled device (smartphone, tablet, or computer) equipped with a working camera and microphone compatible with the virtual intervention delivery,\n5. willingness and ability to participate in virtual video visits per the SCS-PNE intervention (i.e. through Doximity, Zoom, or EPIC MyChart).\n\nExclusion Criteria (pilot study):\n\n1. diagnosis of a severe cognitive impairment, advanced dementia, or active psychosis,\n2. prior formal exposure to structured PNE program within the past 12 months, 3) current involvement in active, unresolved litigation related to their chronic pain condition (i.e., ongoing legal or worker's compensation claim).","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy. SCS uses an implanted device to send mild electrical currents to the spine to block pain signals before they reach the brain. However, long-term success is often limited by how a patient's nervous system and brain process chronic pain, as well as psychological factors like anxiety and excessive worrying about pain, also known as catastrophizing.\n\nTo improve outcomes, this study combines SCS therapy with Pain Neuroscience Education (PNE). PNE is an educational approach that teaches patients how the brain and nervous system handle pain signals, reframing pain as a process that can be changed rather than just ongoing tissue damage. The goal of this pilot trial is to test the feasibility of using virtual, remote PNE sessions to help patients reduce pain catastrophizing and anxiety, while building overall psychological resilience. Additionally, the study explores an innovative, objective way to monitor pain levels by analyzing short voice recordings. Researchers want to see if specific vocal features change when a person's pain is well-controlled versus when it is uncontrolled.\n\nParticipants enrolled in this study will receive either 1) standard spinal cord stimulation or 2) spinal cord stimulation plus the intervention--a virtual, multi-session PNE delivered remotely over a secure telehealth platform. Throughout the study, participants will complete standard clinical surveys to measure their physical function, anxiety, pain catastrophizing, and emotional resilience using standardized tools. Participants will also provide short voice recordings, such as holding a sustained \"\u002Fah\u002F\" vowel sound, during their virtual assessments. This allows researchers to safely evaluate the direct relationship between subtle voice patterns and reported clinical pain levels.",[27,28,29,30,31,32],"Chronic Pain","Chronic Pain Due to Injury","Failed Back Syndrome","Persistent Spinal Pain Syndrome","Chronic Leg Pain","Chronic Neck Pain",[34,35,36,37,38,39,40,41,42,43,44,45],"spinal cord stimulation","neuromodulation","pain neuroscience education","pain science education","telehealth","virtual behavioral health","acoustic biomarker","voice analysis","pain catastrophizing","psychological resilence","anxiety and depression","physical therapy","NOT_YET_RECRUITING","2026-07-31",{"date":49,"type":50},"2026-08-04","ACTUAL",{"date":52,"type":21},"2026-07-27",{"date":54,"type":21},"2028-06-30",{"name":56,"class":57},"University of Arkansas","OTHER",{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":22,"phases":69,"briefSummary":70,"conditions":71,"keywords":76,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":92,"leadSponsor":94,"locationsCount":96},"100640278","botulinum-toxin-type-a-versus-local-anesthetic-injection-for-chronic-neuroma-pain-after-combat-related-amputation-100640278","NCT07626983","Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation","Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation: A Multicenter Randomized Double-Blind Trial","NEUROQUIET","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Persistent neuroma pain lasting ≥3 months\n* Ultrasound-confirmed neuroma\n* Positive Tinel sign over the neuroma\n* Average pain intensity ≥4\u002F10 on the Numeric Rating Scale (NRS)\n* Stable analgesic regimen for at least 14 days before enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at the injection site\n* Previous botulinum toxin injection within 6 months\n* Previous neuroma surgery within 3 months\n* Severe uncontrolled psychiatric disorder\n* Coagulopathy or anticoagulant therapy contraindicating injection\n* Known allergy to botulinum toxin or local anesthetics\n* Severe uncontrolled systemic disease\n* Inability to complete study follow-up or questionnaires","60 Years",{"count":68,"type":21},100,[24],"Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life. Current treatment options often provide only temporary relief. This study aims to compare two ultrasound-guided injection approaches for chronic neuroma pain after combat-related amputation: botulinum toxin type A and local anesthetic injection.\n\nParticipants will be randomly assigned to receive one of the two treatments. Pain intensity, neuropathic pain symptoms, phantom limb pain, prosthesis tolerance, and functional outcomes will be evaluated during follow-up visits over a 24-week period.\n\nThe goal of the study is to determine whether botulinum toxin type A provides longer-lasting pain reduction and improved functional recovery compared with local anesthetic injection in patients with chronic neuroma pain after combat-related amputation.",[28,72,73,74,75],"Neuroma of Lower Limb","Neural Injury","Neuroma of Upper Limb","Combat Related Symptoms",[77,78,79,80,81,82,83,84,85,86,87],"Neuroma pain","Combat-related amputation","Botulinum toxin type A","Local anesthetic injection","Ultrasound-guided injection","Phantom limb pain","Residual limb pain","Neuropathic pain","Military trauma","Chronic post-amputation pain","Ultrasound-guided pain intervention","2026-05-30",{"date":90,"type":50},"2026-06-04",{"date":88,"type":21},{"date":93,"type":21},"2026-12-15",{"name":95,"class":57},"Ukrainian Society of Regional Anesthesia and Pain Therapy",2,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":66,"enrollmentInfo":105,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":123,"locationsCount":125},"100629533","venous-thromboembolism-and-chronic-pain-after-major-limb-trauma-100629533","NCT07475910","Venous Thromboembolism and Chronic Pain After Major Limb Trauma","Venous Thromboembolism and Chronic Pain After Major Limb Trauma: A Prospective Cohort Study","THROMBO-PAIN","Inclusion Criteria:\n\n* Age ≥18 years\n* Major upper or lower limb trauma\n* Surgical treatment and\u002For immobilization ≥72 hours\n* Enrollment within 72 hours of admission\n* Informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic pain unrelated to trauma (investigator judgment)\n* Therapeutic anticoagulation prior to trauma\n* Cognitive inability to complete follow-up\n* Expected survival \\\u003C48 hours",{"count":106,"type":21},150,"OBSERVATIONAL","Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoagulability. While VTE is commonly studied as a short-term complication affecting morbidity and mortality, its potential relationship with long-term pain outcomes after trauma has not been well investigated.\n\nThis prospective observational cohort study aims to evaluate whether objectively confirmed VTE is associated with an increased risk of persistent clinically significant pain after major limb trauma. Adult patients with severe upper or lower limb injuries requiring surgical treatment or prolonged immobilization will be enrolled within 72 hours of hospital admission and followed for six months.\n\nThe study will assess whether patients who develop VTE have a higher likelihood of persistent pain compared with those without VTE. In addition, the study will explore the association between baseline VTE risk (using the Trauma Embolic Scoring System, TESS), thromboprophylaxis timing, and long-term pain outcomes. Secondary analyses will evaluate neuropathic pain symptoms, pain interference with daily activities, quality of life, opioid consumption, and functional recovery.\n\nUnderstanding the relationship between thromboembolic complications and persistent pain may help improve risk stratification, optimize thromboprophylaxis strategies, and support early rehabilitation planning in patients with major limb trauma.",[110,111,27,28],"VTE (Venous Thromboembolism)","Phantom Limb Pain After Amputation",[113,114,84,115,116],"Venous thromboembolism","Post-traumatic chronic pain","Major limb trauma","Trauma Embolic Scoring System (TESS)","2026-03-16",{"date":119,"type":50},"2026-03-18",{"date":121,"type":21},"2026-03-15",{"date":121,"type":21},{"name":124,"class":57},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)",1,{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":66,"enrollmentInfo":134,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":135,"conditions":136,"keywords":141,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":147,"startDateStruct":148,"completionDateStruct":149,"leadSponsor":150,"locationsCount":125},"100629532","negative-pressure-wound-therapy-as-a-predictor-of-persistent-pain-after-war-related-trauma-100629532","NCT07475897","Negative Pressure Wound Therapy as a Predictor of Persistent Pain After War-Related Trauma","Negative Pressure Wound Therapy as a Predictor of Persistent Pain After War-Related Trauma: A Prospective Cohort Study","NPWT-Pain Stud","Inclusion Criteria:\n\n* age ≥18 years\n* war-related trauma (blast injury, fragmentation injury, gunshot wound, burn injury, or crush injury)\n* traumatic soft tissue injury requiring surgical management\n* ability to provide informed consent\n* availability for follow-up assessments\n\nExclusion Criteria:\n\n* chronic pain in the same anatomical region prior to injury\n* severe cognitive impairment preventing pain assessment\n* inability to communicate or complete questionnaires\n* refusal to participate\n* incomplete baseline data or loss to follow-up",{"count":106,"type":21},"War-related trauma frequently causes complex soft tissue injuries that require repeated surgical treatment and advanced wound management techniques such as Negative Pressure Wound Therapy (NPWT). Although NPWT is widely used to promote wound healing and prepare wounds for reconstruction, its relationship with long-term pain outcomes remains unclear.\n\nThis prospective cohort study aims to investigate whether the use of NPWT after war-related trauma is associated with an increased risk of persistent post-traumatic pain six months after injury. Adult patients with traumatic soft tissue injuries requiring surgical management will be enrolled and followed for six months.\n\nIn addition to NPWT exposure, the study will evaluate several early clinical predictors of chronic pain, including acute pain intensity, number of surgical debridements, suspected nerve injury, and mechanism of trauma. Understanding these predictors may help clinicians identify high-risk patients early and develop targeted strategies for pain prevention and rehabilitation after severe trauma.",[111,28,137,138,139,140],"Postoperative Pain","Trauma (Including Fractures)","Amputation Stump","Amputation Stump; Infection",[142,143,144,84,145,146],"Negative Pressure Wound Therapy","War-related trauma","Post-traumatic pain","Chronic pain after trauma","Soft tissue injury",{"date":119,"type":50},{"date":121,"type":21},{"date":121,"type":21},{"name":124,"class":57},{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":66,"enrollmentInfo":158,"targetDuration":159,"studyType":107,"phases":4,"briefSummary":160,"conditions":161,"keywords":163,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":176,"locationsCount":125},"100625562","chronic-pain-after-combat-related-traumatic-brain-injury-ctbi-pain-study-a-prospective-cohort-study-of-pain-chronification-after-combat-related-traumatic-brain-injury-100625562","NCT07424248","Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury","TBI-Pain","Inclusion Criteria:\n\n* Age 18 to 60 years\n* Combat-related traumatic brain injury (blast, impact, or combined mechanism)\n* Mild to moderate traumatic brain injury\n* Enrollment within 14 days after injury\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Severe traumatic brain injury with prolonged impaired consciousness\n* Pre-existing severe psychiatric disorder unrelated to trauma\n* Chronic pain condition predating the traumatic brain injury\n* Inability to complete follow-up assessments\n* Severe medical condition limiting participation",{"count":68,"type":21},"6 Months","Combat-related traumatic brain injury (cTBI), particularly blast-related injury, is frequently associated with the development of persistent and disabling chronic pain. This prospective observational cohort study aims to determine the incidence, phenotypes, and early predictors of chronic pain following mild to moderate combat-related TBI. Adults will be enrolled within 14 days of injury and followed for 6 months. The primary endpoint is clinically significant chronic pain at 3 months, defined by pain intensity and functional interference. The study will evaluate clinical, psychological, and physiological factors to develop and internally validate a prognostic model for chronic pain risk after cTBI.",[162,27,28],"Pain",[164,165,166,167,84,168,169,85],"Combat-related traumatic brain injury","cTBI","Blast injury","Chronic pain","Sleep disturbance","Pain prediction","2026-02-22",{"date":172,"type":50},"2026-02-24",{"date":174,"type":21},"2026-02-15",{"date":93,"type":21},{"name":124,"class":57}]