[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"circadian-variation-in-anti-factor-xa-anti-fxa-activity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:circadian-variation-in-anti-factor-xa-anti-fxa-activity":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100658775","circadian-variation-of-anti-factor-xa-in-hospitalized-trauma-patients-100658775",false,"NCT07856641","Circadian Variation of Anti-Factor Xa in Hospitalized Trauma Patients","Inclusion Criteria:\n\n* Inpatient admission for acute traumatic injury ≥72 hours\n* Prescribed LMWH subcutaneous for VTE chemoprophylaxis\n\nExclusion Criteria:\n\n* Pregnancy\n* Brain hemorrhage or non-survivable injury\n* Chronic Kidney disease ≥ 3b estimated Glomerular Filtration Rate (eGFR) less than 30 interferes with coagulation\n* Chronic liver failure\n\n  •-Acute stimulant use of cocaine and methamphetamine\n* Active VTE or ongoing anticoagulation at admission\n* History of coagulopathy or inherited bleeding disorders\n* Chronic alcohol as defined as a documented diagnosis of alcohol use disorder or alcohol consumption exceeding established risk thresholds (men \\>14 drinks\u002Fweek; women \\>7 drinks\u002Fweek) within the prior 3-6 months\n* Unmanaged psychiatric conditions as defined as diagnosed psychiatric disorder with evidence of inadequate or no active treatment or documented poor symptom control\n* Neurologic injury involving hypothalamic or circadian regulatory centers","ALL","18 Years","80 Years",{"count":19,"type":20},40,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine whether a circadian rhythm exists in anti-FXa levels and AT3 activity in hospitalized trauma patients receiving low-molecular-weight heparin (LMWH) chemoprophylaxis",[24],"Circadian Variation in Anti-Factor Xa (Anti-FXa) Activity",[26,27,28],"Blood thinner","circadian rhythm","Venous thromboembolism (VTE)","RECRUITING","2026-09-28",{"date":32,"type":33},"2026-10-02","ACTUAL",{"date":35,"type":33},"2026-08-26",{"date":37,"type":20},"2028-03-26",{"name":39,"class":40},"The University of Texas Health Science Center, Houston","OTHER"]