[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"clinical-pregnancy-after-single-embryo-transfer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:clinical-pregnancy-after-single-embryo-transfer":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100645453","correlation-of-clinical-outcomes-after-transfer-of-good-quality-morphology-embryos-in-patients-with-a-favorable-prognosis-and-non-invasive-preimplantation-genetic-testing-for-aneuploidy-nipgt-a-results-100645453",false,"NCT07700602","Correlation Of Clinical Outcomes After Transfer Of Good-Quality Morphology Embryos In Patients With A Favorable Prognosis And Non-Invasive Preimplantation Genetic Testing For Aneuploidy (NiPGT-A) Results","Inclusion Criteria:\n\n* Women undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI).\n* Age younger than 35 years at the time of oocyte retrieval.\n* Good ovarian response, defined as having at least four good-quality embryos (Grade 1 or Grade 2) on Day 3 or later.\n* Undergoing the first or second IVF cycle.\n* Normal semen parameters of the male partner.\n* Willing to undergo non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) using spent embryo culture media.\n* Agree to vitrification of a single morphologically best-quality blastocyst and to undergo frozen single embryo transfer.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Presence of untreated uterine abnormalities, including uterine malformations or significant intrauterine pathology.\n* History of uterine surgery.\n* History of ovarian surgery.\n* Known metabolic disorders.\n* Use of donor oocytes.\n* In vitro maturation (IVM) cycles.\n* Participation in another clinical study during the study period.\n* Patients who do not undergo frozen single embryo transfer.",true,"FEMALE","18 Years","34 Years",{"count":20,"type":21},200,"ESTIMATED","24 Months","OBSERVATIONAL","Non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) is an emerging approach that analyzes embryonic cell-free DNA (cfDNA) released into the spent culture medium (SCM) to assess chromosomal status without performing trophectoderm biopsy. This technique has the potential to reduce procedural invasiveness and eliminate biopsy-related risks while providing additional information for embryo selection in assisted reproductive technology (ART). However, the clinical value of NiPGT-A remains uncertain because available evidence is limited and largely derived from observational studies, with few studies reporting live birth outcomes.\n\nThis prospective observational study aims to evaluate the correlation between NiPGT-A results and clinical outcomes after single blastocyst transfer in patients with a favorable prognosis undergoing IVF\u002FICSI treatment. In this study, embryos with good morphological quality will undergo non-invasive sampling of spent culture medium for cfDNA analysis. NiPGT-A results will be categorized into four groups: no result, euploid, mosaic, and aneuploid. The study will compare pregnancy and birth outcomes across these groups to determine the clinical utility of NiPGT-A in embryo selection strategies.",[26,27,28],"Infertility (IVF Patients)","Clinical Pregnancy After Single Embryo Transfer","Embryo Diagnosis and Selection",[30],"NiPGT, IVF, morphology, embryo selection","NOT_YET_RECRUITING","2026-07-13",{"date":34,"type":35},"2026-07-14","ACTUAL",{"date":37,"type":21},"2026-08-01",{"date":39,"type":21},"2029-12-31",{"name":41,"class":42},"Mỹ Đức Hospital","OTHER"]