[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"coarctation-of-the-aorta\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:coarctation-of-the-aorta":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100652257","effects-of-exercise-in-patients-with-repaired-coarctation-of-the-aorta-100652257",false,"NCT07771023","Effects of Exercise in Patients With Repaired Coarctation of the Aorta","Effects of Exercise on Select Indicators of Cardiovascular Health in Patients With Repaired Coarctation of the Aorta","KOREKT","Inclusion Criteria:\n\n* surgically repaired coarctation of the aorta,\n* age at least 18 years, and\n* signed informed consent form.\n\nExclusion Criteria:\n\n* residual aortic stenosis (gradient across the narrowing \\>20 mmHg),\n* presence of ascending aortic aneurysm,\n* recent major cardiovascular event or other event requiring hospitalization (event less than 2 months before inclusion),\n* unstable rhythm disturbances,\n* unstable or low-threshold angina pectoris,\n* NYHA class III or IV heart failure, and\n* pregnancy.","ALL","18 Years",{"count":20,"type":21},45,"ESTIMATED","INTERVENTIONAL",[24],"NA","This interventional study will investigate the effects of high-intensity interval training (HIIT) in adults with repaired coarctation of the aorta. Participants will be randomised into three groups: HIIT performed at home, HIIT performed in a supervised outpatient setting, or a control group receiving usual care. The two HIIT protocols will be identical in intensity and progression, individually prescribed for each patient.\n\nThe study will evaluate the effects of HIIT on exercise capacity, health-related quality of life, blood pressure response to exercise, and other select measures of cardiovascular health, including vascular stiffness and endothelial function. In addition, the study will examine the acute effects of a single exercise session on arterial stiffness.",[27,28],"Coarctation of the Aorta","Coarctation of Aorta",[30,31,32,33,34,35,36,37],"exercise","HIIT","home-based exercise","exercise training","cardiopulmonary exercise testing","arterial stiffness","hypertensive reaction","congenital heart disease","NOT_YET_RECRUITING","2026-08-13",{"date":41,"type":42},"2026-08-18","ACTUAL",{"date":44,"type":21},"2026-08",{"date":46,"type":21},"2027-10",{"name":48,"class":49},"University Medical Centre Ljubljana","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100617302","evaluating-the-feasibility-of-bioresorbable-iron-based-covered-stent-a-clinical-trial-100617302","NCT07316855","Evaluating the Feasibility of Bioresorbable Iron-Based Covered Stent: A Clinical Trial","Safety and Efficacy of Bioresorbable Iron-Based Covered Stent System for the Treatment of Coarctation of the Aorta: A Single-Center Clinical Study","CoA-ICS-I","Inclusion Criteria:\n\n1. Patient must between 1 and 60 years old\n\n   Patients being clinically diagnosed with CoA or patients with post-operative anastomotic stenosis after CoA surgery，meanwhile meeting one of the following conditions:\n\n   A：Pressure gradient of Carctation in a calm state. B：The degree of aortic stenosis is not less than 50% (degree of Carctation Of the Arota = (diameter of adjacent normal segment of blood vessel - residual vessel lumen diameter of stenotic segment)\n   * diameter of adjacent normal segment of blood vessel×100% ) C：Peak velocity of echocardiographic Doppler in the CoA≥2.5m\u002Fs\n2. The patients and their families have high compliance, sign the informed consent and willing to undergo 1-year follow-ups and related examinations.\n3. The patient's expected lifespan is more than one year after successful treatment with the stent.\n4. Reference vessel (diameter of the adjacent normal segment vessel ) diameter：4-16mm\n\nExclusion Criteria:\n\n1. Patients with a history of iron overload or iron disorder, such as hereditary hemochromatosis, etc.\n2. Patients with cardiopulmonary function that cannot tolerate surgery, such as severe heart failure (NYHA Grade III and above) that cannot be controlled by active medical treatment.\n3. Patients with known allergy to contrast agent, iron and its degradation products.\n4. Patients with hemorrhagic disorders\n5. Patients with contraindications on antiplatelet agents and anticoagulant therapy.\n6. Patients with thrombosis at the vascular wall of target lesion and the distal or proximal location of the lesion.\n7. Patients with known severe renal or hepatic insufficiency, which are unsuitable for index procedure\n8. Target lesion to be treated where stent was implanted previously.\n9. Patients with severe stenosis or excessive tortuosity in the targeted vessel, or anatomical abnormalities, which predict the device will have difficulty reaching the target lesion.\n10. Other conditions that are unfavorable for stent delivery or balloon expansion.\n11. Patient who have already participated in another clinical trial, and have not yet completed or withdrawn within 3 months before the screening period of this trial.\n12. Patients who are not suitable for participating the trial as per investigator judgement.","1 Year","60 Years",{"count":61,"type":21},10,[24],"A single-center, feasible clinical study to Evaluate the Treatment of Iron Bioresorbable Covered Scaffold System in patients with Coarctation of the Aorta Diseases",[27],[27,66,67,68,69],"Bioresorbable","covered stent","Biodegradable","iron-based","RECRUITING","2025-12-19",{"date":73,"type":42},"2026-01-05",{"date":75,"type":42},"2024-08-16",{"date":77,"type":21},"2027-12-31",{"name":79,"class":49},"Shubo Song",1]