[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognition-improvement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognition-improvement":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100647283","parent-mediated-social-cognition-intervention-for-young-children-with-autism-spectrum-disorder-100647283",false,"NCT07708246","Parent-Mediated Social Cognition Intervention for Young Children With Autism Spectrum Disorder","Efficacy of a Parent-Mediated, Home-Based Structured Play Intervention on Social Cognitive Development in Young Children With Autism Spectrum Disorder: A Non-Randomized Controlled Study","PMSC-ASD","Inclusion Criteria:\n\nChildren：\n\n* Aged 2.5 to 14 years at time of enrollment, with a primary recruitment focus on children aged 3 to 10 years.\n* Meets diagnostic criteria for autism spectrum disorder (ASD) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by a specialist clinician.\n* Full-scale intelligence quotient (FSIQ) ≥ 70 as assessed by an age-appropriate Wechsler intelligence scale administered.\n* Possesses sufficient verbal ability to engage with structured play-based intervention activities, as judged by the recruiting clinician.\n* Resides with and is cared for by a participating parent or legal guardian who meets the caregiver eligibility criteria below.\n\nCaregiver：\n\n* Is the primary caregiver (parent or legal guardian) of the enrolled child and resides in the same household.\n* Is able and willing to attend an in-person parent training session (approximately 2.5 hours) at the study site prior to intervention commencement.\n* Is able and willing to commit to administering the structured intervention program to the child for a minimum of 30 minutes per day throughout the 6-month intervention period.\n* Is able and willing to participate in monthly online video supervision sessions with the study clinician.\n* Has sufficient literacy and comprehension ability to understand program training materials and follow intervention procedures.\n* Provides written informed consent on behalf of the child and for their own participation prior to any study procedures.\n\nExclusion Criteria:\n\nChildren：\n\n* Known diagnosis of a genetic syndrome associated with ASD or intellectual disability, including but not limited to Fragile X syndrome, Down syndrome, tuberous sclerosis complex, or Rett syndrome.\n* Presence of a neurological disorder, including epilepsy (unless fully controlled with stable medication for ≥ 12 months), acquired brain injury, cerebral palsy, or other significant neurological condition that may confound assessment of social cognition.\n* Uncorrected vision or hearing impairment that would preclude participation in behavioral or eye-tracking assessments.\n* Currently enrolled in another interventional clinical study targeting social cognition, communication, or behavioral outcomes.\n* Any medical, psychiatric, or developmental condition that, in the opinion of the recruiting clinician, would interfere with the child's ability to participate in or benefit from the intervention.\n\nCaregiver：\n\n* Unable to attend the in-person parent training session at the study site due to geographic, occupational, or other constraints.\n* Unable to commit to the daily home-based intervention schedule or monthly online supervision sessions for the full 6-month intervention period.\n* Presence of significant mental health difficulties or other circumstances that, in the opinion of the recruiting clinician, would substantially impair the caregiver's ability to deliver the intervention with adequate fidelity.","ALL","4 Years","8 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study evaluates the efficacy of the Companion Mind-Drawing Cooperative Game Program, a parent-mediated, home-based structured play intervention targeting social cognitive development in young children with autism spectrum disorder (ASD).\n\nChildren with ASD in the intervention group will receive a structured program in which parents attend an in-person training session (approximately 2.5 hours) at the hospital, where parents are taught to administer a series of researcher-designed cooperative game paradigms at home. Parents then deliver the intervention daily for at least 30 minutes per session over a period of six months. Monthly online video reviews by a clinician provide parents with individualized feedback and guidance to ensure program fidelity and quality.\n\nChildren with ASD in the comparison group will continue to receive usual care and will not receive the program during the study period.\n\nSocial cognitive outcomes - including emotion recognition, theory of mind, empathy, joint attention, self-perception, and social communication - will be assessed at baseline and at 12-month follow-up using behavioral experimental tasks and eye-tracking paradigms. This study aims to provide evidence for the efficacy of a scalable, family-implemented social cognition intervention for young children with ASD.",[28,29,30,31],"Autism","Intervention (Training) Condition","Social Cognition","Cognition Improvement","RECRUITING","2026-07-13",{"date":35,"type":36},"2026-07-16","ACTUAL",{"date":38,"type":36},"2025-06-01",{"date":40,"type":22},"2028-12-30",{"name":42,"class":43},"Children's Hospital of Fudan University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":44},"100645736","a-validation-study-of-the-neuro-cognitive-emotion-monitoring-intervention-nemo-i-application-in-adolescents-100645736","NCT07700264","A Validation Study of the Neuro-cognitive Emotion Monitoring-Intervention (NEMO-I) Application in Adolescents","Inclusion Criteria:\n\n* Middle or high school students currently enrolled in school\n* Using an Android-based smartphone\n* Voluntary agreement to participate, with consent from a legal guardian\n\nExclusion Criteria:\n\n* Borderline intellectual functioning or intellectual disability (IQ below 80)\n* Visual or hearing impairment\n* Prior diagnosis of intellectual, visual, or hearing impairment",true,"12 Years","18 Years",{"count":55,"type":22},140,[25],"This study aims to evaluate the validity and effectiveness of NEMO-I (Neuro-cognitive Emotion Monitoring-Intervention), a mobile application designed to help adolescents monitor and manage their cognitive and emotional functioning in everyday settings. NEMO-I delivers evidence-based psychological techniques-such as mindfulness, self-regulation training, and emotion monitoring-in a gamified format consisting of seven brief activities that users can complete at home in about 10 minutes each.\n\nA total of 140 middle and high school students will participate. Participants will complete standardized neuropsychological and psychological assessments before and after the intervention period. During the 21-day intervention period, participants will use the NEMO-I application at home each day at their convenience (a minimum of 10 minutes per day is recommended). By comparing pre- and post-intervention assessment results, this study seeks to determine whether the application produces meaningful benefits for adolescent mental health and to establish its suitability as a digital mental health tool.",[59,60,31],"Adolescent Mental Health","Adolescent - Emotional Problem",[62,63,64,65,66,67],"Digital mental health intervention","adolescents","mobile based intervention","emotion","cognitive function","NEMO-I","NOT_YET_RECRUITING","2026-07-08",{"date":71,"type":36},"2026-07-14",{"date":73,"type":22},"2026-07-10",{"date":75,"type":22},"2027-04-30",{"name":77,"class":43},"Seoul Women's University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":51,"sex":17,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":110},"100621655","westlake-aging-cohort-weac-100621655","NCT07373444","Westlake Aging Cohort (WeAC)","Westlake Aging Cohort","Inclusion Criteria:\n\n1. Age between 55 and 90 years (inclusive) at baseline.\n2. Availability of a companion capable of providing independent functional assessments and fluent in Chinese.\n3. Willingness and ability to regularly complete required surveys and physical examinations as per study protocol.\n4. MMSE scores were required to be 24-30 (inclusive) for healthy controls and MCI; and 20-24 (inclusive) for AD and DLB\u002FPDD patients.\n5. Healthy controls: CDR = 0, memory box = 0. MCI: CDR = 0.5, memory box ≥ 0.5. AD: CDR = 0.5 or 1. The DLB\u002FPDD meets the core features of diagnosis.\n6. Healthy controls exhibit no significant cognitive or functional decline. Patients with MCI have objective cognitive impairment not sufficient for an AD diagnosis. AD patients fulfill the NINCDS-ADRDA criteria. DLB\u002FPDD patients meet their respective international consensus diagnostic criteria. Other neurodegenerative diseases meet the diagnostic criteria.\n\nExclusion Criteria:\n\n1. Participants with major medical or neuropsychiatric conditions unrelated to the study purposes were excluded. These included, but were not limited to, psychiatric disorders, cancer, infectious diseases, structural brain abnormalities, and epilepsy.\n2. Current use of psychoactive medications or any other drugs that may affect the study.\n3. Participants with cardiac pacemakers, artificial heart valves, or metallic implants in the eyes, skin, or any other part of the body.\n4. Participants with any other diseases that may affect the study.","55 Years","90 Years",{"count":88,"type":22},2800,"OBSERVATIONAL","The Westlake Ageing Cohort (WeAC) is a longitudinal cohort study conducted in Hangzhou, Zhejiang Province, China. The investigators aim to enroll 2,800 participants aged 55 years and older for long-term follow-up. The population will include individuals with neurodegenerative diseases or those at the prodromal stage of cognitive impairment, as well as healthy middle-aged and older adults serving as controls. The investigators will collect their sociodemographic, dietary, lifestyle, clinical, and neuroimaging data, as well as biological samples.",[92,31,93,94],"Aging","Cognition Disorders","Cognition",[96,97,98,99,100],"aging","cognition","gut microbiota","multi-omics","brain","2026-01-19",{"date":103,"type":36},"2026-01-28",{"date":105,"type":22},"2026-01-01",{"date":107,"type":22},"2031-12-31",{"name":109,"class":43},"Westlake University",2]