[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-control\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-control":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,92],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":37,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100623836","fascial-yoga-in-menopausal-women-100623836",false,"NCT07401810","Fascial Yoga in Menopausal Women","The Effect of Fascial Yoga on Perceived Stress, Cognitive Control, and Cognitive Flexibility in Menopausal Women","FascialYogaM","Inclusion Criteria:\n\n* Female participants aged 45-65 years\n* In the menopausal period, defined as at least 12 months since the last menstrual period\n* Able to read and understand Turkish and to complete self-report questionnaires\n\nExclusion Criteria:\n\n* Current or past diagnosis of a psychiatric disorder or ongoing psychiatric treatment\n* Regular use of antidepressant, anxiolytic, or corticosteroid medications\n* History of cancer or currently receiving active oncological treatment\n* Participation in fascial yoga, yoga, or similar yoga-based programs within the past 6 months\n* Any medical condition that may prevent safe participation in mild physical activity",true,"FEMALE","45 Years","65 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","Aim:\n\nThe aim of this study is to evaluate the effects of a structured fascial yoga-based behavioral intervention on perceived stress, cognitive control, and cognitive flexibility in menopausal women. The study aims to determine whether a non-pharmacological and non-invasive behavioral intervention can support psychological and cognitive functioning and reduce perceived stress in menopausal women.\n\nDesign:\n\nThis study is designed as a randomized controlled, pretest-posttest experimental study with a post-intervention follow-up assessment. Eligible participants will be randomly assigned to either the intervention group or the control group receiving usual care. Outcomes will be assessed at baseline, immediately after the intervention, and at follow-up to evaluate both the immediate and sustained effects of the intervention.\n\nMethod:\n\nA total of 60 menopausal women aged 45-65 years will be recruited from the menopause outpatient clinic and randomly assigned to either the intervention group or the control group. The intervention group will participate in a 12-week online fascial yoga program consisting of two 60-minute sessions per week.\n\nIn this study, fascial yoga is defined as a fascia-focused, non-pharmacological, and non-invasive behavioral intervention that includes myofascial release techniques, breath regulation, body awareness, and basic yoga practices to support stress regulation and cognitive functioning. The program will include myofascial release techniques, basic yoga postures suitable for all physical fitness levels, and structured breathing exercises. All sessions will be conducted online in a group format, and no audio or video recordings will be taken.\n\nThe control group will continue to receive routine outpatient care during the study period. After completion of the follow-up assessments, the fascial yoga program will be offered to participants in the control group upon request.\n\nData will be collected at three time points: at baseline before the intervention, immediately after completion of the 12-week intervention, and at the follow-up assessment 8 weeks after the intervention. Perceived stress, cognitive control, and cognitive flexibility will be assessed using validated self-report questionnaires.\n\nHypotheses:\n\nH1: Menopausal women participating in the fascial yoga intervention will show a significant reduction in perceived stress levels compared with the control group at post-intervention and follow-up assessments.\n\nH2: Menopausal women participating in the fascial yoga intervention will show a significant improvement in cognitive control and cognitive flexibility compared with the control group at post-intervention and follow-up assessments.",[29,30,31,32,33,34,35,36],"Menopause","Stress, Psychological","Cognitive Flexibility","Nonpharmacological Interventions","Randomized Controlled Trial","Cognitive Control","Perceived Stress","Yoga",[29,35,31,34,36],"NOT_YET_RECRUITING","2026-07-20",{"date":41,"type":42},"2026-07-22","ACTUAL",{"date":44,"type":23},"2026-07-01",{"date":46,"type":23},"2027-06-01",{"name":48,"class":49},"Marmara University","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":64,"conditions":65,"keywords":74,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100648608","early-phase-1-human-cognition-during-surgery-stimulation-based-and-cholinergic-modulation-100648608","NCT07721272","Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation","Studying Human Cognition During Deep Brain Stimulation Surgery Using High-Density Neural Probes and Pharmacological Interventions","Study Population\n\nInclusion Criteria for Essential Tremor Patients:\n\n* Diagnosis of Essential Tremor\n* Recommended to undergo deep brain stimulation implantation surgery for surgical management of medication-resistant tremor based on clinical indications\n\nExclusion Criteria for Essential Tremor Patients:\n\n* Patients with recent use (within one week) of anticoagulant or antiplatelet agent\n* Contraindication to use of cholinergic modulation\n\nInclusion Criteria for Epilepsy Patients\n\n* Diagnosis of intractable epilepsy\n* Undergoing neuromodulation procedure that utilizes insertion of electrodes into subcortical structures, including the thalamus or hippocampus\n* Undergoing neuromodulation procedure that utilizes frame-based insertion of electrodes into the thalamus (ANT or CM)\n\nExclusion Criteria for Epilepsy Patients:\n\n* Patients with recent use (within one week) of anticoagulant or antiplatelet agent\n* Contraindication to use of cholinergic modulation\n\nContraindication for cholinergic modulation in both patient sets will be assessed by members of the treatment team (e.g. epileptologist), as well as a neuroanesthesiologist. Multiple medications and conditions are singular disqualifiers; however some medications are eliminated only in combination following neuroanesthesiologist evaluation. Patients at risk of reaction to the treatment arm based on concurrent or recent medications or other health conditions will be excluded from participation.\n\nInclusion Criteria for Study Participation\n\n* Is patient between 18-70?\n* In general good health, aside from history of epilepsy or essential tremor, as ascertained by medical history, physical exam, clinical labs, and ECG?\n* Candidate for surgery as determined independently by the patient's treating physician\u002Fclinical team as part of the patient's routine medical care?\n* Able to read, understand, and provide written, dated informed consent, and participate in cognitive tasks?\n\nExclusion Criteria for Study Participation\n\n* Female that is pregnant, breastfeeding, or has a positive pregnancy test?\n* Under 18, over 70, or currently a prisoner on medical release?\n* Hepatic impairment (moderate or severe)?\n* Renal impairment (moderate or severe)?\n* Untreated narrow angle glaucoma?\n* Bladder obstruction, prostatic hyperplasia (BPH), diabetic cystopathy, pre-existing urinary retention?\n* History of hypersensitivity to COBENFY or trospium chloride?\n* Biliary disease, including symptomatic gallstones, gallbladder disorders, pancreatitis?\n* Fluoxetine, paroxetine, bupropion, terbinafine?\n* Buspirone or eletriptan?\n* Digoxin, colchicine, apixaban?\n* Diphenhydramine, beztropine, oxybutynin?\n* Benztropine, trihexyphenidyl, tolterodine, solifenacin, darifenacin, fesoterodine, hyoscyamine, dicyclomine, scopolamine?","ALL","18 Years","70 Years",{"count":61,"type":23},30,[63],"EARLY_PHASE1","This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic system.\n\nThis study aims to answer: 1) how cholinergic circuitries act during task performance in humans, and 2) develop a better understanding of how cognitive control interacts with learning, memory and decision making in the setting of cholinergic manipulation.\n\nParticipants will complete a single treatment arm, regardless of which surgical procedure they are to receive. An anesthesiologist or other clinical staff will administer either the drug or the saline at a critical point which addresses the research questions, prior to patient surgery. This will be either with the drug, or the placebo pill. Half of the participants will be randomized to receive the drug, and the other half of these the placebo. Participants will be unaware whether the actual drug has been received.\n\nEssential tremor patients who participate will complete a cognitive task during an awake surgery. Epilepsy patients who participate will have a resting state recording during the procedure from the deep cortical layers of the brain. A probe will be used during the surgery to measure the effects of this drug and other procedures of the study on the cholinergic system. This probe is the clinical probe known as the AlphaOmega, which is FDA approved for standard of care procedures.\n\nResearchers will compare the brain activity between treatment arms to determine what brain activity changes based on the cholinergic manipulation.",[66,67,68,69,70,71,72,34,73],"Epilepsy","Essential Tremor","Seizures","Memory Consolidation","Memory Disorders","Memory Replay","Memory Encoding","Motor Abilities",[75,76,77,78,79,80,81],"interoperative","oscillatory changes","neuronal spiking","time cell","place cell","cholinergic agonist","cholinergic modulation","2026-07-17",{"date":84,"type":42},"2026-07-23",{"date":86,"type":23},"2026-10",{"date":88,"type":23},"2030-09",{"name":90,"class":49},"University of Texas Southwestern Medical Center",1,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":17,"sex":57,"minAge":58,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":24,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":91},"100628948","synchronization-of-theta-to-influence-memory-100628948","NCT07468279","Synchronization of Theta to Influence Memory","Effects of Non-Invasive Brain Stimulation on Task Performance","STIM","Inclusion Criteria:\n\n* 18 years and older\n* Fluent in English\n* Normal or corrected-to-normal vision\n* Willing to be photographed\n\nExclusion Criteria:\n\n* Must not have ever had an injury to the head that's caused you to be knocked out for a period of time (e.g., from a fall, blow to the head, road traffic accident).\n* Must not have an uncorrected vision or physical disability that interferes with your ability to see stimuli presented briefly on a computer screen or click a mouse button rapidly.\n* Must not have a history of epilepsy, convulsions, or seizures (except childhood febrile seizures).\n* Must not have a history of fainting or syncope.\n* For female participants, they must not be pregnant and\u002For must not think they might be pregnant.\n* Must not have skin problems like eczema, dermatitis, or open wounds on the scalp.\n* Must not have had prior brain surgery.\n* Must not have any metal located in the head\u002Fneck (except for dental fillings).\n* Must not have any devices or other implants located in\u002Fnear their head. This includes cochlear implants and aneurysm clips, cardiac pacemaker, or any other implanted electronic device.\n* Must not have a current (active) alcohol or substance use disorder, must have no recent history of withdrawal symptoms, and must be able to safely abstain from alcohol and non-prescribed\u002Fillicit drugs for at least 24 hours before the session.\n* Must not have any alcohol on the day of the session, must limit alcohol consumption to no more than 2 drinks (if legally permitted) in the prior 24 hours, and must not use any non-prescribed or illicit drugs in the 24 hours before the session.\n* Must not be sick with a fever, sleep-deprived, or feel dizzy, unwell, or intoxicated.\n* Must also have eaten and had fluids but not have consumed more caffeine than they typically consume.\n* Must not be taking anticonvulsant\u002Fanti-epileptic drugs or have ever taken them within their lifetime.\n* Must not be taking benzodiazepines or have taken them within the past 3 months.\n* Must not have had a recent change (start, stop, dose change) for any psychiatric\u002Fpsychotropic medications within the past 3 months.\n* Must not be taking Bupropion (Wellbutrin, Zyban), Tricyclic antidepressants (e.g., amitriptyline, imipramine, clomipramine, etc.), Antipsychotics (clozapine; chlorpromazine, haloperidol, etc.), or Tramadol or have taken them within the past 3 months.\n* Must not have experienced cardiac problems, fibrillation, or have taken medications associated with cardiac conditions within the past 3 months.\n* Must not meet the diagnostic threshold for Autism Spectrum Disorder, Intellectual Disability, or Psychotic Disorders.","59 Years",{"count":102,"type":23},90,[26],"This study aims to clarify relations between brain oscillations and two cognitive functions: cognitive control and memory.",[34,106],"Memory","RECRUITING","2026-03-16",{"date":110,"type":42},"2026-03-17",{"date":112,"type":42},"2026-03-13",{"date":114,"type":23},"2031-01",{"name":116,"class":49},"Florida International University"]