[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-dysfunction--mmse--24-\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-dysfunction--mmse--24-":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100649261","animal-assisted-therapy-combined-with-standard-rehabilitation-for-motor-recovery-in-dementia-patients-in-a-medical-and-rehabilitation-care-unit-100649261",false,"NCT07730983","Animal-Assisted Therapy Combined With Standard Rehabilitation for Motor Recovery in Dementia Patients in a Medical and Rehabilitation Care Unit","Impact of a Combined Rehabilitation and Animal-Assisted Therapy Approach on the Recovery of Motor Abilities in Patients With Dementia Hospitalized in a Medical and Rehabilitation Care Unit","RéMédi - A","Inclusion Criteria:\n\n* Hospitalized in the geriatric medical and rehabilitation ward (SMR) of Institut Médical de Sologne (IMDS)\n* Diagnosed dementia or confirmed cognitive decline, shown by a score between 15 and 24 on the Mini-Mental State Examination (MMSE - a short standardized test of memory and thinking)\n* Has active motor rehabilitation goals (identified need to improve movement abilities during hospitalization)\n* Participant and\u002For their legal guardian, trusted person (personne de confiance), curator, or family member has provided written consent to participate in the study\n* Affiliated to a French social security scheme\n\nExclusion Criteria:\n\n* Known allergy to the animals used in the animal-assisted therapy sessions (dog, rabbits)\n* Fear of animals\n* History of aggressive behavior toward animals\n* Concomitant psychiatric disorders\n* Needs only a stimulation and\u002For skills maintenance approach (no active motor rehabilitation goals)\n* Currently enrolled in another interventional research study\n\n(Note: A participant who was previously enrolled in another interventional study may join RÉMÉDI-A once their participation in the prior study has ended, without a washout period, provided all eligibility criteria are met.)","ALL","18 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this randomized study is to find out if animal-assisted therapy (AAT) - a structured program where trained animals take part in care sessions guided by health professionals - can help improve movement abilities in older adults with dementia or memory-related conditions who are staying in a medical rehabilitation unit.\n\nThe main questions this study aims to answer are:\n\n* Can adding animal-assisted therapy to standard rehabilitation improve participants' movement and motor abilities better than standard rehabilitation alone?\n* Can this combined approach help participants stay more independent in daily activities?\n* Can this combined approach improve participants' quality of life?\n* Can this combined approach reduce the risk of falls?\n\nResearchers will compare two groups:\n\n* Group 1 (experimental): Standard rehabilitation + animal-assisted therapy sessions with a trained dog and\u002For rabbits\n* Group 2 (control): Standard rehabilitation alone\n\nBoth groups attend 2 one-hour rehabilitation sessions per week for 4 weeks.\n\nParticipants will:\n\n* Complete movement and daily-life ability tests at the start and end of the study\n* Attend 8 rehabilitation sessions (over 4 weeks)\n* Participants in the animal therapy group will interact with a trained dog and\u002For rabbits during sessions, guided by a certified nurse-animal therapist, a psychomotor therapist, and a nursing assistant\n* Be assessed at the end of the 4-week program (Week 6) to measure any changes in motor abilities, independence, quality of life, and fall risk",[27,28,29],"Dementia","Cognitive Dysfunction ( MMSE \u003C 24 )","Motor Skills Disorders",[27,31,32,33,34,35,36,37],"Animal-Assisted Therapy","Motor Rehabilitation","Psychomotor Function","Geriatric Rehabilitation","Non-Pharmacological Intervention","Cognitive Decline","Medical and Rehabilitation Care","NOT_YET_RECRUITING","2026-07-23",{"date":41,"type":42},"2026-07-28","ACTUAL",{"date":44,"type":21},"2026-09",{"date":46,"type":21},"2027-12",{"name":48,"class":49},"LNA SANTE","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":50},"100600856","the-effects-of-virtual-reality-based-training-for-the-treatment-of-neglect-syndrome-in-stroke-a-randomized-controlled-trial-100600856","NCT07102927","The Effects of Virtual Reality-based Training for the Treatment of Neglect Syndrome in Stroke: a Randomized Controlled Trial","Inclusion Criteria:\n\n* 1\\. Patients diagnosed with right cerebral hemisphere stroke confirmed by MRI or CT, with left hemiplegia, and at least three months post-stroke 2. Patients confirmed to have unilateral neglect based on the BIT score (total BIT score ≤ 196, or subtest scores BITC ≤ 129 or BITB ≤ 67) 3. Individuals with sufficient cognitive ability to participate in virtual reality training (MMSE \\> 18) 4. Adults aged 19 years or older\n\nExclusion Criteria:\n\n* 1\\. Presence of Hemianopsia 2. Impaired neck movement due to orthopedic issues or other causes 3. Visual or hearing impairments that interfere with evaluation and treatment 4. Difficulty maintaining a seating posture in a chair with a backrest and armrests 5. Presence of other medical issues that may affect general cognitive decline 6. Experiencing Cybersickness symptoms such as nausea, vomiting, eye strain, disorientation, ataxia, or dizziness repeatedly, making continued training difficult and requiring discontinuation as determined by the researcher","19 Years","99 Years",{"count":60,"type":21},28,[24],"This study aims to investigate the effectiveness and underlying recovery mechanisms of a virtual reality-based training program for the treatment of neglect syndrome in stroke patients in the chronic phase (more than three months after onset).\n\nNeglect is a neurological condition characterized by a failure to attend to stimuli presented on the side contralateral to a brain lesion, despite preserved visual acuity and visual fields. Patients with neglect commonly exhibit impairments in activities of daily living, including dressing, eating, grooming, reading, and writing, and are prone to collisions with objects on the neglected side. This syndrome is widely acknowledged as a significant negative prognostic indicator for functional recovery following stroke.\n\nPrevious treatments for neglect syndrome have shown promising results. Pizzamiglio et al. reported the effectiveness of visuo-spatial scanning training, while Julkunen et al. confirmed improvement using computer-based therapy. Frascineti et al. demonstrated benefits from prism adaptation therapy, and Robertson et al. found that activating the left limbs helped reduce neglect symptoms. Additionally, Brighina et al. reported that repetitive transcranial magnetic stimulation applied to the unaffected cerebral hemisphere effectively alleviated neglect.\n\nRecently, computer-based diagnostic tools have been developed to more accurately quantify and objectify neglect. Among them, Kim et al. developed a 3D VR program that can be applied regardless of the severity of motor impairment on the affected side. Virtual reality provides simulated, immersive environments that allow users to interact as if in real-world settings, enabling objective and quantitative assessment of neglect symptoms. In particular, visual fixation training within VR encourages spontaneous visual exploration and focused attention toward the affected side, which has been shown to be an effective strategy in reducing neglect in stroke patients.\n\nVirtual reality-based training has been increasingly applied clinically abroad. For example, the University of California's Institute for Creative Technologies uses VR for treating PTSD in Iraq war veterans, and the VRMC in the U.S. applies it for phobia and stress treatments. In Switzerland, programs like Mind Motion Pro are used for neuroregeneration-focused rehabilitation, and Japan has developed mediVR for trunk balance training. Although research on neglect using VR is active, it generally requires active therapist involvement. Few studies have clearly demonstrated the efficacy of VR treatment specifically in stroke patients, and VR applications in rehabilitation medicine remain relatively limited compared to psychiatric fields.\n\nIn light of this background, our research team developed a virtual reality-based training program (NEGTREA) for the treatment of neglect syndrome in stroke. To evaluate its clinical feasibility, we conducted a targeted focus group interview with four out of five stroke patients with neglect who used the program. The study found that the VR-based neglect treatment was well tolerated without adverse effects and achieved high patient satisfaction, alongside improved assessment scores before and after program participation.",[64,28,65],"Stroke ( 3 Months After Onset)","Unilateral Neglect Syndrome","RECRUITING","2025-07-28",{"date":69,"type":42},"2025-08-05",{"date":71,"type":42},"2022-09-22",{"date":73,"type":21},"2026-12",{"name":75,"class":49},"Yonsei University"]