[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cognitive-function-decline\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cognitive-function-decline":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100649393","vestibular-balance-cognition-dual-task-digital-system-development-of-a-smart-rehabilitation-platform-for-the-elderly-and-prediction-of-balance-function-risks-100649393",false,"NCT07735078","Vestibular Balance-Cognition Dual-Task Digital System: Development of a Smart Rehabilitation Platform for the Elderly and Prediction of Balance Function Risks","Inclusion Criteria:\n\n1. Community-dwelling adults aged 55 years or older.\n2. Able to walk at least 30 meters independently or with the use of a walking aid.\n3. Able to understand the study procedures and communicate in Mandarin or Taiwanese.\n4. Adequate corrected vision to go out independently.\n5. Able to participate in 45-minute sessions of moderate-intensity exercise once per week.\n\nExclusion Criteria:\n\n1. Severe central or peripheral neurological diseases.\n2. Blindness or deafness.\n3. Inability to communicate verbally or to understand simple instructions.\n4. Current fractures or major joint injuries.",true,"ALL","55 Years",{"count":19,"type":20},55,"ESTIMATED","OBSERVATIONAL","This study is being done to better understand how vestibular problems and thinking abilities (such as attention and mental flexibility) are related in older adults, and how doing a balance task and a thinking task at the same time affects their performance. Older adults will first complete questionnaires and simple paper-and-pencil tests of attention, memory, and mental rotation while seated. They will then perform standing balance tasks on a portable force platform under different conditions (eyes open, eyes closed, standing on a foam surface) and will repeat some of the thinking tasks at the same time. Next, participants will walk on a treadmill while wearing small motion sensors, both with and without added thinking tasks such as serial subtraction and digit reordering. The total testing time is about 90 minutes. Two groups will be included: healthy older adults and older adults who have had dizziness or falls in the past two years. By comparing these groups, the study aims to provide a basis for designing future dual-task assessment and training programs to reduce balance problems and falls in older adults.",[24,25,26,27,28,29],"Vestibular Dysfunction","Dizziness","Falls (Accidents) in Old Age","Balance Assessment","Cognitive Function Decline","Dual-Task Performance","RECRUITING","2026-07-26",{"date":33,"type":34},"2026-07-29","ACTUAL",{"date":36,"type":34},"2025-02-10",{"date":38,"type":20},"2027-03-11",{"name":40,"class":41},"National Yang Ming Chiao Tung University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":15,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":42},"100644269","beetroot-extract-and-quality-of-life-in-adults-aged-75-and-over-100644269","NCT07666685","Beetroot Extract and Quality of Life in Adults Aged 75 and Over","Assessment of the Benefits of Beetroot Extract for Improving the Quality of Life of Older People: a Randomised Clinical Trial.","BERS","Inclusion Criteria:\n\n1. Adults aged 75 years and older recruited from the Geriatrics Service of the Hospital Universitario de Navarra (HUN) or primary care settings.\n2. Ability to ambulate independently.\n3. Ability to communicate effectively.\n4. Ability to tolerate physical exercise.\n5. Barthel Index score greater than 60 points.\n\nExclusion Criteria:\n\n1. Refusal or inability of the participant, caregiver, or legal guardian to provide written informed consent.\n2. Advanced or severe dementia (Global Deterioration Scale \\[GDS\\] stages 6-7).\n3. Unstable medical condition or terminal illness with a life expectancy of less than 6 months.\n4. Ischemic heart disease or congestive heart failure.\n5. Severe renal insufficiency.\n6. Hypotension.","75 Years",{"count":53,"type":20},120,"INTERVENTIONAL",[56],"NA","The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging. Beetroot extract (BE), derived from \"Beta vulgaris\", contains high levels of inorganic nitrate and other bioactive compounds that may positively influence vascular and neuromuscular function. In parallel, multicomponent physical exercise is recognized as an effective strategy to improve physical and cognitive outcomes in older adults. However, evidence on the independent and combined effects of BE supplementation and structured exercise in very old adults remains limited.\n\nThis randomized controlled trial is designed to evaluate the effects of BE supplementation, alone and in combination with a multicomponent physical exercise program, on blood pressure, functional performance, and cognitive function in adults aged 75 years and older. Participants will be randomly assigned to one of four groups: BE supplementation, multicomponent exercise, combined BE supplementation and exercise, or a control condition, over a predefined intervention period. The exercise program will include strength, balance, mobility, and aerobic components specifically adapted to the abilities and safety requirements of old adults.\n\nThe primary outcomes of the study will assess changes in cardiovascular health, physical and functional performance, and cognitive function using standardized and validated assessment tools. Secondary outcomes will include additional indicators of physical capacity and health-related quality of life. This trial aims to provide clinically relevant evidence on whether BE supplementation, alone or in combination with multicomponent exercise, represents a practical and scalable intervention to improve cardiovascular, functional, and cognitive health in adults aged 75 years and older.",[59,60,28,61],"Cardiovascular Health","Functional Health","Physical Performance Decline in Older Adults",[63,64,65,66,67,68],"beetroot extract","dietary nitrate","cardiovascular health","functional health","quality of life","cognitive function","2026-06-26",{"date":71,"type":34},"2026-06-30",{"date":73,"type":34},"2026-03-24",{"date":75,"type":20},"2027-11",{"name":77,"class":41},"Fundacion Miguel Servet",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":15,"sex":16,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":54,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":42},"100616926","short-term-health-outcomes-of-cooking-ufp-exposure-100616926","NCT07311967","Short-Term Health Outcomes of Cooking UFP Exposure","UFP","Inclusion Criteria\n\nAdults 18 years of age or older\n\nAble to understand and speak English sufficiently to complete cognitive testing\n\nAble and willing to complete two consecutive study sessions lasting approximately 6 hours each\n\nAble to avoid cooking, toasting, and fume-generating household activities (e.g., strong cleaning products, ironing, hair drying) for 24 hours before each session\n\nAble to avoid tobacco, marijuana, vaping, and alcohol use as specified in the study protocol\n\nAble to provide informed consent\n\nExclusion Criteria\n\nYounger than 18 years old\n\nPregnant or planning pregnancy during study participation\n\nCurrent smoking or use of:\n\nCigarettes\n\nE-cigarettes or vaping devices\n\nMarijuana\n\nShisha\u002Fhookah\n\nBinge drinking, heavy alcohol use, or inability to abstain from alcohol for 24 hours before study visits\n\nRestaurant chefs or individuals who perform frequent commercial-level cooking\n\nIndividuals who cook two or more frying or grilling meals per day at home\n\nCooking anxiety or mageirocophobia\n\nAny diagnosed neurological disease, including stroke, seizure disorder, multiple sclerosis, traumatic brain injury, dementia, or similar conditions\n\nAny significant respiratory disease, including:\n\nChronic obstructive pulmonary disease (COPD)\n\nUntreated severe asthma\n\nChronic bronchitis or other major lung disease\n\nAny significant psychiatric condition, including:\n\nSchizophrenia spectrum disorder\n\nUntreated substance use disorder\n\nSevere mood disorder\n\nSevere anxiety disorder\n\nClaustrophobia or anxiety in enclosed spaces (if severe enough to interfere with chamber procedures)\n\nInability to comply with study procedures or safety requirements\n\nAny medical or psychological condition that, in the judgement of the investigators, may increase risk or interfere with study participation","18 Years",{"count":87,"type":20},15,[56],"This study examines the short-term respiratory and cognitive effects of exposure to ultrafine particles (UFPs) generated during typical household cooking. Healthy adults will complete two 6-hour sessions in a controlled exposure chamber at the University of Illinois Chicago: one control day with clean indoor air and one exposure day during which standardized cooking (frying potatoes and grilling beef) is performed by research staff. Participants will not cook or handle food. Lung function will be measured using peak expiratory flow (PEF), and cognitive performance will be assessed using validated tests including the Hopkins Verbal Learning Test-Revised and the Processing Speed Index from the WAIS-IV. Airborne particle and gas concentrations in the chamber will be continuously monitored to ensure that exposures remain within levels typical of everyday home cooking. Findings will help characterize acute physiological responses to indoor cooking emissions and inform future research on indoor air quality and potential mitigation strategies.",[28,91,92],"Air Pollution Exposure","Respiratory Inflammation",[94,95,96,97],"Cooking emissions","Neurocognitive function","Respiratory symptoms","Ultrafine particles","NOT_YET_RECRUITING","2025-12-16",{"date":101,"type":34},"2025-12-31",{"date":103,"type":20},"2026-01-02",{"date":105,"type":20},"2026-06-01",{"name":107,"class":41},"University of Illinois at Chicago"]