[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"combat-related-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:combat-related-symptoms":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":50,"locationsCount":53},"100647332","drone-wound-study-severe-infection-after-drone-related-combat-trauma-100647332",false,"NCT07706608","DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma","DRONE-WOUND Study: Tissue Devitalization and Severe Infection Following Drone-Related Combat Trauma: A Prospective Multicenter Observational Cohort Study","DRONE-WOUND","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Combat-related injury caused by a confirmed drone-related mechanism, including first-person view (FPV) drones, drone-delivered explosive munitions, or other unmanned aerial vehicle (UAV)-associated injuries.\n* Open extremity injury requiring operative surgical debridement.\n* Hospital admission within 24 hours after injury.\n* Written informed consent provided by the participant or legally authorized representative, in accordance with local regulations.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Isolated superficial soft tissue injuries not requiring operative treatment. Injuries requiring immediate primary amputation before initial surgical assessment.\n* Patients transferred more than 24 hours after injury.\n* Pre-existing active infection involving the injured limb before the combat injury.\n* Patients who die before completion of the initial surgical debridement.\n* Prisoners or other individuals unable to provide informed consent when no legally authorized representative is available.","ALL","18 Years","60 Years",{"count":21,"type":22},500,"ESTIMATED","OBSERVATIONAL","Drone-related combat injuries have become one of the most devastating mechanisms of injury in modern warfare. These injuries often cause extensive tissue devitalization, contamination, open fractures, vascular injuries, and complex soft tissue damage, which may substantially increase the risk of severe wound infection, multidrug-resistant bacterial infection, repeated surgical procedures, limb loss, and sepsis. However, the relationship between the extent of tissue devitalization and the development of severe infection has not been systematically investigated.\n\nThe DRONE-WOUND Study is a prospective observational cohort study designed to evaluate the association between tissue devitalization and severe wound infection in patients with drone-related combat trauma. The study will collect detailed clinical, surgical, microbiological, and radiological data from injured patients treated at participating trauma centers. Measures of tissue injury, contamination, surgical management, microbiological findings, and infection outcomes will be analyzed to identify factors associated with severe infection and poor clinical outcomes.\n\nThe findings of this study are expected to improve understanding of the mechanisms leading to infection after drone-related injuries, support early identification of high-risk patients, and inform future strategies for surgical management, antimicrobial therapy, and infection prevention in combat trauma. Ultimately, the study aims to improve limb salvage, reduce infectious complications, and enhance outcomes for patients with severe drone-related injuries.",[26,27,28,29,30,31,32],"Combat Related Symptoms","Combat Trauma","Infection","Infection Complication","Wound - in Medical Care","Wound Infection Post-Traumatic","Surgical Site Infection (SSI)",[34,27,35,36,37,38,39,40,41],"Drone-Related Injury","Tissue Devitalization","Wound Infection","Severe Wound Infection","Surgical Site Infection","Multidrug-Resistant Organisms","Antimicrobial Resistance","Soft Tissue Injury","NOT_YET_RECRUITING","2026-07-11",{"date":45,"type":46},"2026-07-16","ACTUAL",{"date":48,"type":22},"2026-10-23",{"date":48,"type":22},{"name":51,"class":52},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":5},"100640278","botulinum-toxin-type-a-versus-local-anesthetic-injection-for-chronic-neuroma-pain-after-combat-related-amputation-100640278","NCT07626983","Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation","Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation: A Multicenter Randomized Double-Blind Trial","NEUROQUIET","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Persistent neuroma pain lasting ≥3 months\n* Ultrasound-confirmed neuroma\n* Positive Tinel sign over the neuroma\n* Average pain intensity ≥4\u002F10 on the Numeric Rating Scale (NRS)\n* Stable analgesic regimen for at least 14 days before enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at the injection site\n* Previous botulinum toxin injection within 6 months\n* Previous neuroma surgery within 3 months\n* Severe uncontrolled psychiatric disorder\n* Coagulopathy or anticoagulant therapy contraindicating injection\n* Known allergy to botulinum toxin or local anesthetics\n* Severe uncontrolled systemic disease\n* Inability to complete study follow-up or questionnaires",{"count":63,"type":22},100,"INTERVENTIONAL",[66],"NA","Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life. Current treatment options often provide only temporary relief. This study aims to compare two ultrasound-guided injection approaches for chronic neuroma pain after combat-related amputation: botulinum toxin type A and local anesthetic injection.\n\nParticipants will be randomly assigned to receive one of the two treatments. Pain intensity, neuropathic pain symptoms, phantom limb pain, prosthesis tolerance, and functional outcomes will be evaluated during follow-up visits over a 24-week period.\n\nThe goal of the study is to determine whether botulinum toxin type A provides longer-lasting pain reduction and improved functional recovery compared with local anesthetic injection in patients with chronic neuroma pain after combat-related amputation.",[69,70,71,72,26],"Chronic Pain Due to Injury","Neuroma of Lower Limb","Neural Injury","Neuroma of Upper Limb",[74,75,76,77,78,79,80,81,82,83,84],"Neuroma pain","Combat-related amputation","Botulinum toxin type A","Local anesthetic injection","Ultrasound-guided injection","Phantom limb pain","Residual limb pain","Neuropathic pain","Military trauma","Chronic post-amputation pain","Ultrasound-guided pain intervention","2026-05-30",{"date":87,"type":46},"2026-06-04",{"date":85,"type":22},{"date":90,"type":22},"2026-12-15",{"name":51,"class":52}]